nomegestrol acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
steroids, progestogens 1957 58652-20-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • TX 066
  • TX-066
  • nomegestrol acetate
  • Molecular weight: 370.49
  • Formula: C23H30O4
  • CLOGP: 3.25
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 60.44
  • ALOGS: -4.95
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,STK33,TEK 28
kinase-selectivity-class EIF2AK3,GRK2,MAP2K6 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
July 27, 2011 EMA Teva B.V.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Meningioma 290.83 46.05 52 1249 5019 90622127
Intermenstrual bleeding 56.17 46.05 15 1286 9208 90617938

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Meningioma 279.33 39.43 47 863 5618 110582771
Intermenstrual bleeding 52.32 39.43 12 898 6922 110581467
Menometrorrhagia 40.95 39.43 7 903 899 110587490

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:35705 immunosuppressive agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Contraception indication 13197004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D08281 KEGG_DRUG
C0132749 UMLSCUI
CHEBI:135564 CHEBI
CHEMBL1476022 ChEMBL_ID
DB13981 DRUGBANK_ID
C038501 MESH_SUPPLEMENTAL_RECORD_UI
91668 PUBCHEM_CID
83J78V5W05 UNII
31930 RXNORM
005385 NDDF
005386 NDDF
698277001 SNOMEDCT_US
699947006 SNOMEDCT_US
C0068922 UMLSCUI
DB11636 DRUGBANK_ID
68783 PUBCHEM_CID
5359 INN_ID
C047637 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135993 CHEBI
83J78V5W05 INXIGHT DRUGS

Pharmaceutical products:

None