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moclobemide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1825 | 71320-77-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A reversible inhibitor of monoamine oxidase type A (RIMA) that has antidepressive properties.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.30 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 75 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 1.10 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.77 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.50 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 4 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 1.468 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.533 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 52.723 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 6.501 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 61.260 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 67.170 | % | High | 1 |
| herg | hERG pIC50 | 4.572 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.910 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 2.938 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 61.860 | % | High | 1 |
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,JAK1,JAK2,MAP3K21,MAP3K7,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PIK3CB,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK | 35 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,CAMK2D,CDK9,DDR1,DYRK1B,GRK2,JAK1,MAPK7,MAPK8,MARK4,PRKCD,SIK2,SIK3,STK33,TTK,ULK1 | 18 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 0.647 | High | 1 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.857 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 44.978 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 69.810 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 1.552 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 73.050 | % | High | 1 |
| rat-kpuu-brain | Rat brain Kpuu | 0.360 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 20.512 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 92.510 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 66.250 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 984.011 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1990 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Serotonin syndrome | 335.11 | 66.77 | 85 | 1419 | 37802 | 90589141 |
| Physical deconditioning | 246.93 | 66.77 | 41 | 1463 | 2194 | 90624749 |
| Major depression | 202.19 | 66.77 | 44 | 1460 | 9991 | 90616952 |
| Drug interaction | 181.92 | 66.77 | 89 | 1415 | 276364 | 90350579 |
| Intentional overdose | 158.11 | 66.77 | 59 | 1445 | 93775 | 90533168 |
| Suicide attempt | 143.93 | 66.77 | 52 | 1452 | 75347 | 90551596 |
| Metabolic acidosis | 123.65 | 66.77 | 43 | 1461 | 55633 | 90571310 |
| Acute kidney injury | 72.63 | 66.77 | 52 | 1452 | 320335 | 90306608 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Serotonin syndrome | 336.58 | 59.80 | 94 | 1558 | 25751 | 42593932 |
| Physical deconditioning | 240.00 | 59.80 | 46 | 1606 | 2359 | 42617324 |
| Intentional overdose | 208.04 | 59.80 | 77 | 1575 | 51379 | 42568304 |
| Major depression | 186.77 | 59.80 | 43 | 1609 | 5355 | 42614328 |
| Suicide attempt | 136.13 | 59.80 | 55 | 1597 | 46045 | 42573638 |
| Metabolic acidosis | 106.96 | 59.80 | 48 | 1604 | 51810 | 42567873 |
| Dissociative disorder | 74.10 | 59.80 | 14 | 1638 | 658 | 42619025 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Serotonin syndrome | 286.19 | 44.36 | 86 | 2107 | 59067 | 110528039 |
| Drug interaction | 102.33 | 44.36 | 82 | 2111 | 500101 | 110087005 |
| Intentional overdose | 94.55 | 44.36 | 48 | 2145 | 132453 | 110454653 |
| Toxicity to various agents | 92.35 | 44.36 | 76 | 2117 | 480479 | 110106627 |
| Dissociative disorder | 74.77 | 44.36 | 14 | 2179 | 1237 | 110585869 |
| Depressed mood | 64.61 | 44.36 | 29 | 2164 | 60780 | 110526326 |
| Accidental death | 60.41 | 44.36 | 15 | 2178 | 4994 | 110582112 |
| Arrhythmia | 57.83 | 44.36 | 28 | 2165 | 69547 | 110517559 |
| Disturbance in attention | 57.79 | 44.36 | 27 | 2166 | 61968 | 110525138 |
| Electrocardiogram QT prolonged | 56.62 | 44.36 | 32 | 2161 | 108928 | 110478178 |
| Wrong patient received product | 56.14 | 44.36 | 15 | 2178 | 6659 | 110580447 |
| Ischaemic cerebral infarction | 52.00 | 44.36 | 12 | 2181 | 2933 | 110584173 |
| Skin warm | 51.42 | 44.36 | 15 | 2178 | 9155 | 110577951 |
| Apallic syndrome | 51.27 | 44.36 | 10 | 2183 | 1096 | 110586010 |
| Hypertrophic cardiomyopathy | 51.14 | 44.36 | 12 | 2181 | 3151 | 110583955 |
| Suicidal ideation | 44.53 | 44.36 | 26 | 2167 | 93911 | 110493195 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06AG02 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Monoamine oxidase A inhibitors |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D008996 | Monoamine Oxidase Inhibitors |
| MeSH PA | D011619 | Psychotropic Drugs |
| CHEBI has role | CHEBI:35469 | antidepressant |
| CHEBI has role | CHEBI:35474 | anxiolytic drug |
| CHEBI has role | CHEBI:35476 | antipsychotic agent |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
Related Drugs by ATC class:
N06AG Monoamine oxidase A inhibitors 1 drug
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Depressive disorder | indication | 35489007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.45 | acidic |
| pKa2 | 6.83 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] A | Enzyme | INHIBITOR | Ki | 8.30 | CHEMBL | IUPHAR | |||
| 5-hydroxytryptamine receptor 1A | GPCR | Kd | 5.30 | CHEMBL | |||||
| Amine oxidase [flavin-containing] B | Enzyme | Ki | 5.97 | CHEMBL | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 4.10 | CHEMBL | |||||
| Programmed cell death 1 ligand 1 | CD molecules | IC50 | 5.41 | CHEMBL | |||||
| Amine oxidase [flavin-containing] B | Enzyme | Ki | 5.97 | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | Ki | 8.30 | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | Ki | 4.94 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000166883 | NUI |
| D02561 | KEGG_DRUG |
| C0066673 | UMLSCUI |
| CHEBI:83531 | CHEBI |
| CHEMBL86304 | ChEMBL_ID |
| DB01171 | DRUGBANK_ID |
| D020912 | MESH_DESCRIPTOR_UI |
| 4235 | PUBCHEM_CID |
| 7428 | IUPHAR_LIGAND_ID |
| 4914 | INN_ID |
| PJ0Y7AZB63 | UNII |
| 30121 | RXNORM |
| 004179 | NDDF |
| 321911007 | SNOMEDCT_US |
| 395800003 | SNOMEDCT_US |
| PJ0Y7AZB63 | INXIGHT DRUGS |
Pharmaceutical products:
None