All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

paramethadione 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	2059	115-67-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: paramethadione paradione parametadione	Molecular weight: 157.17 Formula: C7H11NO3 CLOGP: 0.41 LIPINSKI: 0 HAC: 4 HDO: 0 TPSA: 46.61 ALOGS: -0.07 ROTB: 1 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.90	g	O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K21,MAP3K7,MAPK7,NTRK2,PDK1,PDK2,PIK3CB,PIM2,PLK1,PLK2,PLK3,PLK4,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK	37
kinase-selectivity-class	ACVR2B,AXL,BRAF,CDK16,CDK4,CDK9,GRK2,IRAK3,MAP2K6,MAPK7,STK33,TEK	12
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
June 15, 1949	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N03AC01	NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Oxazolidine derivatives
CHEBI has role	CHEBI:35623	anticonvulsant

Related Drugs by ATC class:

N03AC Oxazolidine derivatives 2 drugs

ethadionetrimethadione

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Absence seizure	indication	79631006
Epilepsy	indication	84757009	DOID:1826

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Voltage-gated T-type calcium channel	Ion channel	O43497 O95180 Q9P0X4	CAC1G_HUMAN CAC1H_HUMAN CAC1I_HUMAN	BLOCKER				CHEMBL	CHEMBL

External reference:

ID	Source
4018716	VUID
N0000147022	NUI
D00495	KEGG_DRUG
4018716	VANDF
C0070072	UMLSCUI
CHEBI:7921	CHEBI
CHEMBL1100	ChEMBL_ID
DB00617	DRUGBANK_ID
8280	PUBCHEM_CID
4163	INN_ID
C005731	MESH_SUPPLEMENTAL_RECORD_UI
7261	IUPHAR_LIGAND_ID
Z615FRW64N	UNII
219107	RXNORM
4562	MMSL
5233	MMSL
d00944	MMSL
001628	NDDF
400424004	SNOMEDCT_US
61357000	SNOMEDCT_US

Pharmaceutical products:

None