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plicamycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, produced by Streptomyces strains | 2223 | 18378-89-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,CAMK2D,CDK5,EIF2AK3,GRK2,ITK,MAP2K6,MAPK10,NTRK2,PDK1,PDK2,PRKDC | 12 | |||
| kinase-selectivity-class | PDK1 | 1 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 5, 1970 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01DC02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES Other cytotoxic antibiotics |
| MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
| MeSH PA | D000903 | Antibiotics, Antineoplastic |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D004396 | Coloring Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D005456 | Fluorescent Dyes |
| MeSH PA | D007202 | Indicators and Reagents |
| MeSH PA | D011500 | Protein Synthesis Inhibitors |
| MeSH PA | D019384 | Nucleic Acid Synthesis Inhibitors |
| MeSH PA | D049408 | Luminescent Agents |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:37416 | EC 2.7.7.6 (RNA polymerase) inhibitor |
| CHEBI has role | CHEBI:76969 | bacterial metabolite |
Related Drugs by ATC class:
L01DC Other cytotoxic antibiotics 3 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Malignant tumor of testis | indication | 363449006 | DOID:2998 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.75 | acidic |
| pKa2 | 6.99 | acidic |
| pKa3 | 11.08 | acidic |
| pKa4 | 13.24 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4018387 | VUID |
| N0000146714 | NUI |
| D00468 | KEGG_DRUG |
| 4018387 | VANDF |
| C0026234 | UMLSCUI |
| CHEBI:31856 | CHEBI |
| QWP | PDB_CHEM_ID |
| CHEMBL1237054 | ChEMBL_ID |
| CHEMBL2165714 | ChEMBL_ID |
| D008926 | MESH_DESCRIPTOR_UI |
| DB06810 | DRUGBANK_ID |
| C066851 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2029 | INN_ID |
| NIJ123W41V | UNII |
| 163659 | PUBCHEM_CID |
| 204253 | RXNORM |
| 1270 | MMSL |
| 5310 | MMSL |
| d01361 | MMSL |
| 002658 | NDDF |
| 18335001 | SNOMEDCT_US |
| 387101002 | SNOMEDCT_US |
| 8394 | IUPHAR_LIGAND_ID |
Pharmaceutical products:
None