pirlindole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2206 60762-57-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pyrlindole
  • pirlindole hydrochloride
  • pirlindole HCl
  • pirlindol
  • pyrazidol
  • pirlindole
  • pirlindole mesylate
  • pirlindole mesilate
  • Molecular weight: 226.32
  • Formula: C15H18N2
  • CLOGP: 3.27
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 16.96
  • ALOGS: -3.33
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000928 Antidepressive Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D008996 Monoamine Oxidase Inhibitors
MeSH PA D011619 Psychotropic Drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.43 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Amine oxidase [flavin-containing] A Enzyme INHIBITOR Ki 7.41 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Transcriptional enhancer factor TEF-3 Transcription factor IC50 4.44 CHEMBL
Transcriptional enhancer factor TEF-1 Transcription factor Kd 4.92 CHEMBL
Transcriptional enhancer factor TEF-4 Transcription factor IC50 4.48 CHEMBL
Transcriptional enhancer factor TEF-5 Transcription factor IC50 4.36 CHEMBL

External reference:

IDSource
D08392 KEGG_DRUG
16154-78-2 SECONDARY_CAS_RN
C0071143 UMLSCUI
CHEBI:91755 CHEBI
CHEMBL32350 ChEMBL_ID
DB09244 DRUGBANK_ID
68802 PUBCHEM_CID
C009830 MESH_SUPPLEMENTAL_RECORD_UI
6638 IUPHAR_LIGAND_ID
4615 INN_ID
V39YPH45FZ UNII

Pharmaceutical products:

None