pentolonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
quaternary ammonium compounds 2096 144-44-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pentolinium
  • pentapyrrolidinium
  • pentolonium
  • pentolonium tartrate
  • ansolysen
  • pentolinium tartrate
  • pentolinium bitartrate
A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.
  • Molecular weight: 240.43
  • Formula: C15H32N2
  • CLOGP: -6.11
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA:
  • ALOGS: -7.43
  • ROTB: 6
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP2K6,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 35
kinase-selectivity-class AXL,CDK4,EIF2AK3,EPHA2,EPHB4,GRK2,MAP2K6,MAP3K7,MAPK10,MTOR,PDK4,PLK1,PTK2,STK33,TEK,TTK,ZAP70 17
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA WYETH AYERST

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D005730 Ganglionic Blockers
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018733 Nicotinic Antagonists
CHEBI has role CHEBI:35674 antihypertensive agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Neuronal acetylcholine receptor; alpha3/beta4 Ion channel ANTAGONIST CHEMBL CHEMBL
Neuronal acetylcholine receptor subunit alpha-10 Ion channel WOMBAT-PK

External reference:

IDSource
C0030886 UMLSCUI
CHEBI:347401 CHEBI
CHEMBL1271 ChEMBL_ID
CHEMBL1318287 ChEMBL_ID
DB01090 DRUGBANK_ID
52-62-0 SECONDARY_CAS_RN
5850 PUBCHEM_CID
000634 NDDF
004490 NDDF
35946000 SNOMEDCT_US
D010425 MESH_DESCRIPTOR_UI
330 INN_ID
ULL76WPU5X UNII

Pharmaceutical products:

None