lindane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1583 58-89-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lindane
  • hexachlorocyclohexane
  • hexachloran
  • hexachlorane
Any of several polyhalogenated organic compounds consisting of a six-carbon ring with one chlorine and one hydrogen attached to each carbon.
  • Molecular weight: 290.81
  • Formula: C6H6Cl6
  • CLOGP: 3.75
  • LIPINSKI: 0
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS: -4.73
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 19, 1974 FDA REED AND CARNRICK

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P03AB02 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS
ECTOPARASITICIDES, INCL. SCABICIDES
Chlorine containing products
MeSH PA D007306 Insecticides
MeSH PA D010575 Pesticides
CHEBI has role CHEBI:24127 fungicides
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:33286 agricultural chemicals
CHEBI has role CHEBI:33288 rodenticides
CHEBI has role CHEBI:38706 pediculicides
CHEBI has role CHEBI:38999 GABA-gated chloride channel antagonists
CHEBI has role CHEBI:77853 persistent organic pollutants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Infestation by Phthirus pubis indication 71011005 DOID:13760
Pediculosis capitis indication 81000006 DOID:5501
Infestation by Sarcoptes scabiei var hominis indication 128869009 DOID:8295
Alcoholism contraindication 7200002
Psoriasis contraindication 9014002 DOID:8893
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Atopic dermatitis contraindication 24079001 DOID:3310
Injury of head contraindication 82271004
Disorder of skin contraindication 95320005 DOID:37
Seizure disorder contraindication 128613002
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001
Intracerebral Mass contraindication
Uncontrolled Epilepsy contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Gamma-aminobutyric acid receptor subunit rho-1 Ion channel IC50 7.04 CHEMBL
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel IC50 7.68 CHEMBL
GABA-A receptor alpha-6/beta-3/gamma-2 Ion channel IC50 8.31 CHEMBL
Gamma-aminobutyric acid receptor subunit beta-3 Ion channel IC50 9.05 CHEMBL
GABA A receptor alpha-1/beta-1/gamma-2 Ion channel IC50 7.17 CHEMBL
GABA-A receptor Ion channel NEGATIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL
GABA-A receptor Ion channel NEGATIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL
Gamma-aminobutyric acid receptor subunit beta Ion channel IC50 7.96 CHEMBL
Androgen receptor Transcription factor IC50 4.39 CHEMBL

External reference:

IDSource
4018196 VUID
N0000146530 NUI
D00360 KEGG_DRUG
4018196 VANDF
C0005038 UMLSCUI
CHEBI:32888 CHEBI
CHEMBL15891 ChEMBL_ID
DB00431 DRUGBANK_ID
D001556 MESH_DESCRIPTOR_UI
727 PUBCHEM_CID
4901 INN_ID
59NEE7PCAB UNII
1388 RXNORM
1955 MMSL
4981 MMSL
002991 NDDF
333056004 SNOMEDCT_US
77496001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lindane HUMAN PRESCRIPTION DRUG LABEL 1 60432-834 SHAMPOO, SUSPENSION 10 mg TOPICAL ANDA 20 sections
Lindane HUMAN PRESCRIPTION DRUG LABEL 1 61748-400 SHAMPOO 10 mg TOPICAL ANDA 24 sections
Lindane HUMAN PRESCRIPTION DRUG LABEL 1 61748-401 LOTION 10 mg TOPICAL ANDA 24 sections