pirlindole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2206	60762-57-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

pyrlindole
pirlindole hydrochloride
pirlindole HCl
pirlindol
pyrazidol
pirlindole
pirlindole mesylate
pirlindole mesilate

Molecular weight: 226.32
Formula: C15H18N2
CLOGP: 3.27
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 16.96
ALOGS: -3.33
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000928	Antidepressive Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D008996	Monoamine Oxidase Inhibitors
MeSH PA	D011619	Psychotropic Drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Depressive disorder	indication	35489007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.43	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Amine oxidase [flavin-containing] A	Enzyme	P21397	AOFA_HUMAN	INHIBITOR	Ki	7.41		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Transcriptional enhancer factor TEF-3	Transcription factor	Q15561	TEAD4_HUMAN		IC50	4.44		CHEMBL
Transcriptional enhancer factor TEF-1	Transcription factor	P28347	TEAD1_HUMAN		Kd	4.92		CHEMBL
Transcriptional enhancer factor TEF-4	Transcription factor	Q15562	TEAD2_HUMAN		IC50	4.48		CHEMBL
Transcriptional enhancer factor TEF-5	Transcription factor	Q99594	TEAD3_HUMAN		IC50	4.36		CHEMBL

External reference:

ID	Source
D08392	KEGG_DRUG
16154-78-2	SECONDARY_CAS_RN
C0071143	UMLSCUI
CHEBI:91755	CHEBI
CHEMBL32350	ChEMBL_ID
DB09244	DRUGBANK_ID
68802	PUBCHEM_CID
C009830	MESH_SUPPLEMENTAL_RECORD_UI
6638	IUPHAR_LIGAND_ID
4615	INN_ID
V39YPH45FZ	UNII

Pharmaceutical products:

None