sorivudine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
uridine derivatives used as antiviral agents and as antineoplastics 2463 77181-69-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sorivudine
  • brovavir
  • bravavir
  • Molecular weight: 349.14
  • Formula: C11H13BrN2O6
  • CLOGP: -1.15
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 4
  • TPSA: 119.33
  • ALOGS: -1.37
  • ROTB: 3

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 65 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,ZAP70 40
kinase-selectivity-class AXL,CDK16,CDK9,GRK2,MAP2K6,MAP3K14,PDK1,TEK,ZAP70 9
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents
MeSH PA D004791 Enzyme Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.1 acidic
pKa2 12.34 acidic
pKa3 12.78 acidic
pKa4 13.38 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thymidine kinase, mitochondrial Kinase Ki 4.98 CHEMBL
Thymidine kinase Kinase IC50 5.44 CHEMBL
Thymidine kinase Kinase IC50 5.49 CHEMBL
Deoxynucleoside kinase Kinase IC50 4.55 CHEMBL

External reference:

IDSource
D01734 KEGG_DRUG
C0207628 UMLSCUI
CHEBI:32152 CHEBI
CHEMBL70046 ChEMBL_ID
DB11998 DRUGBANK_ID
C031368 MESH_SUPPLEMENTAL_RECORD_UI
5282192 PUBCHEM_CID
6695 INN_ID
C7VOZ162LV UNII

Pharmaceutical products:

None