All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

fenamisal 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
analgesic anti-inflammatory	2143	133-11-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: fenamisal phenyl aminosalicylate phenyl p-aminosalicylate tebamin tebanyl p-aminosalicylic acid phenyl ester	Molecular weight: 229.24 Formula: C13H11NO3 CLOGP: 2.77 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 72.55 ALOGS: -3.12 ROTB: 3 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KIT,MAP2K6,MAP3K1,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70	70
kinase-selectivity-class	ACVR2A,ACVR2B,AXL,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,MAP2K3,MAP2K6,MAPK12,MAPK7,MAPK8,MARK4,SIK2,STK10,STK33,SYK,TEK,TTK,ULK1	22
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
None	FDA	PHARM RES ASSOC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.59	acidic
pKa2	1.89	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Histone deacetylase 6	Enzyme	Q9UBN7	HDAC6_HUMAN		IC50	5.73		CHEMBL

External reference:

ID	Source
D05460	KEGG_DRUG
C0618089	UMLSCUI
CHEBI:114203	CHEBI
CHEMBL1200868	ChEMBL_ID
8609	PUBCHEM_CID
DB06807	DRUGBANK_ID
37262003	SNOMEDCT_US
1844	INN_ID
52936SIP7V	UNII

Pharmaceutical products:

None