menadione Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1683 58-27-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • menadione
  • menadion
  • menaphthon
  • menaphthone
  • menaquinone
  • 2-Methyl-1,4-naphthalenedione
  • Molecular weight: 172.18
  • Formula: C11H8O2
  • CLOGP: 2.45
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS: -2.53
  • ROTB: 0

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
2 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA LILLY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC B02BA02 BLOOD AND BLOOD FORMING ORGANS
ANTIHEMORRHAGICS
VITAMIN K AND OTHER HEMOSTATICS
Vitamin K
CHEBI has role CHEBI:76971 e.coli metabolites
CHEBI has role CHEBI:50733 nutritional supplement

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Amine oxidase [flavin-containing] A Enzyme Ki 4.59 CHEMBL
Glutathione reductase, mitochondrial Enzyme Ki 4.92 CHEMBL
Dual specificity phosphatase Cdc25C Enzyme IC50 4.73 CHEMBL
M-phase inducer phosphatase 2 Enzyme IC50 5.66 CHEMBL
Ubiquitin carboxyl-terminal hydrolase isozyme L3 Enzyme IC50 4.15 CHEMBL
Amine oxidase [flavin-containing] B Enzyme Ki 6.40 CHEMBL
Indoleamine 2,3-dioxygenase 1 Enzyme IC50 6 CHEMBL
Trypanothione reductase Enzyme IC50 4.26 CHEMBL
Dual specificity protein phosphatase 6 Unclassified IC50 4.69 CHEMBL
Dual specificity protein phosphatase 1 Unclassified IC50 4.62 CHEMBL

External reference:

IDSource
4019127 VUID
N0000147378 NUI
D02335 KEGG_DRUG
1182-68-9 SECONDARY_CAS_RN
4019127 VANDF
C0025270 UMLSCUI
CHEBI:28869 CHEBI
VK3 PDB_CHEM_ID
4055 PUBCHEM_CID
CHEMBL590 ChEMBL_ID
CHEMBL4297659 ChEMBL_ID
DB00170 DRUGBANK_ID
DB15381 DRUGBANK_ID
723JX6CXY5 UNII
42781 RXNORM
337527 MMSL
35482 MMSL
NOCODE MMSL
d09345 MMSL
001039 NDDF
012756 NDDF
22606007 SNOMEDCT_US
412244007 SNOMEDCT_US
69576000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dairy Allergen Mix HUMAN OTC DRUG LABEL 38 43742-1277 LIQUID 6 [hp_X] ORAL unapproved drug other 9 sections