Stem definition | Drug id | CAS RN |
---|---|---|
1708 | 50-44-2 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 22 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 16.43 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 12 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 15 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.85 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 11, 1953 | FDA | STASON PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 767.65 | 14.06 | 467 | 18869 | 105078 | 56167653 |
Febrile bone marrow aplasia | 312.28 | 14.06 | 108 | 19228 | 6464 | 56266267 |
Crohn's disease | 295.28 | 14.06 | 103 | 19233 | 6324 | 56266407 |
Venoocclusive liver disease | 250.78 | 14.06 | 83 | 19253 | 4338 | 56268393 |
Colitis ulcerative | 181.88 | 14.06 | 110 | 19226 | 24281 | 56248450 |
Pancytopenia | 161.91 | 14.06 | 175 | 19161 | 88540 | 56184191 |
Temporal lobe epilepsy | 138.25 | 14.06 | 31 | 19305 | 355 | 56272376 |
Hyperbilirubinaemia | 113.83 | 14.06 | 60 | 19276 | 10175 | 56262556 |
Haematotoxicity | 107.24 | 14.06 | 54 | 19282 | 8329 | 56264402 |
Neurotoxicity | 106.93 | 14.06 | 67 | 19269 | 15728 | 56257003 |
Acute lymphocytic leukaemia recurrent | 102.36 | 14.06 | 36 | 19300 | 2261 | 56270470 |
Rhinovirus infection | 100.43 | 14.06 | 41 | 19295 | 3881 | 56268850 |
Off label use | 96.95 | 14.06 | 412 | 18924 | 555768 | 55716963 |
Pyrexia | 94.72 | 14.06 | 337 | 18999 | 418436 | 55854295 |
Haemophagocytic lymphohistiocytosis | 92.17 | 14.06 | 51 | 19285 | 9521 | 56263210 |
Hypertriglyceridaemia | 91.02 | 14.06 | 43 | 19293 | 5773 | 56266958 |
Abdominal pain | 81.92 | 14.06 | 234 | 19102 | 258571 | 56014160 |
Human bocavirus infection | 80.94 | 14.06 | 20 | 19316 | 357 | 56272374 |
Pancreatitis | 73.65 | 14.06 | 84 | 19252 | 44996 | 56227735 |
Perineal necrosis | 66.85 | 14.06 | 14 | 19322 | 113 | 56272618 |
Joint swelling | 66.77 | 14.06 | 10 | 19326 | 289790 | 55982941 |
Pain | 65.72 | 14.06 | 79 | 19257 | 663105 | 55609626 |
Acute myeloid leukaemia | 65.49 | 14.06 | 51 | 19285 | 16921 | 56255810 |
Perineal infection | 65.00 | 14.06 | 14 | 19322 | 131 | 56272600 |
Neoplasm recurrence | 63.91 | 14.06 | 26 | 19310 | 2438 | 56270293 |
Secondary immunodeficiency | 61.30 | 14.06 | 21 | 19315 | 1219 | 56271512 |
Bacterial infection | 60.29 | 14.06 | 49 | 19287 | 17281 | 56255450 |
Enterovirus test positive | 58.87 | 14.06 | 13 | 19323 | 138 | 56272593 |
Enterobacter infection | 57.88 | 14.06 | 23 | 19313 | 2029 | 56270702 |
Gastroenteritis norovirus | 56.78 | 14.06 | 22 | 19314 | 1815 | 56270916 |
Leukaemia recurrent | 56.08 | 14.06 | 20 | 19316 | 1308 | 56271423 |
Pneumatosis intestinalis | 56.00 | 14.06 | 23 | 19313 | 2210 | 56270521 |
Occupational asthma | 54.46 | 14.06 | 12 | 19324 | 126 | 56272605 |
Human rhinovirus test positive | 51.35 | 14.06 | 12 | 19324 | 167 | 56272564 |
Herpes simplex | 51.15 | 14.06 | 32 | 19304 | 7486 | 56265245 |
Alanine aminotransferase increased | 50.33 | 14.06 | 104 | 19232 | 93558 | 56179173 |
Abdominal discomfort | 49.11 | 14.06 | 17 | 19319 | 277257 | 55995474 |
Hepatocellular injury | 47.75 | 14.06 | 52 | 19284 | 26462 | 56246269 |
Colitis | 47.57 | 14.06 | 65 | 19271 | 41746 | 56230985 |
Trichodysplasia spinulosa | 47.27 | 14.06 | 14 | 19322 | 505 | 56272226 |
Bacillus infection | 46.89 | 14.06 | 15 | 19321 | 702 | 56272029 |
Antithrombin III | 46.88 | 14.06 | 11 | 19325 | 156 | 56272575 |
Bone marrow failure | 46.68 | 14.06 | 53 | 19283 | 28233 | 56244498 |
Fall | 46.65 | 14.06 | 33 | 19303 | 357477 | 55915254 |
Mucosal inflammation | 46.37 | 14.06 | 65 | 19271 | 42745 | 56229986 |
Human herpesvirus 6 infection | 45.59 | 14.06 | 21 | 19315 | 2661 | 56270070 |
Neutropenia | 45.15 | 14.06 | 138 | 19198 | 158029 | 56114702 |
Hepatosplenic T-cell lymphoma | 44.82 | 14.06 | 14 | 19322 | 606 | 56272125 |
Arthropathy | 43.68 | 14.06 | 8 | 19328 | 200267 | 56072464 |
Oesophageal dilatation | 43.43 | 14.06 | 12 | 19324 | 336 | 56272395 |
Bacterial vulvovaginitis | 42.74 | 14.06 | 14 | 19322 | 707 | 56272024 |
Peripheral swelling | 42.23 | 14.06 | 14 | 19322 | 234712 | 56038019 |
Acute lymphocytic leukaemia | 42.05 | 14.06 | 20 | 19316 | 2724 | 56270007 |
Partial seizures | 41.94 | 14.06 | 25 | 19311 | 5365 | 56267366 |
Second primary malignancy | 41.73 | 14.06 | 28 | 19308 | 7374 | 56265357 |
Epstein-Barr virus infection | 41.52 | 14.06 | 28 | 19308 | 7435 | 56265296 |
Clostridium difficile colitis | 41.38 | 14.06 | 41 | 19295 | 18697 | 56254034 |
Rectal cancer metastatic | 41.27 | 14.06 | 11 | 19325 | 268 | 56272463 |
Synovitis | 40.96 | 14.06 | 4 | 19332 | 161301 | 56111430 |
Venous thrombosis | 40.28 | 14.06 | 23 | 19313 | 4557 | 56268174 |
Hypoglycaemia | 39.89 | 14.06 | 70 | 19266 | 55745 | 56216986 |
Perirectal abscess | 39.77 | 14.06 | 14 | 19322 | 881 | 56271850 |
Hypertransaminasaemia | 39.69 | 14.06 | 23 | 19313 | 4684 | 56268047 |
Myelopathy | 39.66 | 14.06 | 19 | 19317 | 2629 | 56270102 |
Anal abscess | 39.41 | 14.06 | 22 | 19314 | 4175 | 56268556 |
Hepatotoxicity | 39.38 | 14.06 | 51 | 19285 | 31102 | 56241629 |
Hypoalbuminaemia | 39.06 | 14.06 | 31 | 19305 | 10568 | 56262163 |
Swelling | 38.65 | 14.06 | 17 | 19319 | 239754 | 56032977 |
Female sterilisation | 38.34 | 14.06 | 12 | 19324 | 523 | 56272208 |
Device related infection | 37.82 | 14.06 | 42 | 19294 | 21838 | 56250893 |
Anal fistula | 37.57 | 14.06 | 19 | 19317 | 2955 | 56269776 |
Sepsis | 37.12 | 14.06 | 119 | 19217 | 139721 | 56133010 |
Post lumbar puncture syndrome | 36.98 | 14.06 | 12 | 19324 | 588 | 56272143 |
Intestinal stenosis | 36.76 | 14.06 | 18 | 19318 | 2613 | 56270118 |
Segmental diverticular colitis | 36.19 | 14.06 | 9 | 19327 | 165 | 56272566 |
Pedal pulse abnormal | 35.79 | 14.06 | 9 | 19327 | 173 | 56272558 |
Strongyloidiasis | 35.65 | 14.06 | 14 | 19322 | 1197 | 56271534 |
Death | 35.50 | 14.06 | 39 | 19297 | 341387 | 55931344 |
Cholestasis | 35.50 | 14.06 | 45 | 19291 | 26868 | 56245863 |
Venoocclusive disease | 35.24 | 14.06 | 16 | 19320 | 1961 | 56270770 |
Completed suicide | 34.83 | 14.06 | 3 | 19333 | 133830 | 56138901 |
Bile acid malabsorption | 34.64 | 14.06 | 9 | 19327 | 198 | 56272533 |
Enteritis | 34.57 | 14.06 | 25 | 19311 | 7418 | 56265313 |
Cerebral venous sinus thrombosis | 33.63 | 14.06 | 15 | 19321 | 1763 | 56270968 |
Blood culture positive | 33.40 | 14.06 | 20 | 19316 | 4326 | 56268405 |
Mucormycosis | 32.95 | 14.06 | 17 | 19319 | 2757 | 56269974 |
Fistula | 32.84 | 14.06 | 26 | 19310 | 8829 | 56263902 |
Central obesity | 32.81 | 14.06 | 13 | 19323 | 1138 | 56271593 |
Ileal stenosis | 32.35 | 14.06 | 14 | 19322 | 1531 | 56271200 |
Fatigue | 32.01 | 14.06 | 151 | 19185 | 788401 | 55484330 |
Leukopenia | 31.53 | 14.06 | 73 | 19263 | 70867 | 56201864 |
Pseudomonas test positive | 31.52 | 14.06 | 11 | 19325 | 675 | 56272056 |
Wound | 31.45 | 14.06 | 5 | 19331 | 138799 | 56133932 |
Intestinal resection | 31.36 | 14.06 | 16 | 19320 | 2534 | 56270197 |
Calcium ionised decreased | 31.22 | 14.06 | 9 | 19327 | 295 | 56272436 |
Myelodysplastic syndrome | 30.98 | 14.06 | 33 | 19303 | 16373 | 56256358 |
Glioma | 30.65 | 14.06 | 9 | 19327 | 315 | 56272416 |
Staphylococcal sepsis | 30.35 | 14.06 | 23 | 19313 | 7326 | 56265405 |
Insomnia | 30.29 | 14.06 | 14 | 19322 | 191846 | 56080885 |
Discomfort | 30.18 | 14.06 | 6 | 19330 | 141755 | 56130976 |
Subacute combined cord degeneration | 29.02 | 14.06 | 8 | 19328 | 222 | 56272509 |
Feeding intolerance | 29.00 | 14.06 | 10 | 19326 | 592 | 56272139 |
Lymphoproliferative disorder | 28.78 | 14.06 | 16 | 19320 | 3012 | 56269719 |
Lower respiratory tract infection | 28.74 | 14.06 | 3 | 19333 | 114791 | 56157940 |
Pancreatitis acute | 28.48 | 14.06 | 39 | 19297 | 25085 | 56247646 |
Cytomegalovirus infection | 28.24 | 14.06 | 34 | 19302 | 19262 | 56253469 |
Asthma | 28.09 | 14.06 | 3 | 19333 | 112767 | 56159964 |
Vital capacity decreased | 28.05 | 14.06 | 12 | 19324 | 1276 | 56271455 |
Dyspnoea | 27.98 | 14.06 | 107 | 19229 | 592470 | 55680261 |
Neutrophil count decreased | 27.54 | 14.06 | 56 | 19280 | 49766 | 56222965 |
Superior sagittal sinus thrombosis | 27.15 | 14.06 | 10 | 19326 | 717 | 56272014 |
Histoplasmosis | 26.99 | 14.06 | 13 | 19323 | 1821 | 56270910 |
Porphyria non-acute | 26.95 | 14.06 | 8 | 19328 | 291 | 56272440 |
Leukoencephalopathy | 26.83 | 14.06 | 17 | 19319 | 4065 | 56268666 |
Epstein-Barr virus associated lymphoma | 26.54 | 14.06 | 9 | 19327 | 506 | 56272225 |
Abdominal adhesions | 26.54 | 14.06 | 15 | 19321 | 2914 | 56269817 |
Acute lymphocytic leukaemia refractory | 26.20 | 14.06 | 6 | 19330 | 76 | 56272655 |
Jaundice | 25.99 | 14.06 | 39 | 19297 | 27255 | 56245476 |
Painful respiration | 25.87 | 14.06 | 14 | 19322 | 2500 | 56270231 |
Blood bilirubin increased | 25.36 | 14.06 | 43 | 19293 | 33311 | 56239420 |
Cardiotoxicity | 25.28 | 14.06 | 21 | 19315 | 7629 | 56265102 |
Musculoskeletal stiffness | 25.22 | 14.06 | 11 | 19325 | 155996 | 56116735 |
Drug interaction | 25.17 | 14.06 | 140 | 19196 | 209615 | 56063116 |
Enterovirus infection | 24.89 | 14.06 | 10 | 19326 | 908 | 56271823 |
Chloroma | 24.68 | 14.06 | 7 | 19329 | 216 | 56272515 |
Clostridium difficile infection | 24.68 | 14.06 | 38 | 19298 | 27160 | 56245571 |
Large intestinal stenosis | 24.43 | 14.06 | 12 | 19324 | 1754 | 56270977 |
Systemic lupus erythematosus | 24.28 | 14.06 | 16 | 19320 | 180062 | 56092669 |
Metastases to pancreas | 24.15 | 14.06 | 7 | 19329 | 234 | 56272497 |
Encopresis | 24.03 | 14.06 | 6 | 19330 | 112 | 56272619 |
Lung opacity | 23.99 | 14.06 | 13 | 19323 | 2328 | 56270403 |
Haemolytic uraemic syndrome | 23.64 | 14.06 | 13 | 19323 | 2395 | 56270336 |
Aborted pregnancy | 23.39 | 14.06 | 5 | 19331 | 45 | 56272686 |
Influenza B virus test positive | 23.31 | 14.06 | 7 | 19329 | 265 | 56272466 |
Inflammatory bowel disease | 23.05 | 14.06 | 15 | 19321 | 3753 | 56268978 |
Cytogenetic abnormality | 22.95 | 14.06 | 8 | 19328 | 489 | 56272242 |
Lipase increased | 22.38 | 14.06 | 21 | 19315 | 8958 | 56263773 |
Breakthrough pain | 22.34 | 14.06 | 10 | 19326 | 1186 | 56271545 |
Aplasia | 22.25 | 14.06 | 15 | 19321 | 3981 | 56268750 |
Stress urinary incontinence | 22.16 | 14.06 | 12 | 19324 | 2146 | 56270585 |
Pseudomonal sepsis | 22.01 | 14.06 | 12 | 19324 | 2174 | 56270557 |
Coagulopathy | 21.13 | 14.06 | 29 | 19307 | 18687 | 56254044 |
Seizure | 21.06 | 14.06 | 92 | 19244 | 125027 | 56147704 |
Anaemia megaloblastic | 21.02 | 14.06 | 7 | 19329 | 372 | 56272359 |
Gamma-glutamyltransferase increased | 21.01 | 14.06 | 38 | 19298 | 30967 | 56241764 |
West Nile viral infection | 20.99 | 14.06 | 7 | 19329 | 374 | 56272357 |
Drug specific antibody present | 20.96 | 14.06 | 14 | 19322 | 3658 | 56269073 |
Haematochezia | 20.54 | 14.06 | 46 | 19290 | 43672 | 56229059 |
Vocal cord paralysis | 20.53 | 14.06 | 11 | 19325 | 1926 | 56270805 |
Gastrointestinal sounds abnormal | 20.51 | 14.06 | 14 | 19322 | 3791 | 56268940 |
Overgrowth fungal | 20.09 | 14.06 | 5 | 19331 | 92 | 56272639 |
Appendicitis | 19.93 | 14.06 | 18 | 19318 | 7314 | 56265417 |
Respiratory tract haemorrhage | 19.91 | 14.06 | 7 | 19329 | 439 | 56272292 |
Blood pressure abnormal | 19.87 | 14.06 | 24 | 19312 | 13636 | 56259095 |
Bone marrow disorder | 19.82 | 14.06 | 11 | 19325 | 2063 | 56270668 |
Cushingoid | 19.82 | 14.06 | 18 | 19318 | 7366 | 56265365 |
Rectal abscess | 19.81 | 14.06 | 9 | 19327 | 1105 | 56271626 |
Escherichia infection | 19.43 | 14.06 | 22 | 19314 | 11677 | 56261054 |
Glossitis | 19.37 | 14.06 | 12 | 19324 | 2758 | 56269973 |
Confusional state | 19.25 | 14.06 | 26 | 19310 | 208129 | 56064602 |
Meningitis coccidioides | 19.13 | 14.06 | 4 | 19332 | 32 | 56272699 |
Viral infection | 18.96 | 14.06 | 37 | 19299 | 31909 | 56240822 |
Hyperglycaemia | 18.80 | 14.06 | 41 | 19295 | 38240 | 56234491 |
Transverse sinus thrombosis | 18.79 | 14.06 | 7 | 19329 | 518 | 56272213 |
Pericarditis | 18.71 | 14.06 | 7 | 19329 | 108916 | 56163815 |
Staphylococcal bacteraemia | 18.69 | 14.06 | 15 | 19321 | 5194 | 56267537 |
Precursor T-lymphoblastic lymphoma/leukaemia | 18.52 | 14.06 | 4 | 19332 | 38 | 56272693 |
Herpes zoster meningoencephalitis | 18.34 | 14.06 | 6 | 19330 | 302 | 56272429 |
Histoplasmosis disseminated | 18.27 | 14.06 | 9 | 19327 | 1323 | 56271408 |
Rhinocerebral mucormycosis | 18.26 | 14.06 | 6 | 19330 | 306 | 56272425 |
Myelosuppression | 18.15 | 14.06 | 26 | 19310 | 17429 | 56255302 |
Mucoepidermoid carcinoma | 18.07 | 14.06 | 4 | 19332 | 43 | 56272688 |
Proctalgia | 17.95 | 14.06 | 15 | 19321 | 5494 | 56267237 |
Contusion | 17.87 | 14.06 | 11 | 19325 | 128419 | 56144312 |
Feeling abnormal | 17.83 | 14.06 | 12 | 19324 | 133590 | 56139141 |
Pericardial cyst | 17.64 | 14.06 | 3 | 19333 | 6 | 56272725 |
Pyoderma gangrenosum | 17.55 | 14.06 | 12 | 19324 | 3258 | 56269473 |
Atypical haemolytic uraemic syndrome | 17.51 | 14.06 | 7 | 19329 | 627 | 56272104 |
Small intestinal obstruction | 17.40 | 14.06 | 25 | 19311 | 16800 | 56255931 |
Oesophageal mass | 17.37 | 14.06 | 4 | 19332 | 52 | 56272679 |
Listeria sepsis | 17.32 | 14.06 | 7 | 19329 | 645 | 56272086 |
Haematocolpos | 17.16 | 14.06 | 4 | 19332 | 55 | 56272676 |
Atrial fibrillation | 17.09 | 14.06 | 8 | 19328 | 108889 | 56163842 |
Thrombocytopenia | 17.04 | 14.06 | 92 | 19244 | 136132 | 56136599 |
Acute myelomonocytic leukaemia | 16.81 | 14.06 | 5 | 19331 | 183 | 56272548 |
T-cell lymphoma | 16.79 | 14.06 | 7 | 19329 | 698 | 56272033 |
Lupus-like syndrome | 16.73 | 14.06 | 21 | 19315 | 12406 | 56260325 |
Hemiparesis | 16.72 | 14.06 | 28 | 19308 | 21462 | 56251269 |
Ocular icterus | 16.64 | 14.06 | 12 | 19324 | 3544 | 56269187 |
Drug level decreased | 16.61 | 14.06 | 16 | 19320 | 7048 | 56265683 |
Somnolence | 16.59 | 14.06 | 19 | 19317 | 163394 | 56109337 |
Vulval disorder | 16.56 | 14.06 | 7 | 19329 | 723 | 56272008 |
Cerebral ischaemia | 16.52 | 14.06 | 15 | 19321 | 6135 | 56266596 |
Frequent bowel movements | 16.40 | 14.06 | 24 | 19312 | 16400 | 56256331 |
Intracardiac thrombus | 16.28 | 14.06 | 10 | 19326 | 2265 | 56270466 |
T-cell type acute leukaemia | 16.15 | 14.06 | 4 | 19332 | 72 | 56272659 |
Toe walking | 16.11 | 14.06 | 3 | 19333 | 12 | 56272719 |
Psoriatic arthropathy | 16.02 | 14.06 | 3 | 19333 | 74005 | 56198726 |
Quadriplegia | 16.02 | 14.06 | 9 | 19327 | 1729 | 56271002 |
Functional gastrointestinal disorder | 15.91 | 14.06 | 12 | 19324 | 3795 | 56268936 |
Osteoarthritis | 15.87 | 14.06 | 4 | 19332 | 80292 | 56192439 |
Anal fissure | 15.84 | 14.06 | 12 | 19324 | 3819 | 56268912 |
Dizziness | 15.78 | 14.06 | 71 | 19265 | 376069 | 55896662 |
Pneumocystis jirovecii pneumonia | 15.76 | 14.06 | 23 | 19313 | 15678 | 56257053 |
Rash | 15.76 | 14.06 | 102 | 19234 | 492945 | 55779786 |
Glioblastoma multiforme | 15.75 | 14.06 | 7 | 19329 | 816 | 56271915 |
Hippocampal sclerosis | 15.71 | 14.06 | 4 | 19332 | 81 | 56272650 |
Hepatosplenomegaly | 15.66 | 14.06 | 10 | 19326 | 2423 | 56270308 |
Depersonalisation/derealisation disorder | 15.66 | 14.06 | 8 | 19328 | 1271 | 56271460 |
Pericardial effusion | 15.56 | 14.06 | 31 | 19305 | 27144 | 56245587 |
Gambling | 15.55 | 14.06 | 5 | 19331 | 238 | 56272493 |
Intestinal operation | 15.51 | 14.06 | 6 | 19330 | 493 | 56272238 |
Bronchitis chronic | 15.42 | 14.06 | 12 | 19324 | 3976 | 56268755 |
Amylase increased | 15.35 | 14.06 | 14 | 19322 | 5757 | 56266974 |
Histiocytic sarcoma | 15.31 | 14.06 | 4 | 19332 | 90 | 56272641 |
Pneumonia fungal | 15.28 | 14.06 | 13 | 19323 | 4880 | 56267851 |
Potentiating drug interaction | 15.21 | 14.06 | 12 | 19324 | 4054 | 56268677 |
Malaise | 15.10 | 14.06 | 70 | 19266 | 367790 | 55904941 |
Campylobacter infection | 15.03 | 14.06 | 7 | 19329 | 909 | 56271822 |
Pseudopolyp | 15.01 | 14.06 | 5 | 19331 | 266 | 56272465 |
Anogenital dysplasia | 14.96 | 14.06 | 3 | 19333 | 19 | 56272712 |
Listeriosis | 14.92 | 14.06 | 8 | 19328 | 1402 | 56271329 |
Diarrhoea haemorrhagic | 14.87 | 14.06 | 16 | 19320 | 8027 | 56264704 |
Furuncle | 14.77 | 14.06 | 14 | 19322 | 6045 | 56266686 |
Cerebral haemangioma | 14.72 | 14.06 | 4 | 19332 | 105 | 56272626 |
Lymphoma | 14.65 | 14.06 | 18 | 19318 | 10410 | 56262321 |
Lennox-Gastaut syndrome | 14.65 | 14.06 | 5 | 19331 | 287 | 56272444 |
Inappropriate schedule of product administration | 14.55 | 14.06 | 62 | 19274 | 83325 | 56189406 |
Extraskeletal ossification | 14.51 | 14.06 | 4 | 19332 | 111 | 56272620 |
Papulopustular rosacea | 14.46 | 14.06 | 3 | 19333 | 23 | 56272708 |
Pruritus | 14.36 | 14.06 | 58 | 19278 | 316565 | 55956166 |
Choriomeningitis lymphocytic | 14.24 | 14.06 | 3 | 19333 | 25 | 56272706 |
Vomiting | 14.18 | 14.06 | 245 | 19091 | 497983 | 55774748 |
Blood immunoglobulin G decreased | 14.11 | 14.06 | 9 | 19327 | 2177 | 56270554 |
Aspergillus infection | 14.06 | 14.06 | 15 | 19321 | 7450 | 56265281 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 861.13 | 14.83 | 672 | 19648 | 121177 | 31555847 |
Hepatosplenic T-cell lymphoma | 251.42 | 14.83 | 60 | 20260 | 465 | 31676559 |
Venoocclusive liver disease | 212.70 | 14.83 | 101 | 20219 | 7311 | 31669713 |
Febrile bone marrow aplasia | 201.24 | 14.83 | 99 | 20221 | 7747 | 31669277 |
Haematotoxicity | 197.93 | 14.83 | 95 | 20225 | 7042 | 31669982 |
Crohn's disease | 162.15 | 14.83 | 70 | 20250 | 4051 | 31672973 |
Hypertriglyceridaemia | 155.35 | 14.83 | 83 | 20237 | 7715 | 31669309 |
Death | 138.86 | 14.83 | 31 | 20289 | 360538 | 31316486 |
Acute lymphocytic leukaemia recurrent | 125.21 | 14.83 | 54 | 20266 | 3116 | 31673908 |
Pancytopenia | 122.90 | 14.83 | 209 | 20111 | 87107 | 31589917 |
Colitis ulcerative | 110.42 | 14.83 | 93 | 20227 | 18436 | 31658588 |
Bone marrow failure | 103.94 | 14.83 | 108 | 20212 | 27900 | 31649124 |
Multiple-drug resistance | 95.78 | 14.83 | 50 | 20270 | 4430 | 31672594 |
Pyrexia | 95.67 | 14.83 | 416 | 19904 | 303424 | 31373600 |
Cytomegalovirus chorioretinitis | 93.11 | 14.83 | 45 | 20275 | 3383 | 31673641 |
Haemophagocytic lymphohistiocytosis | 91.83 | 14.83 | 69 | 20251 | 11609 | 31665415 |
Colitis | 87.11 | 14.83 | 108 | 20212 | 33779 | 31643245 |
Abdominal pain | 86.92 | 14.83 | 247 | 20073 | 145705 | 31531319 |
Pancreatitis | 82.47 | 14.83 | 108 | 20212 | 35663 | 31641361 |
Osteonecrosis | 81.30 | 14.83 | 69 | 20251 | 13815 | 31663209 |
Neutropenia | 80.13 | 14.83 | 234 | 20086 | 140130 | 31536894 |
Leukoencephalopathy | 76.20 | 14.83 | 41 | 20279 | 3861 | 31673163 |
Hepatotoxicity | 75.01 | 14.83 | 76 | 20244 | 19050 | 31657974 |
Mucosal inflammation | 70.31 | 14.83 | 98 | 20222 | 34329 | 31642695 |
Lentigo | 63.98 | 14.83 | 19 | 20301 | 362 | 31676662 |
Nodular regenerative hyperplasia | 61.10 | 14.83 | 23 | 20297 | 929 | 31676095 |
Enterovirus infection | 59.08 | 14.83 | 21 | 20299 | 719 | 31676305 |
Myelosuppression | 57.97 | 14.83 | 59 | 20261 | 14861 | 31662163 |
Glioma | 56.14 | 14.83 | 17 | 20303 | 347 | 31676677 |
Frequent bowel movements | 54.43 | 14.83 | 48 | 20272 | 10111 | 31666913 |
Off label use | 53.12 | 14.83 | 392 | 19928 | 346882 | 31330142 |
Acute myeloid leukaemia | 50.37 | 14.83 | 61 | 20259 | 18611 | 31658413 |
Epstein-Barr virus associated lymphoproliferative disorder | 49.93 | 14.83 | 24 | 20296 | 1782 | 31675242 |
Myocardial infarction | 47.18 | 14.83 | 8 | 20312 | 113446 | 31563578 |
Drug clearance decreased | 46.26 | 14.83 | 22 | 20298 | 1595 | 31675429 |
Histoplasmosis disseminated | 46.23 | 14.83 | 20 | 20300 | 1162 | 31675862 |
Epstein-Barr virus infection | 45.79 | 14.83 | 37 | 20283 | 6916 | 31670108 |
Gallbladder oedema | 44.73 | 14.83 | 13 | 20307 | 229 | 31676795 |
Venoocclusive disease | 43.74 | 14.83 | 25 | 20295 | 2647 | 31674377 |
Glioblastoma multiforme | 43.62 | 14.83 | 17 | 20303 | 755 | 31676269 |
Portal hypertension | 43.33 | 14.83 | 28 | 20292 | 3697 | 31673327 |
Gastrointestinal wall thickening | 42.96 | 14.83 | 20 | 20300 | 1382 | 31675642 |
Cytogenetic abnormality | 42.55 | 14.83 | 17 | 20303 | 807 | 31676217 |
Atrial fibrillation | 41.23 | 14.83 | 11 | 20309 | 113772 | 31563252 |
Myelodysplastic syndrome | 41.08 | 14.83 | 56 | 20264 | 19195 | 31657829 |
Fall | 40.34 | 14.83 | 36 | 20284 | 186053 | 31490971 |
Hyperbilirubinaemia | 40.13 | 14.83 | 50 | 20270 | 15700 | 31661324 |
Dyspnoea | 40.05 | 14.83 | 102 | 20218 | 343377 | 31333647 |
Intestinal stenosis | 39.38 | 14.83 | 21 | 20299 | 1942 | 31675082 |
Second primary malignancy | 39.23 | 14.83 | 34 | 20286 | 6998 | 31670026 |
B-cell lymphoma | 38.85 | 14.83 | 28 | 20292 | 4417 | 31672607 |
Rhinovirus infection | 37.49 | 14.83 | 25 | 20295 | 3480 | 31673544 |
Dizziness | 36.97 | 14.83 | 44 | 20276 | 199103 | 31477921 |
Cardiac failure congestive | 36.77 | 14.83 | 4 | 20316 | 79383 | 31597641 |
Haematopoietic neoplasm | 35.29 | 14.83 | 8 | 20312 | 48 | 31676976 |
Sepsis | 33.90 | 14.83 | 189 | 20131 | 151740 | 31525284 |
Candida endophthalmitis | 33.50 | 14.83 | 9 | 20311 | 117 | 31676907 |
Ileal stenosis | 32.63 | 14.83 | 16 | 20304 | 1241 | 31675783 |
Cytomegalovirus infection | 31.87 | 14.83 | 57 | 20263 | 24650 | 31652374 |
Acute monocytic leukaemia | 31.62 | 14.83 | 11 | 20309 | 353 | 31676671 |
Leukopenia | 31.55 | 14.83 | 95 | 20225 | 57733 | 31619291 |
Diffuse large B-cell lymphoma | 31.45 | 14.83 | 33 | 20287 | 8608 | 31668416 |
Hepatocellular injury | 30.79 | 14.83 | 52 | 20268 | 21492 | 31655532 |
Anal inflammation | 30.77 | 14.83 | 11 | 20309 | 383 | 31676641 |
Fistula | 30.58 | 14.83 | 27 | 20293 | 5694 | 31671330 |
Pancreatitis acute | 30.42 | 14.83 | 57 | 20263 | 25543 | 31651481 |
Vomiting | 30.30 | 14.83 | 246 | 20074 | 223727 | 31453297 |
Parainfluenzae virus infection | 29.95 | 14.83 | 19 | 20301 | 2430 | 31674594 |
Intracranial pressure increased | 29.84 | 14.83 | 22 | 20298 | 3593 | 31673431 |
Alanine aminotransferase increased | 29.50 | 14.83 | 110 | 20210 | 74546 | 31602478 |
Neutrophil count decreased | 28.96 | 14.83 | 80 | 20240 | 46314 | 31630710 |
Thrombocytopenia | 28.85 | 14.83 | 173 | 20147 | 142574 | 31534450 |
Xanthogranuloma | 28.30 | 14.83 | 7 | 20313 | 64 | 31676960 |
Stomatitis | 27.65 | 14.83 | 71 | 20249 | 39367 | 31637657 |
Myelopathy | 26.42 | 14.83 | 17 | 20303 | 2228 | 31674796 |
Bacterial infection | 26.38 | 14.83 | 38 | 20282 | 13701 | 31663323 |
Leukaemia recurrent | 26.25 | 14.83 | 15 | 20305 | 1587 | 31675437 |
Proctitis | 26.06 | 14.83 | 17 | 20303 | 2280 | 31674744 |
Depression | 25.78 | 14.83 | 13 | 20307 | 90802 | 31586222 |
Human rhinovirus test positive | 25.64 | 14.83 | 8 | 20312 | 181 | 31676843 |
Lymphopenia | 23.76 | 14.83 | 37 | 20283 | 14292 | 31662732 |
Neurotoxicity | 22.96 | 14.83 | 39 | 20281 | 16187 | 31660837 |
Cytomegalovirus hepatitis | 22.86 | 14.83 | 9 | 20311 | 411 | 31676613 |
Superior sagittal sinus thrombosis | 22.67 | 14.83 | 8 | 20312 | 268 | 31676756 |
Anal fistula | 22.48 | 14.83 | 21 | 20299 | 4762 | 31672262 |
Abscess limb | 22.48 | 14.83 | 18 | 20302 | 3321 | 31673703 |
Neoplasm recurrence | 22.42 | 14.83 | 15 | 20305 | 2099 | 31674925 |
Adrenocortical carcinoma | 22.20 | 14.83 | 5 | 20315 | 29 | 31676995 |
Product dose omission issue | 22.16 | 14.83 | 21 | 20299 | 105565 | 31571459 |
Blood fibrinogen decreased | 22.10 | 14.83 | 12 | 20308 | 1150 | 31675874 |
Peripheral swelling | 21.99 | 14.83 | 8 | 20312 | 67857 | 31609167 |
Fungal infection | 21.96 | 14.83 | 36 | 20284 | 14515 | 31662509 |
Cytopenia | 21.95 | 14.83 | 31 | 20289 | 10979 | 31666045 |
Multiple lentigines syndrome | 21.92 | 14.83 | 5 | 20315 | 31 | 31676993 |
Cytomegalovirus colitis | 21.87 | 14.83 | 16 | 20304 | 2582 | 31674442 |
Steatohepatitis | 21.69 | 14.83 | 8 | 20312 | 305 | 31676719 |
Staphylococcal sepsis | 21.68 | 14.83 | 28 | 20292 | 9109 | 31667915 |
Proctalgia | 21.38 | 14.83 | 20 | 20300 | 4542 | 31672482 |
Small intestinal obstruction | 21.25 | 14.83 | 34 | 20286 | 13438 | 31663586 |
Anal abscess | 20.84 | 14.83 | 22 | 20298 | 5778 | 31671246 |
Cardiac arrest | 20.78 | 14.83 | 16 | 20304 | 89046 | 31587978 |
Otitis media acute | 20.74 | 14.83 | 9 | 20311 | 527 | 31676497 |
Completed suicide | 20.65 | 14.83 | 17 | 20303 | 91497 | 31585527 |
Minimal residual disease | 20.51 | 14.83 | 8 | 20312 | 356 | 31676668 |
Dysplastic naevus syndrome | 20.41 | 14.83 | 4 | 20316 | 10 | 31677014 |
Malignant neoplasm progression | 20 | 14.83 | 13 | 20307 | 78985 | 31598039 |
Mucormycosis | 19.79 | 14.83 | 21 | 20299 | 5549 | 31671475 |
Rhabdomyolysis | 19.76 | 14.83 | 8 | 20312 | 63573 | 31613451 |
Thymus enlargement | 19.72 | 14.83 | 5 | 20315 | 51 | 31676973 |
Coronary artery disease | 19.70 | 14.83 | 3 | 20317 | 46084 | 31630940 |
Intestinal diaphragm disease | 19.63 | 14.83 | 7 | 20313 | 242 | 31676782 |
Trichodysplasia spinulosa | 19.49 | 14.83 | 7 | 20313 | 247 | 31676777 |
Chest pain | 19.45 | 14.83 | 28 | 20292 | 116929 | 31560095 |
Transaminases increased | 19.36 | 14.83 | 46 | 20274 | 24295 | 31652729 |
Metapneumovirus infection | 19.19 | 14.83 | 9 | 20311 | 632 | 31676392 |
Chronic obstructive pulmonary disease | 19.17 | 14.83 | 3 | 20317 | 45163 | 31631861 |
Small intestinal stenosis | 18.96 | 14.83 | 8 | 20312 | 437 | 31676587 |
Asthenia | 18.95 | 14.83 | 77 | 20243 | 224678 | 31452346 |
Bifidobacterium infection | 18.61 | 14.83 | 4 | 20316 | 18 | 31677006 |
Rheumatoid arthritis | 18.52 | 14.83 | 4 | 20316 | 47805 | 31629219 |
Confusional state | 18.41 | 14.83 | 36 | 20284 | 133298 | 31543726 |
T-cell lymphoma | 18.23 | 14.83 | 10 | 20310 | 978 | 31676046 |
Hepatic steatosis | 17.87 | 14.83 | 35 | 20285 | 16204 | 31660820 |
Disease progression | 17.83 | 14.83 | 19 | 20301 | 90445 | 31586579 |
Syncope | 17.80 | 14.83 | 17 | 20303 | 85165 | 31591859 |
Human metapneumovirus test positive | 17.77 | 14.83 | 5 | 20315 | 78 | 31676946 |
Vascular access complication | 17.67 | 14.83 | 7 | 20313 | 325 | 31676699 |
Meningitis enterococcal | 17.48 | 14.83 | 5 | 20315 | 83 | 31676941 |
Pneumocystis jirovecii pneumonia | 17.32 | 14.83 | 37 | 20283 | 18214 | 31658810 |
Renal failure | 17.28 | 14.83 | 33 | 20287 | 123297 | 31553727 |
Acral lentiginous melanoma | 17.24 | 14.83 | 4 | 20316 | 27 | 31676997 |
Viral myelitis | 16.99 | 14.83 | 4 | 20316 | 29 | 31676995 |
Gastrointestinal injury | 16.79 | 14.83 | 7 | 20313 | 371 | 31676653 |
Cutaneous leishmaniasis | 16.70 | 14.83 | 6 | 20314 | 212 | 31676812 |
Disseminated cytomegaloviral infection | 16.70 | 14.83 | 6 | 20314 | 212 | 31676812 |
Hip deformity | 16.56 | 14.83 | 5 | 20315 | 101 | 31676923 |
Rectal haemorrhage | 16.47 | 14.83 | 56 | 20264 | 36248 | 31640776 |
Anorectal cellulitis | 16.13 | 14.83 | 4 | 20316 | 37 | 31676987 |
Cardiac failure | 15.90 | 14.83 | 19 | 20301 | 85934 | 31591090 |
Epstein-Barr virus associated lymphoma | 15.79 | 14.83 | 8 | 20312 | 665 | 31676359 |
Pulmonary mucormycosis | 15.63 | 14.83 | 8 | 20312 | 680 | 31676344 |
Meningoradiculitis | 15.59 | 14.83 | 4 | 20316 | 43 | 31676981 |
Colon dysplasia | 15.52 | 14.83 | 5 | 20315 | 126 | 31676898 |
Somnolence | 15.39 | 14.83 | 25 | 20295 | 99420 | 31577604 |
Aspergillus infection | 15.38 | 14.83 | 27 | 20293 | 11501 | 31665523 |
Central nervous system leukaemia | 15.32 | 14.83 | 6 | 20314 | 270 | 31676754 |
Cheilitis | 15.26 | 14.83 | 12 | 20308 | 2156 | 31674868 |
Escherichia infection | 15.20 | 14.83 | 21 | 20299 | 7283 | 31669741 |
Tonsil cancer | 15.15 | 14.83 | 9 | 20311 | 1024 | 31676000 |
Haemorrhagic diathesis | 15.12 | 14.83 | 13 | 20307 | 2647 | 31674377 |
Herpes zoster | 15.09 | 14.83 | 50 | 20270 | 31943 | 31645081 |
Large intestine infection | 14.90 | 14.83 | 10 | 20310 | 1406 | 31675618 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 1549.98 | 12.45 | 1057 | 33615 | 203261 | 70690511 |
Haematotoxicity | 311.21 | 12.45 | 146 | 34526 | 13528 | 70880244 |
Secondary immunodeficiency | 281.29 | 12.45 | 89 | 34583 | 2800 | 70890972 |
Pancytopenia | 274.16 | 12.45 | 353 | 34319 | 150754 | 70743018 |
Febrile bone marrow aplasia | 257.44 | 12.45 | 123 | 34549 | 11868 | 70881904 |
Bacterial infection | 235.57 | 12.45 | 152 | 34520 | 26340 | 70867432 |
Hepatosplenic T-cell lymphoma | 222.02 | 12.45 | 58 | 34614 | 900 | 70892872 |
Hypertriglyceridaemia | 196.82 | 12.45 | 102 | 34570 | 11709 | 70882063 |
Colitis ulcerative | 194.98 | 12.45 | 149 | 34523 | 33774 | 70859998 |
Haemophagocytic lymphohistiocytosis | 185.46 | 12.45 | 117 | 34555 | 19495 | 70874277 |
Acute lymphocytic leukaemia recurrent | 182.27 | 12.45 | 74 | 34598 | 4830 | 70888942 |
Cytomegalovirus chorioretinitis | 180.11 | 12.45 | 75 | 34597 | 5223 | 70888549 |
Parainfluenzae virus infection | 159.62 | 12.45 | 68 | 34604 | 5012 | 70888760 |
Rhinovirus infection | 156.60 | 12.45 | 73 | 34599 | 6660 | 70887112 |
Mycobacterium chelonae infection | 154.79 | 12.45 | 54 | 34618 | 2310 | 70891462 |
Pyrexia | 153.55 | 12.45 | 644 | 34028 | 606308 | 70287464 |
Bone marrow failure | 145.68 | 12.45 | 148 | 34524 | 48862 | 70844910 |
Pancreatitis | 145.42 | 12.45 | 166 | 34506 | 62502 | 70831270 |
Off label use | 138.42 | 12.45 | 721 | 33951 | 742339 | 70151433 |
Myelodysplastic syndrome transformation | 129.21 | 12.45 | 35 | 34637 | 628 | 70893144 |
Rheumatoid arthritis | 128.34 | 12.45 | 3 | 34669 | 291802 | 70601970 |
Pseudomonal sepsis | 125.58 | 12.45 | 59 | 34613 | 5478 | 70888294 |
Mucosal inflammation | 112.76 | 12.45 | 152 | 34520 | 67698 | 70826074 |
Neutropenia | 111.91 | 12.45 | 327 | 34345 | 256829 | 70636943 |
Human bocavirus infection | 108.84 | 12.45 | 30 | 34642 | 576 | 70893196 |
Second primary malignancy | 106.52 | 12.45 | 71 | 34601 | 12980 | 70880792 |
Acute myeloid leukaemia | 106.01 | 12.45 | 101 | 34571 | 30839 | 70862933 |
Osteonecrosis | 105.29 | 12.45 | 98 | 34574 | 29062 | 70864710 |
Abdominal pain | 103.11 | 12.45 | 384 | 34288 | 341743 | 70552029 |
Human herpesvirus 6 infection | 101.72 | 12.45 | 49 | 34623 | 4810 | 70888962 |
Multiple-drug resistance | 101.40 | 12.45 | 56 | 34616 | 7299 | 70886473 |
Hepatotoxicity | 101.14 | 12.45 | 116 | 34556 | 43870 | 70849902 |
Clostridium difficile colitis | 100.00 | 12.45 | 95 | 34577 | 28901 | 70864871 |
Neurotoxicity | 97.73 | 12.45 | 95 | 34577 | 29731 | 70864041 |
Hyperbilirubinaemia | 97.63 | 12.45 | 84 | 34588 | 22484 | 70871288 |
Leukoencephalopathy | 90.96 | 12.45 | 52 | 34620 | 7242 | 70886530 |
Glioma | 90.82 | 12.45 | 26 | 34646 | 576 | 70893196 |
Fall | 89.75 | 12.45 | 53 | 34619 | 444043 | 70449729 |
Viral infection | 89.54 | 12.45 | 102 | 34570 | 38289 | 70855483 |
Enterovirus infection | 82.56 | 12.45 | 31 | 34641 | 1640 | 70892132 |
Crohn's disease | 82.54 | 12.45 | 35 | 34637 | 2549 | 70891223 |
Thymus hypoplasia | 80.52 | 12.45 | 24 | 34648 | 615 | 70893157 |
Neoplasm recurrence | 77.26 | 12.45 | 38 | 34634 | 3903 | 70889869 |
Temporal lobe epilepsy | 77.25 | 12.45 | 21 | 34651 | 382 | 70893390 |
Dyspnoea | 76.82 | 12.45 | 164 | 34508 | 769896 | 70123876 |
Epstein-Barr virus infection | 75.87 | 12.45 | 58 | 34614 | 13140 | 70880632 |
Venoocclusive disease | 74.97 | 12.45 | 38 | 34634 | 4162 | 70889610 |
Myelodysplastic syndrome | 74.36 | 12.45 | 82 | 34590 | 29703 | 70864069 |
Colitis | 74.33 | 12.45 | 121 | 34551 | 63693 | 70830079 |
Cytogenetic abnormality | 72.44 | 12.45 | 25 | 34647 | 1035 | 70892737 |
Myelopathy | 71.64 | 12.45 | 37 | 34635 | 4214 | 70889558 |
Leukaemia recurrent | 70.52 | 12.45 | 32 | 34640 | 2743 | 70891029 |
Myelosuppression | 70.14 | 12.45 | 80 | 34592 | 30065 | 70863707 |
Lymphoid tissue hypoplasia | 69.13 | 12.45 | 21 | 34651 | 575 | 70893197 |
Joint swelling | 67.48 | 12.45 | 20 | 34652 | 253191 | 70640581 |
Abscess bacterial | 67.22 | 12.45 | 22 | 34650 | 772 | 70893000 |
Aspergillus infection | 66.33 | 12.45 | 61 | 34611 | 17807 | 70875965 |
Human rhinovirus test positive | 66.15 | 12.45 | 19 | 34653 | 426 | 70893346 |
Death | 64.97 | 12.45 | 93 | 34579 | 509968 | 70383804 |
Trichodysplasia spinulosa | 64.63 | 12.45 | 21 | 34651 | 720 | 70893052 |
Lentigo | 64.61 | 12.45 | 19 | 34653 | 464 | 70893308 |
Enterobacter infection | 64.59 | 12.45 | 34 | 34638 | 4026 | 70889746 |
Nodular regenerative hyperplasia | 63.92 | 12.45 | 24 | 34648 | 1269 | 70892503 |
Glioblastoma multiforme | 63.91 | 12.45 | 24 | 34648 | 1270 | 70892502 |
Peripheral swelling | 62.46 | 12.45 | 19 | 34653 | 236544 | 70657228 |
Perineal necrosis | 61.28 | 12.45 | 14 | 34658 | 119 | 70893653 |
Sepsis | 61.07 | 12.45 | 259 | 34413 | 244286 | 70649486 |
Fungal infection | 60.80 | 12.45 | 83 | 34589 | 37384 | 70856388 |
Pneumatosis intestinalis | 60.39 | 12.45 | 37 | 34635 | 5850 | 70887922 |
Enteritis | 60.10 | 12.45 | 50 | 34622 | 12781 | 70880991 |
Cytomegalovirus infection | 59.92 | 12.45 | 85 | 34587 | 39673 | 70854099 |
Leukopenia | 59.82 | 12.45 | 149 | 34523 | 106411 | 70787361 |
Norovirus test positive | 59.74 | 12.45 | 18 | 34654 | 479 | 70893293 |
Histoplasmosis disseminated | 59.45 | 12.45 | 26 | 34646 | 2042 | 70891730 |
Viraemia | 57.89 | 12.45 | 27 | 34645 | 2465 | 70891307 |
Pain | 57.69 | 12.45 | 140 | 34532 | 628676 | 70265096 |
Completed suicide | 56.87 | 12.45 | 20 | 34652 | 227115 | 70666657 |
Epstein-Barr virus associated lymphoproliferative disorder | 56.50 | 12.45 | 29 | 34643 | 3260 | 70890512 |
Enterovirus test positive | 55.97 | 12.45 | 15 | 34657 | 258 | 70893514 |
Pancreatitis acute | 55.74 | 12.45 | 88 | 34584 | 45136 | 70848636 |
Cystitis bacterial | 55.30 | 12.45 | 17 | 34655 | 485 | 70893287 |
Alanine aminotransferase increased | 55.14 | 12.45 | 178 | 34494 | 147302 | 70746470 |
Contraindicated product administered | 53.60 | 12.45 | 3 | 34669 | 134609 | 70759163 |
Intestinal stenosis | 53.01 | 12.45 | 28 | 34644 | 3339 | 70890433 |
Neutrophil count decreased | 50.26 | 12.45 | 120 | 34552 | 83436 | 70810336 |
Atrial fibrillation | 50.13 | 12.45 | 14 | 34658 | 184334 | 70709438 |
Cytomegalovirus viraemia | 49.53 | 12.45 | 43 | 34629 | 11642 | 70882130 |
Coronavirus infection | 48.59 | 12.45 | 33 | 34639 | 6219 | 70887553 |
Dizziness | 48.57 | 12.45 | 96 | 34576 | 464045 | 70429727 |
Thrombocytopenia | 48.34 | 12.45 | 238 | 34434 | 238872 | 70654900 |
Hepatocellular injury | 47.81 | 12.45 | 83 | 34589 | 46008 | 70847764 |
Drug clearance decreased | 47.27 | 12.45 | 25 | 34647 | 2988 | 70890784 |
Bronchopulmonary aspergillosis | 45.94 | 12.45 | 54 | 34618 | 20948 | 70872824 |
Frequent bowel movements | 45.63 | 12.45 | 54 | 34618 | 21099 | 70872673 |
Mucormycosis | 45.58 | 12.45 | 35 | 34637 | 7979 | 70885793 |
Diffuse large B-cell lymphoma | 44.75 | 12.45 | 43 | 34629 | 13259 | 70880513 |
Fistula | 44.03 | 12.45 | 39 | 34633 | 10842 | 70882930 |
Molluscum contagiosum | 43.62 | 12.45 | 14 | 34658 | 461 | 70893311 |
Cell-mediated immune deficiency | 42.68 | 12.45 | 10 | 34662 | 96 | 70893676 |
Venoocclusive liver disease | 42.67 | 12.45 | 38 | 34634 | 10640 | 70883132 |
Feeding intolerance | 42.61 | 12.45 | 15 | 34657 | 659 | 70893113 |
Intestinal resection | 42.22 | 12.45 | 24 | 34648 | 3306 | 70890466 |
Diffuse alveolar damage | 41.99 | 12.45 | 24 | 34648 | 3339 | 70890433 |
Swelling | 41.68 | 12.45 | 20 | 34652 | 188519 | 70705253 |
Intracranial pressure increased | 41.56 | 12.45 | 32 | 34640 | 7324 | 70886448 |
Anal inflammation | 41.29 | 12.45 | 14 | 34658 | 549 | 70893223 |
Superior sagittal sinus thrombosis | 40.24 | 12.45 | 16 | 34656 | 988 | 70892784 |
Acute lymphocytic leukaemia | 40.10 | 12.45 | 28 | 34644 | 5517 | 70888255 |
Subacute combined cord degeneration | 39.56 | 12.45 | 12 | 34660 | 327 | 70893445 |
Oesophageal candidiasis | 39.53 | 12.45 | 33 | 34639 | 8474 | 70885298 |
B-cell lymphoma | 39.25 | 12.45 | 29 | 34643 | 6240 | 70887532 |
Epstein-Barr virus associated lymphoma | 39.06 | 12.45 | 16 | 34656 | 1068 | 70892704 |
Intracardiac thrombus | 38.55 | 12.45 | 24 | 34648 | 3903 | 70889869 |
Encephalitis | 38.48 | 12.45 | 40 | 34632 | 13545 | 70880227 |
Hypertransaminasaemia | 38.09 | 12.45 | 33 | 34639 | 8910 | 70884862 |
Cerebral venous sinus thrombosis | 38.08 | 12.45 | 19 | 34653 | 2012 | 70891760 |
Arthropathy | 37.91 | 12.45 | 13 | 34659 | 150044 | 70743728 |
Lower respiratory tract infection | 37.78 | 12.45 | 5 | 34667 | 111908 | 70781864 |
Device related infection | 37.42 | 12.45 | 61 | 34611 | 32124 | 70861648 |
Perineal infection | 37.31 | 12.45 | 14 | 34658 | 739 | 70893033 |
Asthma | 37.16 | 12.45 | 7 | 34665 | 120786 | 70772986 |
Synovitis | 36.68 | 12.45 | 9 | 34663 | 129219 | 70764553 |
Anal abscess | 35.92 | 12.45 | 31 | 34641 | 8327 | 70885445 |
Anal fistula | 35.68 | 12.45 | 27 | 34645 | 6023 | 70887749 |
Cardiac failure congestive | 35.51 | 12.45 | 11 | 34661 | 135446 | 70758326 |
Gastroenteritis norovirus | 34.62 | 12.45 | 20 | 34652 | 2839 | 70890933 |
Bile acid malabsorption | 34.49 | 12.45 | 10 | 34662 | 232 | 70893540 |
Acute monocytic leukaemia | 34.47 | 12.45 | 12 | 34660 | 510 | 70893262 |
Fatigue | 34.44 | 12.45 | 249 | 34423 | 824070 | 70069702 |
Ileal stenosis | 34.18 | 12.45 | 18 | 34654 | 2133 | 70891639 |
Confusional state | 34.06 | 12.45 | 54 | 34618 | 284344 | 70609428 |
Bacterial vulvovaginitis | 34.03 | 12.45 | 12 | 34660 | 530 | 70893242 |
Pruritus | 33.97 | 12.45 | 74 | 34598 | 345486 | 70548286 |
Proctalgia | 33.83 | 12.45 | 30 | 34642 | 8353 | 70885419 |
Seizure | 33.72 | 12.45 | 174 | 34498 | 177788 | 70715984 |
Pneumocystis jirovecii pneumonia | 33.61 | 12.45 | 56 | 34616 | 30026 | 70863746 |
Bacillus infection | 33.45 | 12.45 | 14 | 34658 | 987 | 70892785 |
Perirectal abscess | 33.44 | 12.45 | 17 | 34655 | 1873 | 70891899 |
Haematopoietic neoplasm | 33.32 | 12.45 | 8 | 34664 | 86 | 70893686 |
Hyperkalaemia | 33.17 | 12.45 | 6 | 34666 | 106585 | 70787187 |
Segmental diverticular colitis | 33.04 | 12.45 | 9 | 34663 | 165 | 70893607 |
Lipase increased | 33.01 | 12.45 | 39 | 34633 | 15207 | 70878565 |
Candida endophthalmitis | 32.69 | 12.45 | 9 | 34663 | 172 | 70893600 |
Discomfort | 32.67 | 12.45 | 6 | 34666 | 105430 | 70788342 |
Cholestasis | 32.35 | 12.45 | 72 | 34600 | 47800 | 70845972 |
Strongyloidiasis | 32.19 | 12.45 | 21 | 34651 | 3702 | 70890070 |
Cytomegalovirus colitis | 32.11 | 12.45 | 22 | 34650 | 4204 | 70889568 |
Pedal pulse abnormal | 32.07 | 12.45 | 9 | 34663 | 185 | 70893587 |
Depression | 32.04 | 12.45 | 30 | 34642 | 198944 | 70694828 |
Hypoalbuminaemia | 31.99 | 12.45 | 43 | 34629 | 19079 | 70874693 |
Muscle spasms | 31.59 | 12.45 | 18 | 34654 | 154028 | 70739744 |
Abdominal discomfort | 31.57 | 12.45 | 35 | 34637 | 214623 | 70679149 |
Histoplasmosis | 31.55 | 12.45 | 17 | 34655 | 2110 | 70891662 |
Blood fibrinogen decreased | 31.43 | 12.45 | 16 | 34656 | 1768 | 70892004 |
Lymphopenia | 30.66 | 12.45 | 51 | 34621 | 27308 | 70866464 |
Rectal cancer metastatic | 30.47 | 12.45 | 11 | 34661 | 520 | 70893252 |
Haemolytic uraemic syndrome | 30.21 | 12.45 | 21 | 34651 | 4109 | 70889663 |
Portal hypertension | 29.78 | 12.45 | 25 | 34647 | 6467 | 70887305 |
Blood bilirubin increased | 29.72 | 12.45 | 80 | 34592 | 59821 | 70833951 |
Pneumonia fungal | 29.45 | 12.45 | 30 | 34642 | 9923 | 70883849 |
Insomnia | 29.39 | 12.45 | 38 | 34634 | 217768 | 70676004 |
Blood culture positive | 29.30 | 12.45 | 27 | 34645 | 7899 | 70885873 |
Escherichia infection | 29.29 | 12.45 | 38 | 34634 | 16293 | 70877479 |
Disseminated aspergillosis | 29.12 | 12.45 | 12 | 34660 | 813 | 70892959 |
Pseudomonas test positive | 29.10 | 12.45 | 15 | 34657 | 1701 | 70892071 |
Atypical haemolytic uraemic syndrome | 28.94 | 12.45 | 12 | 34660 | 826 | 70892946 |
Xanthogranuloma | 28.85 | 12.45 | 7 | 34665 | 79 | 70893693 |
Cardiotoxicity | 28.53 | 12.45 | 31 | 34641 | 11039 | 70882733 |
Vomiting | 28.51 | 12.45 | 427 | 34245 | 592684 | 70301088 |
Intentional overdose | 27.65 | 12.45 | 7 | 34665 | 98428 | 70795344 |
Abdominal adhesions | 27.54 | 12.45 | 18 | 34654 | 3182 | 70890590 |
Cytopenia | 27.53 | 12.45 | 38 | 34634 | 17285 | 70876487 |
Aplasia | 27.39 | 12.45 | 25 | 34647 | 7226 | 70886546 |
Product dose omission issue | 27.27 | 12.45 | 40 | 34632 | 217428 | 70676344 |
Malaise | 27.24 | 12.45 | 114 | 34558 | 432818 | 70460954 |
Coagulopathy | 27.11 | 12.45 | 54 | 34618 | 33195 | 70860577 |
Cytomegalovirus hepatitis | 26.95 | 12.45 | 11 | 34661 | 727 | 70893045 |
Glossodynia | 26.62 | 12.45 | 5 | 34667 | 86482 | 70807290 |
Chloroma | 26.52 | 12.45 | 11 | 34661 | 758 | 70893014 |
Cerebral haemangioma | 25.72 | 12.45 | 7 | 34665 | 128 | 70893644 |
Cellulitis | 25.59 | 12.45 | 106 | 34566 | 98822 | 70794950 |
Syncope | 25.50 | 12.45 | 26 | 34646 | 165683 | 70728089 |
Systemic lupus erythematosus | 25.44 | 12.45 | 9 | 34663 | 101893 | 70791879 |
Hippocampal sclerosis | 25.27 | 12.45 | 7 | 34665 | 137 | 70893635 |
Metapneumovirus infection | 24.95 | 12.45 | 13 | 34659 | 1507 | 70892265 |
Oedema peripheral | 24.83 | 12.45 | 46 | 34626 | 228045 | 70665727 |
Somnolence | 24.81 | 12.45 | 42 | 34630 | 215564 | 70678208 |
Bifidobacterium infection | 24.70 | 12.45 | 5 | 34667 | 22 | 70893750 |
Feeling abnormal | 24.67 | 12.45 | 20 | 34652 | 142299 | 70751473 |
Hepatosplenomegaly | 24.30 | 12.45 | 21 | 34651 | 5649 | 70888123 |
Cushingoid | 24.30 | 12.45 | 25 | 34647 | 8363 | 70885409 |
Acute lymphocytic leukaemia refractory | 24.28 | 12.45 | 7 | 34665 | 159 | 70893613 |
Abscess limb | 23.77 | 12.45 | 22 | 34650 | 6471 | 70887301 |
Staphylococcal sepsis | 23.70 | 12.45 | 31 | 34641 | 13396 | 70880376 |
Suicide attempt | 23.63 | 12.45 | 5 | 34667 | 79505 | 70814267 |
Antithrombin III | 23.34 | 12.45 | 6 | 34666 | 87 | 70893685 |
Neuropathy peripheral | 23.29 | 12.45 | 123 | 34549 | 126773 | 70766999 |
Asthenia | 23.28 | 12.45 | 130 | 34542 | 457536 | 70436236 |
Anorectal cellulitis | 23.03 | 12.45 | 6 | 34666 | 92 | 70893680 |
Transaminases increased | 22.53 | 12.45 | 62 | 34610 | 46956 | 70846816 |
Calcium ionised decreased | 22.42 | 12.45 | 9 | 34663 | 570 | 70893202 |
Hemiparesis | 22.02 | 12.45 | 48 | 34624 | 31421 | 70862351 |
Aborted pregnancy | 21.63 | 12.45 | 5 | 34667 | 45 | 70893727 |
Otitis media acute | 21.58 | 12.45 | 11 | 34661 | 1218 | 70892554 |
Central obesity | 21.53 | 12.45 | 12 | 34660 | 1591 | 70892181 |
Hyponatraemia | 21.51 | 12.45 | 28 | 34644 | 160059 | 70733713 |
Herpes simplex | 21.50 | 12.45 | 27 | 34645 | 11205 | 70882567 |
Coma | 21.45 | 12.45 | 9 | 34663 | 91835 | 70801937 |
Venous thrombosis | 21.44 | 12.45 | 21 | 34651 | 6628 | 70887144 |
Chest pain | 21.37 | 12.45 | 58 | 34614 | 251202 | 70642570 |
Osteoarthritis | 21.36 | 12.45 | 5 | 34667 | 74142 | 70819630 |
Gastrointestinal inflammation | 21.24 | 12.45 | 21 | 34651 | 6702 | 70887070 |
Thymus enlargement | 21.22 | 12.45 | 6 | 34666 | 127 | 70893645 |
Mobility decreased | 21.16 | 12.45 | 12 | 34660 | 102987 | 70790785 |
Splenomegaly | 20.91 | 12.45 | 35 | 34637 | 18835 | 70874937 |
T-cell lymphoma | 20.91 | 12.45 | 11 | 34661 | 1301 | 70892471 |
Drug intolerance | 20.81 | 12.45 | 50 | 34622 | 225637 | 70668135 |
Musculoskeletal stiffness | 20.74 | 12.45 | 25 | 34647 | 147735 | 70746037 |
Coronary artery disease | 20.71 | 12.45 | 3 | 34669 | 62733 | 70831039 |
Drug level decreased | 20.52 | 12.45 | 28 | 34644 | 12596 | 70881176 |
Inflammatory bowel disease | 20.25 | 12.45 | 18 | 34654 | 5028 | 70888744 |
Differentiation syndrome | 20.23 | 12.45 | 13 | 34659 | 2234 | 70891538 |
Meningitis coccidioides | 20.10 | 12.45 | 5 | 34667 | 63 | 70893709 |
Epidermal necrosis | 20.05 | 12.45 | 11 | 34661 | 1414 | 70892358 |
Human metapneumovirus test positive | 20.01 | 12.45 | 6 | 34666 | 157 | 70893615 |
Urinary tract infection | 19.99 | 12.45 | 59 | 34613 | 248710 | 70645062 |
Chest discomfort | 19.73 | 12.45 | 19 | 34653 | 124362 | 70769410 |
Wound | 19.58 | 12.45 | 12 | 34660 | 98720 | 70795052 |
Gastrointestinal wall thickening | 19.56 | 12.45 | 13 | 34659 | 2363 | 70891409 |
Staphylococcal infection | 19.52 | 12.45 | 64 | 34608 | 53340 | 70840432 |
Lymphoproliferative disorder | 19.40 | 12.45 | 18 | 34654 | 5311 | 70888461 |
Anxiety | 19.38 | 12.45 | 50 | 34622 | 220280 | 70673492 |
Myocardial infarction | 19.23 | 12.45 | 34 | 34638 | 171611 | 70722161 |
Chronic obstructive pulmonary disease | 19.13 | 12.45 | 7 | 34665 | 77634 | 70816138 |
Hypoglycaemia | 19.08 | 12.45 | 94 | 34578 | 94270 | 70799502 |
General physical health deterioration | 18.95 | 12.45 | 56 | 34616 | 235975 | 70657797 |
Influenza B virus test positive | 18.94 | 12.45 | 7 | 34665 | 354 | 70893418 |
Hip deformity | 18.92 | 12.45 | 6 | 34666 | 190 | 70893582 |
Listeriosis | 18.90 | 12.45 | 12 | 34660 | 2020 | 70891752 |
Anal fissure | 18.83 | 12.45 | 19 | 34653 | 6214 | 70887558 |
Adrenocortical carcinoma | 18.77 | 12.45 | 5 | 34667 | 84 | 70893688 |
Pericarditis | 18.69 | 12.45 | 9 | 34663 | 84696 | 70809076 |
Large intestinal stenosis | 18.67 | 12.45 | 13 | 34659 | 2550 | 70891222 |
Drug reaction with eosinophilia and systemic symptoms | 18.63 | 12.45 | 3 | 34669 | 58010 | 70835762 |
Hallucination | 18.58 | 12.45 | 7 | 34665 | 76253 | 70817519 |
Transverse sinus thrombosis | 18.47 | 12.45 | 8 | 34664 | 614 | 70893158 |
Rectal abscess | 18.42 | 12.45 | 11 | 34661 | 1660 | 70892112 |
Clostridium difficile infection | 18.42 | 12.45 | 51 | 34621 | 38765 | 70855007 |
Electrocardiogram QT prolonged | 18.23 | 12.45 | 9 | 34663 | 83508 | 70810264 |
Drug specific antibody present | 18.22 | 12.45 | 18 | 34654 | 5740 | 70888032 |
Angioedema | 18.20 | 12.45 | 5 | 34667 | 66605 | 70827167 |
Meningitis enterococcal | 18.14 | 12.45 | 5 | 34667 | 96 | 70893676 |
Platelet count decreased | 18.14 | 12.45 | 149 | 34523 | 178073 | 70715699 |
Neutropenic colitis | 18.09 | 12.45 | 17 | 34655 | 5097 | 70888675 |
Overgrowth fungal | 18.09 | 12.45 | 5 | 34667 | 97 | 70893675 |
Fusarium infection | 18.06 | 12.45 | 11 | 34661 | 1721 | 70892051 |
Posterior reversible encephalopathy syndrome | 17.97 | 12.45 | 38 | 34634 | 24364 | 70869408 |
Vascular access complication | 17.89 | 12.45 | 11 | 34661 | 1750 | 70892022 |
Drug hypersensitivity | 17.83 | 12.45 | 67 | 34605 | 262392 | 70631380 |
Pancreatitis necrotising | 17.76 | 12.45 | 14 | 34658 | 3314 | 70890458 |
Rash | 17.68 | 12.45 | 162 | 34510 | 510400 | 70383372 |
Disseminated cytomegaloviral infection | 17.40 | 12.45 | 7 | 34665 | 446 | 70893326 |
Herpes zoster meningoencephalitis | 17.40 | 12.45 | 8 | 34664 | 707 | 70893065 |
Post lumbar puncture syndrome | 17.39 | 12.45 | 8 | 34664 | 708 | 70893064 |
Antithrombin III decreased | 17.29 | 12.45 | 7 | 34665 | 453 | 70893319 |
Anaemia | 17.27 | 12.45 | 285 | 34387 | 403138 | 70490634 |
Wrong technique in product usage process | 17.26 | 12.45 | 6 | 34666 | 68692 | 70825080 |
Facial paralysis | 17.15 | 12.45 | 33 | 34639 | 19775 | 70873997 |
Porphyria non-acute | 17.09 | 12.45 | 8 | 34664 | 736 | 70893036 |
Tonsil cancer | 17.05 | 12.45 | 9 | 34663 | 1072 | 70892700 |
Overdose | 16.95 | 12.45 | 36 | 34636 | 169709 | 70724063 |
Nasopharyngitis | 16.93 | 12.45 | 54 | 34618 | 222152 | 70671620 |
Bone marrow disorder | 16.89 | 12.45 | 13 | 34659 | 2972 | 70890800 |
Acute promyelocytic leukaemia | 16.85 | 12.45 | 10 | 34662 | 1492 | 70892280 |
Cheilitis | 16.85 | 12.45 | 16 | 34656 | 4861 | 70888911 |
Metastases to pancreas | 16.82 | 12.45 | 7 | 34665 | 486 | 70893286 |
Encopresis | 16.78 | 12.45 | 5 | 34667 | 128 | 70893644 |
Acral lentiginous melanoma | 16.75 | 12.45 | 4 | 34668 | 42 | 70893730 |
Magnetic resonance imaging head abnormal | 16.67 | 12.45 | 12 | 34660 | 2480 | 70891292 |
Precursor T-lymphoblastic lymphoma/leukaemia | 16.67 | 12.45 | 5 | 34667 | 131 | 70893641 |
Toe walking | 16.58 | 12.45 | 3 | 34669 | 6 | 70893766 |
Small intestinal obstruction | 16.56 | 12.45 | 37 | 34635 | 24618 | 70869154 |
Steatohepatitis | 16.36 | 12.45 | 8 | 34664 | 811 | 70892961 |
Hypophagia | 16.26 | 12.45 | 51 | 34621 | 41519 | 70852253 |
Cutaneous leishmaniasis | 16.26 | 12.45 | 6 | 34666 | 302 | 70893470 |
Stomatitis | 16.20 | 12.45 | 113 | 34559 | 128398 | 70765374 |
Haematocolpos | 16.18 | 12.45 | 4 | 34668 | 49 | 70893723 |
Rhabdomyolysis | 15.93 | 12.45 | 14 | 34658 | 95746 | 70798026 |
Enterocolitis infectious | 15.83 | 12.45 | 12 | 34660 | 2682 | 70891090 |
Lower respiratory tract infection fungal | 15.83 | 12.45 | 8 | 34664 | 870 | 70892902 |
Renal failure | 15.80 | 12.45 | 44 | 34628 | 189026 | 70704746 |
Anaemia megaloblastic | 15.73 | 12.45 | 7 | 34665 | 573 | 70893199 |
Faecal calprotectin abnormal | 15.69 | 12.45 | 5 | 34667 | 161 | 70893611 |
Jaundice | 15.65 | 12.45 | 57 | 34615 | 50051 | 70843721 |
Gastrointestinal haemorrhage | 15.59 | 12.45 | 27 | 34645 | 137381 | 70756391 |
Blood growth hormone decreased | 15.50 | 12.45 | 4 | 34668 | 59 | 70893713 |
Malnutrition | 15.38 | 12.45 | 32 | 34640 | 20285 | 70873487 |
Paraplegia | 15.36 | 12.45 | 15 | 34657 | 4715 | 70889057 |
West Nile viral infection | 15.33 | 12.45 | 8 | 34664 | 931 | 70892841 |
Eye opacity | 15.26 | 12.45 | 3 | 34669 | 11 | 70893761 |
Viral myelitis | 15.25 | 12.45 | 4 | 34668 | 63 | 70893709 |
Intestinal dilatation | 15.21 | 12.45 | 11 | 34661 | 2289 | 70891483 |
Urticaria | 15.12 | 12.45 | 36 | 34636 | 163013 | 70730759 |
Agitation | 15.11 | 12.45 | 14 | 34658 | 93361 | 70800411 |
Blood pressure fluctuation | 15.08 | 12.45 | 63 | 34609 | 58949 | 70834823 |
Pericardial cyst | 15.05 | 12.45 | 3 | 34669 | 12 | 70893760 |
Autoimmune lymphoproliferative syndrome | 15.05 | 12.45 | 5 | 34667 | 184 | 70893588 |
Vocal cord paralysis | 15.04 | 12.45 | 11 | 34661 | 2330 | 70891442 |
Oesophageal mass | 15.02 | 12.45 | 4 | 34668 | 67 | 70893705 |
Pulmonary mucormycosis | 15.01 | 12.45 | 8 | 34664 | 971 | 70892801 |
Placental transfusion syndrome | 14.97 | 12.45 | 4 | 34668 | 68 | 70893704 |
Anorectal infection | 14.93 | 12.45 | 6 | 34666 | 381 | 70893391 |
Superinfection | 14.91 | 12.45 | 14 | 34658 | 4192 | 70889580 |
Haematochezia | 14.91 | 12.45 | 73 | 34599 | 73008 | 70820764 |
Blood immunoglobulin G decreased | 14.86 | 12.45 | 12 | 34660 | 2940 | 70890832 |
Multiple lentigines syndrome | 14.77 | 12.45 | 5 | 34667 | 195 | 70893577 |
Cardiac failure | 14.70 | 12.45 | 30 | 34642 | 143511 | 70750261 |
Mucoepidermoid carcinoma | 14.65 | 12.45 | 4 | 34668 | 74 | 70893698 |
Listeria sepsis | 14.63 | 12.45 | 7 | 34665 | 677 | 70893095 |
Stomatitis necrotising | 14.60 | 12.45 | 5 | 34667 | 202 | 70893570 |
Epstein-Barr viraemia | 14.59 | 12.45 | 10 | 34662 | 1913 | 70891859 |
Partial seizures | 14.57 | 12.45 | 19 | 34653 | 8186 | 70885586 |
Gastrointestinal sounds abnormal | 14.51 | 12.45 | 15 | 34657 | 5046 | 70888726 |
Dysplastic naevus syndrome | 14.50 | 12.45 | 3 | 34669 | 15 | 70893757 |
Bacteraemia | 14.39 | 12.45 | 39 | 34633 | 29270 | 70864502 |
Fistula of small intestine | 14.35 | 12.45 | 7 | 34665 | 706 | 70893066 |
Pseudopolyp | 14.33 | 12.45 | 6 | 34666 | 423 | 70893349 |
Hepatic enzyme increased | 14.29 | 12.45 | 35 | 34637 | 156955 | 70736817 |
Cardiac arrest | 14.26 | 12.45 | 36 | 34636 | 159798 | 70733974 |
Acute myocardial infarction | 14.26 | 12.45 | 9 | 34663 | 72878 | 70820894 |
Staphylococcal bacteraemia | 14.25 | 12.45 | 22 | 34650 | 11060 | 70882712 |
Chills | 14.17 | 12.45 | 120 | 34552 | 144666 | 70749106 |
Erythema nodosum | 14.16 | 12.45 | 14 | 34658 | 4467 | 70889305 |
Chronic sinusitis | 14.13 | 12.45 | 19 | 34653 | 8432 | 70885340 |
Blood cholesterol increased | 14.04 | 12.45 | 7 | 34665 | 64597 | 70829175 |
Red blood cell microcytes present | 14.04 | 12.45 | 3 | 34669 | 18 | 70893754 |
Mucocutaneous candidiasis | 14.04 | 12.45 | 4 | 34668 | 87 | 70893685 |
Functional gastrointestinal disorder | 14.03 | 12.45 | 14 | 34658 | 4517 | 70889255 |
Melaena | 14.02 | 12.45 | 5 | 34667 | 56350 | 70837422 |
Multiple organ dysfunction syndrome | 14.02 | 12.45 | 96 | 34576 | 108419 | 70785353 |
Ocular icterus | 13.99 | 12.45 | 15 | 34657 | 5262 | 70888510 |
Cerebrovascular accident | 13.85 | 12.45 | 31 | 34641 | 143439 | 70750333 |
Adenovirus infection | 13.81 | 12.45 | 18 | 34654 | 7750 | 70886022 |
Leukaemia | 13.76 | 12.45 | 15 | 34657 | 5360 | 70888412 |
Lennox-Gastaut syndrome | 13.74 | 12.45 | 5 | 34667 | 242 | 70893530 |
Malignant neoplasm progression | 13.73 | 12.45 | 24 | 34648 | 121715 | 70772057 |
Therapeutic product effect decreased | 13.72 | 12.45 | 31 | 34641 | 142987 | 70750785 |
B precursor type acute leukaemia | 13.70 | 12.45 | 6 | 34666 | 473 | 70893299 |
Lymphoma | 13.69 | 12.45 | 26 | 34646 | 15436 | 70878336 |
Immunosuppression | 13.65 | 12.45 | 22 | 34650 | 11470 | 70882302 |
Mucous stools | 13.64 | 12.45 | 13 | 34659 | 3966 | 70889806 |
Pneumococcal bacteraemia | 13.63 | 12.45 | 4 | 34668 | 97 | 70893675 |
Epstein Barr virus positive mucocutaneous ulcer | 13.62 | 12.45 | 7 | 34665 | 789 | 70892983 |
Eosinophilic pneumonia chronic | 13.61 | 12.45 | 6 | 34666 | 480 | 70893292 |
Cardiac disorder | 13.59 | 12.45 | 6 | 34666 | 59409 | 70834363 |
Hyperglycaemia | 13.48 | 12.45 | 65 | 34607 | 64607 | 70829165 |
Papulopustular rosacea | 13.41 | 12.45 | 3 | 34669 | 23 | 70893749 |
Upper respiratory tract infection | 13.29 | 12.45 | 75 | 34597 | 79199 | 70814573 |
Pneumonia aspiration | 13.17 | 12.45 | 7 | 34665 | 62282 | 70831490 |
Large intestine infection | 13.17 | 12.45 | 11 | 34661 | 2827 | 70890945 |
Neurological examination abnormal | 13.16 | 12.45 | 6 | 34666 | 520 | 70893252 |
T-cell type acute leukaemia | 13.08 | 12.45 | 5 | 34667 | 278 | 70893494 |
Respiratory arrest | 13.06 | 12.45 | 5 | 34667 | 53928 | 70839844 |
Gastrointestinal injury | 13.03 | 12.45 | 7 | 34665 | 864 | 70892908 |
Pleocytosis | 12.96 | 12.45 | 8 | 34664 | 1281 | 70892491 |
Respiratory distress | 12.93 | 12.45 | 57 | 34615 | 54593 | 70839179 |
Proctitis | 12.92 | 12.45 | 12 | 34660 | 3546 | 70890226 |
Disease recurrence | 12.80 | 12.45 | 44 | 34628 | 37559 | 70856213 |
Acute myelomonocytic leukaemia | 12.63 | 12.45 | 5 | 34667 | 305 | 70893467 |
Septic shock | 12.59 | 12.45 | 96 | 34576 | 112162 | 70781610 |
Anaemia macrocytic | 12.53 | 12.45 | 14 | 34658 | 5141 | 70888631 |
Respiratory syncytial virus infection | 12.48 | 12.45 | 17 | 34655 | 7638 | 70886134 |
None
Source | Code | Description |
---|---|---|
ATC | L01BB02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Purine analogues |
CHEBI has role | CHEBI:35221 | antimetabolite |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:149553 | anticoronaviral drug |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D000964 | Antimetabolites, Antineoplastic |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D007155 | Immunologic Factors |
MeSH PA | D007166 | Immunosuppressive Agents |
MeSH PA | D009676 | Noxae |
MeSH PA | D019384 | Nucleic Acid Synthesis Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute lymphoid leukemia | indication | 91857003 | DOID:9952 |
Acute promyelocytic leukemia, FAB M3 | indication | 110004001 | |
Psoriasis with arthropathy | off-label use | 33339001 | |
Crohn's disease | off-label use | 34000006 | |
Ulcerative colitis | off-label use | 64766004 | DOID:8577 |
Acute myeloid leukemia, disease | off-label use | 91861009 | |
Polycythemia vera | off-label use | 109992005 | |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Obstruction of bile duct | contraindication | 30144000 | |
Dehydration | contraindication | 34095006 | |
Gastrointestinal ulcer | contraindication | 40845000 | |
Leukopenia | contraindication | 84828003 | DOID:615 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Liver function tests abnormal | contraindication | 166603001 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Ascites | contraindication | 389026000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Hepatosplenic T-cell lymphoma | contraindication | 445406001 | |
Chemotherapy-Induced Hyperuricemia | contraindication | ||
Thiopurine S-Methyltransferase Deficiency | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 5.99 | acidic |
pKa2 | 10.76 | acidic |
pKa3 | 3.37 | Basic |
pKa4 | 1.4 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Amidophosphoribosyltransferase | Enzyme | INHIBITOR | DRUGBANK | CHEMBL | |||||
Multidrug resistance-associated protein 5 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 4 | Transporter | WOMBAT-PK | |||||||
Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.79 | DRUG MATRIX | |||||
Thiopurine S-methyltransferase | Enzyme | WOMBAT-PK | |||||||
Purine nucleoside phosphorylase | Enzyme | WOMBAT-PK | |||||||
Purine nucleoside phosphorylase | Enzyme | Kd | 4.10 | CHEMBL |
ID | Source |
---|---|
4018776 | VUID |
N0000147079 | NUI |
D00161 | KEGG_DRUG |
6112-76-1 | SECONDARY_CAS_RN |
4018776 | VANDF |
C0000618 | UMLSCUI |
CHEBI:50667 | CHEBI |
PM6 | PDB_CHEM_ID |
CHEMBL1425 | ChEMBL_ID |
CHEMBL1200751 | ChEMBL_ID |
DB01033 | DRUGBANK_ID |
D015122 | MESH_DESCRIPTOR_UI |
667490 | PUBCHEM_CID |
7226 | IUPHAR_LIGAND_ID |
E7WED276I5 | UNII |
103 | RXNORM |
3886 | MMSL |
48948 | MMSL |
5052 | MMSL |
NOCODE | MMSL |
d00289 | MMSL |
002647 | NDDF |
1039008 | SNOMEDCT_US |
386835005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Mercaptopurine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-4581 | TABLET | 50 mg | ORAL | ANDA | 29 sections |
Mercaptopurine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3547 | TABLET | 50 mg | ORAL | ANDA | 29 sections |
Mercaptopurine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3547 | TABLET | 50 mg | ORAL | ANDA | 29 sections |
mercaptopurine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49884-922 | TABLET | 50 mg | ORAL | ANDA | 24 sections |
mercaptopurine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5282 | TABLET | 50 mg | ORAL | ANDA | 24 sections |
PURINETHOL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60763-601 | TABLET | 50 mg | ORAL | NDA | 30 sections |
PURIXAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62484-0020 | SUSPENSION | 20 mg | ORAL | NDA | 19 sections |
PURIXAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62484-0020 | SUSPENSION | 20 mg | ORAL | NDA | 19 sections |
Mercaptopurine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 69076-913 | TABLET | 50 mg | ORAL | NDA authorized generic | 31 sections |