proflavine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
acridine derivatives 2277 92-62-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • proflavine
  • proflavin
  • proflavine hemisulfate
  • proflavin hemisulfate
  • proflavin sulfate
  • proflavine sulfate
Topical antiseptic used mainly in wound dressings.
  • Molecular weight: 209.25
  • Formula: C13H11N3
  • CLOGP: 2.31
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 64.93
  • ALOGS: -3.30
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR1B,ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AURKB,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHA2,EPHB4,ERBB2,FGFR1,FLT3,GRK1,GRK2,GRK3,GSK3B,IKBKB,IRAK1,ITK,JAK1,JAK2,KDR,KIT,MAP2K1,MAP2K6,MAP3K1,MAP3K10,MAP3K11,MAP3K14,MAP3K21,MAP3K7,MAP3K8,MAP4K1,MAP4K3,MAP4K5,MAPK1,MAPK10,MAPK12,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MELK,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM1,PIM2,PLK1,PRKAA1,PRKAA2,PRKCD,PRKDC,SGK1,SIK2,SIK3,SRC,STK10,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 94
kinase-selectivity-class ACVR2A,AURKA,AURKB,AXL,CAMK2D,DYRK1B,GRK2,IKBKB,MAP2K3,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK12,MAPK7,MARK4,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 24
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
CHEBI has role CHEBI:23240 chromophores
CHEBI has role CHEBI:24853 intercalating agents
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:48218 antiseptics
CHEBI has role CHEBI:50903 carcinogen

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Antiseptic preparation indication 261276004
Candidiasis of skin off-label use 49883006
Vaginal irritation contraindication 161816004
Aphthous ulcer of mouth contraindication 426965005 DOID:9663




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.12 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Replicase polyprotein 1ab Enzyme IC50 5.84 CHEMBL

External reference:

IDSource
4019908 VUID
N0000147993 NUI
1811-28-5 SECONDARY_CAS_RN
553-30-0 SECONDARY_CAS_RN
4018859 VANDF
4018860 VANDF
4019908 VANDF
C0033294 UMLSCUI
CHEBI:8452 CHEBI
PF PDB_CHEM_ID
CHEMBL55400 ChEMBL_ID
DB01123 DRUGBANK_ID
CHEMBL465704 ChEMBL_ID
CHEMBL1964546 ChEMBL_ID
D011370 MESH_DESCRIPTOR_UI
7099 PUBCHEM_CID
4181 INN_ID
CY3RNB3K4T UNII
8723 RXNORM
12419 MMSL
002618 NDDF
002620 NDDF
395844000 SNOMEDCT_US
418275007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Perineze Triple Dye HUMAN OTC DRUG LABEL 3 55739-1022 SOLUTION 1.14 mg TOPICAL OTC monograph not final 10 sections