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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
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Smart API
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
omapatrilat 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
endopeptidase inhibitors
1989
167305-00-2
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
BMS-186716
omapatrilat
Molecular weight: 408.53
Formula: C19H24N2O4S2
CLOGP: 2.84
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 86.71
ALOGS: -3.73
ROTB: 5
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
MeSH PA
D000806
Angiotensin-Converting Enzyme Inhibitors
MeSH PA
D000959
Antihypertensive Agents
MeSH PA
D002317
Cardiovascular Agents
MeSH PA
D004791
Enzyme Inhibitors
MeSH PA
D011480
Protease Inhibitors
MeSH PA
D000075563
Vasopeptidase Inhibitors
Showing 1 to 6 of 6 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
3.38
acidic
pKa2
7.71
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Angiotensin-converting enzyme
Enzyme
P12821
ACE_HUMAN
Ki
8.22
CHEMBL
Neprilysin
Enzyme
P08473
NEP_HUMAN
Ki
8.05
CHEMBL
Amyloid beta A4 protein
Unclassified
P05067
A4_HUMAN
IC50
6.70
CHEMBL
Angiotensin-converting enzyme
Enzyme
ACE_RABIT
IC50
8.30
CHEMBL
Neprilysin
Enzyme
NEP_RAT
IC50
8.10
CHEMBL
Showing 1 to 5 of 5 entries
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External reference:
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ID
Source
FT8
PDB_CHEM_ID
36NLI90E7T
UNII
4025254
VANDF
656629
PUBCHEM_CID
7714
INN_ID
C0663645
UMLSCUI
C106266
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135660
CHEBI
CHEMBL289556
ChEMBL_ID
D01970
KEGG_DRUG
Showing 1 to 10 of 11 entries
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Pharmaceutical products:
None
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omapatrilat