picrotin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2163 21416-53-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • picrotin
the less toxic component of picrotoxin lacking GABA activity
  • Molecular weight: 310.30
  • Formula: C15H18O7
  • CLOGP: -1.61
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 105.59
  • ALOGS: -1.10
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.46 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glycine receptor subunit alpha-1 Ion channel IC50 5.28 CHEMBL
Glycine receptor subunit alpha-2 Ion channel BLOCKER IC50 4.90 IUPHAR
Glycine receptor subunit beta Ion channel BLOCKER IC50 4.60 IUPHAR
Glycine receptor subunit alpha-3 Ion channel IC50 5.22 CHEMBL

External reference:

IDSource
C0916220 UMLSCUI
CHEMBL478523 ChEMBL_ID
C411705 MESH_SUPPLEMENTAL_RECORD_UI
442291 PUBCHEM_CID
4286 IUPHAR_LIGAND_ID
U06Z6QD7N2 UNII

Pharmaceutical products:

None