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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	2227	9005-65-6

Description:

Molecule	Description
Synonyms: polysorbate 80 polyethoxylated sorbitan monooleate	Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals. Molecular weight: Formula: C24H44O6(C2H4O)x(C2H4O)w(C2H4O)y(C2H4O)z CLOGP: 4.12 LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

polysorbate 80
polyethoxylated sorbitan monooleate

Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.

Molecular weight:
Formula: C24H44O6(C2H4O)x(C2H4O)w(C2H4O)y(C2H4O)z
CLOGP: 4.12
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D005079	Excipients
MeSH PA	D010592	Pharmaceutic Aids
MeSH PA	D013501	Surface-Active Agents
MeSH PA	D014677	Pharmaceutical Vehicles
CHEBI has role	CHEBI:38828	nonionic surfactant

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Tear film insufficiency	indication	46152009
Keratoconjunctivitis sicca	off-label use	302896008	DOID:12895

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4017948	VUID
N0000178958	NUI
D01067	KEGG_DRUG
4017948	VANDF
C0032601	UMLSCUI
CHEBI:53426	CHEBI
VCG	PDB_CHEM_ID
CHEMBL1697847	ChEMBL_ID
D011136	MESH_DESCRIPTOR_UI
DB11063	DRUGBANK_ID
6OZP39ZG8H	UNII
8560	RXNORM
NOCODE	MMSL
009865	NDDF
255899003	SNOMEDCT_US
411257002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Refresh Optive Mega-3 PF	HUMAN OTC DRUG LABEL	3	0023-3988	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH Optive Mega-3	HUMAN OTC DRUG LABEL	3	0023-4230	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4307	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4307	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4491	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC Monograph Drug	12 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4491	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC Monograph Drug	12 sections
REFRESH Optive Mega-3	HUMAN OTC DRUG LABEL	3	0023-5773	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
Refresh Digital	HUMAN OTC DRUG LABEL	3	0023-6952	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
Refresh Digital PF	HUMAN OTC DRUG LABEL	3	0023-6954	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH Optive Mega-3	HUMAN OTC DRUG LABEL	3	0023-7151	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
Endura	HUMAN PRESCRIPTION DRUG LABEL	2	0023-9235	SOLUTION/ DROPS	1 g	OPHTHALMIC	Export only	1 sections
RohtoCool Relief	HUMAN OTC DRUG LABEL	2	10742-8141	LIQUID	2 mg	OPHTHALMIC	OTC Monograph Drug	12 sections
RohtoCool	HUMAN OTC DRUG LABEL	2	10742-8142	LIQUID	2 mg	OPHTHALMIC	OTC Monograph Drug	12 sections
RohtoMax Strength	HUMAN OTC DRUG LABEL	2	10742-8158	LIQUID	2 mg	OPHTHALMIC	OTC Monograph Drug	12 sections
Avitears	HUMAN OTC DRUG LABEL	1	49869-002	SOLUTION/ DROPS	10 mg	TOPICAL	OTC monograph final	9 sections
Viva	HUMAN OTC DRUG LABEL	1	54891-001	SOLUTION/ DROPS	100 mg	OPHTHALMIC	OTC monograph final	8 sections
Clear Eyes Complete 7 Sympton Relief	HUMAN OTC DRUG LABEL	4	67172-707	LIQUID	1.25 mg	OPHTHALMIC	OTC Monograph Drug	15 sections
IV STABILIZER	HUMAN PRESCRIPTION DRUG LABEL	1	73380-4715	SOLUTION	6.50 mg	INTRAVENOUS	BLA	31 sections
Eyellic Eye Drops (Sterile)	HUMAN OTC DRUG LABEL	4	77684-899	SOLUTION/ DROPS	0.50 g	OPHTHALMIC	export only	14 sections
Droptics Dry Eye Relief	HUMAN OTC DRUG LABEL	3	85211-002	LIQUID	0.50 g	OPHTHALMIC	OTC Monograph Drug	8 sections

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polysorbate 80 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: