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oteracil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| uracil type antineoplastics | 2002 | 937-13-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Antagonist of urate oxidase.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,FLT3,GRK2,GRK3,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MARK4,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,PTK2,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2 | 63 | |||
| kinase-selectivity-class | ACVR2A,AXL,BRAF,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,MAP2K3,MAP3K14,MAPK7,PIK3CB,PRKDC,SIK2,STK33,TEK,TTK | 18 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 14, 2011 | EMA | Nordic Group BV | |
| March 1, 1999 | PMDA | Taiho Pharmaceutical Co, Ltd |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Disease progression | 62.43 | 48.04 | 21 | 172 | 244013 | 110345093 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:231911 | renoprotective agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Malignant tumor of stomach | indication | 363349007 | DOID:10534 |
| Hormone receptor pozitive breast cancer | indication | 417181009 | |
| HER2-negative breast cancer | indication | 767444009 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.67 | acidic |
| pKa2 | 10.06 | acidic |
| pKa3 | 0.5 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Uridine 5'-monophosphate synthase | Enzyme | INHIBITOR | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| C0030032 | UMLSCUI |
| OXC | PDB_CHEM_ID |
| CHEMBL181932 | ChEMBL_ID |
| DB03209 | DRUGBANK_ID |
| 4604 | PUBCHEM_CID |
| 7729 | INN_ID |
| C489337 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2207-75-2 | SECONDARY_CAS_RN |
| 5VT6420TIG | UNII |
| 013265 | NDDF |
| 015260 | NDDF |
| 1286932002 | SNOMEDCT_US |
| 708825002 | SNOMEDCT_US |
| D010094 | MESH_DESCRIPTOR_UI |
| CHEBI:80230 | CHEBI |
Pharmaceutical products:
None