DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
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Structure ๐
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L1000
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
propiram ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
2299
15686-91-6
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
Bay 4503
dirame
propiram
propiram fumarate
Molecular weight: 275.40
Formula: C16H25N3O
CLOGP: 2.17
LIPINSKI: 0
HAC: 4
HDO: 0
TPSA: 36.44
ALOGS: -2.02
ROTB: 5
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)
9.08 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
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Approvals:
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Date
Agency
Company
Orphan
Jan. 1, 1980
YEAR INTRODUCED
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
8.47
Basic
pKa2
1.51
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Mu-type opioid receptor
GPCR
P35372
OPRM_HUMAN
AGONIST
WOMBAT-PK
SCIENTIFIC LITERATURE
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External reference:
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entries
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ID
Source
13717-04-9
SECONDARY_CAS_RN
2152
INN_ID
26216
PUBCHEM_CID
C002107
MESH_SUPPLEMENTAL_RECORD_UI
C0072205
UMLSCUI
CHEBI:135140
CHEBI
CHEMBL2106935
ChEMBL_ID
CHEMBL2110985
ChEMBL_ID
D05631
KEGG_DRUG
WT6247U6PX
UNII
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Pharmaceutical products:
None
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propiram