DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
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Smart API
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
ramatroban 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
thromboxane A2-receptor antagonists; antithrombotic agents
2354
116649-85-5
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
ramatroban
baynas
thromboxane A2 receptor antagonist; BAY u 3405 & 3406 are enantiomers of each other
Molecular weight: 416.47
Formula: C21H21FN2O4S
CLOGP: 3.97
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 88.40
ALOGS: -4.26
ROTB: 5
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
MeSH PA
D006401
Hematologic Agents
MeSH PA
D010975
Platelet Aggregation Inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Allergic rhinitis
indication
61582004
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
4.2
acidic
pKa2
9.56
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Thromboxane A2 receptor
GPCR
P21731
TA2R_HUMAN
INVERSE AGONIST
Ki
9.24
CHEMBL
KEGG DRUG
Prostaglandin D2 receptor 2
GPCR
Q9Y5Y4
PD2R2_HUMAN
Ki
8.37
CHEMBL
Prostaglandin D2 receptor
GPCR
Q13258
PD2R_HUMAN
Ki
4.96
CHEMBL
Prostaglandin D2 receptor 2
GPCR
PD2R2_RAT
ANTAGONIST
IC50
7.30
IUPHAR
Prostaglandin D2 receptor 2
GPCR
PD2R2_MOUSE
ANTAGONIST
Ki
7.30
IUPHAR
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External reference:
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ID
Source
A8X
PDB_CHEM_ID
123879
PUBCHEM_CID
1911
IUPHAR_LIGAND_ID
7273
INN_ID
C063119
MESH_SUPPLEMENTAL_RECORD_UI
C0753318
UMLSCUI
CHEBI:32087
CHEBI
CHEMBL361812
ChEMBL_ID
D01128
KEGG_DRUG
DB13036
DRUGBANK_ID
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Pharmaceutical products:
None
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ramatroban