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tolonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quaternary ammonium compounds | 2701 | 92-31-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 2.808 | Moderate | 0.66 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.551 | Moderate | 0.66 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 73.621 | 10^-6 cm/s | Moderate | 0.66 |
| dh-clint | Dog hepatocyte intrinsic clearance | 161.436 | uL/min/10^6 cells | Moderate | 0.66 |
| dppb | Dog plasma protein binding (% unbound) | 5.240 | % | Moderate | 0.66 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 20.190 | % | Moderate | 0.66 |
| herg | hERG pIC50 | 4.434 | pIC50 | Moderate | 0.66 |
| hh-clint | Human hepatocyte intrinsic clearance | 114.551 | uL/min/10^6 cells | Moderate | 0.66 |
| hlm-clint | Human liver microsomal intrinsic clearance | 247.742 | uL/min/mg protein | Moderate | 0.66 |
| hppb | Human plasma protein binding (% unbound) | 3.020 | % | Moderate | 0.66 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 1.698 | Moderate | 0.66 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 609.537 | Moderate | 0.66 | |
| mppb | Mouse plasma protein binding (% unbound) | 5.030 | Moderate | 0.66 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.906 | Moderate | 0.66 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 10.820 | % | Moderate | 0.66 |
| rh-clint | Rat hepatocyte intrinsic clearance | 179.061 | uL/min/10^6 cells | Moderate | 0.66 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 69.860 | % | Moderate | 0.66 |
| rppb | Rat plasma protein binding (% unbound) | 3.390 | % | Moderate | 0.66 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 36.559 | uM | Moderate | 0.66 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D003029 | Coagulants |
| MeSH PA | D004396 | Coloring Agents |
| MeSH PA | D006401 | Hematologic Agents |
| MeSH PA | D006490 | Hemostatics |
| MeSH PA | D006494 | Heparin Antagonists |
| CHEBI has role | CHEBI:33295 | diagnostic agent |
| CHEBI has role | CHEBI:51217 | fluorochrome |
| CHEBI has role | CHEBI:77178 | histological dye |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.51 | Basic |
| pKa2 | 3.89 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Microtubule-associated protein tau | Structural | Ki | 7.16 | CHEMBL | |||||
| Zinc finger protein mex-5 | Cytosolic other | EC50 | 4.45 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167280 | NUI |
| 3209-30-1 | SECONDARY_CAS_RN |
| 4040795 | VANDF |
| C0040380 | UMLSCUI |
| CHEMBL1622638 | ChEMBL_ID |
| CHEMBL1790006 | ChEMBL_ID |
| 7084 | PUBCHEM_CID |
| P3Y6XJA2D1 | UNII |
| 10638 | RXNORM |
| NOCODE | MMSL |
| 002095 | NDDF |
| 29522004 | SNOMEDCT_US |
| 417083005 | SNOMEDCT_US |
| D014048 | MESH_DESCRIPTOR_UI |
| CHEBI:87647 | CHEBI |
| 231 | INN_ID |
| 56109-24-1 | SECONDARY_CAS_RN |
Pharmaceutical products:
None