mercaptopurine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
aptamers, classical and mirror ones 1708 50-44-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mercaptopurine monohydrate
  • 6-mercaptopurine monohydrate
  • 6-mercaptopurine
  • xaluprine
  • mercaptopurine
  • mercapurin
  • purimethol
  • purinethiol
  • purinethol
  • thiohypoxanthine
  • mercaptopurine hydrate
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
  • Molecular weight: 152.18
  • Formula: C5H4N4S
  • CLOGP: -1.33
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 53.07
  • ALOGS: -2.32
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 22 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 16.43 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 12 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 15 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.85 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 0.18 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Sept. 11, 1953 FDA STASON PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 855.84 14.46 511 20057 117938 63350516
Febrile bone marrow aplasia 306.99 14.46 108 20460 7217 63461237
Venoocclusive liver disease 252.23 14.46 84 20484 4751 63463703
Crohn's disease 231.21 14.46 79 20489 4834 63463620
Pancytopenia 180.44 14.46 188 20380 96745 63371709
Temporal lobe epilepsy 138.12 14.46 31 20537 380 63468074
Neurotoxicity 118.74 14.46 72 20496 16918 63451536
Hyperbilirubinaemia 114.28 14.46 61 20507 11253 63457201
Rhinovirus infection 110.56 14.46 45 20523 4484 63463970
Off label use 105.43 14.46 464 20104 673998 62794456
Acute lymphocytic leukaemia recurrent 104.85 14.46 36 20532 2233 63466221
Pyrexia 104.64 14.46 362 20206 470116 62998338
Haematotoxicity 104.51 14.46 54 20514 9322 63459132
Hypertriglyceridaemia 96.56 14.46 45 20523 6214 63462240
Haemophagocytic lymphohistiocytosis 95.41 14.46 53 20515 10574 63457880
Colitis ulcerative 90.79 14.46 72 20496 26019 63442435
Human bocavirus infection 90.40 14.46 22 20546 391 63468063
Abdominal pain 85.43 14.46 248 20320 293208 63175246
Pancreatitis 76.92 14.46 87 20481 48968 63419486
Joint swelling 72.75 14.46 10 20558 327656 63140798
Acute myeloid leukaemia 69.91 14.46 52 20516 17095 63451359
Secondary immunodeficiency 68.04 14.46 23 20545 1360 63467094
Perineal necrosis 67.66 14.46 14 20554 113 63468341
Bacterial infection 66.10 14.46 53 20515 19446 63449008
Perineal infection 65.16 14.46 14 20554 138 63468316
Occupational asthma 64.44 14.46 14 20554 146 63468308
Enterobacter infection 64.37 14.46 25 20543 2202 63466252
Pain 64.24 14.46 88 20480 740540 62727914
Neoplasm recurrence 63.67 14.46 26 20542 2612 63465842
Gastroenteritis norovirus 62.57 14.46 24 20544 2044 63466410
Pneumatosis intestinalis 62.42 14.46 25 20543 2388 63466066
Enterovirus test positive 58.72 14.46 13 20555 149 63468305
Leukaemia recurrent 57.08 14.46 20 20548 1318 63467136
Bacillus infection 53.31 14.46 17 20551 836 63467618
Abdominal discomfort 52.84 14.46 19 20549 320866 63147588
Herpes simplex 52.56 14.46 33 20535 8238 63460216
Oesophageal dilatation 51.65 14.46 14 20554 387 63468067
Human rhinovirus test positive 51.15 14.46 12 20556 181 63468273
Human herpesvirus 6 infection 51.07 14.46 23 20545 2934 63465520
Colitis 50.34 14.46 70 20498 48458 63419996
Hepatosplenic T-cell lymphoma 50.32 14.46 15 20553 588 63467866
Bacterial vulvovaginitis 50.31 14.46 16 20552 780 63467674
Arthropathy 50.16 14.46 8 20560 234784 63233670
Mucosal inflammation 49.14 14.46 68 20500 46860 63421594
Hepatocellular injury 48.88 14.46 52 20516 27329 63441125
Fall 48.48 14.46 34 20534 392300 63076154
Alanine aminotransferase increased 48.33 14.46 105 20463 103665 63364789
Device related infection 48.22 14.46 48 20520 23344 63445110
Neutropenia 48.05 14.46 145 20423 174860 63293594
Bone marrow failure 47.70 14.46 53 20515 29237 63439217
Clostridium difficile colitis 47.65 14.46 45 20523 20524 63447930
Antithrombin III 47.52 14.46 11 20557 156 63468298
Sepsis 46.96 14.46 132 20436 152991 63315463
Peripheral swelling 46.84 14.46 14 20554 265928 63202526
Trichodysplasia spinulosa 46.62 14.46 14 20554 563 63467891
Synovitis 45.76 14.46 4 20564 186914 63281540
Venous thrombosis 45.51 14.46 25 20543 4877 63463577
Hypoglycaemia 43.05 14.46 73 20495 59992 63408462
Rectal cancer metastatic 42.85 14.46 11 20557 245 63468209
Swelling 42.52 14.46 18 20550 275360 63193094
Cholestasis 42.43 14.46 50 20518 29384 63439070
Female sterilisation 41.52 14.46 13 20555 602 63467852
Partial seizures 41.43 14.46 25 20543 5817 63462637
Second primary malignancy 41.39 14.46 28 20540 7925 63460529
Epstein-Barr virus infection 41.09 14.46 28 20540 8022 63460432
Perirectal abscess 40.15 14.46 14 20554 909 63467545
Central obesity 39.93 14.46 15 20553 1206 63467248
Myelopathy 39.55 14.46 19 20549 2807 63465647
Anal abscess 38.59 14.46 22 20546 4610 63463844
Anal fistula 38.27 14.46 20 20548 3531 63464923
Enteritis 38.03 14.46 27 20541 8259 63460195
Hepatotoxicity 37.77 14.46 53 20515 36988 63431466
Hypoalbuminaemia 37.71 14.46 31 20537 11774 63456680
Drug specific antibody present 37.56 14.46 21 20547 4238 63464216
Post lumbar puncture syndrome 37.36 14.46 12 20556 604 63467850
Death 37.08 14.46 40 20528 374341 63094113
Segmental diverticular colitis 36.72 14.46 9 20559 165 63468289
Pedal pulse abnormal 36.31 14.46 9 20559 173 63468281
Bile acid malabsorption 36.27 14.46 9 20559 174 63468280
Intestinal stenosis 36.19 14.46 18 20550 2866 63465588
Wound 36.15 14.46 5 20563 163258 63305196
Strongyloidiasis 36.03 14.46 14 20554 1234 63467220
Venoocclusive disease 35.52 14.46 16 20552 2042 63466412
Blood culture positive 35.49 14.46 21 20547 4714 63463740
Discomfort 35.07 14.46 6 20562 167368 63301086
Pleuroparenchymal fibroelastosis 34.93 14.46 8 20560 108 63468346
Fistula 34.69 14.46 28 20540 10365 63458089
Leukoencephalopathy 34.20 14.46 20 20548 4393 63464061
Hypertransaminasaemia 33.76 14.46 23 20545 6586 63461868
Leukopenia 33.49 14.46 76 20492 77214 63391240
Mucormycosis 33.33 14.46 17 20551 2854 63465600
Cerebral venous sinus thrombosis 32.99 14.46 15 20553 1957 63466497
Ileal stenosis 31.75 14.46 14 20554 1699 63466755
Vital capacity decreased 31.63 14.46 14 20554 1714 63466740
Calcium ionised decreased 31.59 14.46 9 20559 300 63468154
Enterovirus infection 31.51 14.46 12 20556 1002 63467452
Fatigue 31.33 14.46 165 20403 887863 62580591
Glioma 31.28 14.46 9 20559 311 63468143
Pseudomonas test positive 31.21 14.46 11 20557 737 63467717
Painful respiration 30.98 14.46 16 20552 2758 63465696
Intestinal resection 30.58 14.46 16 20552 2832 63465622
Insomnia 30.25 14.46 16 20552 215236 63253218
Musculoskeletal stiffness 30.24 14.46 11 20557 184607 63283847
Myelodysplastic syndrome 30.22 14.46 32 20536 16722 63451732
Staphylococcal sepsis 29.49 14.46 23 20545 8105 63460349
Subacute combined cord degeneration 29.49 14.46 8 20560 222 63468232
Pancreatitis acute 29.39 14.46 40 20528 27126 63441328
Cytomegalovirus infection 29.22 14.46 35 20533 20917 63447537
Lymphoproliferative disorder 28.87 14.46 16 20552 3174 63465280
Systemic lupus erythematosus 28.67 14.46 16 20552 208902 63259552
Dyspnoea 28.56 14.46 114 20454 661199 62807255
Vocal cord paralysis 28.40 14.46 14 20554 2187 63466267
Stress urinary incontinence 27.50 14.46 14 20554 2341 63466113
Porphyria non-acute 27.46 14.46 8 20560 289 63468165
Histoplasmosis disseminated 27.31 14.46 12 20556 1444 63467010
Lower respiratory tract infection 27.15 14.46 5 20563 132302 63336152
Feeding intolerance 27.11 14.46 10 20558 764 63467690
Epstein-Barr virus associated lymphoma 27.01 14.46 9 20559 509 63467945
Superior sagittal sinus thrombosis 26.90 14.46 10 20558 781 63467673
Large intestinal stenosis 26.87 14.46 13 20555 1950 63466504
Histoplasmosis 26.82 14.46 13 20555 1958 63466496
Acute lymphocytic leukaemia refractory 26.33 14.46 6 20562 79 63468375
Lung opacity 26.26 14.46 15 20553 3153 63465301
Abdominal adhesions 26.20 14.46 15 20553 3167 63465287
Jaundice 25.67 14.46 39 20529 29212 63439242
Blood bilirubin increased 25.11 14.46 44 20524 37096 63431358
Neutrophil count decreased 25.02 14.46 56 20512 56350 63412104
Seizure 25.02 14.46 97 20471 132537 63335917
Clostridium difficile infection 25.01 14.46 39 20529 29883 63438571
Cystitis bacterial 24.70 14.46 7 20561 229 63468225
Cardiotoxicity 24.56 14.46 21 20547 8417 63460037
Chloroma 24.49 14.46 7 20561 236 63468218
Encopresis 24.38 14.46 6 20562 112 63468342
Hepatic infection fungal 24.32 14.46 5 20563 39 63468415
Escherichia infection 24.15 14.46 25 20543 12729 63455725
Glossitis 23.97 14.46 14 20554 3068 63465386
Haemolytic uraemic syndrome 23.88 14.46 13 20555 2490 63465964
Blood pressure abnormal 23.88 14.46 27 20541 15171 63453283
Asthma 23.78 14.46 6 20562 127555 63340899
Influenza B virus test positive 23.69 14.46 7 20561 266 63468188
Aborted pregnancy 23.68 14.46 5 20563 45 63468409
Drug interaction 23.16 14.46 140 20428 228991 63239463
Metastases to pancreas 23.13 14.46 7 20561 289 63468165
Cytogenetic abnormality 23.07 14.46 8 20560 511 63467943
Pericarditis 23.01 14.46 7 20561 131572 63336882
Myelosuppression 22.81 14.46 33 20535 23670 63444784
Confusional state 22.56 14.46 26 20542 236354 63232100
Breakthrough pain 22.50 14.46 10 20558 1236 63467218
Cushingoid 22.45 14.46 20 20548 8465 63459989
Aplasia 22.18 14.46 15 20553 4244 63464210
Coagulopathy 21.84 14.46 30 20538 20514 63447940
Lipase increased 21.68 14.46 21 20547 9879 63458575
Drug level decreased 21.62 14.46 19 20549 7900 63460554
Pseudomonal sepsis 21.62 14.46 12 20556 2389 63466065
Disseminated trichosporonosis 21.40 14.46 5 20563 74 63468380
Haematochezia 21.38 14.46 51 20517 53493 63414961
Small intestinal obstruction 21.36 14.46 28 20540 18309 63450145
Gamma-glutamyltransferase increased 21.32 14.46 39 20529 33992 63434462
Viral infection 21.25 14.46 40 20528 35623 63432831
West Nile viral infection 21.04 14.46 7 20561 394 63468060
Inflammatory bowel disease 20.70 14.46 14 20554 3959 63464495
Gastrointestinal sounds abnormal 20.46 14.46 14 20554 4037 63464417
Overgrowth fungal 20.38 14.46 5 20563 92 63468362
Anaemia megaloblastic 20.25 14.46 7 20561 443 63468011
Hyperglycaemia 20.20 14.46 43 20525 41824 63426630
Respiratory tract haemorrhage 20.16 14.46 7 20561 449 63468005
Contusion 19.85 14.46 12 20556 150032 63318422
Psoriatic arthropathy 19.79 14.46 3 20565 91517 63376937
Meningitis coccidioides 19.71 14.46 4 20564 29 63468425
Bronchitis chronic 19.55 14.46 14 20554 4339 63464115
Proctalgia 19.42 14.46 16 20552 6094 63462360
Rectal abscess 19.09 14.46 9 20559 1274 63467180
Appendicitis 19.05 14.46 18 20550 8211 63460243
Intracardiac thrombus 18.88 14.46 11 20557 2399 63466055
Bone marrow disorder 18.87 14.46 11 20557 2403 63466051
Pneumonia fungal 18.85 14.46 15 20553 5440 63463014
Transverse sinus thrombosis 18.78 14.46 7 20561 551 63467903
Herpes zoster meningoencephalitis 18.76 14.46 6 20562 298 63468156
Rash 18.72 14.46 106 20462 560765 62907689
Staphylococcal bacteraemia 18.67 14.46 15 20553 5515 63462939
Hypophagia 18.55 14.46 35 20533 31224 63437230
Depersonalisation/derealisation disorder 18.52 14.46 9 20559 1363 63467091
Furuncle 18.42 14.46 16 20552 6550 63461904
Mucoepidermoid carcinoma 18.30 14.46 4 20564 43 63468411
Feeling abnormal 18.10 14.46 13 20555 148379 63320075
Hepatosplenomegaly 18.06 14.46 11 20557 2603 63465851
Dizziness 17.96 14.46 75 20493 429850 63038604
Pericardial cyst 17.81 14.46 3 20565 6 63468448
T-cell lymphoma 17.47 14.46 7 20561 669 63467785
Haematocolpos 17.39 14.46 4 20564 55 63468399
Oesophageal mass 17.39 14.46 4 20564 55 63468399
Pyoderma gangrenosum 17.07 14.46 12 20556 3613 63464841
Anal fissure 17.05 14.46 13 20555 4430 63464024
Thrombocytopenia 16.98 14.46 95 20473 151062 63317392
Ocular icterus 16.98 14.46 12 20556 3644 63464810
Acute myelomonocytic leukaemia 16.97 14.46 5 20563 188 63468266
Atypical haemolytic uraemic syndrome 16.91 14.46 7 20561 728 63467726
Listeria sepsis 16.91 14.46 7 20561 728 63467726
Osteoarthritis 16.80 14.46 5 20563 95338 63373116
Vomiting 16.68 14.46 264 20304 559353 62909101
Histiocytic sarcoma 16.55 14.46 4 20564 69 63468385
Blood cholesterol increased 16.44 14.46 5 20563 94027 63374427
Inappropriate schedule of product administration 16.42 14.46 72 20496 103893 63364561
Pruritus 16.39 14.46 61 20507 361392 63107062
Glioblastoma multiforme 16.31 14.46 7 20561 796 63467658
Toe walking 16.28 14.46 3 20565 12 63468442
Hemiparesis 16.28 14.46 28 20540 23254 63445200
Rhinocerebral mucormycosis 16.26 14.46 6 20562 459 63467995
Quadriplegia 16.21 14.46 9 20559 1791 63466663
Cerebral ischaemia 16.12 14.46 15 20553 6713 63461741
Norovirus test positive 16.02 14.46 5 20563 229 63468225
Atrial fibrillation 15.89 14.46 9 20559 116627 63351827
Diarrhoea haemorrhagic 15.83 14.46 17 20551 9025 63459429
Gambling 15.78 14.46 5 20563 241 63468213
Vulval disorder 15.75 14.46 7 20561 865 63467589
Aspergillus infection 15.57 14.46 16 20552 8077 63460377
Hepatic enzyme increased 15.54 14.46 26 20542 202302 63266152
Hippocampal sclerosis 15.50 14.46 4 20564 91 63468363
Intestinal operation 15.50 14.46 6 20562 524 63467930
Intestinal fistula 15.48 14.46 7 20561 901 63467553
Pneumocystis jirovecii pneumonia 15.48 14.46 23 20545 16891 63451563
Drug intolerance 15.40 14.46 50 20518 308611 63159843
Respiratory distress 15.38 14.46 34 20534 33917 63434537
Functional gastrointestinal disorder 15.34 14.46 12 20556 4247 63464207
Malaise 15.31 14.46 76 20492 415878 63052576
Alopecia 15.28 14.46 57 20511 337479 63130975
Lennox-Gastaut syndrome 15.19 14.46 5 20563 272 63468182
Potentiating drug interaction 15.10 14.46 12 20556 4344 63464110
Aplastic anaemia 15.04 14.46 17 20551 9552 63458902
Cerebral fungal infection 15.03 14.46 4 20564 103 63468351
Pseudopolyp 15.00 14.46 5 20563 283 63468171
Cerebral haemangioma 14.96 14.46 4 20564 105 63468349
Amylase increased 14.92 14.46 14 20554 6331 63462123
Listeriosis 14.79 14.46 8 20560 1513 63466941
Anogenital dysplasia 14.75 14.46 3 20565 22 63468432
Pericardial effusion 14.65 14.46 31 20537 30027 63438427
Somnolence 14.64 14.46 22 20546 178663 63289791
Papulopustular rosacea 14.52 14.46 3 20565 24 63468430

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1029.62 14.23 776 21143 136073 34798939
Hepatosplenic T-cell lymphoma 259.34 14.23 60 21859 410 34934602
Venoocclusive liver disease 226.12 14.23 107 21812 7859 34927153
Febrile bone marrow aplasia 202.02 14.23 100 21819 8109 34926903
Haematotoxicity 190.39 14.23 96 21823 8098 34926914
Death 150.90 14.23 33 21886 398016 34536996
Hypertriglyceridaemia 150.82 14.23 83 21836 8365 34926647
Pancytopenia 126.02 14.23 219 21700 94938 34840074
Acute lymphocytic leukaemia recurrent 111.98 14.23 49 21870 2995 34932017
Bone marrow failure 107.37 14.23 111 21808 29142 34905870
Pyrexia 104.90 14.23 449 21470 332564 34602448
Hepatotoxicity 98.36 14.23 92 21827 21393 34913619
Osteonecrosis 97.02 14.23 78 21841 14812 34920200
Pancreatitis 94.22 14.23 119 21800 38772 34896240
Haemophagocytic lymphohistiocytosis 93.23 14.23 72 21847 12901 34922111
Myelosuppression 93.05 14.23 85 21834 19180 34915832
Cytomegalovirus chorioretinitis 92.09 14.23 45 21874 3544 34931468
Multiple-drug resistance 89.47 14.23 50 21869 5189 34929823
Crohn's disease 88.83 14.23 42 21877 3075 34931937
Leukoencephalopathy 82.42 14.23 44 21875 4171 34930841
Colitis 79.77 14.23 108 21811 37642 34897370
Abdominal pain 76.66 14.23 251 21668 163367 34771645
Neutropenia 75.70 14.23 243 21676 156535 34778477
Mucosal inflammation 71.93 14.23 104 21815 38518 34896494
Nodular regenerative hyperplasia 68.45 14.23 25 21894 948 34934064
Off label use 65.06 14.23 467 21452 419057 34515955
Lentigo 59.16 14.23 19 21900 485 34934527
Glioma 56.29 14.23 17 21902 352 34934660
Colitis ulcerative 55.81 14.23 60 21859 16460 34918552
Enterovirus infection 53.66 14.23 21 21898 965 34934047
Acute myeloid leukaemia 52.53 14.23 61 21858 18209 34916803
Portal hypertension 51.55 14.23 32 21887 4030 34930982
Myelodysplastic syndrome 50.06 14.23 61 21858 19147 34915865
Myocardial infarction 50.03 14.23 8 21911 121077 34813935
Frequent bowel movements 49.58 14.23 50 21869 12737 34922275
Epstein-Barr virus associated lymphoproliferative disorder 48.52 14.23 24 21895 1940 34933072
Gastrointestinal wall thickening 48.33 14.23 22 21897 1476 34933536
Epstein-Barr virus infection 47.65 14.23 39 21880 7589 34927423
Drug clearance decreased 47.26 14.23 23 21896 1795 34933217
Pancreatitis acute 46.96 14.23 72 21847 28069 34906943
Dyspnoea 46.50 14.23 105 21814 376677 34558335
Fall 45.96 14.23 36 21883 202849 34732163
Venoocclusive disease 45.27 14.23 26 21893 2841 34932171
Gallbladder oedema 45.01 14.23 13 21906 229 34934783
Cytogenetic abnormality 44.99 14.23 18 21901 877 34934135
Glioblastoma multiforme 44.73 14.23 17 21902 721 34934291
Hyperbilirubinaemia 44.72 14.23 54 21865 16789 34918223
Atrial fibrillation 44.47 14.23 11 21908 122382 34812630
Histoplasmosis disseminated 43.92 14.23 20 21899 1343 34933669
Intestinal stenosis 43.25 14.23 23 21896 2163 34932849
Dizziness 41.00 14.23 46 21873 218475 34716537
B-cell lymphoma 39.87 14.23 28 21891 4335 34930677
Fistula 38.64 14.23 33 21886 6807 34928205
Second primary malignancy 38.46 14.23 35 21884 7851 34927161
Cardiac failure congestive 37.99 14.23 4 21915 83266 34851746
Parainfluenzae virus infection 37.71 14.23 23 21896 2807 34932205
Diffuse large B-cell lymphoma 36.51 14.23 33 21886 7337 34927675
Rhinovirus infection 35.64 14.23 26 21893 4273 34930739
Haematopoietic neoplasm 35.47 14.23 8 21911 48 34934964
Sepsis 34.59 14.23 200 21719 166361 34768651
Neurotoxicity 34.24 14.23 49 21870 17961 34917051
Candida endophthalmitis 34.06 14.23 9 21910 112 34934900
Cytomegalovirus infection 33.01 14.23 59 21860 26076 34908936
Neutrophil count decreased 32.01 14.23 87 21832 51017 34883995
Acute monocytic leukaemia 31.95 14.23 11 21908 350 34934662
Leukopenia 31.68 14.23 99 21820 62757 34872255
Ileal stenosis 31.54 14.23 16 21903 1365 34933647
Alanine aminotransferase increased 30.84 14.23 116 21803 80699 34854313
Hepatocellular injury 30.47 14.23 52 21867 22159 34912853
Inflammatory bowel disease 29.66 14.23 20 21899 2900 34932112
Intracranial pressure increased 28.51 14.23 22 21897 3933 34931079
Xanthogranuloma 28.45 14.23 7 21912 64 34934948
Stomatitis 28.26 14.23 74 21845 42440 34892572
Pneumonia fungal 27.95 14.23 28 21891 7072 34927940
Proctitis 27.85 14.23 18 21901 2431 34932581
Thrombocytopenia 27.62 14.23 180 21739 156067 34778945
Vomiting 26.51 14.23 254 21665 247367 34687645
Leukaemia recurrent 26.45 14.23 15 21904 1600 34933412
Anal abscess 26.36 14.23 26 21893 6447 34928565
Cytopenia 26.24 14.23 36 21883 12687 34922325
Bacterial infection 26.16 14.23 42 21877 17021 34917991
Fungal infection 25.50 14.23 40 21879 15895 34919117
Mixed anxiety and depressive disorder 25.47 14.23 7 21912 102 34934910
Myelopathy 25.11 14.23 17 21902 2480 34932532
Depression 24.92 14.23 15 21904 97083 34837929
Human rhinovirus test positive 24.66 14.23 8 21911 211 34934801
Peripheral swelling 23.96 14.23 9 21910 76532 34858480
Hepatic steatosis 23.89 14.23 42 21877 18320 34916692
Product dose omission issue 23.76 14.23 24 21895 119687 34815325
Malignant neoplasm progression 23.45 14.23 13 21906 88033 34846979
Lymphopenia 23.41 14.23 39 21880 16296 34918716
Asthenia 22.96 14.23 78 21841 245173 34689839
Superior sagittal sinus thrombosis 22.90 14.23 8 21911 266 34934746
Transaminases increased 22.42 14.23 51 21868 26772 34908240
Adrenocortical carcinoma 22.31 14.23 5 21914 29 34934983
Cytomegalovirus hepatitis 22.20 14.23 9 21910 454 34934558
Multiple lentigines syndrome 22.03 14.23 5 21914 31 34934981
Abscess limb 22.00 14.23 18 21901 3499 34931513
Neoplasm recurrence 21.88 14.23 15 21904 2234 34932778
Cardiac arrest 21.82 14.23 17 21902 96142 34838870
Blood fibrinogen decreased 21.71 14.23 12 21907 1218 34933794
Acral lentiginous melanoma 21.63 14.23 5 21914 34 34934978
Completed suicide 21.47 14.23 18 21901 98150 34836862
Steatohepatitis 21.40 14.23 8 21911 324 34934688
Rhabdomyolysis 21.36 14.23 8 21911 68155 34866857
Cytomegalovirus colitis 21.20 14.23 16 21903 2768 34932244
Cerebral venous sinus thrombosis 20.85 14.23 9 21910 532 34934480
Mucormycosis 20.80 14.23 22 21897 5920 34929092
Anal fistula 20.72 14.23 21 21898 5378 34929634
Chronic obstructive pulmonary disease 20.72 14.23 3 21916 48915 34886097
Staphylococcal sepsis 20.52 14.23 28 21891 9816 34925196
Dysplastic naevus syndrome 20.50 14.23 4 21915 10 34935002
Coronary artery disease 20.37 14.23 3 21916 48302 34886710
Chest pain 20.31 14.23 30 21889 126732 34808280
Thymus enlargement 19.83 14.23 5 21914 51 34934961
Intestinal diaphragm disease 19.78 14.23 7 21912 242 34934770
Otitis media acute 19.74 14.23 9 21910 606 34934406
Proctalgia 19.70 14.23 21 21898 5702 34929310
Trichodysplasia spinulosa 19.62 14.23 7 21912 248 34934764
Confusional state 19.53 14.23 38 21881 144122 34790890
Small intestinal obstruction 19.33 14.23 34 21885 14832 34920180
Minimal residual disease 19.27 14.23 8 21911 429 34934583
Somnolence 19.10 14.23 25 21894 111091 34823921
Cholestasis 19.03 14.23 48 21871 26900 34908112
General physical health deterioration 18.99 14.23 32 21887 128237 34806775
Renal failure 18.94 14.23 33 21886 130524 34804488
Aspergillus infection 18.56 14.23 30 21889 12224 34922788
Syncope 18.52 14.23 18 21901 91433 34843579
Anal inflammation 18.44 14.23 11 21908 1289 34933723
Human anaplasmosis 18.38 14.23 5 21914 70 34934942
T-cell lymphoma 18.31 14.23 10 21909 991 34934021
Pneumocystis jirovecii pneumonia 18.19 14.23 39 21880 19671 34915341
Pruritus 17.89 14.23 39 21880 141942 34793070
Small intestinal stenosis 17.73 14.23 8 21911 526 34934486
Vascular access complication 17.60 14.23 7 21912 336 34934676
Meningitis enterococcal 17.59 14.23 5 21914 83 34934929
Neutropenic colitis 17.42 14.23 15 21904 3129 34931883
Metapneumovirus infection 17.39 14.23 9 21910 800 34934212
Cardiac failure 17.30 14.23 19 21900 91229 34843783
Cutaneous leishmaniasis 16.91 14.23 6 21913 209 34934803
Human metapneumovirus test positive 16.81 14.23 5 21914 98 34934914
Disseminated cytomegaloviral infection 16.62 14.23 6 21913 220 34934792
Cheilitis 16.58 14.23 13 21906 2378 34932634
Escherichia infection 16.51 14.23 23 21896 8222 34926790
Hip deformity 16.49 14.23 5 21914 105 34934907
Bifidobacterium infection 16.31 14.23 4 21915 36 34934976
Anorectal cellulitis 16.22 14.23 4 21915 37 34934975
Hypoalbuminaemia 16.03 14.23 28 21891 12146 34922866
Epstein-Barr virus associated lymphoma 16.02 14.23 8 21911 660 34934352
Respiratory distress 15.99 14.23 54 21865 35611 34899401
Posterior reversible encephalopathy syndrome 15.94 14.23 25 21894 9929 34925083
Oedema peripheral 15.86 14.23 32 21887 119780 34815232
Gastrointestinal injury 15.60 14.23 7 21912 454 34934558
Meningoradiculitis 15.51 14.23 4 21915 45 34934967
Pneumonia viral 15.31 14.23 14 21905 3160 34931852
Colon dysplasia 15.30 14.23 5 21914 135 34934877
Central nervous system leukaemia 15.24 14.23 6 21913 280 34934732
Seizure 15.10 14.23 115 21804 104742 34830270
Eosinophilic pneumonia chronic 15.06 14.23 6 21913 289 34934723
Coccidioidomycosis 14.97 14.23 8 21911 759 34934253
Babesiosis 14.93 14.23 5 21914 146 34934866
Coma 14.93 14.23 5 21914 45673 34889339
Blood glucose increased 14.87 14.23 12 21907 66706 34868306
Pulmonary mucormycosis 14.82 14.23 8 21911 775 34934237
Eye opacity 14.73 14.23 3 21916 10 34935002
Haemorrhagic diathesis 14.72 14.23 13 21906 2803 34932209
Clostridium test positive 14.69 14.23 14 21905 3328 34931684
Hallucination 14.60 14.23 7 21912 51491 34883521
Tonsil cancer 14.53 14.23 9 21910 1129 34933883
Large intestine infection 14.47 14.23 10 21909 1508 34933504
Autoimmune lymphoproliferative syndrome 14.46 14.23 5 21914 161 34934851
Clostridium difficile colitis 14.37 14.23 31 21888 15699 34919313
Electrocardiogram QT prolonged 14.25 14.23 4 21915 40948 34894064

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1816.52 12.83 1204 36313 229795 79477076
Secondary immunodeficiency 316.02 12.83 99 37418 3135 79703736
Haematotoxicity 301.91 12.83 147 37370 15372 79691499
Pancytopenia 294.68 12.83 376 37141 165369 79541502
Bacterial infection 256.11 12.83 168 37349 31112 79675759
Febrile bone marrow aplasia 255.28 12.83 124 37393 12896 79693975
Hepatosplenic T-cell lymphoma 234.20 12.83 59 37458 819 79706052
Hypertriglyceridaemia 196.05 12.83 103 37414 12637 79694234
Haemophagocytic lymphohistiocytosis 187.85 12.83 121 37396 21716 79685155
Cytomegalovirus chorioretinitis 183.67 12.83 76 37441 5414 79701457
Rhinovirus infection 174.97 12.83 82 37435 7871 79699000
Acute lymphocytic leukaemia recurrent 173.78 12.83 70 37447 4654 79702217
Parainfluenzae virus infection 171.16 12.83 73 37444 5609 79701262
Pyrexia 166.75 12.83 695 36822 678014 79028857
Pancreatitis 160.26 12.83 179 37338 68396 79638475
Mycobacterium chelonae infection 158.65 12.83 55 37462 2401 79704470
Off label use 156.48 12.83 838 36679 906377 78800494
Bone marrow failure 148.87 12.83 150 37367 50957 79655914
Human bocavirus infection 140.44 12.83 38 37479 707 79706164
Clostridium difficile colitis 131.11 12.83 114 37403 32169 79674702
Myelodysplastic syndrome transformation 129.21 12.83 35 37482 654 79706217
Pseudomonal sepsis 127.67 12.83 61 37456 6113 79700758
Human herpesvirus 6 infection 123.19 12.83 57 37460 5313 79701558
Neurotoxicity 122.42 12.83 110 37407 32408 79674463
Mucosal inflammation 119.43 12.83 162 37355 75418 79631453
Hepatotoxicity 118.17 12.83 133 37384 51219 79655652
Acute myeloid leukaemia 115.33 12.83 104 37413 30781 79676090
Osteonecrosis 114.72 12.83 104 37413 30991 79675880
Neutropenia 111.86 12.83 343 37174 287367 79419504
Myelosuppression 107.80 12.83 113 37404 40183 79666688
Second primary malignancy 105.23 12.83 72 37445 14278 79692593
Leukoencephalopathy 104.92 12.83 58 37459 7871 79699000
Hyperbilirubinaemia 104.47 12.83 89 37428 24429 79682442
Thymus hypoplasia 104.38 12.83 32 37485 941 79705930
Viral infection 101.70 12.83 113 37404 42903 79663968
Fall 97.71 12.83 54 37463 487575 79219296
Abdominal pain 97.67 12.83 402 37115 389167 79317704
Multiple-drug resistance 93.99 12.83 56 37461 8752 79698119
Norovirus test positive 93.81 12.83 27 37490 635 79706236
Lymphoid tissue hypoplasia 93.07 12.83 29 37488 901 79705970
Cystitis bacterial 91.94 12.83 27 37490 683 79706188
Glioma 90.96 12.83 26 37491 596 79706275
Pneumatosis intestinalis 90.75 12.83 49 37468 6348 79700523
Enterovirus infection 86.21 12.83 33 37484 1914 79704957
Dyspnoea 85.39 12.83 172 37345 856853 78850018
Enterobacter infection 85.07 12.83 42 37475 4520 79702351
Rheumatoid arthritis 84.74 12.83 3 37514 208467 79498404
Myelodysplastic syndrome 82.88 12.83 86 37431 30215 79676656
Colitis ulcerative 81.66 12.83 91 37426 34651 79672220
Aspergillus infection 78.47 12.83 68 37449 19093 79687778
Joint swelling 77.67 12.83 20 37497 288626 79418245
Epstein-Barr virus infection 77.62 12.83 60 37457 14356 79692515
Viraemia 77.06 12.83 34 37483 2835 79704036
Neoplasm recurrence 76.22 12.83 38 37479 4176 79702695
Venoocclusive disease 76.17 12.83 39 37478 4534 79702337
Temporal lobe epilepsy 75.94 12.83 21 37496 425 79706446
Cytogenetic abnormality 75.79 12.83 26 37491 1099 79705772
Pancreatitis acute 74.84 12.83 104 37413 49500 79657371
Colitis 74.47 12.83 128 37389 73179 79633692
Enteritis 72.70 12.83 58 37459 14525 79692346
Leukaemia recurrent 71.70 12.83 32 37485 2742 79704129
Sepsis 71.38 12.83 283 37234 269145 79437726
Abscess bacterial 71.03 12.83 23 37494 811 79706060
Nodular regenerative hyperplasia 70.95 12.83 26 37491 1335 79705536
Death 70.86 12.83 98 37419 566416 79140455
Peripheral swelling 70.05 12.83 20 37497 269597 79437274
Myelopathy 69.97 12.83 37 37480 4596 79702275
Crohn's disease 67.16 12.83 28 37489 2032 79704839
Histoplasmosis disseminated 66.82 12.83 29 37488 2324 79704547
Glioblastoma multiforme 66.03 12.83 24 37493 1204 79705667
Human rhinovirus test positive 65.10 12.83 19 37498 470 79706401
Lentigo 64.64 12.83 19 37498 482 79706389
Trichodysplasia spinulosa 64.05 12.83 21 37496 771 79706100
Fungal infection 63.68 12.83 88 37429 41660 79665211
Cytomegalovirus infection 62.23 12.83 88 37429 42556 79664315
Leukopenia 62.11 12.83 156 37361 116357 79590514
Perineal necrosis 61.60 12.83 14 37503 121 79706750
Completed suicide 60.66 12.83 20 37497 245747 79461124
Pain 60.42 12.83 153 37364 703649 79003222
Contraindicated product administered 58.50 12.83 4 37513 157534 79549337
Intestinal stenosis 56.75 12.83 30 37487 3724 79703147
Intracardiac thrombus 55.69 12.83 31 37486 4262 79702609
Epstein-Barr virus associated lymphoproliferative disorder 55.60 12.83 29 37488 3503 79703368
Dizziness 55.47 12.83 102 37415 526339 79180532
Enterovirus test positive 54.89 12.83 15 37502 290 79706581
Venoocclusive liver disease 54.84 12.83 45 37472 11726 79695145
Fistula 53.14 12.83 46 37471 12894 79693977
Alanine aminotransferase increased 52.41 12.83 182 37335 162388 79544483
Bronchopulmonary aspergillosis 51.71 12.83 58 37459 22236 79684635
Cytomegalovirus viraemia 51.49 12.83 45 37472 12776 79694095
Neutrophil count decreased 51.33 12.83 127 37390 93832 79613039
Atrial fibrillation 50.80 12.83 15 37502 197871 79509000
Pneumonia fungal 50.44 12.83 42 37475 11168 79695703
Diffuse large B-cell lymphoma 49.51 12.83 43 37474 12106 79694765
Diffuse alveolar damage 49.44 12.83 27 37490 3577 79703294
Bacillus infection 49.08 12.83 19 37498 1136 79705735
Coronavirus infection 48.86 12.83 35 37482 7462 79699409
Drug clearance decreased 48.64 12.83 26 37491 3301 79703570
Cerebral venous sinus thrombosis 48.48 12.83 23 37494 2268 79704603
Hepatocellular injury 48.19 12.83 83 37434 47510 79659361
Molluscum contagiosum 47.90 12.83 15 37502 474 79706397
Swelling 47.86 12.83 21 37496 216690 79490181
Thrombocytopenia 47.31 12.83 248 37269 265011 79441860
Mucormycosis 47.24 12.83 36 37481 8433 79698438
Device related infection 44.56 12.83 67 37450 34227 79672644
Synovitis 43.39 12.83 9 37508 150725 79556146
Cholestasis 42.78 12.83 83 37434 52026 79654845
Oesophageal candidiasis 42.44 12.83 35 37482 9183 79697688
Anal abscess 41.99 12.83 35 37482 9320 79697551
Bacterial vulvovaginitis 40.83 12.83 14 37503 591 79706280
Cell-mediated immune deficiency 40.58 12.83 10 37507 126 79706745
B-cell lymphoma 40.47 12.83 29 37488 6186 79700685
Seizure 40.40 12.83 186 37331 188648 79518223
Intestinal resection 40.38 12.83 24 37493 3733 79703138
Hypertransaminasaemia 40.32 12.83 38 37479 11886 79694985
Superior sagittal sinus thrombosis 39.95 12.83 16 37501 1047 79705824
Subacute combined cord degeneration 39.94 12.83 12 37505 329 79706542
Feeding intolerance 39.60 12.83 15 37502 845 79706026
Epstein-Barr virus associated lymphoma 39.58 12.83 16 37501 1073 79705798
Discomfort 39.41 12.83 6 37511 125611 79581260
Intracranial pressure increased 39.15 12.83 32 37485 8290 79698581
Gastroenteritis norovirus 39.13 12.83 22 37495 3084 79703787
Hypoalbuminaemia 38.82 12.83 49 37468 21248 79685623
Lower respiratory tract infection 38.70 12.83 7 37510 129213 79577658
Confusional state 38.70 12.83 56 37461 317941 79388930
Pruritus 38.46 12.83 80 37437 394568 79312303
Abdominal discomfort 38.15 12.83 37 37480 250690 79456181
Frequent bowel movements 37.37 12.83 57 37460 29482 79677389
Encephalitis 37.00 12.83 40 37477 14720 79692151
Portal hypertension 37.00 12.83 29 37488 7079 79699792
Perineal infection 36.89 12.83 14 37503 793 79706078
Cardiac failure congestive 36.16 12.83 11 37506 142391 79564480
Inflammatory bowel disease 35.95 12.83 26 37491 5625 79701246
Bile acid malabsorption 35.86 12.83 10 37507 209 79706662
Anal fistula 35.43 12.83 28 37489 6916 79699955
Escherichia infection 35.32 12.83 43 37474 17974 79688897
Fatigue 35.14 12.83 275 37242 929452 78777419
Arthropathy 34.84 12.83 20 37497 177091 79529780
Pneumocystis jirovecii pneumonia 34.63 12.83 58 37459 32450 79674421
Cytopenia 34.18 12.83 45 37472 20338 79686533
Proctalgia 34.06 12.83 32 37485 9969 79696902
Haematopoietic neoplasm 33.63 12.83 8 37509 86 79706785
Segmental diverticular colitis 33.38 12.83 9 37508 165 79706706
Asthma 33.30 12.83 11 37506 135084 79571787
Candida endophthalmitis 33.28 12.83 9 37508 167 79706704
Cytomegalovirus colitis 33.15 12.83 23 37494 4662 79702209
Ileal stenosis 32.99 12.83 18 37499 2380 79704491
Depression 32.97 12.83 32 37485 216758 79490113
Perirectal abscess 32.82 12.83 17 37500 2024 79704847
Muscle spasms 32.60 12.83 21 37496 174709 79532162
Hyperkalaemia 32.57 12.83 7 37510 114391 79592480
Pedal pulse abnormal 32.41 12.83 9 37508 185 79706686
Glossodynia 32.27 12.83 5 37512 103332 79603539
Rectal cancer metastatic 32.06 12.83 11 37506 465 79706406
Strongyloidiasis 32.04 12.83 21 37496 3877 79702994
Lipase increased 31.80 12.83 39 37478 16427 79690444
Coagulopathy 31.59 12.83 59 37458 35947 79670924
Systemic lupus erythematosus 31.42 12.83 9 37508 121140 79585731
Acute monocytic leukaemia 30.73 12.83 11 37506 528 79706343
Blood culture positive 30.70 12.83 28 37489 8401 79698470
Lymphopenia 30.55 12.83 53 37464 30504 79676367
Histoplasmosis 30.47 12.83 17 37500 2348 79704523
Blood fibrinogen decreased 30.44 12.83 16 37501 1963 79704908
Drug specific antibody present 30.09 12.83 25 37492 6627 79700244
Cellulitis 29.99 12.83 116 37401 108944 79597927
Pleuroparenchymal fibroelastosis 29.66 12.83 8 37509 147 79706724
Haemolytic uraemic syndrome 29.52 12.83 21 37496 4428 79702443
Xanthogranuloma 29.45 12.83 7 37510 75 79706796
Disseminated aspergillosis 29.23 12.83 13 37504 1105 79705766
Anal inflammation 29.17 12.83 14 37503 1416 79705455
Malaise 29.14 12.83 125 37392 489744 79217127
Intentional overdose 29.13 12.83 7 37510 105953 79600918
Insomnia 29.01 12.83 44 37473 245126 79461745
Product dose omission issue 28.74 12.83 45 37472 247492 79459379
Venous thrombosis 28.62 12.83 25 37492 7091 79699780
Pseudomonas test positive 28.56 12.83 15 37502 1837 79705034
Blood bilirubin increased 28.54 12.83 82 37435 66150 79640721
Oedema peripheral 28.22 12.83 47 37470 252241 79454630
Cushingoid 27.73 12.83 28 37489 9524 79697347
Musculoskeletal stiffness 27.58 12.83 25 37492 174983 79531888
Atypical haemolytic uraemic syndrome 26.98 12.83 12 37505 1020 79705851
Cardiotoxicity 26.95 12.83 31 37486 12208 79694663
Chloroma 26.91 12.83 11 37506 759 79706112
Cytomegalovirus hepatitis 26.72 12.83 11 37506 773 79706098
Syncope 26.69 12.83 27 37490 179422 79527449
Asthenia 26.65 12.83 137 37380 511552 79195319
Aplasia 26.59 12.83 25 37492 7795 79699076
Central obesity 26.41 12.83 14 37503 1747 79705124
Abdominal adhesions 26.36 12.83 18 37499 3555 79703316
Somnolence 26.29 12.83 45 37472 238936 79467935
Vomiting 26.15 12.83 449 37068 665379 79041492
Drug level decreased 26.03 12.83 33 37484 14369 79692502
Cerebral haemangioma 25.98 12.83 7 37510 128 79706743
Hepatosplenomegaly 25.78 12.83 22 37495 6047 79700824
Transaminases increased 25.20 12.83 67 37450 51676 79655195
Mobility decreased 25.18 12.83 13 37504 122162 79584709
Neutropenic colitis 24.88 12.83 21 37496 5686 79701185
Pericarditis 24.80 12.83 9 37508 104227 79602644
Feeling abnormal 24.78 12.83 23 37494 159176 79547695
Hippocampal sclerosis 24.76 12.83 7 37510 154 79706717
Drug intolerance 24.50 12.83 55 37462 264064 79442807
Wound 24.49 12.83 12 37505 116167 79590704
Chest pain 24.42 12.83 61 37456 282243 79424628
Neuropathy peripheral 24.39 12.83 131 37386 141174 79565697
Acute lymphocytic leukaemia refractory 24.38 12.83 7 37510 163 79706708
Cheilitis 24.00 12.83 20 37497 5321 79701550
Hyponatraemia 23.98 12.83 29 37488 177819 79529052
Malnutrition 23.77 12.83 40 37477 22462 79684409
Antithrombin III 23.57 12.83 6 37511 87 79706784
Osteoarthritis 23.55 12.83 6 37511 87303 79619568
Gastrointestinal wall thickening 23.53 12.83 15 37502 2642 79704229
Metapneumovirus infection 23.46 12.83 13 37504 1771 79705100
Coma 23.43 12.83 9 37508 100640 79606231
General physical health deterioration 23.40 12.83 60 37457 275178 79431693
Anorectal cellulitis 23.26 12.83 6 37511 92 79706779
Abscess limb 23.01 12.83 22 37495 7005 79699866
Calcium ionised decreased 22.63 12.83 9 37508 578 79706293
Large intestinal stenosis 22.54 12.83 15 37502 2841 79704030
Hypoglycaemia 22.40 12.83 101 37416 101493 79605378
Staphylococcal sepsis 22.39 12.83 31 37486 14695 79692176
Bifidobacterium infection 22.34 12.83 5 37512 40 79706831
Herpes simplex 22.14 12.83 28 37489 12159 79694712
Meningitis coccidioides 21.82 12.83 5 37512 45 79706826
Aborted pregnancy 21.82 12.83 5 37512 45 79706826
Suicide attempt 21.80 12.83 6 37511 82926 79623945
Thymus enlargement 21.44 12.83 6 37511 127 79706744
Acral lentiginous melanoma 21.44 12.83 5 37512 49 79706822
Vocal cord paralysis 21.42 12.83 14 37503 2573 79704298
T-cell lymphoma 21.37 12.83 11 37506 1292 79705579
Rash 21.34 12.83 172 37345 578186 79128685
Anal fissure 21.31 12.83 22 37495 7681 79699190
Otitis media acute 21.11 12.83 11 37506 1326 79705545
Hallucination 21.10 12.83 7 37510 85738 79621133
Hemiparesis 21.01 12.83 48 37469 33685 79673186
Urinary tract infection 20.98 12.83 63 37454 274449 79432422
Chronic obstructive pulmonary disease 20.97 12.83 7 37510 85412 79621459
Angioedema 20.95 12.83 5 37512 76030 79630841
Coronary artery disease 20.83 12.83 3 37514 65471 79641400
Clostridium test positive 20.74 12.83 20 37497 6434 79700437
Anxiety 20.49 12.83 55 37462 248457 79458414
Fusarium infection 20.47 12.83 12 37505 1820 79705051
Platelet count decreased 20.36 12.83 159 37358 194505 79512366
Blood cholesterol increased 20.31 12.83 7 37510 83713 79623158
Drug reaction with eosinophilia and systemic symptoms 20.30 12.83 3 37514 64241 79642630
Epidermal necrosis 19.80 12.83 11 37506 1506 79705365
Nasopharyngitis 19.59 12.83 58 37459 253823 79453048
Adrenocortical carcinoma 19.55 12.83 5 37512 74 79706797
Clostridium difficile infection 19.51 12.83 54 37463 42631 79664240
Splenomegaly 19.46 12.83 35 37482 20719 79686152
Hypophagia 19.38 12.83 56 37461 45311 79661560
Posterior reversible encephalopathy syndrome 19.34 12.83 40 37477 26241 79680630
Lymphoproliferative disorder 19.19 12.83 18 37499 5597 79701274
Chest discomfort 19.16 12.83 22 37495 138022 79568849
Human anaplasmosis 19.13 12.83 5 37512 81 79706790
Myocardial infarction 19.05 12.83 36 37481 184093 79522778
Lower respiratory tract infection fungal 19.05 12.83 9 37508 879 79705992
Human metapneumovirus test positive 18.88 12.83 6 37511 199 79706672
Influenza B virus test positive 18.82 12.83 7 37510 375 79706496
Hip deformity 18.77 12.83 6 37511 203 79706668
Systemic mycosis 18.66 12.83 13 37504 2653 79704218
Staphylococcal infection 18.53 12.83 65 37452 58230 79648641
Small intestinal obstruction 18.32 12.83 40 37477 27232 79679639
Mixed anxiety and depressive disorder 18.29 12.83 7 37510 406 79706465
Overgrowth fungal 18.28 12.83 5 37512 97 79706774
Transverse sinus thrombosis 18.25 12.83 8 37509 657 79706214
Meningitis enterococcal 18.23 12.83 5 37512 98 79706773
Wrong technique in product usage process 18.23 12.83 6 37511 73869 79633002
Listeriosis 18.20 12.83 12 37505 2238 79704633
Bone marrow disorder 18.18 12.83 14 37503 3329 79703542
Oral herpes 18.14 12.83 40 37477 27414 79679457
Gastrointestinal inflammation 18.13 12.83 20 37497 7524 79699347
Blood pressure fluctuation 18.11 12.83 71 37446 67074 79639797
Electrocardiogram QT prolonged 18.06 12.83 10 37507 90376 79616495
Drug hypersensitivity 17.92 12.83 76 37441 298840 79408031
Cell death 17.88 12.83 16 37501 4683 79702188
Facial paralysis 17.83 12.83 34 37483 21038 79685833
Multiple organ dysfunction syndrome 17.80 12.83 107 37410 120139 79586732
Hepatic enzyme increased 17.78 12.83 37 37480 182573 79524298
Anaemia 17.75 12.83 301 37216 444714 79262157
Urticaria 17.63 12.83 38 37479 185163 79521708
Disease recurrence 17.46 12.83 53 37464 44056 79662815
Overdose 17.37 12.83 38 37479 184168 79522703
Disseminated cytomegaloviral infection 17.34 12.83 7 37510 468 79706403
Porphyria non-acute 17.33 12.83 8 37509 741 79706130
Herpes zoster meningoencephalitis 17.21 12.83 8 37509 753 79706118
Post lumbar puncture syndrome 17.17 12.83 8 37509 757 79706114
Functional gastrointestinal disorder 17.06 12.83 16 37501 4974 79701897
Antithrombin III decreased 16.99 12.83 7 37510 493 79706378
Therapeutic product effect decreased 16.98 12.83 32 37485 163831 79543040
Differentiation syndrome 16.95 12.83 12 37505 2512 79704359
Wheezing 16.84 12.83 18 37499 116646 79590225
Eosinophilic pneumonia chronic 16.75 12.83 7 37510 511 79706360
Encopresis 16.71 12.83 5 37512 135 79706736
Tonsil cancer 16.71 12.83 9 37508 1159 79705712
Toe walking 16.69 12.83 3 37514 6 79706865
Jaundice 16.54 12.83 59 37458 53290 79653581
Malignant neoplasm progression 16.47 12.83 24 37493 135966 79570905
Sleep disorder 16.38 12.83 10 37507 85667 79621204
Cutaneous leishmaniasis 16.35 12.83 6 37511 309 79706562
Haematocolpos 16.34 12.83 4 37513 49 79706822
Haematochezia 16.32 12.83 83 37434 87562 79619309
Rectal abscess 16.29 12.83 11 37506 2134 79704737
Pancreatitis necrotising 16.26 12.83 14 37503 3894 79702977
Cardiac failure 16.26 12.83 30 37487 154812 79552059
Disseminated trichosporonosis 16.12 12.83 5 37512 153 79706718
Magnetic resonance imaging head abnormal 16.12 12.83 12 37505 2714 79704157
Vascular access complication 16.12 12.83 11 37506 2171 79704700
Gastrointestinal haemorrhage 16.07 12.83 28 37489 147691 79559180
Metastases to pancreas 15.99 12.83 7 37510 573 79706298
Stomatitis 15.97 12.83 121 37396 146636 79560235
Rhabdomyolysis 15.93 12.83 15 37502 103116 79603755
Blood growth hormone decreased 15.65 12.83 4 37513 59 79706812
Enterocolitis infectious 15.57 12.83 12 37505 2857 79704014
Blister 15.56 12.83 20 37497 119456 79587415
Anaemia megaloblastic 15.38 12.83 7 37510 628 79706243
Eye opacity 15.37 12.83 3 37514 11 79706860
Hyperhidrosis 15.34 12.83 30 37487 151462 79555409
Autoimmune lymphoproliferative syndrome 15.24 12.83 5 37512 184 79706687
Acute lymphocytic leukaemia 15.22 12.83 15 37502 4954 79701917
Steatohepatitis 15.22 12.83 8 37509 982 79705889
Respiratory distress 15.18 12.83 61 37456 58278 79648593
Pericardial cyst 15.16 12.83 3 37514 12 79706859
West Nile viral infection 15.12 12.83 8 37509 994 79705877
Cardiac disorder 15.10 12.83 6 37511 65751 79641120
Placental transfusion syndrome 15.07 12.83 4 37513 69 79706802
Oesophageal mass 15.07 12.83 4 37513 69 79706802
Paraplegia 15.01 12.83 15 37502 5038 79701833
Multiple lentigines syndrome 14.96 12.83 5 37512 195 79706676
Melaena 14.93 12.83 5 37512 60885 79645986
Faecal calprotectin abnormal 14.86 12.83 5 37512 199 79706672
Mucoepidermoid carcinoma 14.80 12.83 4 37513 74 79706797
Mucous stools 14.74 12.83 15 37502 5147 79701724
Stomatitis necrotising 14.72 12.83 5 37512 205 79706666
Acute myocardial infarction 14.72 12.83 9 37508 77027 79629844
Dysplastic naevus syndrome 14.62 12.83 3 37514 15 79706856
Anorectal infection 14.51 12.83 6 37511 426 79706445
Bacteraemia 14.49 12.83 41 37476 32783 79674088
Lennox-Gastaut syndrome 14.45 12.83 5 37512 217 79706654
Dry skin 14.36 12.83 7 37510 67988 79638883
Dyspepsia 14.36 12.83 18 37499 108669 79598202
Enterocolitis 14.28 12.83 25 37492 14487 79692384
Memory impairment 14.25 12.83 19 37498 111715 79595156
Drug level above therapeutic 14.22 12.83 19 37498 8704 79698167
Pseudopolyp 14.16 12.83 6 37511 453 79706418
Red blood cell microcytes present 14.16 12.83 3 37514 18 79706853
Hepatic infection fungal 14.11 12.83 5 37512 233 79706638
Gastrointestinal sounds abnormal 14.10 12.83 15 37502 5420 79701451
Hyperglycaemia 14.09 12.83 68 37449 70267 79636604
Listeria sepsis 14.08 12.83 7 37510 765 79706106
Aplastic anaemia 14.06 12.83 28 37489 17877 79688994
Intestinal dilatation 14.02 12.83 11 37506 2689 79704182
Pulmonary mucormycosis 14.00 12.83 8 37509 1157 79705714
Pneumonia aspiration 13.98 12.83 7 37510 66960 79639911
Ocular icterus 13.95 12.83 15 37502 5485 79701386
Bilirubin conjugated increased 13.86 12.83 15 37502 5524 79701347
Mucocutaneous candidiasis 13.86 12.83 4 37513 95 79706776
Immunosuppression 13.84 12.83 23 37494 12780 79694091
Partial seizures 13.80 12.83 19 37498 8959 79697912
Eosinophilic bronchitis 13.76 12.83 6 37511 486 79706385
Blood immunoglobulin G decreased 13.76 12.83 12 37505 3397 79703474
Anaemia macrocytic 13.73 12.83 15 37502 5582 79701289
Agitation 13.71 12.83 16 37501 99699 79607172
Epstein-Barr viraemia 13.70 12.83 10 37507 2195 79704676
Respiratory arrest 13.64 12.83 5 37512 57545 79649326
Fistula of small intestine 13.62 12.83 7 37510 820 79706051
Ill-defined disorder 13.59 12.83 7 37510 65868 79641003
Superinfection 13.56 12.83 14 37503 4888 79701983
Epstein Barr virus positive mucocutaneous ulcer 13.56 12.83 7 37510 828 79706043
Injury 13.53 12.83 10 37507 77486 79629385
Papulopustular rosacea 13.41 12.83 3 37514 24 79706847
Dry mouth 13.36 12.83 13 37504 88006 79618865
Inappropriate schedule of product administration 13.33 12.83 108 37409 133520 79573351
Staphylococcal bacteraemia 13.28 12.83 22 37495 12196 79694675
Blood glucose increased 13.24 12.83 21 37496 114954 79591917
Ewing's sarcoma 13.19 12.83 3 37514 26 79706845
Bone marrow necrosis 13.18 12.83 5 37512 283 79706588
Adenovirus infection 13.17 12.83 18 37499 8429 79698442
Furuncle 13.16 12.83 17 37500 7537 79699334
Systemic candida 13.14 12.83 16 37501 6690 79700181
Chills 13.13 12.83 124 37393 160110 79546761
Acute kidney injury 13.12 12.83 169 37348 519235 79187636
Pneumococcal bacteraemia 13.07 12.83 4 37513 117 79706754
Leukaemia 13.03 12.83 15 37502 5910 79700961
Adrenal insufficiency 12.98 12.83 36 37481 28451 79678420
Contusion 12.97 12.83 32 37485 148744 79558127
Viral myelitis 12.94 12.83 4 37513 121 79706750
Depersonalisation/derealisation disorder 12.84 12.83 9 37508 1853 79705018

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01BB02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Purine analogues
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:149553 anticoronaviral drug
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
MeSH PA D019384 Nucleic Acid Synthesis Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute lymphoid leukemia indication 91857003 DOID:9952
Acute promyelocytic leukemia, FAB M3 indication 110004001
Psoriasis with arthropathy off-label use 33339001
Crohn's disease off-label use 34000006
Ulcerative colitis off-label use 64766004 DOID:8577
Acute myeloid leukemia, disease off-label use 91861009
Polycythemia vera off-label use 109992005
Hyperbilirubinemia contraindication 14783006 DOID:2741
Obstruction of bile duct contraindication 30144000
Dehydration contraindication 34095006
Gastrointestinal ulcer contraindication 40845000
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Ascites contraindication 389026000
Breastfeeding (mother) contraindication 413712001
Hepatosplenic T-cell lymphoma contraindication 445406001
Chemotherapy-Induced Hyperuricemia contraindication
Thiopurine S-Methyltransferase Deficiency contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.99 acidic
pKa2 10.76 acidic
pKa3 3.37 Basic
pKa4 1.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Amidophosphoribosyltransferase Enzyme INHIBITOR DRUGBANK CHEMBL
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Prostaglandin G/H synthase 1 Enzyme IC50 4.79 DRUG MATRIX
Thiopurine S-methyltransferase Enzyme WOMBAT-PK
Purine nucleoside phosphorylase Enzyme WOMBAT-PK
Purine nucleoside phosphorylase Enzyme Kd 4.10 CHEMBL

External reference:

IDSource
4018776 VUID
N0000147079 NUI
D00161 KEGG_DRUG
4018776 VANDF
C0000618 UMLSCUI
CHEBI:50667 CHEBI
PM6 PDB_CHEM_ID
CHEMBL1425 ChEMBL_ID
CHEMBL1200751 ChEMBL_ID
DB01033 DRUGBANK_ID
D015122 MESH_DESCRIPTOR_UI
667490 PUBCHEM_CID
7226 IUPHAR_LIGAND_ID
E7WED276I5 UNII
103 RXNORM
3886 MMSL
48948 MMSL
5052 MMSL
NOCODE MMSL
d00289 MMSL
002647 NDDF
1039008 SNOMEDCT_US
386835005 SNOMEDCT_US
6112-76-1 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 0054-4581 TABLET 50 mg ORAL ANDA 29 sections
Mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3547 TABLET 50 mg ORAL ANDA 29 sections
Mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3547 TABLET 50 mg ORAL ANDA 29 sections
mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 49884-922 TABLET 50 mg ORAL ANDA 24 sections
mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 54868-5282 TABLET 50 mg ORAL ANDA 24 sections
PURINETHOL HUMAN PRESCRIPTION DRUG LABEL 1 60763-601 TABLET 50 mg ORAL NDA 30 sections
PURIXAN HUMAN PRESCRIPTION DRUG LABEL 1 62484-0020 SUSPENSION 20 mg ORAL NDA 19 sections
PURIXAN HUMAN PRESCRIPTION DRUG LABEL 1 62484-0020 SUSPENSION 20 mg ORAL NDA 19 sections
Mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 69076-913 TABLET 50 mg ORAL NDA authorized generic 31 sections