testolactone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2606 968-93-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • teslac
  • testolactone
  • fludestrin
  • teolit
  • testolacton
An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.
  • Molecular weight: 300.40
  • Formula: C19H24O3
  • CLOGP: 2.63
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 43.37
  • ALOGS: -4.12
  • ROTB: 0

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.03 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 13.88 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
June 3, 1969 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175080 Aromatase Inhibitors
FDA EPC N0000175563 Aromatase Inhibitor
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Carcinoma of female breast indication 447782002

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Aromatase Enzyme INHIBITOR Ki 4.46 IUPHAR CHEMBL

External reference:

IDSource
4017729 VUID
N0000146097 NUI
D00153 KEGG_DRUG
4017729 VANDF
C1527155 UMLSCUI
CHEBI:9460 CHEBI
CHEMBL1571 ChEMBL_ID
D013738 MESH_DESCRIPTOR_UI
1839 INN_ID
DB00894 DRUGBANK_ID
6J9BLA949Q UNII
5407 PUBCHEM_CID
7303 IUPHAR_LIGAND_ID
10378 RXNORM
2376 MMSL
5551 MMSL
d01347 MMSL
002665 NDDF
404877009 SNOMEDCT_US
63999004 SNOMEDCT_US

Pharmaceutical products:

None