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succimer 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| polymers | 2486 | 304-55-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 20 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| S (Water solubility) | 288 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKC,AXL,BMX,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHUK,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT1,FLT3,FLT4,GRK2,GRK3,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM1,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 | 78 | |||
| kinase-selectivity-class | AXL,BMX,BRAF,CDK4,CDK9,EIF2AK3,EPHB4,GRK2,JAK2,MAP2K6,MAP3K14,MAPK7,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 | 18 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 30, 1991 | FDA | RECORDATI RARE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000931 | Antidotes |
| MeSH PA | D002614 | Chelating Agents |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D064449 | Sequestering Agents |
| FDA MoA | N0000175962 | Lead Chelating Activity |
| FDA EPC | N0000175963 | Lead Chelator |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:38161 | chelator |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Accidental poisoning by lead and its compounds and fumes | indication | 216777009 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.29 | acidic |
| pKa2 | 3.76 | acidic |
| pKa3 | 9.66 | acidic |
| pKa4 | 11.78 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4019174 | VUID |
| N0000147417 | NUI |
| D00572 | KEGG_DRUG |
| 4019174 | VANDF |
| C0012384 | UMLSCUI |
| CHEBI:63623 | CHEBI |
| CHEMBL1201073 | ChEMBL_ID |
| DB00566 | DRUGBANK_ID |
| D004113 | MESH_DESCRIPTOR_UI |
| 2724354 | PUBCHEM_CID |
| 4621 | INN_ID |
| DX1U2629QE | UNII |
| 3446 | RXNORM |
| 194288 | MMSL |
| 5516 | MMSL |
| NOCODE | MMSL |
| d01417 | MMSL |
| 003583 | NDDF |
| 109104002 | SNOMEDCT_US |
| 397224000 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Chemet | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55292-201 | CAPSULE | 100 mg | ORAL | NDA | 29 sections |
| NephroScan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71083-0020 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | NDA | 24 sections |