thiamphenicol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2624 | 15318-45-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A methylsulfonyl analog of CHLORAMPHENICOL. It is an antibiotic and immunosuppressive agent.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1.50 | g | O |
| 1.50 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 120.31 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01BA02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE AMPHENICOLS Amphenicols |
| ATC | J01BA52 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE AMPHENICOLS Amphenicols |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| CHEBI has role | CHEBI:33281 | antibiotics |
| CHEBI has role | CHEBI:35705 | immunosuppressive agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.75 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cytochrome P450 2C19 | Enzyme | IC50 | 5.12 | WOMBAT-PK | |||||
| 50S ribosomal protein L10 | Ribosomal protein | WOMBAT-PK | |||||||
| Streptokinase A | Enzyme | EC50 | 5.77 | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| N0000166816 | NUI |
| D01407 | KEGG_DRUG |
| C0039854 | UMLSCUI |
| CHEBI:32215 | CHEBI |
| TH8 | PDB_CHEM_ID |
| CHEMBL1236282 | ChEMBL_ID |
| DB08621 | DRUGBANK_ID |
| D013839 | MESH_DESCRIPTOR_UI |
| 27200 | PUBCHEM_CID |
| 12400 | IUPHAR_LIGAND_ID |
| 935 | INN_ID |
| FLQ7571NPM | UNII |
| 10463 | RXNORM |
| 005347 | NDDF |
| 363552000 | SNOMEDCT_US |
| 713763007 | SNOMEDCT_US |
Pharmaceutical products:
None