menadione 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1683 | 58-27-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 10 | mg | O |
| 2 | mg | P |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | LILLY |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | B02BA02 | BLOOD AND BLOOD FORMING ORGANS ANTIHEMORRHAGICS VITAMIN K AND OTHER HEMOSTATICS Vitamin K |
| CHEBI has role | CHEBI:76971 | Escherichia coli metabolites |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:48422 | angiogenesis antagonist |
| CHEBI has role | CHEBI:50733 | Dietary Supplement |
| CHEBI has role | CHEBI:84087 | human urinary metabolites |
| CHEBI has role | CHEBI:147285 | SARS coronavirus main protease inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] A | Enzyme | Ki | 4.59 | CHEMBL | |||||
| Indoleamine 2,3-dioxygenase 1 | Enzyme | IC50 | 6 | CHEMBL | |||||
| M-phase inducer phosphatase 2 | Enzyme | IC50 | 5.66 | CHEMBL | |||||
| Dual specificity phosphatase Cdc25C | Enzyme | IC50 | 4.73 | CHEMBL | |||||
| Ubiquitin carboxyl-terminal hydrolase isozyme L3 | Enzyme | IC50 | 4.15 | CHEMBL | |||||
| Dual specificity phosphatase Cdc25A | Enzyme | IC50 | 5.16 | CHEMBL | |||||
| Alpha-synuclein | Transporter | IC50 | 4.82 | CHEMBL | |||||
| Aldehyde oxidase | Enzyme | IC50 | 4 | CHEMBL | |||||
| Glutathione reductase, mitochondrial | Enzyme | Ki | 4.92 | CHEMBL | |||||
| Amine oxidase [flavin-containing] B | Enzyme | Ki | 6.40 | CHEMBL | |||||
| Trypanothione reductase | Enzyme | IC50 | 4.26 | CHEMBL | |||||
| Dual specificity protein phosphatase 6 | Enzyme | IC50 | 4.69 | CHEMBL | |||||
| Dual specificity protein phosphatase 1 | Enzyme | IC50 | 4.62 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019127 | VUID |
| N0000147378 | NUI |
| D02335 | KEGG_DRUG |
| 1182-68-9 | SECONDARY_CAS_RN |
| 4019127 | VANDF |
| C0025270 | UMLSCUI |
| CHEBI:28869 | CHEBI |
| VK3 | PDB_CHEM_ID |
| CHEMBL590 | ChEMBL_ID |
| DB00170 | DRUGBANK_ID |
| CHEMBL4297659 | ChEMBL_ID |
| 4055 | PUBCHEM_CID |
| 723JX6CXY5 | UNII |
| DB15381 | DRUGBANK_ID |
| 42781 | RXNORM |
| 337527 | MMSL |
| 35482 | MMSL |
| NOCODE | MMSL |
| d09345 | MMSL |
| 001039 | NDDF |
| 012756 | NDDF |
| 22606007 | SNOMEDCT_US |
| 412244007 | SNOMEDCT_US |
| 69576000 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Dairy Allergen Mix | HUMAN OTC DRUG LABEL | 38 | 43742-1277 | LIQUID | 6 [hp_X] | ORAL | unapproved drug other | 9 sections |