proscillaridin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2313 | 466-06-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A cardiotonic glycoside isolated from Scilla maritima var. alba (Squill).
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.75 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.08 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 7 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1967 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01AB01 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC GLYCOSIDES Scilla glycosides |
| ATC | C01AB51 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC GLYCOSIDES Scilla glycosides |
| MeSH PA | D002316 | Cardiotonic Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D020011 | Protective Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.13 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium/potassium-transporting ATPase subunit alpha-1 | Transporter | WOMBAT-PK | |||||||
| Sodium/potassium-transporting ATPase subunit alpha-2 | Ion channel | IC50 | 7.06 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| N0000168447 | NUI |
| D01379 | KEGG_DRUG |
| C0033513 | UMLSCUI |
| CHEBI:32065 | CHEBI |
| CHEMBL600325 | ChEMBL_ID |
| D011442 | MESH_DESCRIPTOR_UI |
| DB13307 | DRUGBANK_ID |
| 2242 | INN_ID |
| KC6BL281EN | UNII |
| 5284613 | PUBCHEM_CID |
| 8795 | RXNORM |
| 003759 | NDDF |
Pharmaceutical products:
None