loxiglumide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
cholecystokinine antagonists, antiulcer, anxiolytic agents 1614 107097-80-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • loxiglumide
cholecystokinin receptor antagonist; RN refers to (+-)-isomer
  • Molecular weight: 461.38
  • Formula: C21H30Cl2N2O5
  • CLOGP: 4.39
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 95.94
  • ALOGS: -4.92
  • ROTB: 14

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.24 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D006727 Hormone Antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.19 acidic
pKa2 13.75 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cholecystokinin receptor type A GPCR IC50 6.71 CHEMBL
Cholecystokinin receptor type A GPCR ANTAGONIST IC50 6.50 IUPHAR

External reference:

IDSource
D01113 KEGG_DRUG
C0065197 UMLSCUI
CHEBI:31785 CHEBI
CHEMBL206025 ChEMBL_ID
C053737 MESH_SUPPLEMENTAL_RECORD_UI
892 IUPHAR_LIGAND_ID
6113 INN_ID
77MPX3N42I UNII
60182 PUBCHEM_CID

Pharmaceutical products:

None