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metrifonate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| insecticides, anthelminthics, pesticides etc., phosphorous derivatives | 1787 | 52-68-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An organochlorophosphate cholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. It is also used in anthelmintic compositions for animals. (From Merck, 11th ed)
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 40 | mg | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 61 | |||
| kinase-selectivity-class | AXL,BRAF,CDK9,DYRK1B,EPHB4,GRK2,MAP2K6,MAPK10,MAPK7,MET,PDK1,PDK2,PRKDC,TEK,ZAP70 | 15 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P02BB01 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTHELMINTICS ANTITREMATODALS Organophosphorous compounds |
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D002800 | Cholinesterase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D007306 | Insecticides |
| MeSH PA | D010575 | Pesticides |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| CHEBI has role | CHEBI:24852 | insecticide |
| CHEBI has role | CHEBI:33286 | agrochemical |
| CHEBI has role | CHEBI:35443 | anthelminthic drug |
| CHEBI has role | CHEBI:37733 | EC 3.1.1.8 (cholinesterase) inhibitor |
| CHEBI has role | CHEBI:38462 | EC 3.1.1.7 (acetylcholinesterase) inhibitor |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Horses | Removal of bots, Gastrophilus nasalis | Indication |
| Horses | Removal of bots, Gastrophilus intestinalis | Indication |
| Horses | Removal of large roundworms, ascarids | Indication |
| Horses | Removal of large roundworms, Parascaris equorum | Indication |
| Horses | Removal of pinworms, Oxyuris equi | Indication |
| Rodents | Treatment of Syphacia obvelata (pinworm) | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Dyrex Bolus, Dyrex Granules | Zoetis Inc. | 1 |
| Freed No. 10, Freed No. 25 | Zoetis Inc. | 2 |
| Dyrex T.F - 1000, Dyrex T.F - 200, Dyrex T.F - 500 | Zoetis Inc. | 3 |
| Dyrex Powder | Zoetis Inc. | 2 |
| Equivet-14, Equizole-B | Farnam Companies Inc. | 2 |
| Telmin B Equine Wormer | Intervet Inc. | 2 |
| Benzelmin Plus Paste | Zoetis Inc. | 2 |
| Telmin B Paste | Intervet Inc. | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.05 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000166428 | NUI |
| D00805 | KEGG_DRUG |
| C0040898 | UMLSCUI |
| CHEBI:6908 | CHEBI |
| CHEMBL167150 | ChEMBL_ID |
| DB11473 | DRUGBANK_ID |
| 5853 | PUBCHEM_CID |
| 1704 | INN_ID |
| DBF2DG4G2K | UNII |
| 1000581 | RXNORM |
| 005474 | NDDF |
| 49849004 | SNOMEDCT_US |
| D014236 | MESH_DESCRIPTOR_UI |
| DBF2DG4G2K | INXIGHT DRUGS |
Pharmaceutical products:
None