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ramatroban 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| thromboxane A2-receptor antagonists; antithrombotic agents | 2354 | 116649-85-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
thromboxane A2 receptor antagonist; BAY u 3405 & 3406 are enantiomers of each other
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 0.418 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 5.728 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 12.942 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 4.677 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 3.790 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 6.440 | % | High | 1 |
| herg | hERG pIC50 | 4.536 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 6.516 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 5.458 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 2.930 | % | High | 1 |
| kinase-safety-class | ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK7,MAPKAPK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PRKDC,TEK,TGFBR1 | 23 | |||
| kinase-selectivity-class | AXL,GRK2,TEK | 3 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 4.764 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 22.284 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 5.090 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 7.161 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 6.840 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 21.429 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 66.870 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 3.080 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 935.406 | uM | High | 1 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D006401 | Hematologic Agents |
| MeSH PA | D010975 | Platelet Aggregation Inhibitors |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:65023 | anti-asthmatic agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Allergic rhinitis | indication | 61582004 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.2 | acidic |
| pKa2 | 9.56 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Thromboxane A2 receptor | GPCR | INVERSE AGONIST | Ki | 9.24 | CHEMBL | KEGG DRUG | |||
| Prostaglandin D2 receptor 2 | GPCR | Ki | 8.37 | CHEMBL | |||||
| Prostaglandin D2 receptor | GPCR | Ki | 4.96 | CHEMBL | |||||
| Prostaglandin D2 receptor 2 | GPCR | ANTAGONIST | IC50 | 7.30 | IUPHAR | ||||
| Prostaglandin D2 receptor 2 | GPCR | ANTAGONIST | Ki | 7.30 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D01128 | KEGG_DRUG |
| C0753318 | UMLSCUI |
| CHEBI:32087 | CHEBI |
| A8X | PDB_CHEM_ID |
| CHEMBL361812 | ChEMBL_ID |
| DB13036 | DRUGBANK_ID |
| C063119 | MESH_SUPPLEMENTAL_RECORD_UI |
| 123879 | PUBCHEM_CID |
| 1911 | IUPHAR_LIGAND_ID |
| 7273 | INN_ID |
| P1ALI72U6C | UNII |
| P1ALI72U6C | INXIGHT DRUGS |
Pharmaceutical products:
None