DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
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Smart API
Redial
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L1000
FAQ
Scroll
Substructure SMILES Example:
n1cnccc1
nifekalant 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
potassium channel blockers
1923
130636-43-0
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
nifekalant
Molecular weight: 405.46
Formula: C19H27N5O5
CLOGP: 2.05
LIPINSKI: 0
HAC: 10
HDO: 2
TPSA: 121.94
ALOGS: -3.38
ROTB: 11
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
CL (Clearance)
20.89 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
1.96 L/kg
Lombardo F, Berellini G, Obach RS
t_half (Half-life)
1.52 hours
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.09 %
Lombardo F, Berellini G, Obach RS
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
MeSH PA
D000889
Anti-Arrhythmia Agents
MeSH PA
D002317
Cardiovascular Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
8.02
Basic
pKa2
2.89
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Potassium voltage-gated channel subfamily H member 2
Ion channel
Q12809
KCNH2_HUMAN
IC50
5
CHEMBL
Solute carrier family 22 member 2
Transporter
O15244
S22A2_HUMAN
IC50
4.99
CHEMBL
Multidrug and toxin extrusion protein 1
Transporter
Q96FL8
S47A1_HUMAN
IC50
6.19
CHEMBL
Multidrug and toxin extrusion protein 2
Transporter
Q86VL8
S47A2_HUMAN
IC50
5.57
CHEMBL
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External reference:
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ID
Source
122188
PUBCHEM_CID
5VZ7GZM43E
UNII
7478
INN_ID
C076259
MESH_SUPPLEMENTAL_RECORD_UI
C2350374
UMLSCUI
CHEMBL360861
ChEMBL_ID
DB16008
DRUGBANK_ID
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Pharmaceutical products:
None
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nifekalant