aminopterin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
folic acid analogues 21 54-62-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • 4-aminofolic acid
  • Aminofolic acid, 4-
  • aminopterin
  • aminopterine
  • pteramina
  • aminopterin sodium
Aminopterin is a folic acid amino derivative with antineoplastic and immunosuppressive properties. It binds competitively to the folate binding site of the enzyme dihydrofolate reductase, blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis.
  • Molecular weight: 440.42
  • Formula: C19H20N8O5
  • CLOGP: -0.86
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 6
  • TPSA: 219.33
  • ALOGS: -3.62
  • ROTB: 9

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Drug Use | Suggest Off label Use Form| |View source of the data|




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

External reference:

Pharmaceutical products:

None

aminopterin