mercaptopurine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1708 50-44-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mercaptopurine monohydrate
  • 6-mercaptopurine monohydrate
  • 6-mercaptopurine
  • xaluprine
  • mercaptopurine
  • mercapurin
  • purimethol
  • purinethiol
  • purinethol
  • thiohypoxanthine
  • mercaptopurine hydrate
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
  • Molecular weight: 152.18
  • Formula: C5H4N4S
  • CLOGP: -1.33
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 53.07
  • ALOGS: -2.32
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 22 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 16.43 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 12 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 15 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.85 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 11, 1953 FDA STASON PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 767.65 14.06 467 18869 105078 56167653
Febrile bone marrow aplasia 312.28 14.06 108 19228 6464 56266267
Crohn's disease 295.28 14.06 103 19233 6324 56266407
Venoocclusive liver disease 250.78 14.06 83 19253 4338 56268393
Colitis ulcerative 181.88 14.06 110 19226 24281 56248450
Pancytopenia 161.91 14.06 175 19161 88540 56184191
Temporal lobe epilepsy 138.25 14.06 31 19305 355 56272376
Hyperbilirubinaemia 113.83 14.06 60 19276 10175 56262556
Haematotoxicity 107.24 14.06 54 19282 8329 56264402
Neurotoxicity 106.93 14.06 67 19269 15728 56257003
Acute lymphocytic leukaemia recurrent 102.36 14.06 36 19300 2261 56270470
Rhinovirus infection 100.43 14.06 41 19295 3881 56268850
Off label use 96.95 14.06 412 18924 555768 55716963
Pyrexia 94.72 14.06 337 18999 418436 55854295
Haemophagocytic lymphohistiocytosis 92.17 14.06 51 19285 9521 56263210
Hypertriglyceridaemia 91.02 14.06 43 19293 5773 56266958
Abdominal pain 81.92 14.06 234 19102 258571 56014160
Human bocavirus infection 80.94 14.06 20 19316 357 56272374
Pancreatitis 73.65 14.06 84 19252 44996 56227735
Perineal necrosis 66.85 14.06 14 19322 113 56272618
Joint swelling 66.77 14.06 10 19326 289790 55982941
Pain 65.72 14.06 79 19257 663105 55609626
Acute myeloid leukaemia 65.49 14.06 51 19285 16921 56255810
Perineal infection 65.00 14.06 14 19322 131 56272600
Neoplasm recurrence 63.91 14.06 26 19310 2438 56270293
Secondary immunodeficiency 61.30 14.06 21 19315 1219 56271512
Bacterial infection 60.29 14.06 49 19287 17281 56255450
Enterovirus test positive 58.87 14.06 13 19323 138 56272593
Enterobacter infection 57.88 14.06 23 19313 2029 56270702
Gastroenteritis norovirus 56.78 14.06 22 19314 1815 56270916
Leukaemia recurrent 56.08 14.06 20 19316 1308 56271423
Pneumatosis intestinalis 56.00 14.06 23 19313 2210 56270521
Occupational asthma 54.46 14.06 12 19324 126 56272605
Human rhinovirus test positive 51.35 14.06 12 19324 167 56272564
Herpes simplex 51.15 14.06 32 19304 7486 56265245
Alanine aminotransferase increased 50.33 14.06 104 19232 93558 56179173
Abdominal discomfort 49.11 14.06 17 19319 277257 55995474
Hepatocellular injury 47.75 14.06 52 19284 26462 56246269
Colitis 47.57 14.06 65 19271 41746 56230985
Trichodysplasia spinulosa 47.27 14.06 14 19322 505 56272226
Bacillus infection 46.89 14.06 15 19321 702 56272029
Antithrombin III 46.88 14.06 11 19325 156 56272575
Bone marrow failure 46.68 14.06 53 19283 28233 56244498
Fall 46.65 14.06 33 19303 357477 55915254
Mucosal inflammation 46.37 14.06 65 19271 42745 56229986
Human herpesvirus 6 infection 45.59 14.06 21 19315 2661 56270070
Neutropenia 45.15 14.06 138 19198 158029 56114702
Hepatosplenic T-cell lymphoma 44.82 14.06 14 19322 606 56272125
Arthropathy 43.68 14.06 8 19328 200267 56072464
Oesophageal dilatation 43.43 14.06 12 19324 336 56272395
Bacterial vulvovaginitis 42.74 14.06 14 19322 707 56272024
Peripheral swelling 42.23 14.06 14 19322 234712 56038019
Acute lymphocytic leukaemia 42.05 14.06 20 19316 2724 56270007
Partial seizures 41.94 14.06 25 19311 5365 56267366
Second primary malignancy 41.73 14.06 28 19308 7374 56265357
Epstein-Barr virus infection 41.52 14.06 28 19308 7435 56265296
Clostridium difficile colitis 41.38 14.06 41 19295 18697 56254034
Rectal cancer metastatic 41.27 14.06 11 19325 268 56272463
Synovitis 40.96 14.06 4 19332 161301 56111430
Venous thrombosis 40.28 14.06 23 19313 4557 56268174
Hypoglycaemia 39.89 14.06 70 19266 55745 56216986
Perirectal abscess 39.77 14.06 14 19322 881 56271850
Hypertransaminasaemia 39.69 14.06 23 19313 4684 56268047
Myelopathy 39.66 14.06 19 19317 2629 56270102
Anal abscess 39.41 14.06 22 19314 4175 56268556
Hepatotoxicity 39.38 14.06 51 19285 31102 56241629
Hypoalbuminaemia 39.06 14.06 31 19305 10568 56262163
Swelling 38.65 14.06 17 19319 239754 56032977
Female sterilisation 38.34 14.06 12 19324 523 56272208
Device related infection 37.82 14.06 42 19294 21838 56250893
Anal fistula 37.57 14.06 19 19317 2955 56269776
Sepsis 37.12 14.06 119 19217 139721 56133010
Post lumbar puncture syndrome 36.98 14.06 12 19324 588 56272143
Intestinal stenosis 36.76 14.06 18 19318 2613 56270118
Segmental diverticular colitis 36.19 14.06 9 19327 165 56272566
Pedal pulse abnormal 35.79 14.06 9 19327 173 56272558
Strongyloidiasis 35.65 14.06 14 19322 1197 56271534
Death 35.50 14.06 39 19297 341387 55931344
Cholestasis 35.50 14.06 45 19291 26868 56245863
Venoocclusive disease 35.24 14.06 16 19320 1961 56270770
Completed suicide 34.83 14.06 3 19333 133830 56138901
Bile acid malabsorption 34.64 14.06 9 19327 198 56272533
Enteritis 34.57 14.06 25 19311 7418 56265313
Cerebral venous sinus thrombosis 33.63 14.06 15 19321 1763 56270968
Blood culture positive 33.40 14.06 20 19316 4326 56268405
Mucormycosis 32.95 14.06 17 19319 2757 56269974
Fistula 32.84 14.06 26 19310 8829 56263902
Central obesity 32.81 14.06 13 19323 1138 56271593
Ileal stenosis 32.35 14.06 14 19322 1531 56271200
Fatigue 32.01 14.06 151 19185 788401 55484330
Leukopenia 31.53 14.06 73 19263 70867 56201864
Pseudomonas test positive 31.52 14.06 11 19325 675 56272056
Wound 31.45 14.06 5 19331 138799 56133932
Intestinal resection 31.36 14.06 16 19320 2534 56270197
Calcium ionised decreased 31.22 14.06 9 19327 295 56272436
Myelodysplastic syndrome 30.98 14.06 33 19303 16373 56256358
Glioma 30.65 14.06 9 19327 315 56272416
Staphylococcal sepsis 30.35 14.06 23 19313 7326 56265405
Insomnia 30.29 14.06 14 19322 191846 56080885
Discomfort 30.18 14.06 6 19330 141755 56130976
Subacute combined cord degeneration 29.02 14.06 8 19328 222 56272509
Feeding intolerance 29.00 14.06 10 19326 592 56272139
Lymphoproliferative disorder 28.78 14.06 16 19320 3012 56269719
Lower respiratory tract infection 28.74 14.06 3 19333 114791 56157940
Pancreatitis acute 28.48 14.06 39 19297 25085 56247646
Cytomegalovirus infection 28.24 14.06 34 19302 19262 56253469
Asthma 28.09 14.06 3 19333 112767 56159964
Vital capacity decreased 28.05 14.06 12 19324 1276 56271455
Dyspnoea 27.98 14.06 107 19229 592470 55680261
Neutrophil count decreased 27.54 14.06 56 19280 49766 56222965
Superior sagittal sinus thrombosis 27.15 14.06 10 19326 717 56272014
Histoplasmosis 26.99 14.06 13 19323 1821 56270910
Porphyria non-acute 26.95 14.06 8 19328 291 56272440
Leukoencephalopathy 26.83 14.06 17 19319 4065 56268666
Epstein-Barr virus associated lymphoma 26.54 14.06 9 19327 506 56272225
Abdominal adhesions 26.54 14.06 15 19321 2914 56269817
Acute lymphocytic leukaemia refractory 26.20 14.06 6 19330 76 56272655
Jaundice 25.99 14.06 39 19297 27255 56245476
Painful respiration 25.87 14.06 14 19322 2500 56270231
Blood bilirubin increased 25.36 14.06 43 19293 33311 56239420
Cardiotoxicity 25.28 14.06 21 19315 7629 56265102
Musculoskeletal stiffness 25.22 14.06 11 19325 155996 56116735
Drug interaction 25.17 14.06 140 19196 209615 56063116
Enterovirus infection 24.89 14.06 10 19326 908 56271823
Chloroma 24.68 14.06 7 19329 216 56272515
Clostridium difficile infection 24.68 14.06 38 19298 27160 56245571
Large intestinal stenosis 24.43 14.06 12 19324 1754 56270977
Systemic lupus erythematosus 24.28 14.06 16 19320 180062 56092669
Metastases to pancreas 24.15 14.06 7 19329 234 56272497
Encopresis 24.03 14.06 6 19330 112 56272619
Lung opacity 23.99 14.06 13 19323 2328 56270403
Haemolytic uraemic syndrome 23.64 14.06 13 19323 2395 56270336
Aborted pregnancy 23.39 14.06 5 19331 45 56272686
Influenza B virus test positive 23.31 14.06 7 19329 265 56272466
Inflammatory bowel disease 23.05 14.06 15 19321 3753 56268978
Cytogenetic abnormality 22.95 14.06 8 19328 489 56272242
Lipase increased 22.38 14.06 21 19315 8958 56263773
Breakthrough pain 22.34 14.06 10 19326 1186 56271545
Aplasia 22.25 14.06 15 19321 3981 56268750
Stress urinary incontinence 22.16 14.06 12 19324 2146 56270585
Pseudomonal sepsis 22.01 14.06 12 19324 2174 56270557
Coagulopathy 21.13 14.06 29 19307 18687 56254044
Seizure 21.06 14.06 92 19244 125027 56147704
Anaemia megaloblastic 21.02 14.06 7 19329 372 56272359
Gamma-glutamyltransferase increased 21.01 14.06 38 19298 30967 56241764
West Nile viral infection 20.99 14.06 7 19329 374 56272357
Drug specific antibody present 20.96 14.06 14 19322 3658 56269073
Haematochezia 20.54 14.06 46 19290 43672 56229059
Vocal cord paralysis 20.53 14.06 11 19325 1926 56270805
Gastrointestinal sounds abnormal 20.51 14.06 14 19322 3791 56268940
Overgrowth fungal 20.09 14.06 5 19331 92 56272639
Appendicitis 19.93 14.06 18 19318 7314 56265417
Respiratory tract haemorrhage 19.91 14.06 7 19329 439 56272292
Blood pressure abnormal 19.87 14.06 24 19312 13636 56259095
Bone marrow disorder 19.82 14.06 11 19325 2063 56270668
Cushingoid 19.82 14.06 18 19318 7366 56265365
Rectal abscess 19.81 14.06 9 19327 1105 56271626
Escherichia infection 19.43 14.06 22 19314 11677 56261054
Glossitis 19.37 14.06 12 19324 2758 56269973
Confusional state 19.25 14.06 26 19310 208129 56064602
Meningitis coccidioides 19.13 14.06 4 19332 32 56272699
Viral infection 18.96 14.06 37 19299 31909 56240822
Hyperglycaemia 18.80 14.06 41 19295 38240 56234491
Transverse sinus thrombosis 18.79 14.06 7 19329 518 56272213
Pericarditis 18.71 14.06 7 19329 108916 56163815
Staphylococcal bacteraemia 18.69 14.06 15 19321 5194 56267537
Precursor T-lymphoblastic lymphoma/leukaemia 18.52 14.06 4 19332 38 56272693
Herpes zoster meningoencephalitis 18.34 14.06 6 19330 302 56272429
Histoplasmosis disseminated 18.27 14.06 9 19327 1323 56271408
Rhinocerebral mucormycosis 18.26 14.06 6 19330 306 56272425
Myelosuppression 18.15 14.06 26 19310 17429 56255302
Mucoepidermoid carcinoma 18.07 14.06 4 19332 43 56272688
Proctalgia 17.95 14.06 15 19321 5494 56267237
Contusion 17.87 14.06 11 19325 128419 56144312
Feeling abnormal 17.83 14.06 12 19324 133590 56139141
Pericardial cyst 17.64 14.06 3 19333 6 56272725
Pyoderma gangrenosum 17.55 14.06 12 19324 3258 56269473
Atypical haemolytic uraemic syndrome 17.51 14.06 7 19329 627 56272104
Small intestinal obstruction 17.40 14.06 25 19311 16800 56255931
Oesophageal mass 17.37 14.06 4 19332 52 56272679
Listeria sepsis 17.32 14.06 7 19329 645 56272086
Haematocolpos 17.16 14.06 4 19332 55 56272676
Atrial fibrillation 17.09 14.06 8 19328 108889 56163842
Thrombocytopenia 17.04 14.06 92 19244 136132 56136599
Acute myelomonocytic leukaemia 16.81 14.06 5 19331 183 56272548
T-cell lymphoma 16.79 14.06 7 19329 698 56272033
Lupus-like syndrome 16.73 14.06 21 19315 12406 56260325
Hemiparesis 16.72 14.06 28 19308 21462 56251269
Ocular icterus 16.64 14.06 12 19324 3544 56269187
Drug level decreased 16.61 14.06 16 19320 7048 56265683
Somnolence 16.59 14.06 19 19317 163394 56109337
Vulval disorder 16.56 14.06 7 19329 723 56272008
Cerebral ischaemia 16.52 14.06 15 19321 6135 56266596
Frequent bowel movements 16.40 14.06 24 19312 16400 56256331
Intracardiac thrombus 16.28 14.06 10 19326 2265 56270466
T-cell type acute leukaemia 16.15 14.06 4 19332 72 56272659
Toe walking 16.11 14.06 3 19333 12 56272719
Psoriatic arthropathy 16.02 14.06 3 19333 74005 56198726
Quadriplegia 16.02 14.06 9 19327 1729 56271002
Functional gastrointestinal disorder 15.91 14.06 12 19324 3795 56268936
Osteoarthritis 15.87 14.06 4 19332 80292 56192439
Anal fissure 15.84 14.06 12 19324 3819 56268912
Dizziness 15.78 14.06 71 19265 376069 55896662
Pneumocystis jirovecii pneumonia 15.76 14.06 23 19313 15678 56257053
Rash 15.76 14.06 102 19234 492945 55779786
Glioblastoma multiforme 15.75 14.06 7 19329 816 56271915
Hippocampal sclerosis 15.71 14.06 4 19332 81 56272650
Hepatosplenomegaly 15.66 14.06 10 19326 2423 56270308
Depersonalisation/derealisation disorder 15.66 14.06 8 19328 1271 56271460
Pericardial effusion 15.56 14.06 31 19305 27144 56245587
Gambling 15.55 14.06 5 19331 238 56272493
Intestinal operation 15.51 14.06 6 19330 493 56272238
Bronchitis chronic 15.42 14.06 12 19324 3976 56268755
Amylase increased 15.35 14.06 14 19322 5757 56266974
Histiocytic sarcoma 15.31 14.06 4 19332 90 56272641
Pneumonia fungal 15.28 14.06 13 19323 4880 56267851
Potentiating drug interaction 15.21 14.06 12 19324 4054 56268677
Malaise 15.10 14.06 70 19266 367790 55904941
Campylobacter infection 15.03 14.06 7 19329 909 56271822
Pseudopolyp 15.01 14.06 5 19331 266 56272465
Anogenital dysplasia 14.96 14.06 3 19333 19 56272712
Listeriosis 14.92 14.06 8 19328 1402 56271329
Diarrhoea haemorrhagic 14.87 14.06 16 19320 8027 56264704
Furuncle 14.77 14.06 14 19322 6045 56266686
Cerebral haemangioma 14.72 14.06 4 19332 105 56272626
Lymphoma 14.65 14.06 18 19318 10410 56262321
Lennox-Gastaut syndrome 14.65 14.06 5 19331 287 56272444
Inappropriate schedule of product administration 14.55 14.06 62 19274 83325 56189406
Extraskeletal ossification 14.51 14.06 4 19332 111 56272620
Papulopustular rosacea 14.46 14.06 3 19333 23 56272708
Pruritus 14.36 14.06 58 19278 316565 55956166
Choriomeningitis lymphocytic 14.24 14.06 3 19333 25 56272706
Vomiting 14.18 14.06 245 19091 497983 55774748
Blood immunoglobulin G decreased 14.11 14.06 9 19327 2177 56270554
Aspergillus infection 14.06 14.06 15 19321 7450 56265281

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 861.13 14.83 672 19648 121177 31555847
Hepatosplenic T-cell lymphoma 251.42 14.83 60 20260 465 31676559
Venoocclusive liver disease 212.70 14.83 101 20219 7311 31669713
Febrile bone marrow aplasia 201.24 14.83 99 20221 7747 31669277
Haematotoxicity 197.93 14.83 95 20225 7042 31669982
Crohn's disease 162.15 14.83 70 20250 4051 31672973
Hypertriglyceridaemia 155.35 14.83 83 20237 7715 31669309
Death 138.86 14.83 31 20289 360538 31316486
Acute lymphocytic leukaemia recurrent 125.21 14.83 54 20266 3116 31673908
Pancytopenia 122.90 14.83 209 20111 87107 31589917
Colitis ulcerative 110.42 14.83 93 20227 18436 31658588
Bone marrow failure 103.94 14.83 108 20212 27900 31649124
Multiple-drug resistance 95.78 14.83 50 20270 4430 31672594
Pyrexia 95.67 14.83 416 19904 303424 31373600
Cytomegalovirus chorioretinitis 93.11 14.83 45 20275 3383 31673641
Haemophagocytic lymphohistiocytosis 91.83 14.83 69 20251 11609 31665415
Colitis 87.11 14.83 108 20212 33779 31643245
Abdominal pain 86.92 14.83 247 20073 145705 31531319
Pancreatitis 82.47 14.83 108 20212 35663 31641361
Osteonecrosis 81.30 14.83 69 20251 13815 31663209
Neutropenia 80.13 14.83 234 20086 140130 31536894
Leukoencephalopathy 76.20 14.83 41 20279 3861 31673163
Hepatotoxicity 75.01 14.83 76 20244 19050 31657974
Mucosal inflammation 70.31 14.83 98 20222 34329 31642695
Lentigo 63.98 14.83 19 20301 362 31676662
Nodular regenerative hyperplasia 61.10 14.83 23 20297 929 31676095
Enterovirus infection 59.08 14.83 21 20299 719 31676305
Myelosuppression 57.97 14.83 59 20261 14861 31662163
Glioma 56.14 14.83 17 20303 347 31676677
Frequent bowel movements 54.43 14.83 48 20272 10111 31666913
Off label use 53.12 14.83 392 19928 346882 31330142
Acute myeloid leukaemia 50.37 14.83 61 20259 18611 31658413
Epstein-Barr virus associated lymphoproliferative disorder 49.93 14.83 24 20296 1782 31675242
Myocardial infarction 47.18 14.83 8 20312 113446 31563578
Drug clearance decreased 46.26 14.83 22 20298 1595 31675429
Histoplasmosis disseminated 46.23 14.83 20 20300 1162 31675862
Epstein-Barr virus infection 45.79 14.83 37 20283 6916 31670108
Gallbladder oedema 44.73 14.83 13 20307 229 31676795
Venoocclusive disease 43.74 14.83 25 20295 2647 31674377
Glioblastoma multiforme 43.62 14.83 17 20303 755 31676269
Portal hypertension 43.33 14.83 28 20292 3697 31673327
Gastrointestinal wall thickening 42.96 14.83 20 20300 1382 31675642
Cytogenetic abnormality 42.55 14.83 17 20303 807 31676217
Atrial fibrillation 41.23 14.83 11 20309 113772 31563252
Myelodysplastic syndrome 41.08 14.83 56 20264 19195 31657829
Fall 40.34 14.83 36 20284 186053 31490971
Hyperbilirubinaemia 40.13 14.83 50 20270 15700 31661324
Dyspnoea 40.05 14.83 102 20218 343377 31333647
Intestinal stenosis 39.38 14.83 21 20299 1942 31675082
Second primary malignancy 39.23 14.83 34 20286 6998 31670026
B-cell lymphoma 38.85 14.83 28 20292 4417 31672607
Rhinovirus infection 37.49 14.83 25 20295 3480 31673544
Dizziness 36.97 14.83 44 20276 199103 31477921
Cardiac failure congestive 36.77 14.83 4 20316 79383 31597641
Haematopoietic neoplasm 35.29 14.83 8 20312 48 31676976
Sepsis 33.90 14.83 189 20131 151740 31525284
Candida endophthalmitis 33.50 14.83 9 20311 117 31676907
Ileal stenosis 32.63 14.83 16 20304 1241 31675783
Cytomegalovirus infection 31.87 14.83 57 20263 24650 31652374
Acute monocytic leukaemia 31.62 14.83 11 20309 353 31676671
Leukopenia 31.55 14.83 95 20225 57733 31619291
Diffuse large B-cell lymphoma 31.45 14.83 33 20287 8608 31668416
Hepatocellular injury 30.79 14.83 52 20268 21492 31655532
Anal inflammation 30.77 14.83 11 20309 383 31676641
Fistula 30.58 14.83 27 20293 5694 31671330
Pancreatitis acute 30.42 14.83 57 20263 25543 31651481
Vomiting 30.30 14.83 246 20074 223727 31453297
Parainfluenzae virus infection 29.95 14.83 19 20301 2430 31674594
Intracranial pressure increased 29.84 14.83 22 20298 3593 31673431
Alanine aminotransferase increased 29.50 14.83 110 20210 74546 31602478
Neutrophil count decreased 28.96 14.83 80 20240 46314 31630710
Thrombocytopenia 28.85 14.83 173 20147 142574 31534450
Xanthogranuloma 28.30 14.83 7 20313 64 31676960
Stomatitis 27.65 14.83 71 20249 39367 31637657
Myelopathy 26.42 14.83 17 20303 2228 31674796
Bacterial infection 26.38 14.83 38 20282 13701 31663323
Leukaemia recurrent 26.25 14.83 15 20305 1587 31675437
Proctitis 26.06 14.83 17 20303 2280 31674744
Depression 25.78 14.83 13 20307 90802 31586222
Human rhinovirus test positive 25.64 14.83 8 20312 181 31676843
Lymphopenia 23.76 14.83 37 20283 14292 31662732
Neurotoxicity 22.96 14.83 39 20281 16187 31660837
Cytomegalovirus hepatitis 22.86 14.83 9 20311 411 31676613
Superior sagittal sinus thrombosis 22.67 14.83 8 20312 268 31676756
Anal fistula 22.48 14.83 21 20299 4762 31672262
Abscess limb 22.48 14.83 18 20302 3321 31673703
Neoplasm recurrence 22.42 14.83 15 20305 2099 31674925
Adrenocortical carcinoma 22.20 14.83 5 20315 29 31676995
Product dose omission issue 22.16 14.83 21 20299 105565 31571459
Blood fibrinogen decreased 22.10 14.83 12 20308 1150 31675874
Peripheral swelling 21.99 14.83 8 20312 67857 31609167
Fungal infection 21.96 14.83 36 20284 14515 31662509
Cytopenia 21.95 14.83 31 20289 10979 31666045
Multiple lentigines syndrome 21.92 14.83 5 20315 31 31676993
Cytomegalovirus colitis 21.87 14.83 16 20304 2582 31674442
Steatohepatitis 21.69 14.83 8 20312 305 31676719
Staphylococcal sepsis 21.68 14.83 28 20292 9109 31667915
Proctalgia 21.38 14.83 20 20300 4542 31672482
Small intestinal obstruction 21.25 14.83 34 20286 13438 31663586
Anal abscess 20.84 14.83 22 20298 5778 31671246
Cardiac arrest 20.78 14.83 16 20304 89046 31587978
Otitis media acute 20.74 14.83 9 20311 527 31676497
Completed suicide 20.65 14.83 17 20303 91497 31585527
Minimal residual disease 20.51 14.83 8 20312 356 31676668
Dysplastic naevus syndrome 20.41 14.83 4 20316 10 31677014
Malignant neoplasm progression 20 14.83 13 20307 78985 31598039
Mucormycosis 19.79 14.83 21 20299 5549 31671475
Rhabdomyolysis 19.76 14.83 8 20312 63573 31613451
Thymus enlargement 19.72 14.83 5 20315 51 31676973
Coronary artery disease 19.70 14.83 3 20317 46084 31630940
Intestinal diaphragm disease 19.63 14.83 7 20313 242 31676782
Trichodysplasia spinulosa 19.49 14.83 7 20313 247 31676777
Chest pain 19.45 14.83 28 20292 116929 31560095
Transaminases increased 19.36 14.83 46 20274 24295 31652729
Metapneumovirus infection 19.19 14.83 9 20311 632 31676392
Chronic obstructive pulmonary disease 19.17 14.83 3 20317 45163 31631861
Small intestinal stenosis 18.96 14.83 8 20312 437 31676587
Asthenia 18.95 14.83 77 20243 224678 31452346
Bifidobacterium infection 18.61 14.83 4 20316 18 31677006
Rheumatoid arthritis 18.52 14.83 4 20316 47805 31629219
Confusional state 18.41 14.83 36 20284 133298 31543726
T-cell lymphoma 18.23 14.83 10 20310 978 31676046
Hepatic steatosis 17.87 14.83 35 20285 16204 31660820
Disease progression 17.83 14.83 19 20301 90445 31586579
Syncope 17.80 14.83 17 20303 85165 31591859
Human metapneumovirus test positive 17.77 14.83 5 20315 78 31676946
Vascular access complication 17.67 14.83 7 20313 325 31676699
Meningitis enterococcal 17.48 14.83 5 20315 83 31676941
Pneumocystis jirovecii pneumonia 17.32 14.83 37 20283 18214 31658810
Renal failure 17.28 14.83 33 20287 123297 31553727
Acral lentiginous melanoma 17.24 14.83 4 20316 27 31676997
Viral myelitis 16.99 14.83 4 20316 29 31676995
Gastrointestinal injury 16.79 14.83 7 20313 371 31676653
Cutaneous leishmaniasis 16.70 14.83 6 20314 212 31676812
Disseminated cytomegaloviral infection 16.70 14.83 6 20314 212 31676812
Hip deformity 16.56 14.83 5 20315 101 31676923
Rectal haemorrhage 16.47 14.83 56 20264 36248 31640776
Anorectal cellulitis 16.13 14.83 4 20316 37 31676987
Cardiac failure 15.90 14.83 19 20301 85934 31591090
Epstein-Barr virus associated lymphoma 15.79 14.83 8 20312 665 31676359
Pulmonary mucormycosis 15.63 14.83 8 20312 680 31676344
Meningoradiculitis 15.59 14.83 4 20316 43 31676981
Colon dysplasia 15.52 14.83 5 20315 126 31676898
Somnolence 15.39 14.83 25 20295 99420 31577604
Aspergillus infection 15.38 14.83 27 20293 11501 31665523
Central nervous system leukaemia 15.32 14.83 6 20314 270 31676754
Cheilitis 15.26 14.83 12 20308 2156 31674868
Escherichia infection 15.20 14.83 21 20299 7283 31669741
Tonsil cancer 15.15 14.83 9 20311 1024 31676000
Haemorrhagic diathesis 15.12 14.83 13 20307 2647 31674377
Herpes zoster 15.09 14.83 50 20270 31943 31645081
Large intestine infection 14.90 14.83 10 20310 1406 31675618

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1549.98 12.45 1057 33615 203261 70690511
Haematotoxicity 311.21 12.45 146 34526 13528 70880244
Secondary immunodeficiency 281.29 12.45 89 34583 2800 70890972
Pancytopenia 274.16 12.45 353 34319 150754 70743018
Febrile bone marrow aplasia 257.44 12.45 123 34549 11868 70881904
Bacterial infection 235.57 12.45 152 34520 26340 70867432
Hepatosplenic T-cell lymphoma 222.02 12.45 58 34614 900 70892872
Hypertriglyceridaemia 196.82 12.45 102 34570 11709 70882063
Colitis ulcerative 194.98 12.45 149 34523 33774 70859998
Haemophagocytic lymphohistiocytosis 185.46 12.45 117 34555 19495 70874277
Acute lymphocytic leukaemia recurrent 182.27 12.45 74 34598 4830 70888942
Cytomegalovirus chorioretinitis 180.11 12.45 75 34597 5223 70888549
Parainfluenzae virus infection 159.62 12.45 68 34604 5012 70888760
Rhinovirus infection 156.60 12.45 73 34599 6660 70887112
Mycobacterium chelonae infection 154.79 12.45 54 34618 2310 70891462
Pyrexia 153.55 12.45 644 34028 606308 70287464
Bone marrow failure 145.68 12.45 148 34524 48862 70844910
Pancreatitis 145.42 12.45 166 34506 62502 70831270
Off label use 138.42 12.45 721 33951 742339 70151433
Myelodysplastic syndrome transformation 129.21 12.45 35 34637 628 70893144
Rheumatoid arthritis 128.34 12.45 3 34669 291802 70601970
Pseudomonal sepsis 125.58 12.45 59 34613 5478 70888294
Mucosal inflammation 112.76 12.45 152 34520 67698 70826074
Neutropenia 111.91 12.45 327 34345 256829 70636943
Human bocavirus infection 108.84 12.45 30 34642 576 70893196
Second primary malignancy 106.52 12.45 71 34601 12980 70880792
Acute myeloid leukaemia 106.01 12.45 101 34571 30839 70862933
Osteonecrosis 105.29 12.45 98 34574 29062 70864710
Abdominal pain 103.11 12.45 384 34288 341743 70552029
Human herpesvirus 6 infection 101.72 12.45 49 34623 4810 70888962
Multiple-drug resistance 101.40 12.45 56 34616 7299 70886473
Hepatotoxicity 101.14 12.45 116 34556 43870 70849902
Clostridium difficile colitis 100.00 12.45 95 34577 28901 70864871
Neurotoxicity 97.73 12.45 95 34577 29731 70864041
Hyperbilirubinaemia 97.63 12.45 84 34588 22484 70871288
Leukoencephalopathy 90.96 12.45 52 34620 7242 70886530
Glioma 90.82 12.45 26 34646 576 70893196
Fall 89.75 12.45 53 34619 444043 70449729
Viral infection 89.54 12.45 102 34570 38289 70855483
Enterovirus infection 82.56 12.45 31 34641 1640 70892132
Crohn's disease 82.54 12.45 35 34637 2549 70891223
Thymus hypoplasia 80.52 12.45 24 34648 615 70893157
Neoplasm recurrence 77.26 12.45 38 34634 3903 70889869
Temporal lobe epilepsy 77.25 12.45 21 34651 382 70893390
Dyspnoea 76.82 12.45 164 34508 769896 70123876
Epstein-Barr virus infection 75.87 12.45 58 34614 13140 70880632
Venoocclusive disease 74.97 12.45 38 34634 4162 70889610
Myelodysplastic syndrome 74.36 12.45 82 34590 29703 70864069
Colitis 74.33 12.45 121 34551 63693 70830079
Cytogenetic abnormality 72.44 12.45 25 34647 1035 70892737
Myelopathy 71.64 12.45 37 34635 4214 70889558
Leukaemia recurrent 70.52 12.45 32 34640 2743 70891029
Myelosuppression 70.14 12.45 80 34592 30065 70863707
Lymphoid tissue hypoplasia 69.13 12.45 21 34651 575 70893197
Joint swelling 67.48 12.45 20 34652 253191 70640581
Abscess bacterial 67.22 12.45 22 34650 772 70893000
Aspergillus infection 66.33 12.45 61 34611 17807 70875965
Human rhinovirus test positive 66.15 12.45 19 34653 426 70893346
Death 64.97 12.45 93 34579 509968 70383804
Trichodysplasia spinulosa 64.63 12.45 21 34651 720 70893052
Lentigo 64.61 12.45 19 34653 464 70893308
Enterobacter infection 64.59 12.45 34 34638 4026 70889746
Nodular regenerative hyperplasia 63.92 12.45 24 34648 1269 70892503
Glioblastoma multiforme 63.91 12.45 24 34648 1270 70892502
Peripheral swelling 62.46 12.45 19 34653 236544 70657228
Perineal necrosis 61.28 12.45 14 34658 119 70893653
Sepsis 61.07 12.45 259 34413 244286 70649486
Fungal infection 60.80 12.45 83 34589 37384 70856388
Pneumatosis intestinalis 60.39 12.45 37 34635 5850 70887922
Enteritis 60.10 12.45 50 34622 12781 70880991
Cytomegalovirus infection 59.92 12.45 85 34587 39673 70854099
Leukopenia 59.82 12.45 149 34523 106411 70787361
Norovirus test positive 59.74 12.45 18 34654 479 70893293
Histoplasmosis disseminated 59.45 12.45 26 34646 2042 70891730
Viraemia 57.89 12.45 27 34645 2465 70891307
Pain 57.69 12.45 140 34532 628676 70265096
Completed suicide 56.87 12.45 20 34652 227115 70666657
Epstein-Barr virus associated lymphoproliferative disorder 56.50 12.45 29 34643 3260 70890512
Enterovirus test positive 55.97 12.45 15 34657 258 70893514
Pancreatitis acute 55.74 12.45 88 34584 45136 70848636
Cystitis bacterial 55.30 12.45 17 34655 485 70893287
Alanine aminotransferase increased 55.14 12.45 178 34494 147302 70746470
Contraindicated product administered 53.60 12.45 3 34669 134609 70759163
Intestinal stenosis 53.01 12.45 28 34644 3339 70890433
Neutrophil count decreased 50.26 12.45 120 34552 83436 70810336
Atrial fibrillation 50.13 12.45 14 34658 184334 70709438
Cytomegalovirus viraemia 49.53 12.45 43 34629 11642 70882130
Coronavirus infection 48.59 12.45 33 34639 6219 70887553
Dizziness 48.57 12.45 96 34576 464045 70429727
Thrombocytopenia 48.34 12.45 238 34434 238872 70654900
Hepatocellular injury 47.81 12.45 83 34589 46008 70847764
Drug clearance decreased 47.27 12.45 25 34647 2988 70890784
Bronchopulmonary aspergillosis 45.94 12.45 54 34618 20948 70872824
Frequent bowel movements 45.63 12.45 54 34618 21099 70872673
Mucormycosis 45.58 12.45 35 34637 7979 70885793
Diffuse large B-cell lymphoma 44.75 12.45 43 34629 13259 70880513
Fistula 44.03 12.45 39 34633 10842 70882930
Molluscum contagiosum 43.62 12.45 14 34658 461 70893311
Cell-mediated immune deficiency 42.68 12.45 10 34662 96 70893676
Venoocclusive liver disease 42.67 12.45 38 34634 10640 70883132
Feeding intolerance 42.61 12.45 15 34657 659 70893113
Intestinal resection 42.22 12.45 24 34648 3306 70890466
Diffuse alveolar damage 41.99 12.45 24 34648 3339 70890433
Swelling 41.68 12.45 20 34652 188519 70705253
Intracranial pressure increased 41.56 12.45 32 34640 7324 70886448
Anal inflammation 41.29 12.45 14 34658 549 70893223
Superior sagittal sinus thrombosis 40.24 12.45 16 34656 988 70892784
Acute lymphocytic leukaemia 40.10 12.45 28 34644 5517 70888255
Subacute combined cord degeneration 39.56 12.45 12 34660 327 70893445
Oesophageal candidiasis 39.53 12.45 33 34639 8474 70885298
B-cell lymphoma 39.25 12.45 29 34643 6240 70887532
Epstein-Barr virus associated lymphoma 39.06 12.45 16 34656 1068 70892704
Intracardiac thrombus 38.55 12.45 24 34648 3903 70889869
Encephalitis 38.48 12.45 40 34632 13545 70880227
Hypertransaminasaemia 38.09 12.45 33 34639 8910 70884862
Cerebral venous sinus thrombosis 38.08 12.45 19 34653 2012 70891760
Arthropathy 37.91 12.45 13 34659 150044 70743728
Lower respiratory tract infection 37.78 12.45 5 34667 111908 70781864
Device related infection 37.42 12.45 61 34611 32124 70861648
Perineal infection 37.31 12.45 14 34658 739 70893033
Asthma 37.16 12.45 7 34665 120786 70772986
Synovitis 36.68 12.45 9 34663 129219 70764553
Anal abscess 35.92 12.45 31 34641 8327 70885445
Anal fistula 35.68 12.45 27 34645 6023 70887749
Cardiac failure congestive 35.51 12.45 11 34661 135446 70758326
Gastroenteritis norovirus 34.62 12.45 20 34652 2839 70890933
Bile acid malabsorption 34.49 12.45 10 34662 232 70893540
Acute monocytic leukaemia 34.47 12.45 12 34660 510 70893262
Fatigue 34.44 12.45 249 34423 824070 70069702
Ileal stenosis 34.18 12.45 18 34654 2133 70891639
Confusional state 34.06 12.45 54 34618 284344 70609428
Bacterial vulvovaginitis 34.03 12.45 12 34660 530 70893242
Pruritus 33.97 12.45 74 34598 345486 70548286
Proctalgia 33.83 12.45 30 34642 8353 70885419
Seizure 33.72 12.45 174 34498 177788 70715984
Pneumocystis jirovecii pneumonia 33.61 12.45 56 34616 30026 70863746
Bacillus infection 33.45 12.45 14 34658 987 70892785
Perirectal abscess 33.44 12.45 17 34655 1873 70891899
Haematopoietic neoplasm 33.32 12.45 8 34664 86 70893686
Hyperkalaemia 33.17 12.45 6 34666 106585 70787187
Segmental diverticular colitis 33.04 12.45 9 34663 165 70893607
Lipase increased 33.01 12.45 39 34633 15207 70878565
Candida endophthalmitis 32.69 12.45 9 34663 172 70893600
Discomfort 32.67 12.45 6 34666 105430 70788342
Cholestasis 32.35 12.45 72 34600 47800 70845972
Strongyloidiasis 32.19 12.45 21 34651 3702 70890070
Cytomegalovirus colitis 32.11 12.45 22 34650 4204 70889568
Pedal pulse abnormal 32.07 12.45 9 34663 185 70893587
Depression 32.04 12.45 30 34642 198944 70694828
Hypoalbuminaemia 31.99 12.45 43 34629 19079 70874693
Muscle spasms 31.59 12.45 18 34654 154028 70739744
Abdominal discomfort 31.57 12.45 35 34637 214623 70679149
Histoplasmosis 31.55 12.45 17 34655 2110 70891662
Blood fibrinogen decreased 31.43 12.45 16 34656 1768 70892004
Lymphopenia 30.66 12.45 51 34621 27308 70866464
Rectal cancer metastatic 30.47 12.45 11 34661 520 70893252
Haemolytic uraemic syndrome 30.21 12.45 21 34651 4109 70889663
Portal hypertension 29.78 12.45 25 34647 6467 70887305
Blood bilirubin increased 29.72 12.45 80 34592 59821 70833951
Pneumonia fungal 29.45 12.45 30 34642 9923 70883849
Insomnia 29.39 12.45 38 34634 217768 70676004
Blood culture positive 29.30 12.45 27 34645 7899 70885873
Escherichia infection 29.29 12.45 38 34634 16293 70877479
Disseminated aspergillosis 29.12 12.45 12 34660 813 70892959
Pseudomonas test positive 29.10 12.45 15 34657 1701 70892071
Atypical haemolytic uraemic syndrome 28.94 12.45 12 34660 826 70892946
Xanthogranuloma 28.85 12.45 7 34665 79 70893693
Cardiotoxicity 28.53 12.45 31 34641 11039 70882733
Vomiting 28.51 12.45 427 34245 592684 70301088
Intentional overdose 27.65 12.45 7 34665 98428 70795344
Abdominal adhesions 27.54 12.45 18 34654 3182 70890590
Cytopenia 27.53 12.45 38 34634 17285 70876487
Aplasia 27.39 12.45 25 34647 7226 70886546
Product dose omission issue 27.27 12.45 40 34632 217428 70676344
Malaise 27.24 12.45 114 34558 432818 70460954
Coagulopathy 27.11 12.45 54 34618 33195 70860577
Cytomegalovirus hepatitis 26.95 12.45 11 34661 727 70893045
Glossodynia 26.62 12.45 5 34667 86482 70807290
Chloroma 26.52 12.45 11 34661 758 70893014
Cerebral haemangioma 25.72 12.45 7 34665 128 70893644
Cellulitis 25.59 12.45 106 34566 98822 70794950
Syncope 25.50 12.45 26 34646 165683 70728089
Systemic lupus erythematosus 25.44 12.45 9 34663 101893 70791879
Hippocampal sclerosis 25.27 12.45 7 34665 137 70893635
Metapneumovirus infection 24.95 12.45 13 34659 1507 70892265
Oedema peripheral 24.83 12.45 46 34626 228045 70665727
Somnolence 24.81 12.45 42 34630 215564 70678208
Bifidobacterium infection 24.70 12.45 5 34667 22 70893750
Feeling abnormal 24.67 12.45 20 34652 142299 70751473
Hepatosplenomegaly 24.30 12.45 21 34651 5649 70888123
Cushingoid 24.30 12.45 25 34647 8363 70885409
Acute lymphocytic leukaemia refractory 24.28 12.45 7 34665 159 70893613
Abscess limb 23.77 12.45 22 34650 6471 70887301
Staphylococcal sepsis 23.70 12.45 31 34641 13396 70880376
Suicide attempt 23.63 12.45 5 34667 79505 70814267
Antithrombin III 23.34 12.45 6 34666 87 70893685
Neuropathy peripheral 23.29 12.45 123 34549 126773 70766999
Asthenia 23.28 12.45 130 34542 457536 70436236
Anorectal cellulitis 23.03 12.45 6 34666 92 70893680
Transaminases increased 22.53 12.45 62 34610 46956 70846816
Calcium ionised decreased 22.42 12.45 9 34663 570 70893202
Hemiparesis 22.02 12.45 48 34624 31421 70862351
Aborted pregnancy 21.63 12.45 5 34667 45 70893727
Otitis media acute 21.58 12.45 11 34661 1218 70892554
Central obesity 21.53 12.45 12 34660 1591 70892181
Hyponatraemia 21.51 12.45 28 34644 160059 70733713
Herpes simplex 21.50 12.45 27 34645 11205 70882567
Coma 21.45 12.45 9 34663 91835 70801937
Venous thrombosis 21.44 12.45 21 34651 6628 70887144
Chest pain 21.37 12.45 58 34614 251202 70642570
Osteoarthritis 21.36 12.45 5 34667 74142 70819630
Gastrointestinal inflammation 21.24 12.45 21 34651 6702 70887070
Thymus enlargement 21.22 12.45 6 34666 127 70893645
Mobility decreased 21.16 12.45 12 34660 102987 70790785
Splenomegaly 20.91 12.45 35 34637 18835 70874937
T-cell lymphoma 20.91 12.45 11 34661 1301 70892471
Drug intolerance 20.81 12.45 50 34622 225637 70668135
Musculoskeletal stiffness 20.74 12.45 25 34647 147735 70746037
Coronary artery disease 20.71 12.45 3 34669 62733 70831039
Drug level decreased 20.52 12.45 28 34644 12596 70881176
Inflammatory bowel disease 20.25 12.45 18 34654 5028 70888744
Differentiation syndrome 20.23 12.45 13 34659 2234 70891538
Meningitis coccidioides 20.10 12.45 5 34667 63 70893709
Epidermal necrosis 20.05 12.45 11 34661 1414 70892358
Human metapneumovirus test positive 20.01 12.45 6 34666 157 70893615
Urinary tract infection 19.99 12.45 59 34613 248710 70645062
Chest discomfort 19.73 12.45 19 34653 124362 70769410
Wound 19.58 12.45 12 34660 98720 70795052
Gastrointestinal wall thickening 19.56 12.45 13 34659 2363 70891409
Staphylococcal infection 19.52 12.45 64 34608 53340 70840432
Lymphoproliferative disorder 19.40 12.45 18 34654 5311 70888461
Anxiety 19.38 12.45 50 34622 220280 70673492
Myocardial infarction 19.23 12.45 34 34638 171611 70722161
Chronic obstructive pulmonary disease 19.13 12.45 7 34665 77634 70816138
Hypoglycaemia 19.08 12.45 94 34578 94270 70799502
General physical health deterioration 18.95 12.45 56 34616 235975 70657797
Influenza B virus test positive 18.94 12.45 7 34665 354 70893418
Hip deformity 18.92 12.45 6 34666 190 70893582
Listeriosis 18.90 12.45 12 34660 2020 70891752
Anal fissure 18.83 12.45 19 34653 6214 70887558
Adrenocortical carcinoma 18.77 12.45 5 34667 84 70893688
Pericarditis 18.69 12.45 9 34663 84696 70809076
Large intestinal stenosis 18.67 12.45 13 34659 2550 70891222
Drug reaction with eosinophilia and systemic symptoms 18.63 12.45 3 34669 58010 70835762
Hallucination 18.58 12.45 7 34665 76253 70817519
Transverse sinus thrombosis 18.47 12.45 8 34664 614 70893158
Rectal abscess 18.42 12.45 11 34661 1660 70892112
Clostridium difficile infection 18.42 12.45 51 34621 38765 70855007
Electrocardiogram QT prolonged 18.23 12.45 9 34663 83508 70810264
Drug specific antibody present 18.22 12.45 18 34654 5740 70888032
Angioedema 18.20 12.45 5 34667 66605 70827167
Meningitis enterococcal 18.14 12.45 5 34667 96 70893676
Platelet count decreased 18.14 12.45 149 34523 178073 70715699
Neutropenic colitis 18.09 12.45 17 34655 5097 70888675
Overgrowth fungal 18.09 12.45 5 34667 97 70893675
Fusarium infection 18.06 12.45 11 34661 1721 70892051
Posterior reversible encephalopathy syndrome 17.97 12.45 38 34634 24364 70869408
Vascular access complication 17.89 12.45 11 34661 1750 70892022
Drug hypersensitivity 17.83 12.45 67 34605 262392 70631380
Pancreatitis necrotising 17.76 12.45 14 34658 3314 70890458
Rash 17.68 12.45 162 34510 510400 70383372
Disseminated cytomegaloviral infection 17.40 12.45 7 34665 446 70893326
Herpes zoster meningoencephalitis 17.40 12.45 8 34664 707 70893065
Post lumbar puncture syndrome 17.39 12.45 8 34664 708 70893064
Antithrombin III decreased 17.29 12.45 7 34665 453 70893319
Anaemia 17.27 12.45 285 34387 403138 70490634
Wrong technique in product usage process 17.26 12.45 6 34666 68692 70825080
Facial paralysis 17.15 12.45 33 34639 19775 70873997
Porphyria non-acute 17.09 12.45 8 34664 736 70893036
Tonsil cancer 17.05 12.45 9 34663 1072 70892700
Overdose 16.95 12.45 36 34636 169709 70724063
Nasopharyngitis 16.93 12.45 54 34618 222152 70671620
Bone marrow disorder 16.89 12.45 13 34659 2972 70890800
Acute promyelocytic leukaemia 16.85 12.45 10 34662 1492 70892280
Cheilitis 16.85 12.45 16 34656 4861 70888911
Metastases to pancreas 16.82 12.45 7 34665 486 70893286
Encopresis 16.78 12.45 5 34667 128 70893644
Acral lentiginous melanoma 16.75 12.45 4 34668 42 70893730
Magnetic resonance imaging head abnormal 16.67 12.45 12 34660 2480 70891292
Precursor T-lymphoblastic lymphoma/leukaemia 16.67 12.45 5 34667 131 70893641
Toe walking 16.58 12.45 3 34669 6 70893766
Small intestinal obstruction 16.56 12.45 37 34635 24618 70869154
Steatohepatitis 16.36 12.45 8 34664 811 70892961
Hypophagia 16.26 12.45 51 34621 41519 70852253
Cutaneous leishmaniasis 16.26 12.45 6 34666 302 70893470
Stomatitis 16.20 12.45 113 34559 128398 70765374
Haematocolpos 16.18 12.45 4 34668 49 70893723
Rhabdomyolysis 15.93 12.45 14 34658 95746 70798026
Enterocolitis infectious 15.83 12.45 12 34660 2682 70891090
Lower respiratory tract infection fungal 15.83 12.45 8 34664 870 70892902
Renal failure 15.80 12.45 44 34628 189026 70704746
Anaemia megaloblastic 15.73 12.45 7 34665 573 70893199
Faecal calprotectin abnormal 15.69 12.45 5 34667 161 70893611
Jaundice 15.65 12.45 57 34615 50051 70843721
Gastrointestinal haemorrhage 15.59 12.45 27 34645 137381 70756391
Blood growth hormone decreased 15.50 12.45 4 34668 59 70893713
Malnutrition 15.38 12.45 32 34640 20285 70873487
Paraplegia 15.36 12.45 15 34657 4715 70889057
West Nile viral infection 15.33 12.45 8 34664 931 70892841
Eye opacity 15.26 12.45 3 34669 11 70893761
Viral myelitis 15.25 12.45 4 34668 63 70893709
Intestinal dilatation 15.21 12.45 11 34661 2289 70891483
Urticaria 15.12 12.45 36 34636 163013 70730759
Agitation 15.11 12.45 14 34658 93361 70800411
Blood pressure fluctuation 15.08 12.45 63 34609 58949 70834823
Pericardial cyst 15.05 12.45 3 34669 12 70893760
Autoimmune lymphoproliferative syndrome 15.05 12.45 5 34667 184 70893588
Vocal cord paralysis 15.04 12.45 11 34661 2330 70891442
Oesophageal mass 15.02 12.45 4 34668 67 70893705
Pulmonary mucormycosis 15.01 12.45 8 34664 971 70892801
Placental transfusion syndrome 14.97 12.45 4 34668 68 70893704
Anorectal infection 14.93 12.45 6 34666 381 70893391
Superinfection 14.91 12.45 14 34658 4192 70889580
Haematochezia 14.91 12.45 73 34599 73008 70820764
Blood immunoglobulin G decreased 14.86 12.45 12 34660 2940 70890832
Multiple lentigines syndrome 14.77 12.45 5 34667 195 70893577
Cardiac failure 14.70 12.45 30 34642 143511 70750261
Mucoepidermoid carcinoma 14.65 12.45 4 34668 74 70893698
Listeria sepsis 14.63 12.45 7 34665 677 70893095
Stomatitis necrotising 14.60 12.45 5 34667 202 70893570
Epstein-Barr viraemia 14.59 12.45 10 34662 1913 70891859
Partial seizures 14.57 12.45 19 34653 8186 70885586
Gastrointestinal sounds abnormal 14.51 12.45 15 34657 5046 70888726
Dysplastic naevus syndrome 14.50 12.45 3 34669 15 70893757
Bacteraemia 14.39 12.45 39 34633 29270 70864502
Fistula of small intestine 14.35 12.45 7 34665 706 70893066
Pseudopolyp 14.33 12.45 6 34666 423 70893349
Hepatic enzyme increased 14.29 12.45 35 34637 156955 70736817
Cardiac arrest 14.26 12.45 36 34636 159798 70733974
Acute myocardial infarction 14.26 12.45 9 34663 72878 70820894
Staphylococcal bacteraemia 14.25 12.45 22 34650 11060 70882712
Chills 14.17 12.45 120 34552 144666 70749106
Erythema nodosum 14.16 12.45 14 34658 4467 70889305
Chronic sinusitis 14.13 12.45 19 34653 8432 70885340
Blood cholesterol increased 14.04 12.45 7 34665 64597 70829175
Red blood cell microcytes present 14.04 12.45 3 34669 18 70893754
Mucocutaneous candidiasis 14.04 12.45 4 34668 87 70893685
Functional gastrointestinal disorder 14.03 12.45 14 34658 4517 70889255
Melaena 14.02 12.45 5 34667 56350 70837422
Multiple organ dysfunction syndrome 14.02 12.45 96 34576 108419 70785353
Ocular icterus 13.99 12.45 15 34657 5262 70888510
Cerebrovascular accident 13.85 12.45 31 34641 143439 70750333
Adenovirus infection 13.81 12.45 18 34654 7750 70886022
Leukaemia 13.76 12.45 15 34657 5360 70888412
Lennox-Gastaut syndrome 13.74 12.45 5 34667 242 70893530
Malignant neoplasm progression 13.73 12.45 24 34648 121715 70772057
Therapeutic product effect decreased 13.72 12.45 31 34641 142987 70750785
B precursor type acute leukaemia 13.70 12.45 6 34666 473 70893299
Lymphoma 13.69 12.45 26 34646 15436 70878336
Immunosuppression 13.65 12.45 22 34650 11470 70882302
Mucous stools 13.64 12.45 13 34659 3966 70889806
Pneumococcal bacteraemia 13.63 12.45 4 34668 97 70893675
Epstein Barr virus positive mucocutaneous ulcer 13.62 12.45 7 34665 789 70892983
Eosinophilic pneumonia chronic 13.61 12.45 6 34666 480 70893292
Cardiac disorder 13.59 12.45 6 34666 59409 70834363
Hyperglycaemia 13.48 12.45 65 34607 64607 70829165
Papulopustular rosacea 13.41 12.45 3 34669 23 70893749
Upper respiratory tract infection 13.29 12.45 75 34597 79199 70814573
Pneumonia aspiration 13.17 12.45 7 34665 62282 70831490
Large intestine infection 13.17 12.45 11 34661 2827 70890945
Neurological examination abnormal 13.16 12.45 6 34666 520 70893252
T-cell type acute leukaemia 13.08 12.45 5 34667 278 70893494
Respiratory arrest 13.06 12.45 5 34667 53928 70839844
Gastrointestinal injury 13.03 12.45 7 34665 864 70892908
Pleocytosis 12.96 12.45 8 34664 1281 70892491
Respiratory distress 12.93 12.45 57 34615 54593 70839179
Proctitis 12.92 12.45 12 34660 3546 70890226
Disease recurrence 12.80 12.45 44 34628 37559 70856213
Acute myelomonocytic leukaemia 12.63 12.45 5 34667 305 70893467
Septic shock 12.59 12.45 96 34576 112162 70781610
Anaemia macrocytic 12.53 12.45 14 34658 5141 70888631
Respiratory syncytial virus infection 12.48 12.45 17 34655 7638 70886134

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01BB02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Purine analogues
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:149553 anticoronaviral drug
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
MeSH PA D019384 Nucleic Acid Synthesis Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute lymphoid leukemia indication 91857003 DOID:9952
Acute promyelocytic leukemia, FAB M3 indication 110004001
Psoriasis with arthropathy off-label use 33339001
Crohn's disease off-label use 34000006
Ulcerative colitis off-label use 64766004 DOID:8577
Acute myeloid leukemia, disease off-label use 91861009
Polycythemia vera off-label use 109992005
Hyperbilirubinemia contraindication 14783006 DOID:2741
Obstruction of bile duct contraindication 30144000
Dehydration contraindication 34095006
Gastrointestinal ulcer contraindication 40845000
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Ascites contraindication 389026000
Breastfeeding (mother) contraindication 413712001
Hepatosplenic T-cell lymphoma contraindication 445406001
Chemotherapy-Induced Hyperuricemia contraindication
Thiopurine S-Methyltransferase Deficiency contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.99 acidic
pKa2 10.76 acidic
pKa3 3.37 Basic
pKa4 1.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Amidophosphoribosyltransferase Enzyme INHIBITOR DRUGBANK CHEMBL
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Prostaglandin G/H synthase 1 Enzyme IC50 4.79 DRUG MATRIX
Thiopurine S-methyltransferase Enzyme WOMBAT-PK
Purine nucleoside phosphorylase Enzyme WOMBAT-PK
Purine nucleoside phosphorylase Enzyme Kd 4.10 CHEMBL

External reference:

IDSource
4018776 VUID
N0000147079 NUI
D00161 KEGG_DRUG
6112-76-1 SECONDARY_CAS_RN
4018776 VANDF
C0000618 UMLSCUI
CHEBI:50667 CHEBI
PM6 PDB_CHEM_ID
CHEMBL1425 ChEMBL_ID
CHEMBL1200751 ChEMBL_ID
DB01033 DRUGBANK_ID
D015122 MESH_DESCRIPTOR_UI
667490 PUBCHEM_CID
7226 IUPHAR_LIGAND_ID
E7WED276I5 UNII
103 RXNORM
3886 MMSL
48948 MMSL
5052 MMSL
NOCODE MMSL
d00289 MMSL
002647 NDDF
1039008 SNOMEDCT_US
386835005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 0054-4581 TABLET 50 mg ORAL ANDA 29 sections
Mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3547 TABLET 50 mg ORAL ANDA 29 sections
Mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3547 TABLET 50 mg ORAL ANDA 29 sections
mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 49884-922 TABLET 50 mg ORAL ANDA 24 sections
mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 54868-5282 TABLET 50 mg ORAL ANDA 24 sections
PURINETHOL HUMAN PRESCRIPTION DRUG LABEL 1 60763-601 TABLET 50 mg ORAL NDA 30 sections
PURIXAN HUMAN PRESCRIPTION DRUG LABEL 1 62484-0020 SUSPENSION 20 mg ORAL NDA 19 sections
PURIXAN HUMAN PRESCRIPTION DRUG LABEL 1 62484-0020 SUSPENSION 20 mg ORAL NDA 19 sections
Mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 69076-913 TABLET 50 mg ORAL NDA authorized generic 31 sections