tibolone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anabolic steroids 2655 5630-53-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tibolone
  • liviella
  • xyvion
used in prevention of postmenopausal osteoporosis
  • Molecular weight: 312.45
  • Formula: C21H28O2
  • CLOGP: 2.97
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -4.64
  • ROTB: 0

Drug dosage:

DoseUnitRoute
2.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1988 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03CX01 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
ESTROGENS
Other estrogens
MeSH PA D045930 Anabolic Agents
MeSH PA D000726 Androgen Antagonists
MeSH PA D000959 Antihypertensive Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D002317 Cardiovascular Agents
MeSH PA D020847 Estrogen Receptor Modulators
MeSH PA D006727 Hormone Antagonists
MeSH PA D006728 Hormones
CHEBI has role CHEBI:50646 anti-osteoporotics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Postmenopausal osteoporosis indication 102447009

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter Ki 7.32 DRUG MATRIX
Estrogen receptor Nuclear hormone receptor Ki 6.91 DRUG MATRIX
Androgen receptor Nuclear hormone receptor WOMBAT-PK
Progesterone receptor Nuclear hormone receptor WOMBAT-PK
Cytochrome P450 2C19 Enzyme IC50 5.52 DRUG MATRIX
Steryl-sulfatase Enzyme WOMBAT-PK
Androgen receptor Transcription factor Ki 7.12 DRUG MATRIX
Progesterone receptor Transcription factor Ki 7.54 DRUG MATRIX

External reference:

IDSource
4025274 VUID
N0000179266 NUI
D01639 KEGG_DRUG
4025274 VANDF
C0076660 UMLSCUI
CHEBI:32223 CHEBI
CHEMBL2103774 ChEMBL_ID
DB09070 DRUGBANK_ID
C027385 MESH_SUPPLEMENTAL_RECORD_UI
444008 PUBCHEM_CID
9711 IUPHAR_LIGAND_ID
2777 INN_ID
FF9X0205V2 UNII
225594 RXNORM
004056 NDDF
325567003 SNOMEDCT_US
395903002 SNOMEDCT_US

Pharmaceutical products:

None