pargyline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| monoamine oxydase (MAO)-inhibitors type B | 2065 | 555-57-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A monoamine oxidase inhibitor with antihypertensive properties.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Hosey CM, Chan R, Benet LZ |
| S (Water solubility) | 39 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1961 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C02KC01 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES OTHER ANTIHYPERTENSIVES MAO inhibitors |
| ATC | C02LL01 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION MAO inhibitors and diuretics |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D008996 | Monoamine Oxidase Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.84 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] B | Enzyme | INHIBITOR | Ki | 5.74 | CHEMBL | CHEMBL | |||
| Amine oxidase [flavin-containing] A | Enzyme | INHIBITOR | IC50 | 5.47 | CHEMBL | CHEMBL | |||
| Amine oxidase [flavin-containing] B | Enzyme | Ki | 5.47 | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | Ki | 5.07 | CHEMBL | |||||
| Aldehyde dehydrogenase, mitochondrial | Enzyme | IC50 | 5.25 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018734 | VUID |
| N0000179439 | NUI |
| D02564 | KEGG_DRUG |
| 306-07-0 | SECONDARY_CAS_RN |
| 4018734 | VANDF |
| 4019877 | VANDF |
| C0030557 | UMLSCUI |
| CHEBI:7930 | CHEBI |
| CHEMBL673 | ChEMBL_ID |
| DB01626 | DRUGBANK_ID |
| CHEMBL1200425 | ChEMBL_ID |
| D010293 | MESH_DESCRIPTOR_UI |
| 4688 | PUBCHEM_CID |
| 1350 | INN_ID |
| 7262 | IUPHAR_LIGAND_ID |
| 9MV14S8G3E | UNII |
| 7930 | RXNORM |
| 001497 | NDDF |
| 004598 | NDDF |
| 1536005 | SNOMEDCT_US |
| 21159006 | SNOMEDCT_US |
| 373749006 | SNOMEDCT_US |
Pharmaceutical products:
None