proscillaridin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2313 466-06-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • proscillaridin
  • caradrin
  • cardiovite
  • procardin
  • desglucotransvaaline
  • scillacrist
  • proscillaridin A
A cardiotonic glycoside isolated from Scilla maritima var. alba (Squill).
  • Molecular weight: 530.66
  • Formula: C30H42O8
  • CLOGP: 2.55
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 4
  • TPSA: 125.68
  • ALOGS: -4.09
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.75 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.08 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 7 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1967 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01AB01 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC GLYCOSIDES
Scilla glycosides
ATC C01AB51 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC GLYCOSIDES
Scilla glycosides
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D020011 Protective Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.13 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter WOMBAT-PK
Sodium/potassium-transporting ATPase subunit alpha-2 Ion channel IC50 7.06 DRUG MATRIX

External reference:

IDSource
N0000168447 NUI
D01379 KEGG_DRUG
C0878454 UMLSCUI
CHEBI:32065 CHEBI
CHEMBL600325 ChEMBL_ID
D011442 MESH_DESCRIPTOR_UI
DB13307 DRUGBANK_ID
4951 PUBCHEM_CID
2242 INN_ID
KC6BL281EN UNII
8795 RXNORM
003759 NDDF

Pharmaceutical products:

None