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androstenediol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids, androgens | 214 | 521-17-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,BRAF,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,NTRK2,PDK1,PDK2,PDK4,PRKDC | 13 | |||
| kinase-selectivity-class | EIF2AK3 | 1 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D006728 | Hormones |
| MeSH PA | D045930 | Anabolic Agents |
| CHEBI has role | CHEBI:50113 | androgene |
| CHEBI has role | CHEBI:66987 | radiation protective drugs |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Estrogen receptor | Nuclear hormone receptor | IC50 | 6.74 | CHEMBL | |||||
| Androgen receptor | Nuclear hormone receptor | IC50 | 6.64 | CHEMBL | |||||
| Estrogen receptor beta | Nuclear hormone receptor | IC50 | 8 | CHEMBL | |||||
| Corticosteroid-binding globulin | Secreted | Ki | 5 | CHEMBL | |||||
| Sex hormone-binding globulin | Secreted | Kd | 9.17 | CHEMBL | |||||
| Androgen receptor | Transcription factor | IC50 | 5.86 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D00179 | KEGG_DRUG |
| C0524764 | UMLSCUI |
| CHEBI:2710 | CHEBI |
| CHEMBL440283 | ChEMBL_ID |
| DB01524 | DRUGBANK_ID |
| D015114 | MESH_DESCRIPTOR_UI |
| 10634 | PUBCHEM_CID |
| 95PS51EMXY | UNII |
| B81 | PDB_CHEM_ID |
| 103051007 | SNOMEDCT_US |
Pharmaceutical products:
None