meproscillarin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1705 33396-37-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • meproscillarin
  • methyl proscillaridin
  • Methyl proscillaridin A
  • Proscillaridin 4-methyl ether
semi-synthetic derivative of proscillaridin of Scilla (Liliaceae); structure in Negwer, 5th ed, #6625; RN given refers to (3beta)-isomer
  • Molecular weight: 544.69
  • Formula: C31H44O8
  • CLOGP: 2.20
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 3
  • TPSA: 114.68
  • ALOGS: -4.62
  • ROTB: 4

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.05 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.82 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter WOMBAT-PK

External reference:

IDSource
C0065971 UMLSCUI
CHEBI:135824 CHEBI
CHEMBL2106427 ChEMBL_ID
C009079 MESH_SUPPLEMENTAL_RECORD_UI
4012 INN_ID
WYR1723LO7 UNII
15942714 PUBCHEM_CID
006573 NDDF

Pharmaceutical products:

None