protokylol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2318 136-70-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • protochilolo
  • protokylol
  • caytine
  • protochylol
  • ventaire
  • protokylol hydrochloride
  • JB-251
  • protokylol HCl
  • asmetil
  • Molecular weight: 331.37
  • Formula: C18H21NO5
  • CLOGP: 1.69
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 91.18
  • ALOGS: -3.15
  • ROTB: 6
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IGF1R,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 65
kinase-selectivity-class ACVR2B,AXL,EIF2AK3,EPHB4,GRK2,MAP2K6 6
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.97 acidic
pKa2 12.82 acidic
pKa3 13.52 acidic
pKa4 8.15 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST CHEMBL CHEMBL

External reference:

IDSource
C0163026 UMLSCUI
CHEBI:135413 CHEBI
CHEMBL1201273 ChEMBL_ID
CHEMBL1200893 ChEMBL_ID
DB06814 DRUGBANK_ID
C010312 MESH_SUPPLEMENTAL_RECORD_UI
4969 PUBCHEM_CID
920 INN_ID
136-69-6 SECONDARY_CAS_RN
8Y5Y4EEO2V UNII
001781 NDDF
004719 NDDF
6260007 SNOMEDCT_US
782180003 SNOMEDCT_US
8Y5Y4EEO2V INXIGHT DRUGS

Pharmaceutical products:

None