amitriptylinoxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
181 4317-14-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amitriptylinoxide
  • amitriptyline N-oxide
  • amitriptyline oxide
  • Molecular weight: 293.41
  • Formula: C20H23NO
  • CLOGP: 2.22
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 23.06
  • ALOGS: -6.02
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.84 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Proto-oncogene tyrosine-protein kinase receptor Ret Kinase IC50 5 CHEMBL

External reference:

IDSource
TYR2U59WMA UNII
D07449 KEGG_DRUG
236734 RXNORM
C0051694 UMLSCUI
CHEBI:135224 CHEBI
CHEMBL627 ChEMBL_ID
20313 PUBCHEM_CID
DB13114 DRUGBANK_ID
3926 INN_ID
C006566 MESH_SUPPLEMENTAL_RECORD_UI
006696 NDDF

Pharmaceutical products:

None