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triamcinolone diacetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids not used as glucocorticosteroids | 2727 | 67-78-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
lysyl oxidase antagonist; Polcortolon may also refers to triamcinolone
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,SYK,TEK | 21 | |||
| kinase-selectivity-class | AXL,GRK2,MAP2K6 | 3 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 12, 1959 | FDA | SANDOZ |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Psoriasis | 67.99 | 47.80 | 26 | 428 | 147728 | 90480265 |
| Skin discolouration | 48.66 | 47.80 | 15 | 439 | 44300 | 90583693 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drug |
| CHEBI has role | CHEBI:35480 | analgesic |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:50177 | dermatologic drug |
| CHEBI has role | CHEBI:50748 | antipsoriatic |
| CHEBI has role | CHEBI:50857 | anti-allergic agent |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
| CHEBI has role | CHEBI:67079 | anti-inflammatory agent |
| CHEBI has role | CHEBI:77715 | nasal decongestant |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Disorder of musculoskeletal system | indication | 928000 | DOID:17 |
| Cerebral edema | indication | 2032001 | |
| Lichen planus | indication | 4776004 | DOID:9201 |
| Berylliosis | indication | 8247009 | DOID:10322 |
| Psoriasis | indication | 9014002 | DOID:8893 |
| Ankylosing spondylitis | indication | 9631008 | DOID:7147 |
| Rheumatic heart disease | indication | 23685000 | |
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
| Inflammatory bowel disease | indication | 24526004 | DOID:0050589 |
| Multiple sclerosis | indication | 24700007 | DOID:2377 |
| Severe adrenal insufficiency | indication | 24867002 | |
| Sarcoidosis | indication | 31541009 | DOID:11335 |
| Idiopathic thrombocytopenic purpura | indication | 32273002 | DOID:8924 |
| Psoriasis with arthropathy | indication | 33339001 | |
| Keloid scar | indication | 33659008 | |
| Crohn's disease | indication | 34000006 | |
| Tendinitis | indication | 34840004 | DOID:971 |
| Erythema multiforme | indication | 36715001 | |
| Contact dermatitis | indication | 40275004 | DOID:2773 |
| Angioedema | indication | 41291007 | DOID:1558 |
| Miliary tuberculosis | indication | 47604008 | DOID:9861 |
| Humoral hypercalcemia of malignancy | indication | 47709007 | |
| Articular gout | indication | 48440001 | DOID:13189 |
| Edema of larynx | indication | 51599000 | |
| Nephrotic syndrome | indication | 52254009 | DOID:1184 |
| Lichen simplex chronicus | indication | 53891004 | |
| Systemic lupus erythematosus | indication | 55464009 | DOID:9074 |
| Allergic rhinitis | indication | 61582004 | |
| Löffler's syndrome | indication | 64936001 | DOID:9503 |
| Pemphigus | indication | 65172003 | DOID:9182 |
| Granuloma annulare | indication | 65508009 | DOID:3777 |
| Tenosynovitis | indication | 67801009 | DOID:970 |
| Alopecia areata | indication | 68225006 | DOID:986 |
| Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
| Transfusion reaction due to serum protein reaction | indication | 72284000 | |
| Epicondylitis | indication | 73583000 | DOID:14087 |
| Acquired thrombocytopenia | indication | 74576004 | DOID:11126 |
| Thyroiditis | indication | 82119001 | DOID:7166 |
| Bursitis | indication | 84017003 | DOID:2965 |
| Autoimmune disease | indication | 85828009 | |
| Infection by larvae of Trichinella spiralis | indication | 88264003 | |
| Congenital hypoplastic anemia | indication | 88854002 | DOID:1339 |
| Acute lymphoid leukemia | indication | 91857003 | DOID:9952 |
| Disorder of skin | indication | 95320005 | DOID:37 |
| Subacute bursitis | indication | 109298000 | |
| Dermatitis herpetiformis | indication | 111196000 | DOID:8505 |
| Hodgkin's disease | indication | 118599009 | |
| Non-Hodgkin's lymphoma | indication | 118601006 | |
| Mycosis fungoides | indication | 118618005 | |
| Aspiration pneumonitis | indication | 155597006 | |
| Asthma | indication | 195967001 | DOID:2841 |
| Discoid lupus erythematosus | indication | 200938002 | |
| Plaque psoriasis | indication | 200965009 | |
| Transplanted organ rejection | indication | 213148006 | |
| Congenital adrenal hyperplasia | indication | 237751000 | |
| Adrenogenital disorder | indication | 267395000 | DOID:0050811 |
| Eruption of skin | indication | 271807003 | DOID:0050486 |
| Follicular non-Hodgkin's lymphoma | indication | 308121000 | |
| Disorder of eye | indication | 371405004 | DOID:5614 |
| Primary adrenocortical insufficiency | indication | 373662000 | |
| Adrenal cortical hypofunction | indication | 386584007 | DOID:10493 |
| Erythroderma | indication | 399992009 | |
| Juvenile rheumatoid arthritis | indication | 410795001 | |
| Autoimmune hemolytic anemia | indication | 413603009 | DOID:718 |
| Synovitis | indication | 416209007 | DOID:2703 |
| Post traumatic osteoarthritis | indication | 699262001 | |
| Synovitis due to Osteoarthritis | indication | ||
| Transfusion Reaction Urticaria | indication | ||
| Systemic Dermatomyositis | indication | ||
| Cystic Aponeurosis Tumor | indication | ||
| Diagnostic Test for Cushing's Syndrome | indication | ||
| Erythroblastic Anemia | indication | ||
| Pericarditis | off-label use | 3238004 | DOID:1787 |
| Chronic obstructive lung disease | off-label use | 13645005 | DOID:3083 |
| West syndrome | off-label use | 28055006 | |
| Vasculitis | off-label use | 31996006 | DOID:865 |
| Bronchitis | off-label use | 32398004 | DOID:6132 |
| Eczema | off-label use | 43116000 | |
| Respiratory distress syndrome in the newborn | off-label use | 46775006 | |
| Nasal polyp | off-label use | 52756005 | |
| Rheumatic fever | off-label use | 58718002 | DOID:1586 |
| Pseudogout | off-label use | 60782007 | |
| Polymyalgia rheumatica | off-label use | 65323003 | DOID:853 |
| Chronic hepatitis | off-label use | 76783007 | DOID:2237 |
| Pemphigoid | off-label use | 86142006 | |
| Hepatic necrosis | off-label use | 87248009 | |
| Multiple myeloma | off-label use | 109989006 | DOID:9538 |
| Polyarteritis nodosa | off-label use | 155441006 | DOID:9810 |
| Celiac disease | off-label use | 396331005 | DOID:10608 |
| Carditis | off-label use | 399617002 | |
| Giant cell arteritis | off-label use | 414341000 | DOID:13375 |
| Hypercalcemia associated with Sarcoidosis | off-label use | ||
| Neonatal Bronchopulmonary Dysplasia | off-label use | ||
| Infection by Strongyloides | contraindication | 1214006 | DOID:10955 |
| Mycosis | contraindication | 3218000 | DOID:1564 |
| Gastritis | contraindication | 4556007 | DOID:4029 |
| Inactive tuberculosis | contraindication | 11999007 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Hypercholesterolemia | contraindication | 13644009 | |
| Measles | contraindication | 14189004 | DOID:8622 |
| Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
| Arginase deficiency | contraindication | 23501004 | DOID:9278 |
| Immunosuppression | contraindication | 38013005 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Infectious disease | contraindication | 40733004 | |
| Hypothyroidism | contraindication | 40930008 | DOID:1459 |
| Hypokalemia | contraindication | 43339004 | |
| Chronic heart failure | contraindication | 48447003 | |
| Cerebral malaria | contraindication | 53622003 | DOID:14069 |
| Tuberculosis | contraindication | 56717001 | |
| Congenital hyperammonemia, type I | contraindication | 62522004 | |
| Osteoporosis | contraindication | 64859006 | DOID:11476 |
| Psychotic disorder | contraindication | 69322001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Hypopituitarism | contraindication | 74728003 | DOID:9406 |
| Hyperglycemia | contraindication | 80394007 | DOID:4195 |
| Ornithine Carbamyltransferase Deficiency | contraindication | 80908008 | DOID:9271 |
| Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
| Muscle atrophy | contraindication | 88092000 | DOID:767 |
| Herpes simplex | contraindication | 88594005 | DOID:8566 |
| Bilateral cataracts | contraindication | 95722004 | |
| Seizure disorder | contraindication | 128613002 | |
| Disorder of muscle | contraindication | 129565002 | DOID:423 |
| Ophthalmic herpes simplex | contraindication | 186542001 | |
| Anastomosis of intestine | contraindication | 235407009 | |
| Edema | contraindication | 267038008 | |
| Pathological fracture | contraindication | 268029009 | |
| Diverticulitis of gastrointestinal tract | contraindication | 271366000 | |
| Cerebral trauma | contraindication | 275382005 | |
| Varicella-zoster virus infection | contraindication | 309465005 | |
| Osteopenia | contraindication | 312894000 | |
| Avascular necrosis of bone | contraindication | 397758007 | DOID:10159 |
| Citrullinemia | contraindication | 398680004 | DOID:9273 |
| Traumatic rupture of tendon | contraindication | 415749005 | |
| Exposure to varicella | contraindication | 444453009 | |
| Arginosuccinate Lyase Deficiency | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.57 | acidic |
| pKa2 | 12.44 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017598 | VUID |
| N0000178996 | NUI |
| D00984 | KEGG_DRUG |
| 4017598 | VANDF |
| 4017599 | VANDF |
| C0040867 | UMLSCUI |
| CHEBI:9669 | CHEBI |
| CHEMBL1200449 | ChEMBL_ID |
| C030262 | MESH_SUPPLEMENTAL_RECORD_UI |
| A73MM2Q32P | UNII |
| 6216 | PUBCHEM_CID |
| 10759 | RXNORM |
| 3078 | MMSL |
| 4582 | MMSL |
| 5613 | MMSL |
| 5615 | MMSL |
| d00620 | MMSL |
| 002188 | NDDF |
| 002190 | NDDF |
| 016282 | NDDF |
| 116594009 | SNOMEDCT_US |
| 116595005 | SNOMEDCT_US |
| 6028009 | SNOMEDCT_US |
| C0040864 | UMLSCUI |
| DB00620 | DRUGBANK_ID |
| 31307 | PUBCHEM_CID |
| 755 | INN_ID |
| D014221 | MESH_DESCRIPTOR_UI |
| CHEBI:9667 | CHEBI |
| A73MM2Q32P | INXIGHT DRUGS |
Pharmaceutical products:
None