aspartic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1550 56-84-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • L-Aspartic acid
  • asparagic acid
  • aspartic acid
One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
  • Molecular weight: 133.10
  • Formula: C4H7NO4
  • CLOGP: -2.41
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 100.62
  • ALOGS: 0.03
  • ROTB: 3

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 643.97 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -3.613 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.888 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 1.081 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 0.473 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 94.240 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 73.090 % High 1
herg hERG pIC50 5.193 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.343 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 2.972 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 97.060 % High 1
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT1,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPKAPK2,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 61
kinase-selectivity-class AXL,BRAF,CDK4,CDK9,EIF2AK3,EPHB4,GRK2,MAP2K6,MAP3K14,MAPK7,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 16
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.274 High 1
mh-clint Mouse hepatocyte intrinsic clearance 0.361 High 1
mppb Mouse plasma protein binding (% unbound) 99.600 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.449 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 96.430 % High 1
rh-clint Rat hepatocyte intrinsic clearance 1.262 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 83.590 % High 1
rppb Rat plasma protein binding (% unbound) 99.350 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 693.426 uM High 1

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hand deformity 137.28 10.07 3 46422 296359 90285663
Pemphigus 129.53 10.07 10 46415 326854 90255168
Electric shock 117.30 10.07 41 46384 1681 90580341
Systemic lupus erythematosus 116.78 10.07 22 46403 361874 90220148
Glossodynia 116.56 10.07 14 46411 321765 90260257
Macular degeneration 107.14 10.07 114 46311 37856 90544166
Low turnover osteopathy 106.13 10.07 49 46376 4169 90577853
Maternal exposure during pregnancy 103.93 10.07 28 46397 360035 90221987
Synovitis 102.31 10.07 22 46403 329730 90252292
Duodenal ulcer perforation 99.59 10.07 3 46422 221285 90360737
Back pain 93.34 10.07 365 46060 316810 90265212
Femur fracture 90.79 10.07 115 46310 45967 90536055
Wound 90.41 10.07 22 46403 302958 90279064
Pericarditis 90.22 10.07 15 46410 270136 90311886
Treatment failure 88.90 10.07 23 46402 303905 90278117
General physical health deterioration 87.82 10.07 36 46389 355079 90226943
Anti-cyclic citrullinated peptide antibody positive 83.86 10.07 11 46414 236422 90345600
Intervertebral discitis 82.05 10.07 42 46383 4478 90577544
Therapy cessation 81.76 10.07 97 46328 36264 90545758
Post-traumatic stress disorder 78.63 10.07 47 46378 6781 90575241
Rheumatoid factor positive 74.87 10.07 3 46422 171647 90410375
Multiple sclerosis 74.00 10.07 81 46344 27759 90554263
Helicobacter infection 72.69 10.07 14 46411 226836 90355186
Contraindicated product administered 72.08 10.07 37 46388 320102 90261920
Constipation 70.88 10.07 308 46117 280087 90301935
Drug intolerance 70.73 10.07 75 46350 447516 90134506
Temperature intolerance 69.40 10.07 54 46371 11976 90570046
Post cholecystectomy syndrome 67.87 10.07 23 46402 858 90581164
Vitamin B12 increased 64.73 10.07 27 46398 1799 90580223
Chronic sinusitis 64.57 10.07 70 46355 23732 90558290
Blood immunoglobulin A increased 63.01 10.07 24 46401 1259 90580763
Weight decreased 60.74 10.07 367 46058 379543 90202479
Demyelination 59.20 10.07 42 46383 8098 90573924
Vitamin D deficiency 59.13 10.07 58 46367 17498 90564524
Exposure during pregnancy 57.57 10.07 25 46400 238385 90343637
Muscle spasticity 57.05 10.07 80 46345 35242 90546780
Blood uric acid increased 56.60 10.07 40 46385 7664 90574358
Radiculopathy 56.56 10.07 58 46367 18447 90563575
Granulocyte count increased 55.45 10.07 23 46402 1511 90580511
Liver injury 53.64 10.07 11 46414 170556 90411466
Off label use 52.73 10.07 340 46085 1101912 89480110
Vaginal flatulence 52.66 10.07 47 46378 12591 90569431
Glomerular filtration rate increased 52.04 10.07 24 46401 2036 90579986
Folliculitis 51.66 10.07 20 46405 204333 90377689
Hyperlipidaemia 51.29 10.07 61 46364 22855 90559167
Intervertebral disc degeneration 48.96 10.07 52 46373 17222 90564800
Proctitis 48.78 10.07 49 46376 15210 90566812
Toxicity to various agents 47.98 10.07 46 46379 287800 90294222
Aspartate aminotransferase 47.93 10.07 17 46408 728 90581294
Balance disorder 47.64 10.07 133 46292 96947 90485075
Female genital tract fistula 47.51 10.07 52 46373 17816 90564206
Vaginal discharge 47.22 10.07 54 46371 19410 90562612
Fall 46.22 10.07 412 46013 481398 90100624
Product use issue 45.97 10.07 61 46364 329858 90252164
Rheumatoid factor increased 45.50 10.07 23 46402 2388 90579634
Joint noise 44.85 10.07 30 46395 5260 90576762
Anaemia postoperative 44.38 10.07 22 46403 2191 90579831
Paraesthesia oral 44.29 10.07 67 46358 31592 90550430
Progressive multifocal leukoencephalopathy 44.15 10.07 47 46378 15608 90566414
Coordination abnormal 43.18 10.07 54 46371 21302 90560720
Therapeutic product effect decreased 42.16 10.07 48 46377 277523 90304499
Spinal osteoarthritis 41.26 10.07 50 46375 19098 90562924
Intentional product use issue 40.60 10.07 31 46394 216861 90365161
Completed suicide 40.47 10.07 12 46413 145046 90436976
Discomfort 39.99 10.07 49 46376 274286 90307736
Swelling 39.97 10.07 98 46327 418960 90163062
Haematochezia 39.68 10.07 102 46323 70811 90511211
Arthropathy 39.55 10.07 80 46345 366162 90215860
Intramedullary rod insertion 38.90 10.07 20 46405 2152 90579870
Muscle injury 38.87 10.07 21 46404 176633 90405389
Red blood cell count decreased 38.55 10.07 78 46347 46273 90535749
Procedural pain 36.31 10.07 63 46362 33297 90548725
Coronary artery disease 35.95 10.07 63 46362 33560 90548462
Dactylitis 35.35 10.07 23 46402 3850 90578172
Spinal disorder 34.60 10.07 36 46389 11643 90570379
Facet joint syndrome 33.87 10.07 5 46420 98384 90483638
Stress fracture 33.87 10.07 31 46394 8580 90573442
Oral candidiasis 33.54 10.07 63 46362 35392 90546630
Diverticulum 33.51 10.07 36 46389 12077 90569945
Abdominal discomfort 33.17 10.07 129 46296 477199 90104823
Dry eye 33.11 10.07 84 46341 57847 90524175
Throat clearing 33.05 10.07 22 46403 3825 90578197
Infective pulmonary exacerbation of cystic fibrosis 32.84 10.07 33 46392 10246 90571776
Depression 32.44 10.07 264 46161 300337 90281685
Psoriatic arthropathy 32.01 10.07 42 46383 228293 90353729
Sleep disorder due to general medical condition, insomnia type 31.85 10.07 13 46412 128681 90453341
Intentional overdose 31.77 10.07 5 46420 93829 90488193
Blood test abnormal 31.69 10.07 46 46379 20906 90561116
Joint range of motion decreased 31.52 10.07 15 46410 135628 90446394
C-reactive protein increased 31.38 10.07 28 46397 181361 90400661
Mobility decreased 31.34 10.07 50 46375 250684 90331338
Ear pain 31.26 10.07 82 46343 57620 90524402
Product use in unapproved indication 30.98 10.07 80 46345 336156 90245866
Fibromyalgia 30.95 10.07 36 46389 206233 90375789
Lip dry 30.74 10.07 7 46418 100948 90481074
Wheezing 30.20 10.07 47 46378 238033 90343989
Dental caries 30.01 10.07 33 46392 11364 90570658
Depressed mood 29.94 10.07 74 46351 50148 90531874
Asthenia 29.73 10.07 410 46015 533341 90048681
Vitamin B12 deficiency 29.54 10.07 27 46398 7459 90574563
Intervertebral disc protrusion 29.13 10.07 51 46374 27145 90554877
Neuropathy peripheral 29.04 10.07 143 46282 136827 90445195
Drug interaction 28.47 10.07 62 46363 276391 90305631
Blood pressure systolic decreased 28.23 10.07 29 46396 9241 90572781
Blister 28.11 10.07 55 46370 254943 90327079
Cholecystitis acute 27.88 10.07 29 46396 9375 90572647
Body temperature increased 27.84 10.07 67 46358 44643 90537379
Bronchitis 27.82 10.07 153 46272 152774 90429248
Lumbar spinal stenosis 27.76 10.07 23 46402 5574 90576448
Breast cancer stage III 27.49 10.07 5 46420 84442 90497580
Prescribed overdose 27.37 10.07 8 46417 97617 90484405
Hepatic enzyme increased 27.34 10.07 94 46331 360642 90221380
Cystocele 27.11 10.07 14 46411 1520 90580502
Ulcer 26.94 10.07 55 46370 32827 90549195
Flatulence 26.85 10.07 63 46362 41304 90540718
Spinal epidural haematoma 25.98 10.07 13 46412 1321 90580701
Myalgia 25.32 10.07 165 46260 174960 90407062
Throat irritation 25.16 10.07 68 46357 48627 90533395
Mitral valve incompetence 25.12 10.07 43 46382 22481 90559541
Confusional state 24.55 10.07 108 46317 386097 90195925
Irritable bowel syndrome 24.41 10.07 43 46382 207405 90374617
Hypersensitivity 24.39 10.07 135 46290 454542 90127480
Wound infection 24.36 10.07 12 46413 106390 90475632
Transient ischaemic attack 24.04 10.07 62 46363 43114 90538908
Product complaint 23.95 10.07 32 46393 13468 90568554
Blood glucose decreased 23.89 10.07 43 46382 23386 90558636
Diarrhoea 23.74 10.07 639 45786 938551 89643471
Blood alkaline phosphatase increased 23.71 10.07 66 46359 48013 90534009
Monocyte count increased 23.36 10.07 26 46399 9071 90572951
Urinary incontinence 23.08 10.07 56 46369 37510 90544512
Syncope 22.98 10.07 131 46294 132532 90449490
Ill-defined disorder 22.97 10.07 37 46388 184854 90397168
Headache 22.95 10.07 591 45834 862155 89719867
Spondylolisthesis 22.87 10.07 18 46407 4057 90577965
Bladder prolapse 22.67 10.07 14 46411 2141 90579881
Aspartate aminotransferase abnormal 22.40 10.07 15 46410 2634 90579388
Type 2 diabetes mellitus 22.26 10.07 44 46381 203200 90378822
Dysphagia 22.23 10.07 115 46310 112163 90469859
Adrenal insufficiency 22.13 10.07 48 46377 29873 90552149
Blood calcium increased 22.03 10.07 29 46396 12029 90569993
Muscle strain 22.03 10.07 26 46399 9661 90572361
Musculoskeletal stiffness 21.97 10.07 78 46347 296454 90285568
Alopecia 21.90 10.07 156 46269 494915 90087107
Glycosylated haemoglobin increased 21.86 10.07 33 46392 15529 90566493
Drug ineffective 21.76 10.07 542 45883 1383756 89198266
Therapy non-responder 21.44 10.07 23 46402 136681 90445341
Injury 21.37 10.07 43 46382 197306 90384716
Febrile neutropenia 21.30 10.07 30 46395 158319 90423703
Joint swelling 21.11 10.07 161 46264 503139 90078883
Epilepsy 20.84 10.07 8 46417 82198 90499824
Aspartate aminotransferase increased 20.78 10.07 106 46319 102831 90479191
Body height decreased 20.70 10.07 28 46397 11921 90570101
Blood urea increased 20.49 10.07 47 46378 30366 90551656
Grip strength decreased 20.36 10.07 11 46414 92565 90489457
Cough 20.34 10.07 283 46142 368679 90213343
Condition aggravated 20.32 10.07 201 46224 595344 89986678
Gastrooesophageal reflux disease 20.09 10.07 150 46275 166187 90415835
Alanine aminotransferase increased 19.93 10.07 116 46309 118222 90463800
Myocardial infarction 19.92 10.07 107 46318 105865 90476157
Fracture nonunion 19.43 10.07 13 46412 2279 90579743
Delusional disorder, persecutory type 19.21 10.07 7 46418 324 90581698
White blood cells urine positive 19.20 10.07 20 46405 6478 90575544
Ventricular hypertrophy 19.08 10.07 15 46410 3376 90578646
Renal cyst 18.96 10.07 28 46397 12922 90569100
Pain in extremity 18.90 10.07 330 46095 450199 90131823
Blepharospasm 18.67 10.07 3 46422 55442 90526580
Stress urinary incontinence 18.64 10.07 13 46412 2439 90579583
Inflammation 18.42 10.07 40 46385 178552 90403470
Urinary tract infection 18.31 10.07 238 46187 305394 90276628
Drug-induced liver injury 18.09 10.07 12 46413 90306 90491716
Infection 18.07 10.07 110 46315 361984 90220038
Respiratory disorder 17.73 10.07 73 46352 64743 90517279
Miosis 17.62 10.07 23 46402 9461 90572561
Nausea 17.60 10.07 715 45710 1109601 89472421
Cardiac failure congestive 17.44 10.07 98 46327 98596 90483426
Product dose omission issue 17.42 10.07 227 46198 291460 90290562
Overdose 17.39 10.07 34 46391 157675 90424347
Dizziness 17.22 10.07 409 46016 588875 89993147
Osteopenia 17.13 10.07 37 46388 22965 90559057
Feeling abnormal 17.01 10.07 145 46280 167090 90414932
Lung disorder 16.79 10.07 32 46393 149851 90432171
Vision blurred 16.60 10.07 105 46320 110188 90471834
White blood cell count decreased 16.53 10.07 144 46281 166965 90415057
Bone pain 16.32 10.07 69 46356 61914 90520108
Distal intestinal obstruction syndrome 16.11 10.07 7 46418 516 90581506
Multiple sclerosis relapse 15.99 10.07 61 46364 52244 90529778
Angina unstable 15.96 10.07 19 46406 7124 90574898
Cerumen impaction 15.87 10.07 9 46416 1177 90580845
Impaired healing 15.79 10.07 64 46361 234135 90347887
Insomnia 15.72 10.07 249 46176 333225 90248797
Peripheral venous disease 15.69 10.07 12 46413 83909 90498113
Tooth disorder 15.64 10.07 43 46382 31047 90550975
Autoimmune disorder 15.63 10.07 10 46415 76734 90505288
Limb asymmetry 15.38 10.07 8 46417 881 90581141
Tooth fracture 15.31 10.07 25 46400 12575 90569447
Cognitive disorder 15.09 10.07 73 46352 69334 90512688
Benign vulval neoplasm 15.07 10.07 4 46421 63 90581959
Gingival disorder 14.98 10.07 14 46411 3977 90578045
Dislocation of vertebra 14.94 10.07 5 46420 55963 90526059
Pulmonary fibrosis 14.83 10.07 20 46405 107483 90474539
Rotator cuff syndrome 14.70 10.07 28 46397 15891 90566131
Malignant neoplasm progression 14.62 10.07 20 46405 106850 90475172
Foot fracture 14.60 10.07 38 46387 26568 90555454
Bone loss 14.57 10.07 13 46412 3479 90578543
Haemorrhoids 14.51 10.07 38 46387 26664 90555358
Gastrointestinal disorder 14.42 10.07 75 46350 256612 90325410
Spinal compression fracture 14.39 10.07 27 46398 15151 90566871
Interstitial lung disease 14.19 10.07 11 46414 76394 90505628
X-ray abnormal 14.13 10.07 3 46422 45421 90536601
Low density lipoprotein increased 14.09 10.07 19 46406 8066 90573956
Cardiac arrest 13.99 10.07 20 46405 104915 90477107
Sinus disorder 13.86 10.07 44 46381 34403 90547619
Aortic valve incompetence 13.79 10.07 17 46408 6607 90575415
Coeliac disease 13.77 10.07 3 46422 44607 90537415
Lupus-like syndrome 13.69 10.07 4 46421 48842 90533180
Cataract 13.69 10.07 73 46352 72019 90510003
Neutropenia 13.61 10.07 64 46361 224840 90357182
Nasal congestion 13.55 10.07 81 46344 83333 90498689
Infusion related reaction 13.24 10.07 143 46282 416637 90165385
Frequent bowel movements 13.19 10.07 61 46364 56874 90525148
Lower respiratory tract infection 13.11 10.07 75 46350 250584 90331438
Fatigue 13.10 10.07 719 45706 1153304 89428718
Oedema peripheral 13.08 10.07 195 46230 257720 90324302
Nail disorder 13.02 10.07 7 46418 59060 90522962
Chronic obstructive pulmonary disease 12.84 10.07 73 46352 73756 90508266
Loss of personal independence in daily activities 12.82 10.07 32 46393 136073 90445949
Cyst 12.75 10.07 27 46398 16534 90565488
Rib fracture 12.75 10.07 36 46389 26399 90555623
Hiatus hernia 12.68 10.07 35 46390 25326 90556696
Endodontic procedure 12.68 10.07 12 46413 3463 90578559
Scoliosis 12.67 10.07 19 46406 8888 90573134
Bone disorder 12.67 10.07 33 46392 23087 90558935
Abdominal pain upper 12.64 10.07 240 46185 332434 90249588
Lactic acidosis 12.64 10.07 5 46420 50458 90531564
Infantile apnoea 12.63 10.07 8 46417 1279 90580743
Suicide attempt 12.60 10.07 12 46413 75387 90506635
Stress 12.56 10.07 78 46347 81317 90500705
Hot flush 12.52 10.07 62 46363 59426 90522596
Blood triglycerides increased 12.46 10.07 24 46401 13737 90568285
Blood pressure increased 12.41 10.07 155 46270 197062 90384960
Tardive dyskinesia 12.36 10.07 21 46404 10909 90571113
Influenza like illness 12.29 10.07 77 46348 80534 90501488
Obesity 12.28 10.07 22 46403 105485 90476537
Ageusia 12.13 10.07 26 46399 16050 90565972
Neutrophil count increased 12.01 10.07 29 46396 19361 90562661
Lung neoplasm 12.00 10.07 16 46409 6719 90575303
Laryngeal pain 11.98 10.07 13 46412 4409 90577613
Pelvic fracture 11.93 10.07 25 46400 15194 90566828
Stomatitis 11.91 10.07 87 46338 274611 90307411
Uterine prolapse 11.91 10.07 8 46417 1412 90580610
Pneumonia aspiration 11.91 10.07 47 46378 40893 90541129
Pyrexia 11.88 10.07 253 46172 660232 89921790
Acute kidney injury 11.82 10.07 106 46319 320281 90261741
Coronary artery occlusion 11.82 10.07 18 46407 8536 90573486
Diverticulitis 11.66 10.07 50 46375 45137 90536885
Hepatitis B antibody positive 11.56 10.07 3 46422 43 90581979
Pain in jaw 11.55 10.07 52 46373 47933 90534089
Oedema 11.54 10.07 58 46367 200237 90381785
Pancytopenia 11.54 10.07 28 46397 120235 90461787
Skin cancer 11.54 10.07 23 46402 13496 90568526
Cataract operation 11.54 10.07 15 46410 6148 90575874
Traumatic arthritis 11.50 10.07 3 46422 44 90581978
Colitis 11.41 10.07 68 46357 69874 90512148
Cystic fibrosis 11.41 10.07 12 46413 3929 90578093
Drug hypersensitivity 11.39 10.07 168 46257 463441 90118581
Anxiety 11.27 10.07 222 46203 309550 90272472
Cholelithiasis 11.25 10.07 55 46370 52451 90529571
Breast fibrosis 11.20 10.07 3 46422 49 90581973
Thrombosis 11.18 10.07 70 46355 73181 90508841
Carotid bruit 11.12 10.07 6 46419 712 90581310
Musculoskeletal chest pain 11.12 10.07 32 46393 23718 90558304
Drug reaction with eosinophilia and systemic symptoms 11.11 10.07 4 46421 42754 90539268
Lacunar infarction 11.08 10.07 11 46414 3366 90578656
Liver disorder 11.04 10.07 29 46396 121240 90460782
Dyspepsia 10.90 10.07 152 46273 198008 90384014
Open reduction of fracture 10.85 10.07 7 46418 1155 90580867
Serotonin syndrome 10.81 10.07 3 46422 37884 90544138
Quadriplegia 10.72 10.07 9 46416 2222 90579800
Hip arthroplasty 10.69 10.07 14 46411 76194 90505828
Aortic valve sclerosis 10.59 10.07 7 46418 1203 90580819
Pollakiuria 10.51 10.07 39 46386 32966 90549056
Cerebrovascular accident 10.47 10.07 103 46322 123430 90458592
Medication error 10.45 10.07 17 46408 84635 90497387
Incisional drainage 10.45 10.07 5 46420 461 90581561
Metabolic acidosis 10.36 10.07 8 46417 55668 90526354
Prescribed underdose 10.30 10.07 14 46411 75005 90507017
Sleep disorder therapy 10.25 10.07 5 46420 481 90581541
Hysterectomy 10.24 10.07 20 46405 11564 90570458
Pregnancy 10.23 10.07 10 46415 62037 90519985
Bone marrow oedema syndrome 10.15 10.07 3 46422 71 90581951
Spinal laminectomy 10.14 10.07 6 46419 850 90581172

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood phosphorus increased 85.04 13.10 61 20920 12464 42587890
Appendicolith 83.36 13.10 62 20919 13394 42586960
Blood cholesterol increased 74.05 13.10 78 20903 26663 42573691
Toxicity to various agents 65.77 13.10 16 20965 229120 42371234
Fractional exhaled nitric oxide increased 65.58 13.10 26 20955 1583 42598771
Infective pulmonary exacerbation of cystic fibrosis 64.67 13.10 43 20938 7775 42592579
Appendicitis 64.09 13.10 64 20917 20549 42579805
Coronary artery disease 63.63 13.10 103 20878 53617 42546737
Stress 61.06 13.10 91 20890 44121 42556233
Myasthenia gravis 59.42 13.10 55 20926 16082 42584272
Blood uric acid increased 59.21 13.10 54 20927 15493 42584861
Plantar fasciitis 55.27 13.10 28 20953 3042 42597312
Dry mouth 50.71 13.10 79 20902 39800 42560554
Ventricular fibrillation 50.46 13.10 68 20913 30055 42570299
Cardiogenic shock 48.70 13.10 73 20908 35567 42564787
Sensation of foreign body 48.24 13.10 27 20954 3586 42596768
Hyperlipidaemia 47.90 13.10 56 20925 21460 42578894
Hyperphosphataemia 47.25 13.10 44 20937 12960 42587394
Drug interaction 46.49 13.10 38 20943 266961 42333393
Myoglobin blood increased 45.07 13.10 26 20955 3656 42596698
Acute kidney injury 43.74 13.10 71 20910 367266 42233088
Constipation 42.33 13.10 175 20806 162116 42438238
Activated partial thromboplastin time prolonged 39.82 13.10 44 20937 15859 42584495
Iron deficiency 39.37 13.10 37 20944 11024 42589330
Analgesic therapy 38.04 13.10 29 20952 6495 42593859
Bacterial infection 37.93 13.10 57 20924 27822 42572532
Ascites 36.56 13.10 84 20897 56594 42543760
Drug therapy 36.41 13.10 28 20953 6352 42594002
Abdominal distension 35.41 13.10 96 20885 71639 42528715
Brain natriuretic peptide increased 34.94 13.10 28 20953 6742 42593612
Hypophosphataemia 34.64 13.10 47 20934 20898 42579456
Neuralgia 34.27 13.10 52 20929 25595 42574759
Sleep disorder 31.81 13.10 72 20909 48023 42552331
Chronic obstructive pulmonary disease 31.69 13.10 85 20896 63029 42537325
Sleep disorder therapy 30.35 13.10 26 20955 6868 42593486
Completed suicide 29.12 13.10 6 20975 96459 42503895
Thrombosis 28.30 13.10 86 20895 68425 42531929
Secretion discharge 28.06 13.10 26 20955 7609 42592745
Off label use 28.01 13.10 192 20789 638143 41962211
Muscle spasms 27.48 13.10 99 20882 85945 42514409
Chest discomfort 25.47 13.10 79 20902 63537 42536817
Incorrect route of product administration 25.29 13.10 44 20937 24261 42576093
Diabetes mellitus 24.41 13.10 75 20906 60012 42540342
Exostosis 24.30 13.10 21 20960 5610 42594744
Febrile neutropenia 23.87 13.10 34 20947 185669 42414685
Cardiac disorder 23.65 13.10 65 20916 48867 42551487
Dyspnoea exertional 22.65 13.10 65 20916 50083 42550271
Anticoagulant therapy 21.81 13.10 18 20963 4517 42595837
Rubber sensitivity 21.68 13.10 8 20973 400 42599954
Drug ineffective 21.41 13.10 203 20778 629994 41970360
Therapy cessation 21.25 13.10 37 20944 20413 42579941
Antacid therapy 21.19 13.10 18 20963 4699 42595655
Blood calcium increased 20.49 13.10 23 20958 8431 42591923
Swelling 20.00 13.10 66 20915 54819 42545535
Aortic stenosis 19.86 13.10 23 20958 8722 42591632
Overdose 19.53 13.10 14 20967 105250 42495104
Malignant neoplasm progression 19.36 13.10 15 20966 108385 42491969
Dysphonia 19.26 13.10 43 20938 28407 42571947
Cardiac failure 18.82 13.10 15 20966 106841 42493513
Nasopharyngitis 18.38 13.10 86 20895 83910 42516444
Ulcer 17.41 13.10 30 20951 16411 42583943
Blood glucose increased 17.27 13.10 77 20904 73622 42526732
Benign prostatic hyperplasia 16.77 13.10 34 20947 21018 42579336
Treatment failure 16.75 13.10 5 20976 62619 42537735
Cataract nuclear 16.51 13.10 8 20973 789 42599565
Gout 16.37 13.10 40 20941 28015 42572339
Carotid bruit 15.48 13.10 5 20976 167 42600187
End stage renal disease 14.71 13.10 28 20953 16530 42583824
Hyponatraemia 14.19 13.10 92 20889 101370 42498984
Bacteroides infection 13.99 13.10 11 20970 2576 42597778
C-reactive protein increased 13.82 13.10 7 20974 63553 42536801
Metal poisoning 13.80 13.10 4 20977 92 42600262
Flatulence 13.76 13.10 35 20946 25117 42575237
Dilatation atrial 13.42 13.10 10 20971 2165 42598189

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood uric acid increased 119.25 10.66 92 53182 21437 110514588
Electric shock 117.37 10.66 41 53233 1787 110534238
Toxicity to various agents 103.65 10.66 51 53223 480504 110055521
Therapy cessation 97.28 10.66 114 53160 44743 110491282
Appendicolith 92.52 10.66 67 53207 14188 110521837
Hand deformity 91.69 10.66 3 53271 218503 110317522
Blood phosphorus increased 90.88 10.66 70 53204 16270 110519755
Hyperlipidaemia 87.73 10.66 97 53177 35751 110500274
Constipation 86.92 10.66 372 52902 357414 110178611
Post-traumatic stress disorder 80.13 10.66 46 53228 6550 110529475
Infective pulmonary exacerbation of cystic fibrosis 79.36 10.66 62 53212 14709 110521316
Synovitis 78.29 10.66 18 53256 274074 110261951
Intervertebral discitis 77.65 10.66 46 53228 6944 110529081
Maternal exposure during pregnancy 72.28 10.66 17 53257 254866 110281159
Treatment failure 71.99 10.66 22 53252 277212 110258813
Coronary artery disease 71.70 10.66 126 53148 71564 110464461
Pemphigus 70.09 10.66 10 53264 214560 110321465
Post cholecystectomy syndrome 70.01 10.66 23 53251 829 110535196
Back pain 69.73 10.66 358 52916 370638 110165387
Drug interaction 69.73 10.66 83 53191 500100 110035925
Multiple sclerosis 68.95 10.66 73 53201 25625 110510400
Systemic lupus erythematosus 68.21 10.66 19 53255 254319 110281706
Completed suicide 67.10 10.66 17 53257 242364 110293661
Vitamin B12 increased 66.58 10.66 28 53246 2027 110533998
Temperature intolerance 65.27 10.66 54 53220 13896 110522129
Chronic sinusitis 65.08 10.66 70 53204 25014 110511011
Duodenal ulcer perforation 63.72 10.66 6 53268 177694 110358331
Myasthenia gravis 62.91 10.66 64 53210 21447 110514578
Radiculopathy 61.10 10.66 60 53214 19276 110516749
Macular degeneration 60.74 10.66 63 53211 21596 110514429
Glossodynia 60.63 10.66 16 53258 221988 110314037
Low turnover osteopathy 60.37 10.66 26 53248 1996 110534029
Stress 60.18 10.66 147 53127 105201 110430824
Glomerular filtration rate increased 58.04 10.66 25 53249 1920 110534105
Appendicitis 57.86 10.66 70 53204 28394 110507631
Vaginal flatulence 56.80 10.66 47 53227 12097 110523928
Demyelination 55.97 10.66 42 53232 9387 110526638
Wound 55.03 10.66 22 53252 234415 110301610
Pericarditis 54.04 10.66 19 53255 219095 110316930
Anti-cyclic citrullinated peptide antibody positive 53.89 10.66 11 53263 181973 110354052
Muscle spasticity 53.81 10.66 76 53198 35839 110500186
Blood immunoglobulin A increased 52.94 10.66 22 53252 1546 110534479
Off label use 52.84 10.66 466 52808 1499719 109036306
Hyperphosphataemia 52.08 10.66 51 53223 16330 110519695
Female genital tract fistula 51.72 10.66 51 53223 16468 110519557
Granulocyte count increased 51.13 10.66 23 53251 1960 110534065
Proctitis 50.67 10.66 51 53223 16876 110519149
Ulcer 50.04 10.66 81 53193 43035 110492990
Rheumatoid factor positive 48.39 10.66 4 53270 131636 110404389
Vaginal discharge 48.27 10.66 51 53223 17857 110518168
Acute kidney injury 47.92 10.66 152 53122 635278 109900747
Intervertebral disc degeneration 47.85 10.66 51 53223 18034 110517991
Weight decreased 47.78 10.66 387 52887 467670 110068355
Febrile neutropenia 46.91 10.66 50 53224 316717 110219308
Analgesic therapy 46.73 10.66 34 53240 7250 110528775
Intentional product use issue 46.69 10.66 31 53243 247875 110288150
Blood test abnormal 46.65 10.66 63 53211 28491 110507534
Intentional overdose 46.13 10.66 5 53269 132496 110403529
Rheumatoid factor increased 46.01 10.66 23 53251 2482 110533543
Ventricular fibrillation 45.77 10.66 76 53198 41237 110494788
Aspartate aminotransferase 44.59 10.66 17 53257 952 110535073
Helicobacter infection 44.46 10.66 16 53258 181861 110354164
Drug therapy 44.45 10.66 33 53241 7258 110528767
Thrombosis 40.66 10.66 130 53144 108532 110427493
Contraindicated product administered 40.44 10.66 36 53238 248231 110287794
Paraesthesia oral 40.09 10.66 64 53210 33607 110502418
Joint noise 39.98 10.66 27 53247 5116 110530909
Drug ineffective 39.80 10.66 506 52768 1520034 109015991
Sleep disorder therapy 39.36 10.66 31 53243 7440 110528585
Femur fracture 39.18 10.66 74 53200 44395 110491630
Exposure during pregnancy 38.81 10.66 16 53258 167408 110368617
Incorrect route of product administration 38.30 10.66 91 53183 63970 110472055
Coordination abnormal 37.22 10.66 53 53221 25175 110510850
Cardiogenic shock 37.08 10.66 84 53190 57254 110478771
Neuralgia 37.06 10.66 76 53198 48402 110487623
Lip dry 36.90 10.66 3 53271 100080 110435945
Iron deficiency 36.84 10.66 45 53229 18431 110517594
Vitamin D deficiency 36.69 10.66 45 53229 18507 110517518
C-reactive protein increased 36.22 10.66 31 53243 217888 110318137
Liver injury 35.48 10.66 14 53260 150399 110385626
Dactylitis 35.27 10.66 23 53251 4110 110531915
Diverticulum 34.56 10.66 40 53234 15486 110520539
Myelosuppression 34.31 10.66 3 53271 94337 110441688
Folliculitis 34.30 10.66 19 53255 167634 110368391
Bronchitis 34.08 10.66 158 53116 156874 110379151
Balance disorder 33.67 10.66 128 53146 116432 110419593
Procedural pain 33.61 10.66 61 53213 35504 110500521
Chronic obstructive pulmonary disease 33.31 10.66 122 53152 109036 110426989
Progressive multifocal leukoencephalopathy 33.30 10.66 50 53224 24906 110511119
Neutropenia 33.09 10.66 83 53191 374537 110161488
Activated partial thromboplastin time prolonged 33.01 10.66 47 53227 22321 110513704
Blood calcium increased 32.87 10.66 42 53232 17998 110518027
Ear pain 32.24 10.66 76 53198 53150 110482875
Throat clearing 31.91 10.66 22 53252 4311 110531714
Aspartate aminotransferase increased 31.87 10.66 157 53117 159779 110376246
Hypophosphataemia 31.47 10.66 57 53217 33125 110502900
Product complaint 31.11 10.66 36 53238 13936 110522089
Depression 31.06 10.66 260 53014 317075 110218950
Spinal disorder 30.90 10.66 33 53241 11695 110524330
Facet joint syndrome 30.50 10.66 5 53269 96823 110439202
Overdose 30.24 10.66 41 53233 233753 110302272
Asthenia 29.95 10.66 482 52792 688517 109847508
Anticoagulant therapy 29.88 10.66 23 53251 5338 110530687
Antacid therapy 29.42 10.66 23 53251 5461 110530564
Suicide attempt 29.09 10.66 7 53267 103387 110432638
Flatulence 28.95 10.66 72 53202 52077 110483948
Red blood cell count decreased 28.52 10.66 83 53191 65840 110470185
Product use issue 28.35 10.66 68 53206 311627 110224398
Oral candidiasis 28.30 10.66 65 53209 44695 110491330
Angina unstable 27.98 10.66 37 53237 16395 110519630
Dry eye 27.85 10.66 74 53200 55719 110480306
Diabetes mellitus 27.77 10.66 108 53166 99273 110436752
Therapeutic product effect decreased 27.60 10.66 47 53227 244269 110291756
Abdominal distension 27.48 10.66 161 53113 174942 110361083
Blood glucose decreased 27.14 10.66 50 53224 29438 110506587
Depressed mood 26.73 10.66 77 53197 60732 110475293
Throat irritation 26.70 10.66 71 53203 53481 110482544
Drug reaction with eosinophilia and systemic symptoms 26.40 10.66 4 53270 82091 110453934
Ventricular hypertrophy 26.34 10.66 24 53250 7021 110529004
Cardiac failure 26.25 10.66 31 53243 187595 110348430
Lumbar spinal stenosis 26.21 10.66 23 53251 6410 110529615
Bacterial infection 26.02 10.66 64 53210 45972 110490053
Vitamin B12 deficiency 25.98 10.66 28 53246 10027 110525998
Glycosylated haemoglobin increased 25.56 10.66 43 53231 23576 110512449
Interstitial lung disease 25.45 10.66 18 53256 139316 110396709
Ascites 25.24 10.66 100 53174 92708 110443317
Blood triglycerides increased 25.15 10.66 43 53231 23883 110512142
Breast cancer stage III 25.11 10.66 4 53270 79113 110456912
White blood cells urine positive 25.00 10.66 24 53250 7500 110528525
Spinal osteoarthritis 24.91 10.66 39 53235 20144 110515881
Fall 24.66 10.66 418 52856 603064 109932961
Respiratory disorder 24.55 10.66 83 53191 71299 110464726
Transient ischaemic attack 24.34 10.66 77 53197 63905 110472120
Mitral valve incompetence 24.01 10.66 51 53223 33278 110502747
Carotid bruit 23.74 10.66 10 53264 727 110535298
Dental caries 23.69 10.66 30 53244 12743 110523282
Nausea 23.48 10.66 769 52505 1234921 109301104
Muscle injury 23.43 10.66 20 53254 140787 110395238
Fibromyalgia 23.10 10.66 29 53245 170880 110365145
Cholecystitis acute 23.05 10.66 33 53241 15749 110520276
Myocardial infarction 22.44 10.66 164 53110 191919 110344106
General physical health deterioration 22.40 10.66 117 53157 425178 110110847
Benign prostatic hyperplasia 22.18 10.66 35 53239 18199 110517826
Pancytopenia 22.17 10.66 42 53232 209571 110326454
Sleep disorder due to general medical condition, insomnia type 21.57 10.66 12 53262 105631 110430394
Alanine aminotransferase increased 21.52 10.66 157 53117 183616 110352409
Rotator cuff syndrome 21.49 10.66 33 53241 16761 110519264
Blood alkaline phosphatase increased 21.40 10.66 79 53195 70856 110465169
Monocyte count increased 21.21 10.66 29 53245 13264 110522761
Malignant neoplasm progression 21.20 10.66 32 53242 174535 110361490
Epilepsy 21.02 10.66 11 53263 100198 110435827
Blood pressure systolic decreased 20.96 10.66 29 53245 13412 110522613
Spinal epidural haematoma 20.87 10.66 12 53262 1713 110534312
Joint range of motion decreased 20.64 10.66 17 53257 121815 110414210
Spondylolisthesis 20.53 10.66 16 53258 3782 110532243
Headache 20.47 10.66 563 52711 881814 109654211
Cystocele 20.33 10.66 10 53264 1042 110534983
Drug intolerance 20.21 10.66 114 53160 406398 110129627
Inflammation 20.19 10.66 39 53235 193199 110342826
Aspartate aminotransferase abnormal 20.16 10.66 15 53259 3310 110532715
Aortic stenosis 20.10 10.66 28 53246 13031 110522994
Body temperature increased 20.04 10.66 65 53209 54648 110481377
Hepatic function abnormal 19.95 10.66 9 53265 89286 110446739
Fatigue 19.91 10.66 744 52530 1215214 109320811
Mobility decreased 19.88 10.66 54 53220 237368 110298657
Low density lipoprotein increased 19.70 10.66 25 53249 10641 110525384
Anaemia postoperative 19.68 10.66 12 53262 1909 110534116
Dry mouth 19.64 10.66 164 53110 199784 110336241
Wound infection 19.63 10.66 11 53263 96454 110439571
Stress urinary incontinence 19.61 10.66 12 53262 1921 110534104
Intervertebral disc protrusion 19.51 10.66 42 53232 27656 110508369
Psoriatic arthropathy 19.45 10.66 41 53233 196720 110339305
Neuropathy peripheral 19.21 10.66 150 53124 179127 110356898
Arthropathy 18.79 10.66 73 53201 287449 110248576
Cataract 18.75 10.66 82 53192 79403 110456622
Serotonin syndrome 18.75 10.66 3 53271 59150 110476875
Discomfort 18.61 10.66 48 53226 214659 110321366
Blood cholesterol increased 18.38 10.66 152 53122 184633 110351392
Body height decreased 18.32 10.66 24 53250 10539 110525486
Metabolic acidosis 18.07 10.66 13 53261 99731 110436294
Myalgia 18.06 10.66 175 53099 222206 110313819
Gastrooesophageal reflux disease 17.88 10.66 148 53126 179828 110356197
Laryngeal pain 17.88 10.66 18 53256 5957 110530068
Gout 17.74 10.66 48 53226 36518 110499507
Distal intestinal obstruction syndrome 17.62 10.66 9 53265 1016 110535009
Product use in unapproved indication 17.43 10.66 135 53139 447242 110088783
Thrombocytopenia 17.25 10.66 98 53176 348787 110187238
Blood urea increased 17.25 10.66 62 53212 54895 110481130
Gingival disorder 17.22 10.66 15 53259 4138 110531887
Ill-defined disorder 16.96 10.66 31 53243 156822 110379203
Renal cyst 16.96 10.66 31 53243 18141 110517884
Blepharospasm 16.90 10.66 3 53271 54848 110481177
Fractional exhaled nitric oxide increased 16.88 10.66 8 53266 768 110535257
Fracture nonunion 16.79 10.66 10 53264 1524 110534501
Stress fracture 16.74 10.66 19 53255 7202 110528823
Cytomegalovirus infection 16.73 10.66 3 53271 54441 110481584
Haematochezia 16.70 10.66 104 53170 115420 110420605
Blister 16.67 10.66 55 53219 227321 110308704
Cardiac failure congestive 16.54 10.66 127 53147 150873 110385152
Haemorrhoids 16.49 10.66 46 53228 35626 110500399
Product dose omission issue 15.82 10.66 230 53044 321552 110214473
Muscle strain 15.74 10.66 23 53251 11179 110524846
Renal impairment 15.67 10.66 43 53231 188402 110347623
Toxic epidermal necrolysis 15.65 10.66 4 53270 56723 110479302
End stage renal disease 15.63 10.66 33 53241 21440 110514585
Dizziness 15.47 10.66 443 52831 697750 109838275
Cough 15.43 10.66 310 52964 461331 110074694
Benign vulval neoplasm 15.31 10.66 4 53270 63 110535962
Delusional disorder, persecutory type 15.23 10.66 7 53267 627 110535398
Hypersensitivity 15.23 10.66 123 53151 403875 110132150
Grip strength decreased 15.12 10.66 10 53264 80164 110455861
Oral pain 15.11 10.66 46 53228 37398 110498627
Pyrexia 15.08 10.66 324 52950 897941 109638084
Limb asymmetry 14.98 10.66 7 53267 651 110535374
Cataract nuclear 14.96 10.66 9 53265 1397 110534628
Rubber sensitivity 14.86 10.66 11 53263 2407 110533618
Blood glucose increased 14.83 10.66 112 53162 132384 110403641
Bladder prolapse 14.75 10.66 9 53265 1433 110534592
Plantar fasciitis 14.59 10.66 15 53259 5086 110530939
Drug-induced liver injury 14.59 10.66 22 53252 120045 110415980
Nasal congestion 14.54 10.66 89 53185 98193 110437832
Troponin increased 14.37 10.66 39 53235 29727 110506298
Cytokine release syndrome 14.33 10.66 8 53266 70298 110465727
Nail disorder 14.32 10.66 5 53269 57930 110478095
Cardio-respiratory arrest 14.29 10.66 21 53253 115815 110420210
Agranulocytosis 14.15 10.66 6 53268 61754 110474271
Peripheral venous disease 13.93 10.66 12 53262 84105 110451920
Pulmonary function test decreased 13.91 10.66 19 53255 8681 110527344
Septic shock 13.82 10.66 35 53239 157493 110378532
Therapy non-responder 13.76 10.66 35 53239 157272 110378753
Breast fibrosis 13.69 10.66 3 53271 21 110536004
Influenza like illness 13.67 10.66 81 53193 88331 110447694
Cholestasis 13.65 10.66 7 53267 64511 110471514
Feeling abnormal 13.60 10.66 140 53134 180571 110355454
Coronary artery occlusion 13.59 10.66 26 53248 15746 110520279
Hypoglycaemia unawareness 13.45 10.66 5 53269 261 110535764
Bacteroides infection 13.03 10.66 11 53263 2908 110533117
Insomnia 13.01 10.66 245 53029 360345 110175680
Wheezing 12.99 10.66 71 53203 255159 110280866
Muscle spasms 12.96 10.66 197 53077 277960 110258065
Type 2 diabetes mellitus 12.90 10.66 43 53231 177189 110358836
Dermatitis atopic 12.87 10.66 34 53240 25507 110510518
Dementia Alzheimer's type 12.70 10.66 7 53267 922 110535103
Peripheral vascular disorder 12.63 10.66 18 53256 8558 110527467
Urinary tract infection 12.58 10.66 224 53050 326058 110209967
Somnolence 12.47 10.66 207 53067 297242 110238783
Carpal tunnel syndrome 12.32 10.66 31 53243 22579 110513446
Bone pain 12.30 10.66 63 53211 65070 110470955
Lactic acidosis 12.28 10.66 16 53258 92795 110443230
Dilatation atrial 12.26 10.66 12 53262 3840 110532185
Hiatus hernia 12.17 10.66 35 53239 27571 110508454
Confusional state 12.15 10.66 156 53118 468524 110067501
Pain 12.11 10.66 569 52705 954386 109581639
Total lung capacity decreased 12.08 10.66 16 53258 7098 110528927
Ligament sprain 12.05 10.66 25 53249 16043 110519982
Lacunar infarction 12.03 10.66 15 53259 6271 110529754
Lung neoplasm 11.96 10.66 17 53257 8059 110527966
Cystic fibrosis 11.92 10.66 13 53261 4718 110531307
Diarrhoea 11.81 10.66 666 52608 1138839 109397186
Oedema peripheral 11.75 10.66 223 53051 328437 110207588
Pregnancy 11.64 10.66 5 53269 51062 110484963
Osteopenia 11.63 10.66 30 53244 22179 110513846
Lung disorder 11.58 10.66 46 53228 180001 110356024
Abdominal pain upper 11.51 10.66 234 53040 348877 110187148
Cystic fibrosis lung 11.48 10.66 4 53270 173 110535852
Urinary incontinence 11.36 10.66 50 53224 48537 110487488
Traumatic arthritis 11.33 10.66 3 53271 50 110535975
Mucosal inflammation 11.31 10.66 18 53256 96123 110439902
Medication error 11.23 10.66 21 53253 105345 110430680
Multiple sclerosis relapse 11.22 10.66 51 53223 50189 110485836
Death 11.16 10.66 254 53020 698615 109837410
Diabetic retinopathy 11.15 10.66 11 53263 3553 110532472
Drug eruption 11.09 10.66 6 53268 53653 110482372
Burning sensation 11.08 10.66 64 53210 69148 110466877
Dysphagia 11.08 10.66 118 53156 153482 110382543
Cervicobrachial syndrome 11.08 10.66 7 53267 1185 110534840
Hepatic enzyme increased 11.06 10.66 100 53174 320792 110215233
Neurodermatitis 10.99 10.66 10 53264 2922 110533103
Adrenal insufficiency 10.98 10.66 45 53229 42345 110493680
Cognitive disorder 10.96 10.66 76 53198 87435 110448590
Injury 10.95 10.66 46 53228 177219 110358806
Scoliosis 10.95 10.66 17 53257 8716 110527309
Abdominal pain 10.94 10.66 324 52950 512665 110023360
Breast disorder 10.91 10.66 9 53265 2305 110533720
Obesity 10.88 10.66 24 53250 113327 110422698
Increased upper airway secretion 10.85 10.66 13 53261 5219 110530806
Dyspepsia 10.81 10.66 140 53134 190825 110345200
Prescribed overdose 10.68 10.66 16 53258 87565 110448460
Animal bite 10.68 10.66 10 53264 3029 110532996
Rash maculo-papular 10.66 10.66 12 53262 74210 110461815

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:25512 neurotransmitter
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:78675 fundamental metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypokalemia indication 43339004
Hypokalemia Prevention indication
Hyperkalemia contraindication 14140009
Complete atrioventricular block contraindication 27885002
Gastrointestinal ulcer contraindication 40845000
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Gastroparesis contraindication 235675006
Chronic diarrhea contraindication 236071009
Hyporeninemic hypoaldosteronism contraindication 236464008
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Severe dehydration contraindication 450316000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.45 acidic
pKa2 3.18 acidic
pKa3 10.47 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Calcium-binding mitochondrial carrier protein Aralar1 Transporter WOMBAT-PK
Aspartate aminotransferase, cytoplasmic Enzyme WOMBAT-PK
Aspartoacylase Enzyme WOMBAT-PK
Asparagine synthetase [glutamine-hydrolyzing] Enzyme WOMBAT-PK
Argininosuccinate synthase Enzyme WOMBAT-PK
Aminoacylase-1 Enzyme WOMBAT-PK
Aspartate aminotransferase, mitochondrial Enzyme WOMBAT-PK
Aspartate--tRNA ligase, cytoplasmic Enzyme WOMBAT-PK
Aspartyl/asparaginyl beta-hydroxylase Enzyme WOMBAT-PK
Excitatory amino acid transporter 1 Transporter IC50 5.03 CHEMBL
Excitatory amino acid transporter 2 Transporter IC50 4.50 CHEMBL
Excitatory amino acid transporter 3 Transporter IC50 4.71 CHEMBL
Calcium-binding mitochondrial carrier protein Aralar2 Transporter WOMBAT-PK
Glutamate NMDA receptor Ion channel IC50 5.79 CHEMBL
Excitatory amino acid transporter 4 Transporter IC50 4.96 CHEMBL
Glutamate transporter homolog Transporter Kd 9 CHEMBL
4-hydroxy-tetrahydrodipicolinate synthase Enzyme Ki 4.05 CHEMBL

External reference:

IDSource
4018680 VUID
N0000146991 NUI
D00013 KEGG_DRUG
4018680 VANDF
C0004015 UMLSCUI
CHEBI:17053 CHEBI
ASP PDB_CHEM_ID
CHEMBL274323 ChEMBL_ID
D001224 MESH_DESCRIPTOR_UI
DB00128 DRUGBANK_ID
1570 INN_ID
30KYC7MIAI UNII
5960 PUBCHEM_CID
1169 RXNORM
NOCODE MMSL
000933 NDDF
44970006 SNOMEDCT_US
3309 IUPHAR_LIGAND_ID
30KYC7MIAI INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-1933 SOLUTION 0.32 g INTRAVENOUS NDA 23 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-4500 SOLUTION 434 mg INTRAVENOUS ANDA 20 sections
ProSol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0499 INJECTION, SOLUTION 600 mg INTRAVENOUS NDA 21 sections
Clinisol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0502 INJECTION, SOLUTION 434 mg INTRAVENOUS ANDA 18 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1130 INJECTION, SOLUTION 0.32 g INTRAVENOUS ANDA 15 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1131 INJECTION, SOLUTION 0.19 g INTRAVENOUS ANDA 15 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0990-4178 INJECTION, SOLUTION 370 mg INTRAVENOUS NDA 13 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0990-4178 INJECTION, SOLUTION 370 mg INTRAVENOUS NDA 13 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0990-4179 INJECTION, SOLUTION 527 mg INTRAVENOUS NDA 14 sections
Aminosyn-PF HUMAN PRESCRIPTION DRUG LABEL 18 0990-4179 INJECTION, SOLUTION 527 mg INTRAVENOUS NDA 14 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0990-7171 INJECTION, SOLUTION 1050 mg INTRAVENOUS NDA 19 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0990-7171 INJECTION, SOLUTION 1050 mg INTRAVENOUS NDA 19 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0990-7172 INJECTION, SOLUTION 700 mg INTRAVENOUS NDA 19 sections
Aminosyn II HUMAN PRESCRIPTION DRUG LABEL 17 0990-7172 INJECTION, SOLUTION 700 mg INTRAVENOUS NDA 19 sections
Kabiven HUMAN PRESCRIPTION DRUG LABEL 24 63323-712 INJECTION, EMULSION 99 mg INTRAVENOUS NDA 26 sections
Perikabiven HUMAN PRESCRIPTION DRUG LABEL 24 63323-714 INJECTION, EMULSION 71 mg INTRAVENOUS NDA 26 sections
XIMONTH Presbyopia Vision Herbal Drops HUMAN OTC DRUG LABEL 4 84660-054 LIQUID 3 mg TOPICAL OTC Monograph Drug 8 sections
STYE EYE RELIEF SERUM HUMAN OTC DRUG LABEL 5 84896-001 PASTE 2 g TOPICAL OTC Monograph Drug 9 sections
STYE EYE RELIEF SERUM HUMAN OTC DRUG LABEL 5 84896-005 LIQUID 0.02 g OPHTHALMIC OTC Monograph Drug 9 sections