tolonium Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2701 92-31-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tolonium
  • dimethyltoluthionine chloride
  • tolazul
  • tolonium chloride
  • toluidine blue
A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.
  • Molecular weight: 270.37
  • Formula: C15H16N3S
  • CLOGP: 0.27
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 42.15
  • ALOGS: -2.99
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003029 Coagulants
MeSH PA D004396 Coloring Agents
MeSH PA D006401 Hematologic Agents
MeSH PA D006490 Hemostatics
MeSH PA D006494 Heparin Antagonists
CHEBI has role CHEBI:33295 diagnostic aid
CHEBI has role CHEBI:51217 fluorochromes
CHEBI has role CHEBI:77178 histological stain

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.51 Basic
pKa2 3.89 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Microtubule-associated protein tau Structural Ki 7.16 CHEMBL
Zinc finger protein mex-5 Cytosolic other EC50 4.45 CHEMBL

External reference:

IDSource
N0000167280 NUI
4040795 VANDF
C0040380 UMLSCUI
CHEBI:87647 CHEBI
CHEMBL1197206 ChEMBL_ID
CHEMBL1622638 ChEMBL_ID
CHEMBL1790006 ChEMBL_ID
7084 PUBCHEM_CID
231 INN_ID
56109-24-1 SECONDARY_CAS_RN
P3Y6XJA2D1 UNII
10638 RXNORM
NOCODE MMSL
002095 NDDF
29522004 SNOMEDCT_US
417083005 SNOMEDCT_US
D014048 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None