tolonium Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2701 92-31-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tolonium
  • dimethyltoluthionine chloride
  • tolazul
  • tolonium chloride
  • toluidine blue
A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.
  • Molecular weight: 270.37
  • Formula: C15H16N3S
  • CLOGP: 0.27
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 42.15
  • ALOGS: -2.99
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:51217 fluorochrome
CHEBI has role CHEBI:77178 histological dye
CHEBI has role CHEBI:33295 diagnostic agent
MeSH PA D003029 Coagulants
MeSH PA D004396 Coloring Agents
MeSH PA D006401 Hematologic Agents
MeSH PA D006490 Hemostatics
MeSH PA D006494 Heparin Antagonists

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.51 Basic
pKa2 3.89 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Microtubule-associated protein tau Structural Ki 7.16 CHEMBL
Zinc finger protein mex-5 Cytosolic other EC50 4.45 CHEMBL

External reference:

IDSource
N0000167280 NUI
C0040380 UMLSCUI
15XUH0X66N UNII
231 INN_ID
CHEBI:87647 CHEBI
CHEMBL1197206 ChEMBL_ID
3209-30-1 SECONDARY_CAS_RN
7084 PUBCHEM_CID
D014048 MESH_DESCRIPTOR_UI
CHEMBL1622638 ChEMBL_ID
CHEMBL1790006 ChEMBL_ID
417083005 SNOMEDCT_US
29522004 SNOMEDCT_US
10638 RXNORM
NOCODE MMSL
002095 NDDF

Pharmaceutical products:

None