ramatroban 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| thromboxane A2-receptor antagonists; antithrombotic agents | 2354 | 116649-85-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
thromboxane A2 receptor antagonist; BAY u 3405 & 3406 are enantiomers of each other
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D006401 | Hematologic Agents |
| MeSH PA | D010975 | Platelet Aggregation Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Allergic rhinitis | indication | 61582004 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.2 | acidic |
| pKa2 | 9.56 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Thromboxane A2 receptor | GPCR | INVERSE AGONIST | Ki | 9.24 | CHEMBL | KEGG DRUG | |||
| Prostaglandin D2 receptor 2 | GPCR | Ki | 8.37 | CHEMBL | |||||
| Prostaglandin D2 receptor | GPCR | Ki | 4.96 | CHEMBL | |||||
| Prostaglandin D2 receptor 2 | GPCR | ANTAGONIST | IC50 | 7.30 | IUPHAR | ||||
| Prostaglandin D2 receptor 2 | GPCR | ANTAGONIST | Ki | 7.30 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D01128 | KEGG_DRUG |
| C0753318 | UMLSCUI |
| CHEBI:32087 | CHEBI |
| A8X | PDB_CHEM_ID |
| CHEMBL361812 | ChEMBL_ID |
| DB13036 | DRUGBANK_ID |
| C063119 | MESH_SUPPLEMENTAL_RECORD_UI |
| 123879 | PUBCHEM_CID |
| 1911 | IUPHAR_LIGAND_ID |
| 7273 | INN_ID |
| P1ALI72U6C | UNII |
Pharmaceutical products:
None