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tartaric acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2566 | 87-69-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -4.725 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 7.145 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 0.318 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 0.343 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 77.170 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 86.180 | % | High | 1 |
| herg | hERG pIC50 | 4.973 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 0.889 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.119 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 85.990 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 55 | |||
| kinase-selectivity-class | ACVRL1,AXL,BMX,BRAF,CDK4,CDK9,EIF2AK3,EPHB4,GRK2,JAK2,MAP2K6,MAP3K14,MAPK7,MAPK8,PIK3CD,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 | 21 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.338 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 0.859 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 99.450 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.274 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 95.400 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 0.824 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 92.770 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 95.060 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 792.501 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 7, 1985 | FDA | MALLINCKRODT INC |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:76924 | plant metabolites |
| CHEBI has role | CHEBI:76967 | human xenobiotic metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.83 | acidic |
| pKa2 | 4.3 | acidic |
| pKa3 | 12.43 | acidic |
| pKa4 | 12.97 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4017886 | VUID |
| N0000146239 | NUI |
| D00103 | KEGG_DRUG |
| 4017886 | VANDF |
| C1289966 | UMLSCUI |
| TLA | PDB_CHEM_ID |
| CHEMBL1236315 | ChEMBL_ID |
| DB09459 | DRUGBANK_ID |
| 444305 | PUBCHEM_CID |
| C029768 | MESH_SUPPLEMENTAL_RECORD_UI |
| W4888I119H | UNII |
| 37578 | RXNORM |
| 15456 | MMSL |
| NOCODE | MMSL |
| d07118 | MMSL |
| 001957 | NDDF |
| 109233007 | SNOMEDCT_US |
| 421487007 | SNOMEDCT_US |
| CHEBI:15671 | CHEBI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| 1 Detoxification | HUMAN OTC DRUG LABEL | 81 | 55146-011 | LIQUID | 30 [hp_X] | ORAL | unapproved homeopathic | 9 sections |
| BICARUVAS | HUMAN OTC DRUG LABEL | 4 | 69728-0001 | POWDER, FOR SOLUTION | 2 g | ORAL | OTC monograph final | 11 sections |
| BICARUVAS | HUMAN OTC DRUG LABEL | 4 | 69728-0002 | POWDER, FOR SOLUTION | 220 mg | ORAL | OTC monograph final | 11 sections |
| BICARUVAS | HUMAN OTC DRUG LABEL | 4 | 69728-0003 | POWDER, FOR SOLUTION | 2 g | ORAL | OTC monograph final | 11 sections |
| Retinol plus AHA Cream | HUMAN OTC DRUG LABEL | 15 | 84785-0008 | SOLUTION | 0.30 mg | TOPICAL | OTC Monograph Drug | 8 sections |