succimer 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
polymers 2486 304-55-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • succimer
  • meso-2,3-Dimercaptosuccinic acid
  • meso-Dimercaptosuccinic acid
A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.
  • Molecular weight: 182.21
  • Formula: C4H6O4S2
  • CLOGP: -1.48
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 74.60
  • ALOGS: -1.87
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 20 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 288 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKC,AXL,BMX,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHUK,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT1,FLT3,FLT4,GRK2,GRK3,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM1,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 78
kinase-selectivity-class AXL,BMX,BRAF,CDK4,CDK9,EIF2AK3,EPHB4,GRK2,JAK2,MAP2K6,MAP3K14,MAPK7,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 18
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Jan. 30, 1991 FDA RECORDATI RARE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000931 Antidotes
MeSH PA D002614 Chelating Agents
MeSH PA D020011 Protective Agents
MeSH PA D064449 Sequestering Agents
FDA MoA N0000175962 Lead Chelating Activity
FDA EPC N0000175963 Lead Chelator
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:38161 chelator

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Accidental poisoning by lead and its compounds and fumes indication 216777009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.29 acidic
pKa2 3.76 acidic
pKa3 9.66 acidic
pKa4 11.78 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019174 VUID
N0000147417 NUI
D00572 KEGG_DRUG
4019174 VANDF
C0012384 UMLSCUI
CHEBI:63623 CHEBI
CHEMBL1201073 ChEMBL_ID
DB00566 DRUGBANK_ID
D004113 MESH_DESCRIPTOR_UI
2724354 PUBCHEM_CID
4621 INN_ID
DX1U2629QE UNII
3446 RXNORM
194288 MMSL
5516 MMSL
NOCODE MMSL
d01417 MMSL
003583 NDDF
109104002 SNOMEDCT_US
397224000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Chemet HUMAN PRESCRIPTION DRUG LABEL 1 55292-201 CAPSULE 100 mg ORAL NDA 29 sections
NephroScan HUMAN PRESCRIPTION DRUG LABEL 1 71083-0020 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 mg INTRAVENOUS NDA 24 sections