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lindane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1583 | 58-89-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Any of several polyhalogenated organic compounds consisting of a six-carbon ring with one chlorine and one hydrogen attached to each carbon.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.01 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CG,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 48 | |||
| kinase-selectivity-class | PDK1,PDK2 | 2 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 19, 1974 | FDA | REED AND CARNRICK |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P03AB02 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES Chlorine containing products |
| MeSH PA | D007306 | Insecticides |
| MeSH PA | D010575 | Pesticides |
| CHEBI has role | CHEBI:24127 | fungicides |
| CHEBI has role | CHEBI:33282 | bactericides |
| CHEBI has role | CHEBI:33286 | agricultural chemicals |
| CHEBI has role | CHEBI:33288 | rodenticides |
| CHEBI has role | CHEBI:38706 | pediculicides |
| CHEBI has role | CHEBI:38999 | GABA-gated chloride channel antagonists |
| CHEBI has role | CHEBI:77853 | persistent organic pollutants |
Related Drugs by ATC class:
P03AB Chlorine containing products 1 drug
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Infestation by Phthirus pubis | indication | 71011005 | DOID:13760 |
| Pediculosis capitis | indication | 81000006 | DOID:5501 |
| Infestation by Sarcoptes scabiei var hominis | indication | 128869009 | DOID:8295 |
| Alcoholism | contraindication | 7200002 | |
| Psoriasis | contraindication | 9014002 | DOID:8893 |
| Lowered convulsive threshold | contraindication | 19260006 | |
| Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
| Atopic dermatitis | contraindication | 24079001 | DOID:3310 |
| Injury of head | contraindication | 82271004 | |
| Disorder of skin | contraindication | 95320005 | DOID:37 |
| Seizure disorder | contraindication | 128613002 | |
| Pregnancy, function | contraindication | 289908002 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Intracerebral Mass | contraindication | ||
| Uncontrolled Epilepsy | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit rho-1 | Ion channel | IC50 | 7.04 | CHEMBL | |||||
| GABA-A receptor alpha-1/beta-3/gamma-2 | Ion channel | IC50 | 7.68 | CHEMBL | |||||
| GABA-A receptor alpha-6/beta-3/gamma-2 | Ion channel | IC50 | 8.31 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit beta-3 | Ion channel | IC50 | 9.05 | CHEMBL | |||||
| GABA A receptor alpha-1/beta-1/gamma-2 | Ion channel | IC50 | 7.17 | CHEMBL | |||||
| GABA-A receptor | Ion channel | NEGATIVE ALLOSTERIC MODULATOR | CHEMBL | CHEMBL | |||||
| GABA-A receptor | Ion channel | NEGATIVE ALLOSTERIC MODULATOR | CHEMBL | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit beta | Ion channel | IC50 | 7.96 | CHEMBL | |||||
| Androgen receptor | Transcription factor | IC50 | 4.39 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018196 | VUID |
| N0000146530 | NUI |
| D00360 | KEGG_DRUG |
| 4018196 | VANDF |
| C0005038 | UMLSCUI |
| CHEBI:32888 | CHEBI |
| CHEMBL15891 | ChEMBL_ID |
| DB00431 | DRUGBANK_ID |
| D001556 | MESH_DESCRIPTOR_UI |
| 727 | PUBCHEM_CID |
| 4901 | INN_ID |
| 59NEE7PCAB | UNII |
| 1388 | RXNORM |
| 1955 | MMSL |
| 4981 | MMSL |
| 002991 | NDDF |
| 333056004 | SNOMEDCT_US |
| 77496001 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Lindane | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61748-400 | SHAMPOO | 10 mg | TOPICAL | ANDA | 24 sections |