nandrolone decanoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
steroids, androgens 1881 360-70-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • durabolin
  • nandrolone decanoate
  • hybolin decanoate
  • norandrostenolone decanoate
  • nortestosterone decanoate
Decanoic acid ester of nandrolone that is used as an anabolic agent to prevent or treat WASTING SYNDROME associated with severe chronic illness or HIV infection (HIV WASTING SYNDROME). It may also be used in the treatment of POSTMENOPAUSAL OSTEOPOROSIS.
  • Molecular weight: 428.66
  • Formula: C28H44O3
  • CLOGP: 8.07
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 43.37
  • ALOGS: -6.44
  • ROTB: 10
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 3.09 mg/mL Bocci G, Oprea TI, Benet LZ
S (Water solubility) 0.00 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 2 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,MAP2K6,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PIM2,PRKDC,STK33,SYK,TEK,TGFBR1 34
kinase-selectivity-class AXL,EIF2AK3,GRK2,MAP2K6 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Oct. 5, 1962 FDA ASPEN GLOBAL INC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D006728 Hormones
MeSH PA D045930 Anabolic Agents
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D000728 Androgens
FDA EPC N0000175824 Androgen
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77746 human metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Anemia in chronic kidney disease indication 707323002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Androgen receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL
Corticosteroid-binding globulin Secreted Ki 6.14 CHEMBL
Sex hormone-binding globulin Secreted Kd 6.30 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.46 CHEMBL
Androgen receptor Transcription factor Ki 8.68 CHEMBL
Progesterone receptor Transcription factor Ki 7.65 CHEMBL

External reference:

IDSource
4018519 VUID
N0000179200 NUI
D00955 KEGG_DRUG
4018519 VANDF
4019854 VANDF
C0068395 UMLSCUI
CHEBI:7467 CHEBI
CHEMBL1200946 ChEMBL_ID
CHEMBL1200412 ChEMBL_ID
D000077603 MESH_DESCRIPTOR_UI
DB08804 DRUGBANK_ID
9677 PUBCHEM_CID
C008580 MESH_SUPPLEMENTAL_RECORD_UI
H45187T098 UNII
217575 RXNORM
2095 MMSL
4555 MMSL
458 MMSL
5152 MMSL
5463 MMSL
d00568 MMSL
001259 NDDF
001260 NDDF
126171003 SNOMEDCT_US
412253000 SNOMEDCT_US
86162003 SNOMEDCT_US
C0027368 UMLSCUI
DB13169 DRUGBANK_ID
9904 PUBCHEM_CID
295 INN_ID
D009277 MESH_DESCRIPTOR_UI
CHEBI:7466 CHEBI
H45187T098 INXIGHT DRUGS

Pharmaceutical products:

None