Substructure SMILES Example: n1cnccc1

mercaptopurine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1708	50-44-2

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: mercaptopurine monohydrate 6-mercaptopurine monohydrate 6-mercaptopurine xaluprine mercaptopurine mercapurin purimethol purinethiol purinethol thiohypoxanthine mercaptopurine hydrate

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. Molecular weight: 152.18 Formula: C5H4N4S CLOGP: -1.33 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 53.07 ALOGS: -2.32 ROTB: 0 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	22 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	16.43 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	12 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	1 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	15 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.85 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	1 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Sept. 11, 1953	FDA	STASON PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	767.65	14.06	467	18869	105078	56167653
Febrile bone marrow aplasia	312.28	14.06	108	19228	6464	56266267
Crohn's disease	295.28	14.06	103	19233	6324	56266407
Venoocclusive liver disease	250.78	14.06	83	19253	4338	56268393
Colitis ulcerative	181.88	14.06	110	19226	24281	56248450
Pancytopenia	161.91	14.06	175	19161	88540	56184191
Temporal lobe epilepsy	138.25	14.06	31	19305	355	56272376
Hyperbilirubinaemia	113.83	14.06	60	19276	10175	56262556
Haematotoxicity	107.24	14.06	54	19282	8329	56264402
Neurotoxicity	106.93	14.06	67	19269	15728	56257003
Acute lymphocytic leukaemia recurrent	102.36	14.06	36	19300	2261	56270470
Rhinovirus infection	100.43	14.06	41	19295	3881	56268850
Off label use	96.95	14.06	412	18924	555768	55716963
Pyrexia	94.72	14.06	337	18999	418436	55854295
Haemophagocytic lymphohistiocytosis	92.17	14.06	51	19285	9521	56263210
Hypertriglyceridaemia	91.02	14.06	43	19293	5773	56266958
Abdominal pain	81.92	14.06	234	19102	258571	56014160
Human bocavirus infection	80.94	14.06	20	19316	357	56272374
Pancreatitis	73.65	14.06	84	19252	44996	56227735
Perineal necrosis	66.85	14.06	14	19322	113	56272618
Joint swelling	66.77	14.06	10	19326	289790	55982941
Pain	65.72	14.06	79	19257	663105	55609626
Acute myeloid leukaemia	65.49	14.06	51	19285	16921	56255810
Perineal infection	65.00	14.06	14	19322	131	56272600
Neoplasm recurrence	63.91	14.06	26	19310	2438	56270293
Secondary immunodeficiency	61.30	14.06	21	19315	1219	56271512
Bacterial infection	60.29	14.06	49	19287	17281	56255450
Enterovirus test positive	58.87	14.06	13	19323	138	56272593
Enterobacter infection	57.88	14.06	23	19313	2029	56270702
Gastroenteritis norovirus	56.78	14.06	22	19314	1815	56270916
Leukaemia recurrent	56.08	14.06	20	19316	1308	56271423
Pneumatosis intestinalis	56.00	14.06	23	19313	2210	56270521
Occupational asthma	54.46	14.06	12	19324	126	56272605
Human rhinovirus test positive	51.35	14.06	12	19324	167	56272564
Herpes simplex	51.15	14.06	32	19304	7486	56265245
Alanine aminotransferase increased	50.33	14.06	104	19232	93558	56179173
Abdominal discomfort	49.11	14.06	17	19319	277257	55995474
Hepatocellular injury	47.75	14.06	52	19284	26462	56246269
Colitis	47.57	14.06	65	19271	41746	56230985
Trichodysplasia spinulosa	47.27	14.06	14	19322	505	56272226
Bacillus infection	46.89	14.06	15	19321	702	56272029
Antithrombin III	46.88	14.06	11	19325	156	56272575
Bone marrow failure	46.68	14.06	53	19283	28233	56244498
Fall	46.65	14.06	33	19303	357477	55915254
Mucosal inflammation	46.37	14.06	65	19271	42745	56229986
Human herpesvirus 6 infection	45.59	14.06	21	19315	2661	56270070
Neutropenia	45.15	14.06	138	19198	158029	56114702
Hepatosplenic T-cell lymphoma	44.82	14.06	14	19322	606	56272125
Arthropathy	43.68	14.06	8	19328	200267	56072464
Oesophageal dilatation	43.43	14.06	12	19324	336	56272395
Bacterial vulvovaginitis	42.74	14.06	14	19322	707	56272024
Peripheral swelling	42.23	14.06	14	19322	234712	56038019
Acute lymphocytic leukaemia	42.05	14.06	20	19316	2724	56270007
Partial seizures	41.94	14.06	25	19311	5365	56267366
Second primary malignancy	41.73	14.06	28	19308	7374	56265357
Epstein-Barr virus infection	41.52	14.06	28	19308	7435	56265296
Clostridium difficile colitis	41.38	14.06	41	19295	18697	56254034
Rectal cancer metastatic	41.27	14.06	11	19325	268	56272463
Synovitis	40.96	14.06	4	19332	161301	56111430
Venous thrombosis	40.28	14.06	23	19313	4557	56268174
Hypoglycaemia	39.89	14.06	70	19266	55745	56216986
Perirectal abscess	39.77	14.06	14	19322	881	56271850
Hypertransaminasaemia	39.69	14.06	23	19313	4684	56268047
Myelopathy	39.66	14.06	19	19317	2629	56270102
Anal abscess	39.41	14.06	22	19314	4175	56268556
Hepatotoxicity	39.38	14.06	51	19285	31102	56241629
Hypoalbuminaemia	39.06	14.06	31	19305	10568	56262163
Swelling	38.65	14.06	17	19319	239754	56032977
Female sterilisation	38.34	14.06	12	19324	523	56272208
Device related infection	37.82	14.06	42	19294	21838	56250893
Anal fistula	37.57	14.06	19	19317	2955	56269776
Sepsis	37.12	14.06	119	19217	139721	56133010
Post lumbar puncture syndrome	36.98	14.06	12	19324	588	56272143
Intestinal stenosis	36.76	14.06	18	19318	2613	56270118
Segmental diverticular colitis	36.19	14.06	9	19327	165	56272566
Pedal pulse abnormal	35.79	14.06	9	19327	173	56272558
Strongyloidiasis	35.65	14.06	14	19322	1197	56271534
Death	35.50	14.06	39	19297	341387	55931344
Cholestasis	35.50	14.06	45	19291	26868	56245863
Venoocclusive disease	35.24	14.06	16	19320	1961	56270770
Completed suicide	34.83	14.06	3	19333	133830	56138901
Bile acid malabsorption	34.64	14.06	9	19327	198	56272533
Enteritis	34.57	14.06	25	19311	7418	56265313
Cerebral venous sinus thrombosis	33.63	14.06	15	19321	1763	56270968
Blood culture positive	33.40	14.06	20	19316	4326	56268405
Mucormycosis	32.95	14.06	17	19319	2757	56269974
Fistula	32.84	14.06	26	19310	8829	56263902
Central obesity	32.81	14.06	13	19323	1138	56271593
Ileal stenosis	32.35	14.06	14	19322	1531	56271200
Fatigue	32.01	14.06	151	19185	788401	55484330
Leukopenia	31.53	14.06	73	19263	70867	56201864
Pseudomonas test positive	31.52	14.06	11	19325	675	56272056
Wound	31.45	14.06	5	19331	138799	56133932
Intestinal resection	31.36	14.06	16	19320	2534	56270197
Calcium ionised decreased	31.22	14.06	9	19327	295	56272436
Myelodysplastic syndrome	30.98	14.06	33	19303	16373	56256358
Glioma	30.65	14.06	9	19327	315	56272416
Staphylococcal sepsis	30.35	14.06	23	19313	7326	56265405
Insomnia	30.29	14.06	14	19322	191846	56080885
Discomfort	30.18	14.06	6	19330	141755	56130976
Subacute combined cord degeneration	29.02	14.06	8	19328	222	56272509
Feeding intolerance	29.00	14.06	10	19326	592	56272139
Lymphoproliferative disorder	28.78	14.06	16	19320	3012	56269719
Lower respiratory tract infection	28.74	14.06	3	19333	114791	56157940
Pancreatitis acute	28.48	14.06	39	19297	25085	56247646
Cytomegalovirus infection	28.24	14.06	34	19302	19262	56253469
Asthma	28.09	14.06	3	19333	112767	56159964
Vital capacity decreased	28.05	14.06	12	19324	1276	56271455
Dyspnoea	27.98	14.06	107	19229	592470	55680261
Neutrophil count decreased	27.54	14.06	56	19280	49766	56222965
Superior sagittal sinus thrombosis	27.15	14.06	10	19326	717	56272014
Histoplasmosis	26.99	14.06	13	19323	1821	56270910
Porphyria non-acute	26.95	14.06	8	19328	291	56272440
Leukoencephalopathy	26.83	14.06	17	19319	4065	56268666
Epstein-Barr virus associated lymphoma	26.54	14.06	9	19327	506	56272225
Abdominal adhesions	26.54	14.06	15	19321	2914	56269817
Acute lymphocytic leukaemia refractory	26.20	14.06	6	19330	76	56272655
Jaundice	25.99	14.06	39	19297	27255	56245476
Painful respiration	25.87	14.06	14	19322	2500	56270231
Blood bilirubin increased	25.36	14.06	43	19293	33311	56239420
Cardiotoxicity	25.28	14.06	21	19315	7629	56265102
Musculoskeletal stiffness	25.22	14.06	11	19325	155996	56116735
Drug interaction	25.17	14.06	140	19196	209615	56063116
Enterovirus infection	24.89	14.06	10	19326	908	56271823
Chloroma	24.68	14.06	7	19329	216	56272515
Clostridium difficile infection	24.68	14.06	38	19298	27160	56245571
Large intestinal stenosis	24.43	14.06	12	19324	1754	56270977
Systemic lupus erythematosus	24.28	14.06	16	19320	180062	56092669
Metastases to pancreas	24.15	14.06	7	19329	234	56272497
Encopresis	24.03	14.06	6	19330	112	56272619
Lung opacity	23.99	14.06	13	19323	2328	56270403
Haemolytic uraemic syndrome	23.64	14.06	13	19323	2395	56270336
Aborted pregnancy	23.39	14.06	5	19331	45	56272686
Influenza B virus test positive	23.31	14.06	7	19329	265	56272466
Inflammatory bowel disease	23.05	14.06	15	19321	3753	56268978
Cytogenetic abnormality	22.95	14.06	8	19328	489	56272242
Lipase increased	22.38	14.06	21	19315	8958	56263773
Breakthrough pain	22.34	14.06	10	19326	1186	56271545
Aplasia	22.25	14.06	15	19321	3981	56268750
Stress urinary incontinence	22.16	14.06	12	19324	2146	56270585
Pseudomonal sepsis	22.01	14.06	12	19324	2174	56270557
Coagulopathy	21.13	14.06	29	19307	18687	56254044
Seizure	21.06	14.06	92	19244	125027	56147704
Anaemia megaloblastic	21.02	14.06	7	19329	372	56272359
Gamma-glutamyltransferase increased	21.01	14.06	38	19298	30967	56241764
West Nile viral infection	20.99	14.06	7	19329	374	56272357
Drug specific antibody present	20.96	14.06	14	19322	3658	56269073
Haematochezia	20.54	14.06	46	19290	43672	56229059
Vocal cord paralysis	20.53	14.06	11	19325	1926	56270805
Gastrointestinal sounds abnormal	20.51	14.06	14	19322	3791	56268940
Overgrowth fungal	20.09	14.06	5	19331	92	56272639
Appendicitis	19.93	14.06	18	19318	7314	56265417
Respiratory tract haemorrhage	19.91	14.06	7	19329	439	56272292
Blood pressure abnormal	19.87	14.06	24	19312	13636	56259095
Bone marrow disorder	19.82	14.06	11	19325	2063	56270668
Cushingoid	19.82	14.06	18	19318	7366	56265365
Rectal abscess	19.81	14.06	9	19327	1105	56271626
Escherichia infection	19.43	14.06	22	19314	11677	56261054
Glossitis	19.37	14.06	12	19324	2758	56269973
Confusional state	19.25	14.06	26	19310	208129	56064602
Meningitis coccidioides	19.13	14.06	4	19332	32	56272699
Viral infection	18.96	14.06	37	19299	31909	56240822
Hyperglycaemia	18.80	14.06	41	19295	38240	56234491
Transverse sinus thrombosis	18.79	14.06	7	19329	518	56272213
Pericarditis	18.71	14.06	7	19329	108916	56163815
Staphylococcal bacteraemia	18.69	14.06	15	19321	5194	56267537
Precursor T-lymphoblastic lymphoma/leukaemia	18.52	14.06	4	19332	38	56272693
Herpes zoster meningoencephalitis	18.34	14.06	6	19330	302	56272429
Histoplasmosis disseminated	18.27	14.06	9	19327	1323	56271408
Rhinocerebral mucormycosis	18.26	14.06	6	19330	306	56272425
Myelosuppression	18.15	14.06	26	19310	17429	56255302
Mucoepidermoid carcinoma	18.07	14.06	4	19332	43	56272688
Proctalgia	17.95	14.06	15	19321	5494	56267237
Contusion	17.87	14.06	11	19325	128419	56144312
Feeling abnormal	17.83	14.06	12	19324	133590	56139141
Pericardial cyst	17.64	14.06	3	19333	6	56272725
Pyoderma gangrenosum	17.55	14.06	12	19324	3258	56269473
Atypical haemolytic uraemic syndrome	17.51	14.06	7	19329	627	56272104
Small intestinal obstruction	17.40	14.06	25	19311	16800	56255931
Oesophageal mass	17.37	14.06	4	19332	52	56272679
Listeria sepsis	17.32	14.06	7	19329	645	56272086
Haematocolpos	17.16	14.06	4	19332	55	56272676
Atrial fibrillation	17.09	14.06	8	19328	108889	56163842
Thrombocytopenia	17.04	14.06	92	19244	136132	56136599
Acute myelomonocytic leukaemia	16.81	14.06	5	19331	183	56272548
T-cell lymphoma	16.79	14.06	7	19329	698	56272033
Lupus-like syndrome	16.73	14.06	21	19315	12406	56260325
Hemiparesis	16.72	14.06	28	19308	21462	56251269
Ocular icterus	16.64	14.06	12	19324	3544	56269187
Drug level decreased	16.61	14.06	16	19320	7048	56265683
Somnolence	16.59	14.06	19	19317	163394	56109337
Vulval disorder	16.56	14.06	7	19329	723	56272008
Cerebral ischaemia	16.52	14.06	15	19321	6135	56266596
Frequent bowel movements	16.40	14.06	24	19312	16400	56256331
Intracardiac thrombus	16.28	14.06	10	19326	2265	56270466
T-cell type acute leukaemia	16.15	14.06	4	19332	72	56272659
Toe walking	16.11	14.06	3	19333	12	56272719
Psoriatic arthropathy	16.02	14.06	3	19333	74005	56198726
Quadriplegia	16.02	14.06	9	19327	1729	56271002
Functional gastrointestinal disorder	15.91	14.06	12	19324	3795	56268936
Osteoarthritis	15.87	14.06	4	19332	80292	56192439
Anal fissure	15.84	14.06	12	19324	3819	56268912
Dizziness	15.78	14.06	71	19265	376069	55896662
Pneumocystis jirovecii pneumonia	15.76	14.06	23	19313	15678	56257053
Rash	15.76	14.06	102	19234	492945	55779786
Glioblastoma multiforme	15.75	14.06	7	19329	816	56271915
Hippocampal sclerosis	15.71	14.06	4	19332	81	56272650
Hepatosplenomegaly	15.66	14.06	10	19326	2423	56270308
Depersonalisation/derealisation disorder	15.66	14.06	8	19328	1271	56271460
Pericardial effusion	15.56	14.06	31	19305	27144	56245587
Gambling	15.55	14.06	5	19331	238	56272493
Intestinal operation	15.51	14.06	6	19330	493	56272238
Bronchitis chronic	15.42	14.06	12	19324	3976	56268755
Amylase increased	15.35	14.06	14	19322	5757	56266974
Histiocytic sarcoma	15.31	14.06	4	19332	90	56272641
Pneumonia fungal	15.28	14.06	13	19323	4880	56267851
Potentiating drug interaction	15.21	14.06	12	19324	4054	56268677
Malaise	15.10	14.06	70	19266	367790	55904941
Campylobacter infection	15.03	14.06	7	19329	909	56271822
Pseudopolyp	15.01	14.06	5	19331	266	56272465
Anogenital dysplasia	14.96	14.06	3	19333	19	56272712
Listeriosis	14.92	14.06	8	19328	1402	56271329
Diarrhoea haemorrhagic	14.87	14.06	16	19320	8027	56264704
Furuncle	14.77	14.06	14	19322	6045	56266686
Cerebral haemangioma	14.72	14.06	4	19332	105	56272626
Lymphoma	14.65	14.06	18	19318	10410	56262321
Lennox-Gastaut syndrome	14.65	14.06	5	19331	287	56272444
Inappropriate schedule of product administration	14.55	14.06	62	19274	83325	56189406
Extraskeletal ossification	14.51	14.06	4	19332	111	56272620
Papulopustular rosacea	14.46	14.06	3	19333	23	56272708
Pruritus	14.36	14.06	58	19278	316565	55956166
Choriomeningitis lymphocytic	14.24	14.06	3	19333	25	56272706
Vomiting	14.18	14.06	245	19091	497983	55774748
Blood immunoglobulin G decreased	14.11	14.06	9	19327	2177	56270554
Aspergillus infection	14.06	14.06	15	19321	7450	56265281

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	861.13	14.83	672	19648	121177	31555847
Hepatosplenic T-cell lymphoma	251.42	14.83	60	20260	465	31676559
Venoocclusive liver disease	212.70	14.83	101	20219	7311	31669713
Febrile bone marrow aplasia	201.24	14.83	99	20221	7747	31669277
Haematotoxicity	197.93	14.83	95	20225	7042	31669982
Crohn's disease	162.15	14.83	70	20250	4051	31672973
Hypertriglyceridaemia	155.35	14.83	83	20237	7715	31669309
Death	138.86	14.83	31	20289	360538	31316486
Acute lymphocytic leukaemia recurrent	125.21	14.83	54	20266	3116	31673908
Pancytopenia	122.90	14.83	209	20111	87107	31589917
Colitis ulcerative	110.42	14.83	93	20227	18436	31658588
Bone marrow failure	103.94	14.83	108	20212	27900	31649124
Multiple-drug resistance	95.78	14.83	50	20270	4430	31672594
Pyrexia	95.67	14.83	416	19904	303424	31373600
Cytomegalovirus chorioretinitis	93.11	14.83	45	20275	3383	31673641
Haemophagocytic lymphohistiocytosis	91.83	14.83	69	20251	11609	31665415
Colitis	87.11	14.83	108	20212	33779	31643245
Abdominal pain	86.92	14.83	247	20073	145705	31531319
Pancreatitis	82.47	14.83	108	20212	35663	31641361
Osteonecrosis	81.30	14.83	69	20251	13815	31663209
Neutropenia	80.13	14.83	234	20086	140130	31536894
Leukoencephalopathy	76.20	14.83	41	20279	3861	31673163
Hepatotoxicity	75.01	14.83	76	20244	19050	31657974
Mucosal inflammation	70.31	14.83	98	20222	34329	31642695
Lentigo	63.98	14.83	19	20301	362	31676662
Nodular regenerative hyperplasia	61.10	14.83	23	20297	929	31676095
Enterovirus infection	59.08	14.83	21	20299	719	31676305
Myelosuppression	57.97	14.83	59	20261	14861	31662163
Glioma	56.14	14.83	17	20303	347	31676677
Frequent bowel movements	54.43	14.83	48	20272	10111	31666913
Off label use	53.12	14.83	392	19928	346882	31330142
Acute myeloid leukaemia	50.37	14.83	61	20259	18611	31658413
Epstein-Barr virus associated lymphoproliferative disorder	49.93	14.83	24	20296	1782	31675242
Myocardial infarction	47.18	14.83	8	20312	113446	31563578
Drug clearance decreased	46.26	14.83	22	20298	1595	31675429
Histoplasmosis disseminated	46.23	14.83	20	20300	1162	31675862
Epstein-Barr virus infection	45.79	14.83	37	20283	6916	31670108
Gallbladder oedema	44.73	14.83	13	20307	229	31676795
Venoocclusive disease	43.74	14.83	25	20295	2647	31674377
Glioblastoma multiforme	43.62	14.83	17	20303	755	31676269
Portal hypertension	43.33	14.83	28	20292	3697	31673327
Gastrointestinal wall thickening	42.96	14.83	20	20300	1382	31675642
Cytogenetic abnormality	42.55	14.83	17	20303	807	31676217
Atrial fibrillation	41.23	14.83	11	20309	113772	31563252
Myelodysplastic syndrome	41.08	14.83	56	20264	19195	31657829
Fall	40.34	14.83	36	20284	186053	31490971
Hyperbilirubinaemia	40.13	14.83	50	20270	15700	31661324
Dyspnoea	40.05	14.83	102	20218	343377	31333647
Intestinal stenosis	39.38	14.83	21	20299	1942	31675082
Second primary malignancy	39.23	14.83	34	20286	6998	31670026
B-cell lymphoma	38.85	14.83	28	20292	4417	31672607
Rhinovirus infection	37.49	14.83	25	20295	3480	31673544
Dizziness	36.97	14.83	44	20276	199103	31477921
Cardiac failure congestive	36.77	14.83	4	20316	79383	31597641
Haematopoietic neoplasm	35.29	14.83	8	20312	48	31676976
Sepsis	33.90	14.83	189	20131	151740	31525284
Candida endophthalmitis	33.50	14.83	9	20311	117	31676907
Ileal stenosis	32.63	14.83	16	20304	1241	31675783
Cytomegalovirus infection	31.87	14.83	57	20263	24650	31652374
Acute monocytic leukaemia	31.62	14.83	11	20309	353	31676671
Leukopenia	31.55	14.83	95	20225	57733	31619291
Diffuse large B-cell lymphoma	31.45	14.83	33	20287	8608	31668416
Hepatocellular injury	30.79	14.83	52	20268	21492	31655532
Anal inflammation	30.77	14.83	11	20309	383	31676641
Fistula	30.58	14.83	27	20293	5694	31671330
Pancreatitis acute	30.42	14.83	57	20263	25543	31651481
Vomiting	30.30	14.83	246	20074	223727	31453297
Parainfluenzae virus infection	29.95	14.83	19	20301	2430	31674594
Intracranial pressure increased	29.84	14.83	22	20298	3593	31673431
Alanine aminotransferase increased	29.50	14.83	110	20210	74546	31602478
Neutrophil count decreased	28.96	14.83	80	20240	46314	31630710
Thrombocytopenia	28.85	14.83	173	20147	142574	31534450
Xanthogranuloma	28.30	14.83	7	20313	64	31676960
Stomatitis	27.65	14.83	71	20249	39367	31637657
Myelopathy	26.42	14.83	17	20303	2228	31674796
Bacterial infection	26.38	14.83	38	20282	13701	31663323
Leukaemia recurrent	26.25	14.83	15	20305	1587	31675437
Proctitis	26.06	14.83	17	20303	2280	31674744
Depression	25.78	14.83	13	20307	90802	31586222
Human rhinovirus test positive	25.64	14.83	8	20312	181	31676843
Lymphopenia	23.76	14.83	37	20283	14292	31662732
Neurotoxicity	22.96	14.83	39	20281	16187	31660837
Cytomegalovirus hepatitis	22.86	14.83	9	20311	411	31676613
Superior sagittal sinus thrombosis	22.67	14.83	8	20312	268	31676756
Anal fistula	22.48	14.83	21	20299	4762	31672262
Abscess limb	22.48	14.83	18	20302	3321	31673703
Neoplasm recurrence	22.42	14.83	15	20305	2099	31674925
Adrenocortical carcinoma	22.20	14.83	5	20315	29	31676995
Product dose omission issue	22.16	14.83	21	20299	105565	31571459
Blood fibrinogen decreased	22.10	14.83	12	20308	1150	31675874
Peripheral swelling	21.99	14.83	8	20312	67857	31609167
Fungal infection	21.96	14.83	36	20284	14515	31662509
Cytopenia	21.95	14.83	31	20289	10979	31666045
Multiple lentigines syndrome	21.92	14.83	5	20315	31	31676993
Cytomegalovirus colitis	21.87	14.83	16	20304	2582	31674442
Steatohepatitis	21.69	14.83	8	20312	305	31676719
Staphylococcal sepsis	21.68	14.83	28	20292	9109	31667915
Proctalgia	21.38	14.83	20	20300	4542	31672482
Small intestinal obstruction	21.25	14.83	34	20286	13438	31663586
Anal abscess	20.84	14.83	22	20298	5778	31671246
Cardiac arrest	20.78	14.83	16	20304	89046	31587978
Otitis media acute	20.74	14.83	9	20311	527	31676497
Completed suicide	20.65	14.83	17	20303	91497	31585527
Minimal residual disease	20.51	14.83	8	20312	356	31676668
Dysplastic naevus syndrome	20.41	14.83	4	20316	10	31677014
Malignant neoplasm progression	20	14.83	13	20307	78985	31598039
Mucormycosis	19.79	14.83	21	20299	5549	31671475
Rhabdomyolysis	19.76	14.83	8	20312	63573	31613451
Thymus enlargement	19.72	14.83	5	20315	51	31676973
Coronary artery disease	19.70	14.83	3	20317	46084	31630940
Intestinal diaphragm disease	19.63	14.83	7	20313	242	31676782
Trichodysplasia spinulosa	19.49	14.83	7	20313	247	31676777
Chest pain	19.45	14.83	28	20292	116929	31560095
Transaminases increased	19.36	14.83	46	20274	24295	31652729
Metapneumovirus infection	19.19	14.83	9	20311	632	31676392
Chronic obstructive pulmonary disease	19.17	14.83	3	20317	45163	31631861
Small intestinal stenosis	18.96	14.83	8	20312	437	31676587
Asthenia	18.95	14.83	77	20243	224678	31452346
Bifidobacterium infection	18.61	14.83	4	20316	18	31677006
Rheumatoid arthritis	18.52	14.83	4	20316	47805	31629219
Confusional state	18.41	14.83	36	20284	133298	31543726
T-cell lymphoma	18.23	14.83	10	20310	978	31676046
Hepatic steatosis	17.87	14.83	35	20285	16204	31660820
Disease progression	17.83	14.83	19	20301	90445	31586579
Syncope	17.80	14.83	17	20303	85165	31591859
Human metapneumovirus test positive	17.77	14.83	5	20315	78	31676946
Vascular access complication	17.67	14.83	7	20313	325	31676699
Meningitis enterococcal	17.48	14.83	5	20315	83	31676941
Pneumocystis jirovecii pneumonia	17.32	14.83	37	20283	18214	31658810
Renal failure	17.28	14.83	33	20287	123297	31553727
Acral lentiginous melanoma	17.24	14.83	4	20316	27	31676997
Viral myelitis	16.99	14.83	4	20316	29	31676995
Gastrointestinal injury	16.79	14.83	7	20313	371	31676653
Cutaneous leishmaniasis	16.70	14.83	6	20314	212	31676812
Disseminated cytomegaloviral infection	16.70	14.83	6	20314	212	31676812
Hip deformity	16.56	14.83	5	20315	101	31676923
Rectal haemorrhage	16.47	14.83	56	20264	36248	31640776
Anorectal cellulitis	16.13	14.83	4	20316	37	31676987
Cardiac failure	15.90	14.83	19	20301	85934	31591090
Epstein-Barr virus associated lymphoma	15.79	14.83	8	20312	665	31676359
Pulmonary mucormycosis	15.63	14.83	8	20312	680	31676344
Meningoradiculitis	15.59	14.83	4	20316	43	31676981
Colon dysplasia	15.52	14.83	5	20315	126	31676898
Somnolence	15.39	14.83	25	20295	99420	31577604
Aspergillus infection	15.38	14.83	27	20293	11501	31665523
Central nervous system leukaemia	15.32	14.83	6	20314	270	31676754
Cheilitis	15.26	14.83	12	20308	2156	31674868
Escherichia infection	15.20	14.83	21	20299	7283	31669741
Tonsil cancer	15.15	14.83	9	20311	1024	31676000
Haemorrhagic diathesis	15.12	14.83	13	20307	2647	31674377
Herpes zoster	15.09	14.83	50	20270	31943	31645081
Large intestine infection	14.90	14.83	10	20310	1406	31675618

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	1549.98	12.45	1057	33615	203261	70690511
Haematotoxicity	311.21	12.45	146	34526	13528	70880244
Secondary immunodeficiency	281.29	12.45	89	34583	2800	70890972
Pancytopenia	274.16	12.45	353	34319	150754	70743018
Febrile bone marrow aplasia	257.44	12.45	123	34549	11868	70881904
Bacterial infection	235.57	12.45	152	34520	26340	70867432
Hepatosplenic T-cell lymphoma	222.02	12.45	58	34614	900	70892872
Hypertriglyceridaemia	196.82	12.45	102	34570	11709	70882063
Colitis ulcerative	194.98	12.45	149	34523	33774	70859998
Haemophagocytic lymphohistiocytosis	185.46	12.45	117	34555	19495	70874277
Acute lymphocytic leukaemia recurrent	182.27	12.45	74	34598	4830	70888942
Cytomegalovirus chorioretinitis	180.11	12.45	75	34597	5223	70888549
Parainfluenzae virus infection	159.62	12.45	68	34604	5012	70888760
Rhinovirus infection	156.60	12.45	73	34599	6660	70887112
Mycobacterium chelonae infection	154.79	12.45	54	34618	2310	70891462
Pyrexia	153.55	12.45	644	34028	606308	70287464
Bone marrow failure	145.68	12.45	148	34524	48862	70844910
Pancreatitis	145.42	12.45	166	34506	62502	70831270
Off label use	138.42	12.45	721	33951	742339	70151433
Myelodysplastic syndrome transformation	129.21	12.45	35	34637	628	70893144
Rheumatoid arthritis	128.34	12.45	3	34669	291802	70601970
Pseudomonal sepsis	125.58	12.45	59	34613	5478	70888294
Mucosal inflammation	112.76	12.45	152	34520	67698	70826074
Neutropenia	111.91	12.45	327	34345	256829	70636943
Human bocavirus infection	108.84	12.45	30	34642	576	70893196
Second primary malignancy	106.52	12.45	71	34601	12980	70880792
Acute myeloid leukaemia	106.01	12.45	101	34571	30839	70862933
Osteonecrosis	105.29	12.45	98	34574	29062	70864710
Abdominal pain	103.11	12.45	384	34288	341743	70552029
Human herpesvirus 6 infection	101.72	12.45	49	34623	4810	70888962
Multiple-drug resistance	101.40	12.45	56	34616	7299	70886473
Hepatotoxicity	101.14	12.45	116	34556	43870	70849902
Clostridium difficile colitis	100.00	12.45	95	34577	28901	70864871
Neurotoxicity	97.73	12.45	95	34577	29731	70864041
Hyperbilirubinaemia	97.63	12.45	84	34588	22484	70871288
Leukoencephalopathy	90.96	12.45	52	34620	7242	70886530
Glioma	90.82	12.45	26	34646	576	70893196
Fall	89.75	12.45	53	34619	444043	70449729
Viral infection	89.54	12.45	102	34570	38289	70855483
Enterovirus infection	82.56	12.45	31	34641	1640	70892132
Crohn's disease	82.54	12.45	35	34637	2549	70891223
Thymus hypoplasia	80.52	12.45	24	34648	615	70893157
Neoplasm recurrence	77.26	12.45	38	34634	3903	70889869
Temporal lobe epilepsy	77.25	12.45	21	34651	382	70893390
Dyspnoea	76.82	12.45	164	34508	769896	70123876
Epstein-Barr virus infection	75.87	12.45	58	34614	13140	70880632
Venoocclusive disease	74.97	12.45	38	34634	4162	70889610
Myelodysplastic syndrome	74.36	12.45	82	34590	29703	70864069
Colitis	74.33	12.45	121	34551	63693	70830079
Cytogenetic abnormality	72.44	12.45	25	34647	1035	70892737
Myelopathy	71.64	12.45	37	34635	4214	70889558
Leukaemia recurrent	70.52	12.45	32	34640	2743	70891029
Myelosuppression	70.14	12.45	80	34592	30065	70863707
Lymphoid tissue hypoplasia	69.13	12.45	21	34651	575	70893197
Joint swelling	67.48	12.45	20	34652	253191	70640581
Abscess bacterial	67.22	12.45	22	34650	772	70893000
Aspergillus infection	66.33	12.45	61	34611	17807	70875965
Human rhinovirus test positive	66.15	12.45	19	34653	426	70893346
Death	64.97	12.45	93	34579	509968	70383804
Trichodysplasia spinulosa	64.63	12.45	21	34651	720	70893052
Lentigo	64.61	12.45	19	34653	464	70893308
Enterobacter infection	64.59	12.45	34	34638	4026	70889746
Nodular regenerative hyperplasia	63.92	12.45	24	34648	1269	70892503
Glioblastoma multiforme	63.91	12.45	24	34648	1270	70892502
Peripheral swelling	62.46	12.45	19	34653	236544	70657228
Perineal necrosis	61.28	12.45	14	34658	119	70893653
Sepsis	61.07	12.45	259	34413	244286	70649486
Fungal infection	60.80	12.45	83	34589	37384	70856388
Pneumatosis intestinalis	60.39	12.45	37	34635	5850	70887922
Enteritis	60.10	12.45	50	34622	12781	70880991
Cytomegalovirus infection	59.92	12.45	85	34587	39673	70854099
Leukopenia	59.82	12.45	149	34523	106411	70787361
Norovirus test positive	59.74	12.45	18	34654	479	70893293
Histoplasmosis disseminated	59.45	12.45	26	34646	2042	70891730
Viraemia	57.89	12.45	27	34645	2465	70891307
Pain	57.69	12.45	140	34532	628676	70265096
Completed suicide	56.87	12.45	20	34652	227115	70666657
Epstein-Barr virus associated lymphoproliferative disorder	56.50	12.45	29	34643	3260	70890512
Enterovirus test positive	55.97	12.45	15	34657	258	70893514
Pancreatitis acute	55.74	12.45	88	34584	45136	70848636
Cystitis bacterial	55.30	12.45	17	34655	485	70893287
Alanine aminotransferase increased	55.14	12.45	178	34494	147302	70746470
Contraindicated product administered	53.60	12.45	3	34669	134609	70759163
Intestinal stenosis	53.01	12.45	28	34644	3339	70890433
Neutrophil count decreased	50.26	12.45	120	34552	83436	70810336
Atrial fibrillation	50.13	12.45	14	34658	184334	70709438
Cytomegalovirus viraemia	49.53	12.45	43	34629	11642	70882130
Coronavirus infection	48.59	12.45	33	34639	6219	70887553
Dizziness	48.57	12.45	96	34576	464045	70429727
Thrombocytopenia	48.34	12.45	238	34434	238872	70654900
Hepatocellular injury	47.81	12.45	83	34589	46008	70847764
Drug clearance decreased	47.27	12.45	25	34647	2988	70890784
Bronchopulmonary aspergillosis	45.94	12.45	54	34618	20948	70872824
Frequent bowel movements	45.63	12.45	54	34618	21099	70872673
Mucormycosis	45.58	12.45	35	34637	7979	70885793
Diffuse large B-cell lymphoma	44.75	12.45	43	34629	13259	70880513
Fistula	44.03	12.45	39	34633	10842	70882930
Molluscum contagiosum	43.62	12.45	14	34658	461	70893311
Cell-mediated immune deficiency	42.68	12.45	10	34662	96	70893676
Venoocclusive liver disease	42.67	12.45	38	34634	10640	70883132
Feeding intolerance	42.61	12.45	15	34657	659	70893113
Intestinal resection	42.22	12.45	24	34648	3306	70890466
Diffuse alveolar damage	41.99	12.45	24	34648	3339	70890433
Swelling	41.68	12.45	20	34652	188519	70705253
Intracranial pressure increased	41.56	12.45	32	34640	7324	70886448
Anal inflammation	41.29	12.45	14	34658	549	70893223
Superior sagittal sinus thrombosis	40.24	12.45	16	34656	988	70892784
Acute lymphocytic leukaemia	40.10	12.45	28	34644	5517	70888255
Subacute combined cord degeneration	39.56	12.45	12	34660	327	70893445
Oesophageal candidiasis	39.53	12.45	33	34639	8474	70885298
B-cell lymphoma	39.25	12.45	29	34643	6240	70887532
Epstein-Barr virus associated lymphoma	39.06	12.45	16	34656	1068	70892704
Intracardiac thrombus	38.55	12.45	24	34648	3903	70889869
Encephalitis	38.48	12.45	40	34632	13545	70880227
Hypertransaminasaemia	38.09	12.45	33	34639	8910	70884862
Cerebral venous sinus thrombosis	38.08	12.45	19	34653	2012	70891760
Arthropathy	37.91	12.45	13	34659	150044	70743728
Lower respiratory tract infection	37.78	12.45	5	34667	111908	70781864
Device related infection	37.42	12.45	61	34611	32124	70861648
Perineal infection	37.31	12.45	14	34658	739	70893033
Asthma	37.16	12.45	7	34665	120786	70772986
Synovitis	36.68	12.45	9	34663	129219	70764553
Anal abscess	35.92	12.45	31	34641	8327	70885445
Anal fistula	35.68	12.45	27	34645	6023	70887749
Cardiac failure congestive	35.51	12.45	11	34661	135446	70758326
Gastroenteritis norovirus	34.62	12.45	20	34652	2839	70890933
Bile acid malabsorption	34.49	12.45	10	34662	232	70893540
Acute monocytic leukaemia	34.47	12.45	12	34660	510	70893262
Fatigue	34.44	12.45	249	34423	824070	70069702
Ileal stenosis	34.18	12.45	18	34654	2133	70891639
Confusional state	34.06	12.45	54	34618	284344	70609428
Bacterial vulvovaginitis	34.03	12.45	12	34660	530	70893242
Pruritus	33.97	12.45	74	34598	345486	70548286
Proctalgia	33.83	12.45	30	34642	8353	70885419
Seizure	33.72	12.45	174	34498	177788	70715984
Pneumocystis jirovecii pneumonia	33.61	12.45	56	34616	30026	70863746
Bacillus infection	33.45	12.45	14	34658	987	70892785
Perirectal abscess	33.44	12.45	17	34655	1873	70891899
Haematopoietic neoplasm	33.32	12.45	8	34664	86	70893686
Hyperkalaemia	33.17	12.45	6	34666	106585	70787187
Segmental diverticular colitis	33.04	12.45	9	34663	165	70893607
Lipase increased	33.01	12.45	39	34633	15207	70878565
Candida endophthalmitis	32.69	12.45	9	34663	172	70893600
Discomfort	32.67	12.45	6	34666	105430	70788342
Cholestasis	32.35	12.45	72	34600	47800	70845972
Strongyloidiasis	32.19	12.45	21	34651	3702	70890070
Cytomegalovirus colitis	32.11	12.45	22	34650	4204	70889568
Pedal pulse abnormal	32.07	12.45	9	34663	185	70893587
Depression	32.04	12.45	30	34642	198944	70694828
Hypoalbuminaemia	31.99	12.45	43	34629	19079	70874693
Muscle spasms	31.59	12.45	18	34654	154028	70739744
Abdominal discomfort	31.57	12.45	35	34637	214623	70679149
Histoplasmosis	31.55	12.45	17	34655	2110	70891662
Blood fibrinogen decreased	31.43	12.45	16	34656	1768	70892004
Lymphopenia	30.66	12.45	51	34621	27308	70866464
Rectal cancer metastatic	30.47	12.45	11	34661	520	70893252
Haemolytic uraemic syndrome	30.21	12.45	21	34651	4109	70889663
Portal hypertension	29.78	12.45	25	34647	6467	70887305
Blood bilirubin increased	29.72	12.45	80	34592	59821	70833951
Pneumonia fungal	29.45	12.45	30	34642	9923	70883849
Insomnia	29.39	12.45	38	34634	217768	70676004
Blood culture positive	29.30	12.45	27	34645	7899	70885873
Escherichia infection	29.29	12.45	38	34634	16293	70877479
Disseminated aspergillosis	29.12	12.45	12	34660	813	70892959
Pseudomonas test positive	29.10	12.45	15	34657	1701	70892071
Atypical haemolytic uraemic syndrome	28.94	12.45	12	34660	826	70892946
Xanthogranuloma	28.85	12.45	7	34665	79	70893693
Cardiotoxicity	28.53	12.45	31	34641	11039	70882733
Vomiting	28.51	12.45	427	34245	592684	70301088
Intentional overdose	27.65	12.45	7	34665	98428	70795344
Abdominal adhesions	27.54	12.45	18	34654	3182	70890590
Cytopenia	27.53	12.45	38	34634	17285	70876487
Aplasia	27.39	12.45	25	34647	7226	70886546
Product dose omission issue	27.27	12.45	40	34632	217428	70676344
Malaise	27.24	12.45	114	34558	432818	70460954
Coagulopathy	27.11	12.45	54	34618	33195	70860577
Cytomegalovirus hepatitis	26.95	12.45	11	34661	727	70893045
Glossodynia	26.62	12.45	5	34667	86482	70807290
Chloroma	26.52	12.45	11	34661	758	70893014
Cerebral haemangioma	25.72	12.45	7	34665	128	70893644
Cellulitis	25.59	12.45	106	34566	98822	70794950
Syncope	25.50	12.45	26	34646	165683	70728089
Systemic lupus erythematosus	25.44	12.45	9	34663	101893	70791879
Hippocampal sclerosis	25.27	12.45	7	34665	137	70893635
Metapneumovirus infection	24.95	12.45	13	34659	1507	70892265
Oedema peripheral	24.83	12.45	46	34626	228045	70665727
Somnolence	24.81	12.45	42	34630	215564	70678208
Bifidobacterium infection	24.70	12.45	5	34667	22	70893750
Feeling abnormal	24.67	12.45	20	34652	142299	70751473
Hepatosplenomegaly	24.30	12.45	21	34651	5649	70888123
Cushingoid	24.30	12.45	25	34647	8363	70885409
Acute lymphocytic leukaemia refractory	24.28	12.45	7	34665	159	70893613
Abscess limb	23.77	12.45	22	34650	6471	70887301
Staphylococcal sepsis	23.70	12.45	31	34641	13396	70880376
Suicide attempt	23.63	12.45	5	34667	79505	70814267
Antithrombin III	23.34	12.45	6	34666	87	70893685
Neuropathy peripheral	23.29	12.45	123	34549	126773	70766999
Asthenia	23.28	12.45	130	34542	457536	70436236
Anorectal cellulitis	23.03	12.45	6	34666	92	70893680
Transaminases increased	22.53	12.45	62	34610	46956	70846816
Calcium ionised decreased	22.42	12.45	9	34663	570	70893202
Hemiparesis	22.02	12.45	48	34624	31421	70862351
Aborted pregnancy	21.63	12.45	5	34667	45	70893727
Otitis media acute	21.58	12.45	11	34661	1218	70892554
Central obesity	21.53	12.45	12	34660	1591	70892181
Hyponatraemia	21.51	12.45	28	34644	160059	70733713
Herpes simplex	21.50	12.45	27	34645	11205	70882567
Coma	21.45	12.45	9	34663	91835	70801937
Venous thrombosis	21.44	12.45	21	34651	6628	70887144
Chest pain	21.37	12.45	58	34614	251202	70642570
Osteoarthritis	21.36	12.45	5	34667	74142	70819630
Gastrointestinal inflammation	21.24	12.45	21	34651	6702	70887070
Thymus enlargement	21.22	12.45	6	34666	127	70893645
Mobility decreased	21.16	12.45	12	34660	102987	70790785
Splenomegaly	20.91	12.45	35	34637	18835	70874937
T-cell lymphoma	20.91	12.45	11	34661	1301	70892471
Drug intolerance	20.81	12.45	50	34622	225637	70668135
Musculoskeletal stiffness	20.74	12.45	25	34647	147735	70746037
Coronary artery disease	20.71	12.45	3	34669	62733	70831039
Drug level decreased	20.52	12.45	28	34644	12596	70881176
Inflammatory bowel disease	20.25	12.45	18	34654	5028	70888744
Differentiation syndrome	20.23	12.45	13	34659	2234	70891538
Meningitis coccidioides	20.10	12.45	5	34667	63	70893709
Epidermal necrosis	20.05	12.45	11	34661	1414	70892358
Human metapneumovirus test positive	20.01	12.45	6	34666	157	70893615
Urinary tract infection	19.99	12.45	59	34613	248710	70645062
Chest discomfort	19.73	12.45	19	34653	124362	70769410
Wound	19.58	12.45	12	34660	98720	70795052
Gastrointestinal wall thickening	19.56	12.45	13	34659	2363	70891409
Staphylococcal infection	19.52	12.45	64	34608	53340	70840432
Lymphoproliferative disorder	19.40	12.45	18	34654	5311	70888461
Anxiety	19.38	12.45	50	34622	220280	70673492
Myocardial infarction	19.23	12.45	34	34638	171611	70722161
Chronic obstructive pulmonary disease	19.13	12.45	7	34665	77634	70816138
Hypoglycaemia	19.08	12.45	94	34578	94270	70799502
General physical health deterioration	18.95	12.45	56	34616	235975	70657797
Influenza B virus test positive	18.94	12.45	7	34665	354	70893418
Hip deformity	18.92	12.45	6	34666	190	70893582
Listeriosis	18.90	12.45	12	34660	2020	70891752
Anal fissure	18.83	12.45	19	34653	6214	70887558
Adrenocortical carcinoma	18.77	12.45	5	34667	84	70893688
Pericarditis	18.69	12.45	9	34663	84696	70809076
Large intestinal stenosis	18.67	12.45	13	34659	2550	70891222
Drug reaction with eosinophilia and systemic symptoms	18.63	12.45	3	34669	58010	70835762
Hallucination	18.58	12.45	7	34665	76253	70817519
Transverse sinus thrombosis	18.47	12.45	8	34664	614	70893158
Rectal abscess	18.42	12.45	11	34661	1660	70892112
Clostridium difficile infection	18.42	12.45	51	34621	38765	70855007
Electrocardiogram QT prolonged	18.23	12.45	9	34663	83508	70810264
Drug specific antibody present	18.22	12.45	18	34654	5740	70888032
Angioedema	18.20	12.45	5	34667	66605	70827167
Meningitis enterococcal	18.14	12.45	5	34667	96	70893676
Platelet count decreased	18.14	12.45	149	34523	178073	70715699
Neutropenic colitis	18.09	12.45	17	34655	5097	70888675
Overgrowth fungal	18.09	12.45	5	34667	97	70893675
Fusarium infection	18.06	12.45	11	34661	1721	70892051
Posterior reversible encephalopathy syndrome	17.97	12.45	38	34634	24364	70869408
Vascular access complication	17.89	12.45	11	34661	1750	70892022
Drug hypersensitivity	17.83	12.45	67	34605	262392	70631380
Pancreatitis necrotising	17.76	12.45	14	34658	3314	70890458
Rash	17.68	12.45	162	34510	510400	70383372
Disseminated cytomegaloviral infection	17.40	12.45	7	34665	446	70893326
Herpes zoster meningoencephalitis	17.40	12.45	8	34664	707	70893065
Post lumbar puncture syndrome	17.39	12.45	8	34664	708	70893064
Antithrombin III decreased	17.29	12.45	7	34665	453	70893319
Anaemia	17.27	12.45	285	34387	403138	70490634
Wrong technique in product usage process	17.26	12.45	6	34666	68692	70825080
Facial paralysis	17.15	12.45	33	34639	19775	70873997
Porphyria non-acute	17.09	12.45	8	34664	736	70893036
Tonsil cancer	17.05	12.45	9	34663	1072	70892700
Overdose	16.95	12.45	36	34636	169709	70724063
Nasopharyngitis	16.93	12.45	54	34618	222152	70671620
Bone marrow disorder	16.89	12.45	13	34659	2972	70890800
Acute promyelocytic leukaemia	16.85	12.45	10	34662	1492	70892280
Cheilitis	16.85	12.45	16	34656	4861	70888911
Metastases to pancreas	16.82	12.45	7	34665	486	70893286
Encopresis	16.78	12.45	5	34667	128	70893644
Acral lentiginous melanoma	16.75	12.45	4	34668	42	70893730
Magnetic resonance imaging head abnormal	16.67	12.45	12	34660	2480	70891292
Precursor T-lymphoblastic lymphoma/leukaemia	16.67	12.45	5	34667	131	70893641
Toe walking	16.58	12.45	3	34669	6	70893766
Small intestinal obstruction	16.56	12.45	37	34635	24618	70869154
Steatohepatitis	16.36	12.45	8	34664	811	70892961
Hypophagia	16.26	12.45	51	34621	41519	70852253
Cutaneous leishmaniasis	16.26	12.45	6	34666	302	70893470
Stomatitis	16.20	12.45	113	34559	128398	70765374
Haematocolpos	16.18	12.45	4	34668	49	70893723
Rhabdomyolysis	15.93	12.45	14	34658	95746	70798026
Enterocolitis infectious	15.83	12.45	12	34660	2682	70891090
Lower respiratory tract infection fungal	15.83	12.45	8	34664	870	70892902
Renal failure	15.80	12.45	44	34628	189026	70704746
Anaemia megaloblastic	15.73	12.45	7	34665	573	70893199
Faecal calprotectin abnormal	15.69	12.45	5	34667	161	70893611
Jaundice	15.65	12.45	57	34615	50051	70843721
Gastrointestinal haemorrhage	15.59	12.45	27	34645	137381	70756391
Blood growth hormone decreased	15.50	12.45	4	34668	59	70893713
Malnutrition	15.38	12.45	32	34640	20285	70873487
Paraplegia	15.36	12.45	15	34657	4715	70889057
West Nile viral infection	15.33	12.45	8	34664	931	70892841
Eye opacity	15.26	12.45	3	34669	11	70893761
Viral myelitis	15.25	12.45	4	34668	63	70893709
Intestinal dilatation	15.21	12.45	11	34661	2289	70891483
Urticaria	15.12	12.45	36	34636	163013	70730759
Agitation	15.11	12.45	14	34658	93361	70800411
Blood pressure fluctuation	15.08	12.45	63	34609	58949	70834823
Pericardial cyst	15.05	12.45	3	34669	12	70893760
Autoimmune lymphoproliferative syndrome	15.05	12.45	5	34667	184	70893588
Vocal cord paralysis	15.04	12.45	11	34661	2330	70891442
Oesophageal mass	15.02	12.45	4	34668	67	70893705
Pulmonary mucormycosis	15.01	12.45	8	34664	971	70892801
Placental transfusion syndrome	14.97	12.45	4	34668	68	70893704
Anorectal infection	14.93	12.45	6	34666	381	70893391
Superinfection	14.91	12.45	14	34658	4192	70889580
Haematochezia	14.91	12.45	73	34599	73008	70820764
Blood immunoglobulin G decreased	14.86	12.45	12	34660	2940	70890832
Multiple lentigines syndrome	14.77	12.45	5	34667	195	70893577
Cardiac failure	14.70	12.45	30	34642	143511	70750261
Mucoepidermoid carcinoma	14.65	12.45	4	34668	74	70893698
Listeria sepsis	14.63	12.45	7	34665	677	70893095
Stomatitis necrotising	14.60	12.45	5	34667	202	70893570
Epstein-Barr viraemia	14.59	12.45	10	34662	1913	70891859
Partial seizures	14.57	12.45	19	34653	8186	70885586
Gastrointestinal sounds abnormal	14.51	12.45	15	34657	5046	70888726
Dysplastic naevus syndrome	14.50	12.45	3	34669	15	70893757
Bacteraemia	14.39	12.45	39	34633	29270	70864502
Fistula of small intestine	14.35	12.45	7	34665	706	70893066
Pseudopolyp	14.33	12.45	6	34666	423	70893349
Hepatic enzyme increased	14.29	12.45	35	34637	156955	70736817
Cardiac arrest	14.26	12.45	36	34636	159798	70733974
Acute myocardial infarction	14.26	12.45	9	34663	72878	70820894
Staphylococcal bacteraemia	14.25	12.45	22	34650	11060	70882712
Chills	14.17	12.45	120	34552	144666	70749106
Erythema nodosum	14.16	12.45	14	34658	4467	70889305
Chronic sinusitis	14.13	12.45	19	34653	8432	70885340
Blood cholesterol increased	14.04	12.45	7	34665	64597	70829175
Red blood cell microcytes present	14.04	12.45	3	34669	18	70893754
Mucocutaneous candidiasis	14.04	12.45	4	34668	87	70893685
Functional gastrointestinal disorder	14.03	12.45	14	34658	4517	70889255
Melaena	14.02	12.45	5	34667	56350	70837422
Multiple organ dysfunction syndrome	14.02	12.45	96	34576	108419	70785353
Ocular icterus	13.99	12.45	15	34657	5262	70888510
Cerebrovascular accident	13.85	12.45	31	34641	143439	70750333
Adenovirus infection	13.81	12.45	18	34654	7750	70886022
Leukaemia	13.76	12.45	15	34657	5360	70888412
Lennox-Gastaut syndrome	13.74	12.45	5	34667	242	70893530
Malignant neoplasm progression	13.73	12.45	24	34648	121715	70772057
Therapeutic product effect decreased	13.72	12.45	31	34641	142987	70750785
B precursor type acute leukaemia	13.70	12.45	6	34666	473	70893299
Lymphoma	13.69	12.45	26	34646	15436	70878336
Immunosuppression	13.65	12.45	22	34650	11470	70882302
Mucous stools	13.64	12.45	13	34659	3966	70889806
Pneumococcal bacteraemia	13.63	12.45	4	34668	97	70893675
Epstein Barr virus positive mucocutaneous ulcer	13.62	12.45	7	34665	789	70892983
Eosinophilic pneumonia chronic	13.61	12.45	6	34666	480	70893292
Cardiac disorder	13.59	12.45	6	34666	59409	70834363
Hyperglycaemia	13.48	12.45	65	34607	64607	70829165
Papulopustular rosacea	13.41	12.45	3	34669	23	70893749
Upper respiratory tract infection	13.29	12.45	75	34597	79199	70814573
Pneumonia aspiration	13.17	12.45	7	34665	62282	70831490
Large intestine infection	13.17	12.45	11	34661	2827	70890945
Neurological examination abnormal	13.16	12.45	6	34666	520	70893252
T-cell type acute leukaemia	13.08	12.45	5	34667	278	70893494
Respiratory arrest	13.06	12.45	5	34667	53928	70839844
Gastrointestinal injury	13.03	12.45	7	34665	864	70892908
Pleocytosis	12.96	12.45	8	34664	1281	70892491
Respiratory distress	12.93	12.45	57	34615	54593	70839179
Proctitis	12.92	12.45	12	34660	3546	70890226
Disease recurrence	12.80	12.45	44	34628	37559	70856213
Acute myelomonocytic leukaemia	12.63	12.45	5	34667	305	70893467
Septic shock	12.59	12.45	96	34576	112162	70781610
Anaemia macrocytic	12.53	12.45	14	34658	5141	70888631
Respiratory syncytial virus infection	12.48	12.45	17	34655	7638	70886134

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01BB02	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Purine analogues
CHEBI has role	CHEBI:35221	antimetabolite
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:149553	anticoronaviral drug
MeSH PA	D000963	Antimetabolites
MeSH PA	D000964	Antimetabolites, Antineoplastic
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D007155	Immunologic Factors
MeSH PA	D007166	Immunosuppressive Agents
MeSH PA	D009676	Noxae
MeSH PA	D019384	Nucleic Acid Synthesis Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Acute lymphoid leukemia	indication	91857003	DOID:9952
Acute promyelocytic leukemia, FAB M3	indication	110004001
Psoriasis with arthropathy	off-label use	33339001
Crohn's disease	off-label use	34000006
Ulcerative colitis	off-label use	64766004	DOID:8577
Acute myeloid leukemia, disease	off-label use	91861009
Polycythemia vera	off-label use	109992005
Hyperbilirubinemia	contraindication	14783006	DOID:2741
Obstruction of bile duct	contraindication	30144000
Dehydration	contraindication	34095006
Gastrointestinal ulcer	contraindication	40845000
Leukopenia	contraindication	84828003	DOID:615
Kidney disease	contraindication	90708001	DOID:557
Liver function tests abnormal	contraindication	166603001
Acute pancreatitis	contraindication	197456007	DOID:2913
Disease of liver	contraindication	235856003	DOID:409
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Bone marrow depression	contraindication	307762000
Ascites	contraindication	389026000
Breastfeeding (mother)	contraindication	413712001
Hepatosplenic T-cell lymphoma	contraindication	445406001
Chemotherapy-Induced Hyperuricemia	contraindication
Thiopurine S-Methyltransferase Deficiency	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	5.99	acidic
pKa2	10.76	acidic
pKa3	3.37	Basic
pKa4	1.4	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Amidophosphoribosyltransferase	Enzyme	Q06203	PUR1_HUMAN	INHIBITOR				DRUGBANK	CHEMBL
Multidrug resistance-associated protein 5	Transporter	O15440	MRP5_HUMAN					WOMBAT-PK
Multidrug resistance-associated protein 4	Transporter	O15439	MRP4_HUMAN					WOMBAT-PK
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	4.79		DRUG MATRIX
Thiopurine S-methyltransferase	Enzyme	P51580	TPMT_HUMAN					WOMBAT-PK
Purine nucleoside phosphorylase	Enzyme	P00491	PNPH_HUMAN					WOMBAT-PK
Purine nucleoside phosphorylase	Enzyme		PUNA_MYCTU		Kd	4.10		CHEMBL

External reference:

ID	Source
4018776	VUID
N0000147079	NUI
D00161	KEGG_DRUG
6112-76-1	SECONDARY_CAS_RN
4018776	VANDF
C0000618	UMLSCUI
CHEBI:50667	CHEBI
PM6	PDB_CHEM_ID
CHEMBL1425	ChEMBL_ID
CHEMBL1200751	ChEMBL_ID
DB01033	DRUGBANK_ID
D015122	MESH_DESCRIPTOR_UI
667490	PUBCHEM_CID
7226	IUPHAR_LIGAND_ID
E7WED276I5	UNII
103	RXNORM
3886	MMSL
48948	MMSL
5052	MMSL
NOCODE	MMSL
d00289	MMSL
002647	NDDF
1039008	SNOMEDCT_US
386835005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Mercaptopurine	HUMAN PRESCRIPTION DRUG LABEL	1	0054-4581	TABLET	50 mg	ORAL	ANDA	29 sections
Mercaptopurine	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3547	TABLET	50 mg	ORAL	ANDA	29 sections
Mercaptopurine	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3547	TABLET	50 mg	ORAL	ANDA	29 sections
mercaptopurine	HUMAN PRESCRIPTION DRUG LABEL	1	49884-922	TABLET	50 mg	ORAL	ANDA	24 sections
mercaptopurine	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5282	TABLET	50 mg	ORAL	ANDA	24 sections
PURINETHOL	HUMAN PRESCRIPTION DRUG LABEL	1	60763-601	TABLET	50 mg	ORAL	NDA	30 sections
PURIXAN	HUMAN PRESCRIPTION DRUG LABEL	1	62484-0020	SUSPENSION	20 mg	ORAL	NDA	19 sections
PURIXAN	HUMAN PRESCRIPTION DRUG LABEL	1	62484-0020	SUSPENSION	20 mg	ORAL	NDA	19 sections
Mercaptopurine	HUMAN PRESCRIPTION DRUG LABEL	1	69076-913	TABLET	50 mg	ORAL	NDA authorized generic	31 sections