isosorbide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1501 652-67-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • isosorbide
  • (+)-D-Isosorbide
  • isobide
1,4:3,6-Dianhydro D-glucitol. Chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma.
  • Molecular weight: 146.14
  • Formula: C6H10O4
  • CLOGP: -1.53
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.92
  • ALOGS: 0.92
  • ROTB: 0
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AURKA,AXL,BRAF,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK2,PDK2,PDK4,PIK3CD,PRKDC,SIK2,STK33,TEK 25
kinase-selectivity-class CHUK,MAP2K6,PDK1 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Jan. 30, 1974 FDA ALCON

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiospasm 316.68 11.48 87 22270 3359 90602731
Palmoplantar keratoderma 315.17 11.48 87 22270 3420 90602670
Sleep terror 294.41 11.48 87 22270 4377 90601713
Subarachnoid haemorrhage 294.26 11.48 124 22233 17780 90588310
Pruritus genital 292.62 11.48 87 22270 4471 90601619
Carotid artery occlusion 284.58 11.48 92 22265 6250 90599840
Myocardial infarction 279.89 11.48 222 22135 105750 90500340
Atrial tachycardia 269.21 11.48 87 22270 5903 90600187
Tension headache 257.65 11.48 89 22268 7420 90598670
Anosmia 226.90 11.48 87 22270 9761 90596329
Immunisation 217.91 11.48 59 22298 2154 90603936
Facial pain 202.35 11.48 87 22270 13095 90592995
Pain of skin 191.97 11.48 89 22268 15993 90590097
Ventricular tachycardia 186.06 11.48 100 22257 24608 90581482
Vasculitis 171.31 11.48 92 22265 22601 90583489
Transient ischaemic attack 169.51 11.48 115 22242 43061 90563029
Muscle twitching 168.50 11.48 93 22264 24109 90581981
Blindness 165.74 11.48 95 22262 26473 90579617
Eye pruritus 147.66 11.48 91 22266 28936 90577154
Diplopia 143.48 11.48 89 22268 28625 90577465
Hallucination 126.38 11.48 115 22242 65844 90540246
Lip swelling 126.32 11.48 92 22265 38518 90567572
Cardiac failure congestive 120.86 11.48 135 22222 98559 90507531
Tinnitus 113.00 11.48 90 22267 43012 90563078
Disturbance in attention 110.11 11.48 92 22265 47017 90559073
Intentional product misuse 103.63 11.48 119 22238 89485 90516605
Chest pain 98.83 11.48 233 22124 319412 90286678
Blood glucose increased 97.75 11.48 119 22238 95127 90510963
Angioedema 95.74 11.48 98 22259 64778 90541312
Cognitive disorder 93.76 11.48 100 22257 69307 90536783
Rash papular 89.00 11.48 58 22299 20297 90585793
Dehydration 83.42 11.48 162 22195 194285 90411805
Palpitations 83.42 11.48 133 22224 136595 90469495
Dry skin 77.61 11.48 102 22255 87971 90518119
Hyperhidrosis 71.63 11.48 124 22233 136181 90469909
Heart rate increased 70.48 11.48 111 22246 112791 90493299
Amnesia 69.57 11.48 108 22249 108397 90497693
Visual impairment 67.71 11.48 119 22238 132246 90473844
Joint swelling 64.32 11.48 22 22335 503278 90102812
Feeling abnormal 62.96 11.48 132 22225 167103 90438987
Pemphigus 61.86 11.48 5 22352 326859 90279231
Drug ineffective 60.17 11.48 161 22196 1384137 89221953
Coronary artery disease 59.29 11.48 56 22301 33567 90572523
Infusion related reaction 57.22 11.48 16 22341 416764 90189326
Drug intolerance 54.74 11.48 21 22336 447570 90158520
Vascular stent stenosis 52.66 11.48 15 22342 661 90605429
Synovitis 52.65 11.48 9 22348 329743 90276347
Tachycardia 50.88 11.48 117 22240 157556 90448534
Systemic lupus erythematosus 49.47 11.48 14 22343 361882 90244208
Angina pectoris 48.64 11.48 54 22303 39106 90566984
Arthropathy 48.54 11.48 15 22342 366227 90239863
Hand deformity 47.50 11.48 8 22349 296354 90309736
Hepatic enzyme increased 47.41 11.48 15 22342 360721 90245369
Glossodynia 46.74 11.48 11 22346 321768 90284322
Acute myocardial infarction 46.62 11.48 50 22307 34840 90571250
Angina unstable 45.76 11.48 26 22331 7117 90598973
Maternal exposure during pregnancy 45.52 11.48 16 22341 360047 90246043
Treatment failure 44.92 11.48 10 22347 303918 90302172
Contraindicated product administered 44.47 11.48 12 22345 320127 90285963
Bradycardia 43.66 11.48 76 22281 83771 90522319
COVID-19 42.55 11.48 114 22243 168729 90437361
Generalised bullous fixed drug eruption 42.01 11.48 11 22346 352 90605738
Anti-cyclic citrullinated peptide antibody positive 41.11 11.48 5 22352 236428 90369662
Wound 40.88 11.48 12 22345 302968 90303122
Muscular weakness 40.03 11.48 127 22230 206539 90399551
Therapeutic product effect decreased 37.43 11.48 11 22346 277560 90328530
Swelling 31.68 11.48 34 22323 419024 90187066
Rheumatoid arthritis 31.42 11.48 26 22331 362588 90243502
Duodenal ulcer perforation 31.28 11.48 8 22349 221280 90384810
Hypersensitivity 31.04 11.48 40 22317 454637 90151453
Nasopharyngitis 30.80 11.48 33 22324 407071 90199019
Dyspnoea 30.75 11.48 342 22015 880613 89725477
Helicobacter infection 30.56 11.48 9 22348 226841 90379249
Discomfort 30.14 11.48 15 22342 274320 90331770
Memory impairment 29.29 11.48 111 22246 197133 90408957
Arteriospasm coronary 28.68 11.48 17 22340 5033 90601057
Lower respiratory tract infection 28.61 11.48 13 22344 250646 90355444
Drug hypersensitivity 28.45 11.48 44 22313 463565 90142525
Migraine 28.15 11.48 107 22250 190285 90415805
Muscle injury 27.79 11.48 5 22352 176649 90429441
Folliculitis 27.73 11.48 8 22349 204345 90401745
Renal failure 26.72 11.48 82 22275 130925 90475165
Infection 26.67 11.48 30 22327 362064 90244026
Myocardial ischaemia 26.27 11.48 24 22333 13790 90592300
Psoriatic arthropathy 25.82 11.48 12 22345 228323 90377767
Anxiety 25.70 11.48 147 22210 309625 90296465
Cardiac failure 25.65 11.48 72 22285 109424 90496666
Shock 24.82 11.48 33 22324 28745 90577345
BRASH syndrome 24.30 11.48 11 22346 1868 90604222
Mesenteric arterial occlusion 23.42 11.48 6 22351 176 90605914
Irritable bowel syndrome 21.81 11.48 12 22345 207436 90398654
Chronic kidney disease 21.70 11.48 42 22315 50149 90555941
Fibromyalgia 21.58 11.48 12 22345 206257 90399833
Musculoskeletal stiffness 21.36 11.48 25 22332 296507 90309583
Cerebrovascular accident 21.29 11.48 73 22284 123460 90482630
Impaired healing 21.27 11.48 16 22341 234183 90371907
Dizziness 21.06 11.48 230 22127 589054 90017036
Liver injury 20.82 11.48 8 22349 170559 90435531
Arrhythmia 20.26 11.48 37 22320 42295 90563795
Insomnia 19.54 11.48 145 22212 333329 90272761
Exposure during pregnancy 19.54 11.48 18 22339 238392 90367698
Rheumatoid factor positive 19.43 11.48 9 22348 171641 90434449
Hypotension 19.36 11.48 142 22215 325255 90280835
Blood urea increased 19.09 11.48 30 22327 30383 90575707
Hypovolaemic shock 18.98 11.48 15 22342 7079 90599011
Sinus bradycardia 18.72 11.48 22 22335 16930 90589160
Left ventricular hypertrophy 18.64 11.48 14 22343 6130 90599960
Lip erosion 18.43 11.48 8 22349 1230 90604860
Febrile neutropenia 18.40 11.48 8 22349 158341 90447749
Mucosal erosion 18.32 11.48 9 22348 1836 90604254
Paraesthesia 18.14 11.48 21 22336 250305 90355785
Incorrect product administration duration 17.97 11.48 23 22334 19299 90586791
Sinusitis 17.92 11.48 36 22321 343052 90263038
Drug interaction 17.81 11.48 123 22234 276330 90329760
Upper gastrointestinal haemorrhage 17.78 11.48 25 22332 22951 90583139
Coronary arterial stent insertion 17.29 11.48 10 22347 2830 90603260
Gynaecomastia 17.10 11.48 5 22352 242 90605848
Urticaria 17.03 11.48 32 22325 312702 90293388
Blood cholesterol increased 16.70 11.48 16 22341 207996 90398094
Hyperkalaemia 16.48 11.48 44 22313 64920 90541170
Electrocardiogram ST segment elevation 16.47 11.48 11 22346 4005 90602085
Neutropenia 16.15 11.48 19 22338 224885 90381205
Jugular vein distension 16.07 11.48 7 22350 1086 90605004
Pseudophaeochromocytoma 15.96 11.48 4 22353 107 90605983
Stomatitis 15.96 11.48 27 22330 274671 90331419
Type 2 diabetes mellitus 15.89 11.48 16 22341 203228 90402862
Rheumatic fever 15.88 11.48 9 22348 153112 90452978
Therapeutic product effect incomplete 15.46 11.48 15 22342 193881 90412209
Ischaemic cardiomyopathy 15.37 11.48 9 22348 2604 90603486
Back pain 15.34 11.48 132 22225 317043 90289047
Respiratory acidosis 15.23 11.48 14 22343 8105 90597985
Inflammation 15.21 11.48 13 22344 178579 90427511
Cardiac disorder 14.92 11.48 39 22318 56833 90549257
Off label use 14.69 11.48 188 22169 1102064 89504026
Atrioventricular block first degree 14.67 11.48 14 22343 8497 90597593
Coronary artery occlusion 14.61 11.48 14 22343 8540 90597550
Blood pressure decreased 14.45 11.48 46 22311 74849 90531241
Rhabdomyolysis 14.32 11.48 36 22321 51220 90554870
Acute kidney injury 14.29 11.48 131 22226 320256 90285834
Genital erosion 14.01 11.48 5 22352 458 90605632
Product use issue 13.74 11.48 39 22318 329880 90276210
Gastrointestinal haemorrhage 13.56 11.48 51 22306 90197 90515893
Acidosis 13.19 11.48 16 22341 12720 90593370
Cardiac failure chronic 13.13 11.48 11 22346 5635 90600455
Malaise 13.08 11.48 210 22147 585776 90020314
Abdominal pain upper 12.86 11.48 132 22225 332542 90273548
Haematocrit abnormal 12.81 11.48 6 22351 1101 90604989
Cerebral infarction 12.42 11.48 23 22334 26573 90579517
Condition aggravated 12.40 11.48 91 22266 595454 90010636
Weight increased 12.37 11.48 57 22300 417870 90188220
Pulseless electrical activity 12.28 11.48 13 22344 8919 90597171
Conjunctival cyst 12.21 11.48 3 22354 74 90606016
Hepatic atrophy 12.19 11.48 4 22353 284 90605806
Liver function test increased 12.11 11.48 3 22354 84852 90521238
Breast cancer stage III 12.03 11.48 3 22354 84444 90521646
Disseminated cytomegaloviral infection 12.02 11.48 4 22353 297 90605793
Bursitis 11.94 11.48 9 22348 131645 90474445
Therapeutic product effect increased 11.90 11.48 6 22351 1293 90604797
Peripheral vascular disorder 11.89 11.48 11 22346 6420 90599670
Acute coronary syndrome 11.88 11.48 14 22343 10799 90595291
Blood glucose decreased 11.88 11.48 21 22336 23408 90582682
Blood creatinine increased 11.83 11.48 53 22304 101333 90504757
Injection site reaction 11.78 11.48 4 22353 92076 90514014
Glomerular filtration rate abnormal 11.70 11.48 6 22351 1339 90604751
Nephrogenic systemic fibrosis 11.67 11.48 9 22348 4099 90601991
Hepatosplenic candidiasis 11.64 11.48 4 22353 328 90605762
Renal hypoplasia 11.58 11.48 3 22354 92 90605998

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiospasm 248.79 14.56 74 21327 1833 42598101
Palmoplantar keratoderma 228.26 14.56 72 21329 2182 42597752
Pruritus genital 217.10 14.56 72 21329 2567 42597367
Sleep terror 209.81 14.56 72 21329 2854 42597080
Atrial tachycardia 203.34 14.56 77 21324 4063 42595871
Tension headache 202.69 14.56 73 21328 3341 42596593
Myocardial infarction 196.80 14.56 275 21126 123734 42476200
Facial pain 194.05 14.56 75 21326 4185 42595749
Carotid artery occlusion 191.62 14.56 74 21327 4120 42595814
Anosmia 176.54 14.56 74 21327 5102 42594832
Immunisation 164.90 14.56 49 21352 1209 42598725
Chest pain 151.85 14.56 260 21141 139270 42460664
Cardiac failure congestive 149.52 14.56 199 21202 85403 42514531
Pain of skin 139.25 14.56 72 21329 8008 42591926
Muscle twitching 118.99 14.56 74 21327 11706 42588228
Pericarditis 117.30 14.56 77 21324 13367 42586567
Ventricular tachycardia 111.72 14.56 104 21297 30056 42569878
Eye pruritus 111.02 14.56 70 21331 11342 42588592
Subarachnoid haemorrhage 109.78 14.56 76 21325 14396 42585538
Blindness 108.08 14.56 82 21319 17896 42582038
Lip swelling 103.86 14.56 82 21319 18971 42580963
Vasculitis 99.91 14.56 79 21322 18315 42581619
Transient ischaemic attack 94.65 14.56 100 21301 33639 42566295
Diplopia 93.02 14.56 79 21322 20237 42579697
Amnesia 91.96 14.56 91 21310 28346 42571588
Rash papular 84.85 14.56 60 21341 11751 42588183
Drug ineffective 78.09 14.56 123 21278 630074 41969860
Disturbance in attention 74.12 14.56 83 21318 29783 42570151
Tinnitus 72.81 14.56 81 21320 28857 42571077
Migraine 67.16 14.56 73 21328 25341 42574593
Alopecia 66.97 14.56 78 21323 29198 42570736
Acute myocardial infarction 65.23 14.56 110 21291 58055 42541879
Cognitive disorder 65.10 14.56 83 21318 34089 42565845
Blood glucose increased 64.34 14.56 125 21276 73574 42526360
Angioedema 61.02 14.56 90 21311 42387 42557547
Coronary artery disease 59.45 14.56 101 21300 53619 42546315
Palpitations 58.20 14.56 97 21304 50700 42549234
Dry skin 57.66 14.56 94 21307 48244 42551690
Feeling abnormal 56.86 14.56 115 21286 69671 42530263
Hallucination 54.46 14.56 101 21300 57406 42542528
Visual impairment 54.38 14.56 86 21315 43027 42556907
Angina unstable 51.34 14.56 44 21357 11404 42588530
Dizziness 51.32 14.56 254 21147 249000 42350934
Heart rate increased 51.02 14.56 94 21307 53161 42546773
Silent myocardial infarction 50.28 14.56 15 21386 375 42599559
Abdominal discomfort 46.52 14.56 111 21290 75144 42524790
Off label use 45.20 14.56 167 21234 638168 41961766
Hyperhidrosis 45.05 14.56 123 21278 90389 42509545
Dehydration 44.26 14.56 164 21237 141603 42458331
Memory impairment 43.59 14.56 85 21316 50137 42549797
Angina pectoris 42 14.56 66 21335 32830 42567104
Muscular weakness 41.08 14.56 113 21288 83385 42516549
Myocardial ischaemia 40.07 14.56 47 21354 17715 42582219
Febrile neutropenia 35.45 14.56 25 21376 185678 42414256
Toxic epidermal necrolysis 34.60 14.56 54 21347 26696 42573238
Oral mucosal eruption 33.05 14.56 11 21390 396 42599538
Peripheral swelling 29.47 14.56 106 21295 90164 42509770
Product use in unapproved indication 28.89 14.56 30 21371 184426 42415508
Cardiac failure 28.75 14.56 118 21283 106738 42493196
Cutaneous lupus erythematosus 28.52 14.56 12 21389 834 42599100
Dyspnoea 27.56 14.56 341 21060 442280 42157654
Neutropenia 27.41 14.56 36 21365 199395 42400539
Coronary artery occlusion 26.31 14.56 30 21371 10967 42588967
Abdominal pain upper 26.11 14.56 96 21305 82513 42517421
Prinzmetal angina 26.02 14.56 13 21388 1344 42598590
Hypotension 25.32 14.56 218 21183 257413 42342521
Intentional product misuse 23.99 14.56 77 21324 61823 42538111
Anxiety 23.04 14.56 119 21282 118441 42481493
Bradycardia 22.67 14.56 94 21307 85390 42514544
Toxicity to various agents 22.66 14.56 51 21350 229085 42370849
Insomnia 21.81 14.56 117 21284 118136 42481798
Coma uraemic 21.80 14.56 5 21396 42 42599892
Back pain 21.41 14.56 133 21268 141643 42458291
Bleeding time prolonged 20.82 14.56 9 21392 669 42599265
Drug intolerance 19.46 14.56 8 21393 80416 42519518
Drug abuse 18.82 14.56 15 21386 104756 42495178
Pulmonary oedema 18.61 14.56 64 21337 53208 42546726
Chronic kidney disease 18.51 14.56 59 21342 47182 42552752
Condition aggravated 17.82 14.56 69 21332 260685 42339249
Pruritus 17.10 14.56 157 21244 188614 42411320
Malaise 17.03 14.56 172 21229 211984 42387950
Arteriospasm coronary 16.88 14.56 16 21385 4722 42595212
Syncope 16.75 14.56 96 21305 99310 42500624
Ischaemia 16.02 14.56 16 21385 5031 42594903
Tachycardia 15.99 14.56 96 21305 100991 42498943
Renal failure 15.90 14.56 125 21276 143601 42456333
Cardiac disorder 15.56 14.56 57 21344 48875 42551059
Disease progression 14.99 14.56 31 21370 143625 42456309
Oesophageal ulcer haemorrhage 14.84 14.56 6 21395 377 42599557

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiospasm 543.29 11.87 155 38492 4812 110545840
Palmoplantar keratoderma 522.04 11.87 153 38494 5234 110545418
Pruritus genital 493.19 11.87 153 38494 6369 110544283
Sleep terror 491.17 11.87 153 38494 6457 110544195
Myocardial infarction 465.70 11.87 445 38202 191638 110359014
Atrial tachycardia 461.27 11.87 158 38489 9020 110541632
Carotid artery occlusion 454.88 11.87 158 38489 9407 110541245
Tension headache 442.49 11.87 155 38492 9463 110541189
Anosmia 403.20 11.87 155 38492 12317 110538335
Subarachnoid haemorrhage 381.92 11.87 193 38454 29509 110521143
Facial pain 378.88 11.87 157 38490 15182 110535470
Immunisation 364.66 11.87 103 38544 3080 110547572
Pain of skin 332.41 11.87 155 38492 19874 110530778
Muscle twitching 287.15 11.87 160 38487 29775 110520877
Ventricular tachycardia 286.03 11.87 192 38455 49817 110500835
Blindness 276.19 11.87 167 38480 36192 110514460
Vasculitis 265.38 11.87 162 38485 35711 110514941
Cardiac failure congestive 261.07 11.87 292 38355 150708 110399944
Eye pruritus 257.91 11.87 154 38493 32621 110518031
Transient ischaemic attack 250.07 11.87 195 38452 63787 110486865
Diplopia 239.93 11.87 161 38486 41733 110508919
Lip swelling 223.51 11.87 166 38481 50501 110500151
Disturbance in attention 198.05 11.87 168 38479 61827 110488825
Chest pain 194.43 11.87 415 38232 375960 110174692
Tinnitus 187.15 11.87 161 38486 60379 110490273
Hallucination 183.59 11.87 201 38446 101231 110449421
Rash papular 174.72 11.87 113 38534 27526 110523126
Blood glucose increased 174.26 11.87 223 38424 132273 110418379
Cognitive disorder 159.37 11.87 174 38473 87337 110463315
Angioedema 154.12 11.87 181 38466 98319 110452333
Amnesia 153.93 11.87 187 38460 105221 110445431
Dry skin 141.23 11.87 181 38466 107472 110443180
Dehydration 129.25 11.87 295 38352 279216 110271436
Hyperhidrosis 126.12 11.87 231 38416 187067 110363585
Intentional product misuse 122.97 11.87 189 38458 132715 110417937
Visual impairment 121.34 11.87 189 38458 134239 110416413
Drug ineffective 120.43 11.87 218 38429 1520322 109030330
Heart rate increased 119.90 11.87 195 38452 143639 110407013
Palpitations 119.59 11.87 206 38441 159006 110391646
Acute myocardial infarction 116.44 11.87 145 38502 83632 110467020
Coronary artery disease 114.23 11.87 133 38514 71557 110479095
Feeling abnormal 105.76 11.87 210 38437 180501 110370151
Angina unstable 98.51 11.87 65 38582 16367 110534285
Muscular weakness 77.27 11.87 226 38421 248242 110302410
Joint swelling 75.74 11.87 30 38617 442815 110107837
Drug intolerance 75.57 11.87 24 38623 406488 110144164
Myocardial ischaemia 72.53 11.87 66 38581 26618 110524034
Infusion related reaction 71.75 11.87 22 38625 381140 110169512
Tachycardia 67.46 11.87 203 38444 226442 110324210
Bradycardia 67.26 11.87 160 38487 155357 110395295
Migraine 67.23 11.87 170 38477 171482 110379170
Treatment failure 66.60 11.87 9 38638 277225 110273427
Synovitis 65.60 11.87 9 38638 274083 110276569
Dizziness 59.25 11.87 432 38215 697761 109852891
Silent myocardial infarction 59.10 11.87 18 38629 703 110549949
Memory impairment 58.22 11.87 176 38471 196768 110353884
Arthropathy 57.05 11.87 15 38632 287507 110263145
Angina pectoris 56.75 11.87 88 38559 62207 110488445
Pemphigus 51.45 11.87 7 38640 214563 110336089
Hepatic enzyme increased 51.24 11.87 24 38623 320868 110229784
Hand deformity 50.37 11.87 8 38639 218498 110332154
Rheumatoid arthritis 50.06 11.87 21 38626 299592 110251060
Systemic lupus erythematosus 49.08 11.87 14 38633 254324 110296328
Nasopharyngitis 48.46 11.87 40 38607 394321 110156331
Anxiety 48.04 11.87 243 38404 344835 110205817
COVID-19 47.19 11.87 190 38457 244870 110305782
Swelling 46.45 11.87 33 38614 351008 110199644
Anti-cyclic citrullinated peptide antibody positive 45.93 11.87 5 38642 181979 110368673
Cardiac failure 45.76 11.87 157 38490 187469 110363183
Maternal exposure during pregnancy 45.67 11.87 16 38631 254867 110295785
Hypotension 43.15 11.87 322 38325 523527 110027125
Dyspnoea 43.08 11.87 582 38065 1106290 109444362
Arteriospasm coronary 42.78 11.87 31 38616 9069 110541583
Lower respiratory tract infection 42.31 11.87 16 38631 243090 110307562
Febrile neutropenia 41.62 11.87 30 38617 316737 110233915
Off label use 41.53 11.87 331 38316 1499854 109050798
Therapeutic product effect decreased 41.00 11.87 17 38630 244299 110306353
Wound 39.85 11.87 16 38631 234421 110316231
Glossodynia 39.66 11.87 14 38633 221990 110328662
Renal failure 39.18 11.87 170 38477 226404 110324248
Insomnia 38.25 11.87 236 38411 360354 110190298
Duodenal ulcer perforation 37.74 11.87 8 38639 177692 110372960
Coronary artery occlusion 37.08 11.87 36 38611 15736 110534916
Pericarditis 36.82 11.87 163 38484 218951 110331701
Back pain 36.37 11.87 238 38409 370758 110179894
Contraindicated product administered 36.03 11.87 21 38626 248246 110302406
Neutropenia 35.86 11.87 47 38600 374573 110176079
Psoriatic arthropathy 34.15 11.87 13 38634 196748 110353904
Prinzmetal angina 32.87 11.87 16 38631 2253 110548399
Folliculitis 32.76 11.87 9 38638 167644 110383008
Musculoskeletal stiffness 32.40 11.87 30 38617 279792 110270860
Drug hypersensitivity 32.33 11.87 69 38578 454021 110096631
Drug interaction 32.30 11.87 291 38356 499892 110050760
Toxic epidermal necrolysis 32.04 11.87 65 38582 56662 110493990
Helicobacter infection 31.59 11.87 12 38635 181865 110368787
Condition aggravated 31.44 11.87 141 38506 734695 109815957
Syncope 31.29 11.87 147 38500 202389 110348263
Hypersensitivity 30.79 11.87 59 38588 403939 110146713
Muscle injury 30.61 11.87 6 38641 140801 110409851
Infection 30.21 11.87 50 38597 362150 110188502
Blood urea increased 29.89 11.87 62 38585 54895 110495757
Therapeutic product effect incomplete 29.64 11.87 21 38626 223784 110326868
Generalised bullous fixed drug eruption 29.62 11.87 11 38636 793 110549859
Impaired healing 29.46 11.87 16 38631 196701 110353951
Product use in unapproved indication 29.39 11.87 71 38576 447306 110103346
Discomfort 28.63 11.87 20 38627 214687 110335965
Irritable bowel syndrome 28.24 11.87 11 38636 164204 110386448
Rhabdomyolysis 27.83 11.87 99 38548 120302 110430350
Inflammation 27.11 11.87 17 38630 193221 110357431
Fibromyalgia 26.93 11.87 13 38634 170896 110379756
Chronic kidney disease 26.22 11.87 72 38575 76219 110474433
Abdominal pain upper 26.15 11.87 210 38437 348901 110201751
Oral mucosal eruption 25.56 11.87 11 38636 1166 110549486
Cerebrovascular accident 25.43 11.87 128 38519 181156 110369496
Weight increased 24.96 11.87 70 38577 419574 110131078
Stomatitis 24.74 11.87 35 38612 270207 110280445
Gastrointestinal haemorrhage 24.74 11.87 119 38528 165399 110385253
Acute coronary syndrome 24.41 11.87 35 38612 23077 110527575
Hyperkalaemia 23.54 11.87 102 38545 135694 110414958
Bursitis 23.53 11.87 8 38639 129910 110420742
Coma uraemic 23.50 11.87 5 38642 43 110550609
C-reactive protein abnormal 23.47 11.87 8 38639 129687 110420965
Occult blood positive 23.40 11.87 20 38627 7425 110543227
Product use issue 23.32 11.87 46 38601 311649 110239003
Blood creatinine increased 22.81 11.87 125 38522 182764 110367888
General physical health deterioration 22.40 11.87 75 38572 425220 110125432
Rheumatoid factor positive 22.34 11.87 9 38638 131631 110419021
Ischaemic cardiomyopathy 22.13 11.87 20 38627 7991 110542661
Sinusitis 22.01 11.87 44 38603 296644 110254008
Atrioventricular block first degree 21.99 11.87 26 38621 14199 110536453
Ischaemia 21.86 11.87 21 38626 9062 110541590
Pulmonary oedema 21.76 11.87 81 38566 100578 110450074
Cardiac disorder 21.43 11.87 67 38580 76213 110474439
Liver injury 21.42 11.87 13 38634 150400 110400252
Cutaneous lupus erythematosus 21.40 11.87 14 38633 3474 110547178
Pruritus 21.37 11.87 303 38344 581257 109969395
Inappropriate schedule of product administration 21.11 11.87 24 38623 203613 110347039
Wheezing 20.57 11.87 36 38611 255194 110295458
Type 2 diabetes mellitus 20.51 11.87 19 38628 177213 110373439
Rheumatic fever 19.81 11.87 9 38638 122570 110428082
Coronary artery stenosis 19.40 11.87 24 38623 13734 110536918
Exposure during pregnancy 19.31 11.87 18 38629 167406 110383246
Dry mouth 19.21 11.87 25 38622 199923 110350729
Mesenteric arterial occlusion 18.92 11.87 6 38641 268 110550384
Lung disorder 18.90 11.87 21 38626 180026 110370626
Coronary arterial stent insertion 18.81 11.87 16 38631 5899 110544753
Neuropathy peripheral 18.72 11.87 21 38626 179256 110371396
Gastrointestinal disorder 18.71 11.87 35 38612 241917 110308735
Night sweats 18.50 11.87 12 38635 133971 110416681
Bleeding time prolonged 18.32 11.87 9 38638 1293 110549359
Electrocardiogram ST segment elevation 18.04 11.87 19 38628 9141 110541511
Breast cancer stage III 17.99 11.87 3 38644 79114 110471538
Blood cholesterol increased 17.85 11.87 23 38624 184762 110365890
Cardiac failure chronic 17.74 11.87 23 38624 13788 110536864
Drug ineffective for unapproved indication 17.50 11.87 7 38640 102831 110447821
Blood pressure decreased 17.38 11.87 83 38564 115008 110435644
International normalised ratio increased 17.26 11.87 68 38579 86704 110463948
Pulseless electrical activity 17.15 11.87 25 38622 16732 110533920
Hypoglycaemia 17.00 11.87 83 38564 116021 110434631
Asthma 16.20 11.87 40 38607 250251 110300401
Atrial fibrillation 16.03 11.87 136 38511 229506 110321146
Sleep disorder 16.02 11.87 28 38619 198616 110352036
Shock 15.92 11.87 48 38599 53540 110497112
Arrhythmia 15.89 11.87 57 38590 69518 110481134
Intentional product use issue 15.85 11.87 144 38503 247762 110302890
Renal hypoplasia 15.68 11.87 3 38644 14 110550638
Mucosal inflammation 15.63 11.87 7 38640 96134 110454518
Urticaria 15.60 11.87 58 38589 318799 110231853
Arterial injury 15.54 11.87 7 38640 827 110549825
Peripheral vascular disorder 15.51 11.87 17 38630 8559 110542093
Musculoskeletal pain 15.50 11.87 25 38622 182998 110367654
Peripheral swelling 15.43 11.87 212 38435 403822 110146830
Osteoarthritis 15.41 11.87 25 38622 182598 110368054
Injection site reaction 15.26 11.87 6 38641 89064 110461588
Sleep disorder due to general medical condition, insomnia type 15.23 11.87 9 38638 105634 110445018
Myelosuppression 15.13 11.87 7 38640 94333 110456319
Arthritis 15.04 11.87 22 38625 167564 110383088
Incorrect product administration duration 14.69 11.87 26 38621 20472 110530180
Myopathy 14.57 11.87 29 38618 24931 110525721
Cardio-respiratory arrest 14.32 11.87 79 38568 115757 110434895
Facet joint syndrome 14.31 11.87 8 38639 96820 110453832
C-reactive protein increased 13.97 11.87 35 38612 217884 110332768
Left ventricular hypertrophy 13.90 11.87 20 38627 13224 110537428
Pseudophaeochromocytoma 13.81 11.87 4 38643 131 110550521
Epilepsy 13.80 11.87 9 38638 100200 110450452
BRASH syndrome 13.78 11.87 11 38636 3712 110546940
Jugular vein distension 13.77 11.87 8 38639 1608 110549044
Lip dry 13.77 11.87 9 38638 100074 110450578
Adverse drug reaction 13.73 11.87 73 38574 105486 110445166
Ill-defined disorder 13.68 11.87 21 38626 156832 110393820
Dyspepsia 13.58 11.87 29 38618 190936 110359716
Liver function test increased 13.55 11.87 7 38640 88541 110462111
Cytokine release syndrome 13.31 11.87 4 38643 70302 110480350
Ephelides 13.31 11.87 4 38643 149 110550503
Abdominal discomfort 13.19 11.87 202 38445 393656 110156996
Upper gastrointestinal haemorrhage 13.16 11.87 43 38604 50053 110500599
Paraesthesia 13.07 11.87 51 38596 276470 110274182
Malaise 13.05 11.87 317 38330 671502 109879150
Pulmonary fibrosis 12.95 11.87 10 38637 102032 110448620
Cardiac failure acute 12.90 11.87 27 38620 24051 110526601
Lip erosion 12.71 11.87 8 38639 1858 110548794
Acute kidney injury 12.69 11.87 301 38346 635129 109915523
Pulmonary embolism 12.57 11.87 36 38611 214438 110336214
Atrioventricular block complete 12.53 11.87 24 38623 20058 110530594
Loss of consciousness 12.53 11.87 114 38533 196192 110354460
Hepatic function abnormal 12.48 11.87 63 38584 89232 110461420
Hypovolaemic shock 12.44 11.87 20 38627 14563 110536089
Peripheral venous disease 12.36 11.87 7 38640 84110 110466542
Swollen joint count increased 12.24 11.87 7 38640 83654 110466998
Obesity 12.14 11.87 13 38634 113338 110437314
Mucosal erosion 11.88 11.87 9 38638 2815 110547837

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D004232 Diuretics
MeSH PA D004234 Diuretics, Osmotic
MeSH PA D045283 Natriuretic Agents
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ocular hypertension indication 4210003 DOID:9282




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018584 VUID
N0000146900 NUI
D00347 KEGG_DRUG
4018584 VANDF
C0022251 UMLSCUI
CHEBI:6060 CHEBI
CHEMBL1200660 ChEMBL_ID
DB09401 DRUGBANK_ID
D007547 MESH_DESCRIPTOR_UI
5780 PUBCHEM_CID
6433 INN_ID
WXR179L51S UNII
6057 RXNORM
4933 MMSL
d00653 MMSL
000687 NDDF
108478001 SNOMEDCT_US
386853004 SNOMEDCT_US

Pharmaceutical products:

None