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levopropoxyphene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1573 | 2338-37-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A propionate derivative that is used to suppress coughing.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-selectivity-class | AXL,EIF2AK3,EPHB4,GRK2,PDK4,TEK | 6 | |||
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK12,MAPK7,MET,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKDC,SIK2,SIK3,TEK | 34 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 21, 1962 | FDA | LILLY |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000996 | Antitussive Agents |
| MeSH PA | D019141 | Respiratory System Agents |
| CHEBI has role | CHEBI:51177 | antitussive |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.26 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.56 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000178576 | NUI |
| D04718 | KEGG_DRUG |
| C0023582 | UMLSCUI |
| CHEBI:51174 | CHEBI |
| CHEMBL1738990 | ChEMBL_ID |
| DB06793 | DRUGBANK_ID |
| D054816 | MESH_DESCRIPTOR_UI |
| 200742 | PUBCHEM_CID |
| 731 | INN_ID |
| 55557-30-7 | SECONDARY_CAS_RN |
| U75VZ9PK1J | UNII |
| 402519 | RXNORM |
| 001655 | NDDF |
| 004670 | NDDF |
| 20413008 | SNOMEDCT_US |
| CHEMBL1593906 | ChEMBL_ID |
| 5714-90-9 | SECONDARY_CAS_RN |
Pharmaceutical products:
None