anisindione ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
222 117-37-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anisindione
  • andion
  • miradon
  • unidone
a synthetic anticoagulant it exercises its therapeutic action by reducing the prothrombin activity of the blood by inhibiting the vitamin Kโ€“mediated gamma-carboxylation of precursor proteins
  • Molecular weight: 252.27
  • Formula: C16H12O3
  • CLOGP: 2.73
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 43.37
  • ALOGS: -4.30
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 5, 1957 FDA SCHERING

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:50249 anticoagulants
CHEBI has role CHEBI:55347 vitamin K antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

None




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.96 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin K-dependent gamma-carboxylase Enzyme INHIBITOR DRUGBANK CHEMBL
Arachidonate 5-lipoxygenase Enzyme IC50 5.04 CHEMBL

External reference:

IDSource
4018805 VUID
N0000147108 NUI
D07457 KEGG_DRUG
17941 RXNORM
C0051919 UMLSCUI
CHEBI:133809 CHEBI
CHEMBL712 ChEMBL_ID
DB01125 DRUGBANK_ID
C010679 MESH_SUPPLEMENTAL_RECORD_UI
2197 PUBCHEM_CID
6960 IUPHAR_LIGAND_ID
854 INN_ID
S747T1ERAJ UNII
1255 MMSL
4203 MMSL
d00519 MMSL
38122009 SNOMEDCT_US
397228002 SNOMEDCT_US
4018805 VANDF
002091 NDDF

Pharmaceutical products:

None