pamabrom 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2047	10381-75-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: 8-bromotheophylline bromotheophylline pamabrom predema	Molecular weight: 259.06 Formula: C7H7BrN4O2 CLOGP: 0.93 LIPINSKI: 0 HAC: 6 HDO: 1 TPSA: 69.30 ALOGS: -1.82 ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

8-bromotheophylline
bromotheophylline
pamabrom
predema

Molecular weight: 259.06
Formula: C7H7BrN4O2
CLOGP: 0.93
LIPINSKI: 0
HAC: 6
HDO: 1
TPSA: 69.30
ALOGS: -1.82
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ocular hypertension	contraindication	4210003	DOID:9282
Alcoholism	contraindication	7200002
Peptic ulcer	contraindication	13200003	DOID:750
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Hepatic failure	contraindication	59927004
Blood coagulation disorder	contraindication	64779008	DOID:1247
Poisoning by acetaminophen	contraindication	70273001
Chronic idiopathic constipation	contraindication	82934008
Disease of liver	contraindication	235856003	DOID:409
Bladder outflow obstruction	contraindication	236645006
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Vitamin K Deficiency Induced Hypoprothrombinemia	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.87	acidic
pKa2	2.43	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Adenosine receptor A1	GPCR		AA1R_RAT		Ki	4.99		CHEMBL

External reference:

ID	Source
4019460	VUID
N0000179338	NUI
D08962	KEGG_DRUG
4019460	VANDF
C0135166	UMLSCUI
CHEMBL316160	ChEMBL_ID
CHEMBL2104825	ChEMBL_ID
C069987	MESH_SUPPLEMENTAL_RECORD_UI
11806	PUBCHEM_CID
UA8U0KJM72	UNII
DB14018	DRUGBANK_ID
1546386	RXNORM
5225	MMSL
d03585	MMSL
002318	NDDF
116552006	SNOMEDCT_US
398981003	SNOMEDCT_US
606-04-2	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Midol Bloat Relief	HUMAN OTC DRUG LABEL	1	0280-0070	TABLET	50 mg	ORAL	OTC monograph final	12 sections
Midol Teen	HUMAN OTC DRUG LABEL	2	0280-8030	TABLET, COATED	25 mg	ORAL	OTC monograph not final	15 sections
Pamabrom	HUMAN OTC DRUG LABEL	1	0363-0795	CAPSULE, LIQUID FILLED	50 mg	ORAL	unapproved drug other	8 sections
Fem Relief	HUMAN OTC DRUG LABEL	2	0498-7000	TABLET	25 mg	ORAL	OTC monograph not final	15 sections
Fem Relief	HUMAN OTC DRUG LABEL	2	0498-7001	TABLET	25 mg	ORAL	OTC monograph not final	15 sections
Menstrual Relief	HUMAN OTC DRUG LABEL	3	11673-967	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	16 sections
Menstrual Relief	HUMAN OTC DRUG LABEL	3	11673-967	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	16 sections
menstrual pain reliefmaximum strength	HUMAN OTC DRUG LABEL	3	11822-6790	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	16 sections
menstrual pain reliefmaximum strength	HUMAN OTC DRUG LABEL	3	11822-6790	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	16 sections
menstrual pain reliefmaximum strength	HUMAN OTC DRUG LABEL	3	11822-6790	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	16 sections
Pain Aid PMF	HUMAN OTC DRUG LABEL	2	35418-710	TABLET	25 mg	ORAL	OTC monograph not final	9 sections
Menstrual ReliefMaximum Strength	HUMAN OTC DRUG LABEL	3	36800-979	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	16 sections
Menstrual ReliefMaximum Strength	HUMAN OTC DRUG LABEL	3	36800-979	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	16 sections
Leader Premenstrual	HUMAN OTC DRUG LABEL	3	37205-339	CAPSULE	25 mg	ORAL	OTC monograph not final	16 sections
Pain Aid PMF	HUMAN OTC DRUG LABEL	2	42961-046	TABLET	25 mg	ORAL	OTC monograph not final	9 sections
Green Guard PMS Relief	HUMAN OTC DRUG LABEL	2	47682-016	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	15 sections
Green Guard PMS Relief	HUMAN OTC DRUG LABEL	2	47682-016	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	15 sections
Green Guard PMS Relief	HUMAN OTC DRUG LABEL	2	47682-016	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	15 sections
Green Guard Cramp Relief	HUMAN OTC DRUG LABEL	3	47682-049	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	17 sections
Medi First Plus PMS Relief	HUMAN OTC DRUG LABEL	3	47682-723	TABLET, COATED	25 mg	ORAL	OTC monograph not final	17 sections
Medi First Plus PMS Relief	HUMAN OTC DRUG LABEL	3	47682-723	TABLET, COATED	25 mg	ORAL	OTC monograph not final	17 sections
Medi First Cramp	HUMAN OTC DRUG LABEL	2	47682-810	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	15 sections
Medi First Cramp	HUMAN OTC DRUG LABEL	2	47682-810	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	15 sections
Medi First Cramp	HUMAN OTC DRUG LABEL	2	47682-810	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	15 sections
Medi First PMS Relief	HUMAN OTC DRUG LABEL	3	47682-823	TABLET, COATED	25 mg	ORAL	OTC monograph not final	17 sections
Medi First PMS Relief	HUMAN OTC DRUG LABEL	3	47682-823	TABLET, COATED	25 mg	ORAL	OTC monograph not final	17 sections
Medi First Plus Cramp	HUMAN OTC DRUG LABEL	2	47682-910	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	15 sections
Medi First Plus Cramp	HUMAN OTC DRUG LABEL	2	47682-910	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	15 sections
Medi First Plus Cramp	HUMAN OTC DRUG LABEL	2	47682-910	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	15 sections
Unishield Cramp	HUMAN OTC DRUG LABEL	2	49314-8103	TABLET, FILM COATED	25 mg	ORAL	OTC monograph not final	17 sections