methylthiouracil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
uracil derivatives used as thyroid antagonists 1773 56-04-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methylthiouracil
  • thiomecil
  • 6-Methyl-2-thiouracil
  • thiothymin
A thiourea antithyroid agent that inhibits the synthesis of thyroid hormone. It is used in the treatment of hyperthyroidism.
  • Molecular weight: 142.18
  • Formula: C5H6N2OS
  • CLOGP: -0.09
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 41.13
  • ALOGS: -1.88
  • ROTB: 0

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H03BA01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
THYROID THERAPY
ANTITHYROID PREPARATIONS
Thiouracils
MeSH PA D013956 Antithyroid Agents
MeSH PA D006727 Hormone Antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.9 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07231 KEGG_DRUG
C0025830 UMLSCUI
CHEBI:82346 CHEBI
CHEMBL1330588 ChEMBL_ID
DB13644 DRUGBANK_ID
D008779 MESH_DESCRIPTOR_UI
667493 PUBCHEM_CID
4150 INN_ID
C000599236 MESH_SUPPLEMENTAL_RECORD_UI
QW24888U5F UNII
002138 NDDF
387356006 SNOMEDCT_US
64878006 SNOMEDCT_US

Pharmaceutical products:

None