proflavine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| acridine derivatives | 2277 | 92-62-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Topical antiseptic used mainly in wound dressings.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000891 | Anti-Infective Agents, Local |
| CHEBI has role | CHEBI:23240 | chromophores |
| CHEBI has role | CHEBI:24853 | intercalating agents |
| CHEBI has role | CHEBI:33282 | bactericides |
| CHEBI has role | CHEBI:48218 | antiseptics |
| CHEBI has role | CHEBI:50903 | carcinogen |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Antiseptic preparation | indication | 261276004 | |
| Candidiasis of skin | off-label use | 49883006 | |
| Vaginal irritation | contraindication | 161816004 | |
| Aphthous ulcer of mouth | contraindication | 426965005 | DOID:9663 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.12 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Replicase polyprotein 1ab | Enzyme | IC50 | 5.84 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019908 | VUID |
| N0000147993 | NUI |
| 1811-28-5 | SECONDARY_CAS_RN |
| 553-30-0 | SECONDARY_CAS_RN |
| 4018859 | VANDF |
| 4018860 | VANDF |
| 4019908 | VANDF |
| C0033294 | UMLSCUI |
| CHEBI:8452 | CHEBI |
| PF | PDB_CHEM_ID |
| CHEMBL55400 | ChEMBL_ID |
| DB01123 | DRUGBANK_ID |
| D011370 | MESH_DESCRIPTOR_UI |
| 7099 | PUBCHEM_CID |
| 4181 | INN_ID |
| CY3RNB3K4T | UNII |
| 8723 | RXNORM |
| 12419 | MMSL |
| 002618 | NDDF |
| 002620 | NDDF |
| 395844000 | SNOMEDCT_US |
| 418275007 | SNOMEDCT_US |
| CHEMBL465704 | ChEMBL_ID |
| CHEMBL1964546 | ChEMBL_ID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Perineze Triple Dye | HUMAN OTC DRUG LABEL | 3 | 55739-1022 | SOLUTION | 1.14 mg | TOPICAL | OTC monograph not final | 10 sections |
| Kerr 100 Triple Dye Dispos-A | HUMAN OTC DRUG LABEL | 3 | 66689-710 | SWAB | 1.14 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 11 sections |
| Kerr 100 Triple Dye Dispos-A | HUMAN OTC DRUG LABEL | 3 | 66689-710 | SWAB | 1.14 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 11 sections |