nicocodine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
nicotinic acid or nicotinoyl alcohol derivatives 1914 3688-66-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nicocodine
  • codeine nicotinate
  • lyopect
  • nicocodine hydrochloride
  • nicocodine HCl
  • Molecular weight: 404.47
  • Formula: C24H24N2O4
  • CLOGP: 2.39
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 60.89
  • ALOGS: -3.11
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1,TTK,ZAP70 41
kinase-selectivity-class AXL,EIF2AK3,EPHB4,GRK2 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.18 Basic
pKa2 3.04 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D08272 KEGG_DRUG
C0068697 UMLSCUI
CHEBI:135650 CHEBI
CHEMBL2105136 ChEMBL_ID
C021063 MESH_SUPPLEMENTAL_RECORD_UI
5463872 PUBCHEM_CID
1249 INN_ID
58263-01-7 SECONDARY_CAS_RN
DYX391P13E UNII

Pharmaceutical products:

None