muzolimine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1858 55294-15-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Bay G 2821
  • Bay-G-2821
  • muzolimine
  • edrul
A pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects.
  • Molecular weight: 272.13
  • Formula: C11H11Cl2N3O
  • CLOGP: 1.33
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 58.69
  • ALOGS: -3.21
  • ROTB: 2

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03CD01 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Pyrazolone derivatives
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D045283 Natriuretic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D05093 KEGG_DRUG
C0026885 UMLSCUI
CHEBI:135124 CHEBI
CHEMBL1697760 ChEMBL_ID
DB13801 DRUGBANK_ID
D009156 MESH_DESCRIPTOR_UI
41386 PUBCHEM_CID
4119 INN_ID
07Z36289ZX UNII

Pharmaceutical products:

None