medroxalol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
aromatic ring -CH(-OH)-CH2-NH-R 1658 56290-94-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • medroxalol monohydrochloride
  • medroxalol
  • medroxalol hydrochloride
  • medroxalol HCl
  • Molecular weight: 372.42
  • Formula: C20H24N2O5
  • CLOGP: 2.46
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 4
  • TPSA: 114.04
  • ALOGS: -3.72
  • ROTB: 8

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 38 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 7.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 16 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 11 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D000317 Adrenergic alpha-Antagonists
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.81 acidic
pKa2 12.65 acidic
pKa3 8.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR pA2 7.82 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR pA2 6.08 WOMBAT-PK

External reference:

IDSource
D04888 KEGG_DRUG
C0065863 UMLSCUI
CHEBI:135571 CHEBI
CHEMBL1203104 ChEMBL_ID
CHEMBL113278 ChEMBL_ID
C024892 MESH_SUPPLEMENTAL_RECORD_UI
41835 PUBCHEM_CID
4784 INN_ID
70161-10-3 SECONDARY_CAS_RN
7PX96289JA UNII

Pharmaceutical products:

None