phensuximide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2139 86-34-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phensuccimide
  • phensuximide
  • phensuximid
  • RS-Phensuximide
  • racemic phensuximide
  • succitimal
  • fensuccimide
major descriptor (73-84); on-line search SUCCINIMIDES (73-84); Index Medicus search PHENSUXIMIDE (73-84); RN given refers to cpd without isomeric designation
  • Molecular weight: 189.21
  • Formula: C11H11NO2
  • CLOGP: 0.74
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 37.38
  • ALOGS: -1.93
  • ROTB: 1
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 264.25 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP3K21,MAP3K7,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,SIK2,SIK3,STK33,TEK 29
kinase-selectivity-class AXL,GRK2 2
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA PARKE DAVIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AD02 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Succinimide derivatives
CHEBI has role CHEBI:35623 anticonvulsant

Related Drugs by ATC class:

N03AD Succinimide derivatives 2 drugs
ethosuximidemethsuximide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Absence seizure indication 79631006
Epilepsy indication 84757009 DOID:1826




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-gated T-type calcium channel Ion channel BLOCKER CHEMBL CHEMBL

External reference:

IDSource
4018636 VUID
N0000146949 NUI
D00508 KEGG_DRUG
4018636 VANDF
C0070592 UMLSCUI
CHEBI:8079 CHEBI
CHEMBL797 ChEMBL_ID
DB00832 DRUGBANK_ID
6839 PUBCHEM_CID
C100129 MESH_SUPPLEMENTAL_RECORD_UI
7612 IUPHAR_LIGAND_ID
513 INN_ID
6WVL9C355G UNII
33309 RXNORM
5277 MMSL
d00943 MMSL
001629 NDDF
400807000 SNOMEDCT_US
61904007 SNOMEDCT_US

Pharmaceutical products:

None