riboflavin phosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2374 | 130-40-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 20, 1953 | FDA | HOSPIRA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Corneal thinning | 24.15 | 19.64 | 4 | 1974 | 109 | 63486935 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Corneal epithelium defect | 109.50 | 24.63 | 17 | 912 | 362 | 34955640 |
| Corneal infiltrates | 107.56 | 24.63 | 15 | 914 | 146 | 34955856 |
| Corneal opacity | 102.09 | 24.63 | 17 | 912 | 569 | 34955433 |
| Corneal scar | 83.35 | 24.63 | 12 | 917 | 149 | 34955853 |
| Ulcerative keratitis | 43.93 | 24.63 | 10 | 919 | 1719 | 34954283 |
| Corneal oedema | 40.80 | 24.63 | 9 | 920 | 1342 | 34954660 |
| Keratitis | 40.16 | 24.63 | 9 | 920 | 1442 | 34954560 |
| Corneal thinning | 30.79 | 24.63 | 5 | 924 | 142 | 34955860 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Corneal infiltrates | 101.59 | 19.42 | 16 | 2641 | 294 | 79741437 |
| Corneal opacity | 94.99 | 19.42 | 18 | 2639 | 1002 | 79740729 |
| Corneal epithelium defect | 62.65 | 19.42 | 12 | 2645 | 707 | 79741024 |
| Corneal scar | 58.85 | 19.42 | 10 | 2647 | 298 | 79741433 |
| Corneal thinning | 41.96 | 19.42 | 7 | 2650 | 186 | 79741545 |
| Keratitis | 32.57 | 19.42 | 10 | 2647 | 4312 | 79737419 |
| Ulcerative keratitis | 25.54 | 19.42 | 8 | 2649 | 3681 | 79738050 |
| Corneal oedema | 23.79 | 19.42 | 7 | 2650 | 2613 | 79739118 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D018977 | Micronutrients |
| MeSH PA | D014803 | Vitamin B Complex |
| MeSH PA | D014815 | Vitamins |
| CHEBI has role | CHEBI:23354 | coenzymes |
| CHEBI has role | CHEBI:23357 | cofactor |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.57 | acidic |
| pKa2 | 6.62 | acidic |
| pKa3 | 10.13 | acidic |
| pKa4 | 12.34 | acidic |
| pKa5 | 13.19 | acidic |
| pKa6 | 2.49 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4017670 | VUID |
| N0000178985 | NUI |
| D01622 | KEGG_DRUG |
| 4017670 | VANDF |
| 4017770 | VANDF |
| C0016388 | UMLSCUI |
| CHEBI:32098 | CHEBI |
| FMN | PDB_CHEM_ID |
| CHEMBL1201794 | ChEMBL_ID |
| 643976 | PUBCHEM_CID |
| DB03247 | DRUGBANK_ID |
| CHEMBL3989697 | ChEMBL_ID |
| 5185 | IUPHAR_LIGAND_ID |
| 1925820 | RXNORM |
| 31895 | MMSL |
| 001060 | NDDF |
| 014666 | NDDF |
| 442346000 | SNOMEDCT_US |
| 53499005 | SNOMEDCT_US |
| D005486 | MESH_DESCRIPTOR_UI |
| 6184-17-4 | SECONDARY_CAS_RN |
| 20RD1DZH99 | UNII |
| 7N464URE7E | UNII |
| 957E53WV42 | UNII |
Pharmaceutical products:
None