isosorbide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1501 652-67-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • isosorbide
  • (+)-D-Isosorbide
  • isobide
1,4:3,6-Dianhydro D-glucitol. Chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma.
  • Molecular weight: 146.14
  • Formula: C6H10O4
  • CLOGP: -1.53
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.92
  • ALOGS: 0.92
  • ROTB: 0
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 30, 1974 FDA ALCON

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 197.77 13.87 183 16668 99710 63372461
Subarachnoid haemorrhage 195.89 13.87 89 16762 14194 63457977
Cardiospasm 194.10 13.87 53 16798 1854 63470317
Palmoplantar keratoderma 191.42 13.87 53 16798 1954 63470217
Pruritus genital 176.78 13.87 53 16798 2601 63469570
Sleep terror 176.27 13.87 53 16798 2627 63469544
Carotid artery occlusion 166.10 13.87 58 16793 4636 63467535
Atrial tachycardia 152.37 13.87 53 16798 4187 63467984
Tension headache 149.29 13.87 55 16796 5131 63467040
Anosmia 127.56 13.87 53 16798 6807 63465364
Immunisation 120.68 13.87 33 16818 1160 63471011
Cardiac failure congestive 109.97 13.87 129 16722 92304 63379867
Ventricular tachycardia 105.83 13.87 66 16785 19913 63452258
Facial pain 105.68 13.87 53 16798 10508 63461663
Pain of skin 103.69 13.87 54 16797 11580 63460591
Transient ischaemic attack 98.45 13.87 81 16770 37672 63434499
Vasculitis 91.05 13.87 58 16793 18151 63454020
Chest pain 89.58 13.87 185 16666 215774 63256397
Blindness 88.81 13.87 61 16790 21638 63450533
Eye pruritus 84.82 13.87 56 16795 18615 63453556
Muscle twitching 84.56 13.87 57 16794 19611 63452560
Intentional product misuse 82.57 13.87 91 16760 60826 63411345
Hallucination 74.48 13.87 82 16769 54735 63417436
Diplopia 70.56 13.87 55 16796 23673 63448498
Lip swelling 63.47 13.87 58 16793 31005 63441166
Drug ineffective 60.11 13.87 117 16734 1044648 62427523
Blood glucose increased 56.82 13.87 89 16762 83667 63388504
Generalised bullous fixed drug eruption 54.18 13.87 11 16840 100 63472071
Joint swelling 53.40 13.87 11 16840 327655 63144516
Amnesia 52.28 13.87 69 16782 55516 63416655
Angioedema 52.16 13.87 64 16787 47901 63424270
Disturbance in attention 51.64 13.87 57 16794 38132 63434039
Tinnitus 51.35 13.87 55 16796 35573 63436598
Coronary artery disease 50.26 13.87 52 16799 32325 63439846
Rash papular 45.82 13.87 36 16815 15666 63456505
Systemic lupus erythematosus 43.78 13.87 3 16848 208915 63263256
Dry skin 42.16 13.87 63 16788 56824 63415347
Drug intolerance 41.59 13.87 15 16836 308646 63163525
Angina unstable 41.55 13.87 25 16826 7070 63465101
Contraindicated product administered 40.62 13.87 5 16846 217643 63254528
Visual impairment 40.53 13.87 77 16774 84369 63387802
Bradycardia 40.50 13.87 71 16780 73156 63399015
Infusion related reaction 40.48 13.87 8 16843 245513 63226658
Acute myocardial infarction 40.10 13.87 46 16805 32078 63440093
Dehydration 39.30 13.87 118 16733 173236 63298935
Cognitive disorder 38.80 13.87 60 16791 55755 63416416
Therapeutic product effect decreased 37.14 13.87 4 16847 193183 63278988
Glossodynia 36.25 13.87 3 16848 178873 63293298
Hyperhidrosis 36.24 13.87 85 16766 107751 63364420
Arthropathy 35.99 13.87 9 16842 234783 63237388
Angina pectoris 35.75 13.87 42 16809 30036 63442135
Maternal exposure during pregnancy 34.58 13.87 8 16843 220054 63252117
Palpitations 32.70 13.87 84 16767 112686 63359485
Hepatic enzyme increased 32.50 13.87 7 16844 202321 63269850
Heart rate increased 30.27 13.87 73 16778 94165 63378006
Rheumatoid arthritis 29.92 13.87 15 16836 253804 63218367
Wound 29.85 13.87 4 16847 163259 63308912
Feeling abnormal 27.24 13.87 94 16757 148298 63323873
Swelling 25.98 13.87 21 16830 275357 63196814
Muscular weakness 25.58 13.87 81 16770 122272 63349899
Tachycardia 25.42 13.87 79 16772 118077 63354094
Cerebrovascular accident 24.90 13.87 74 16777 107950 63364221
COVID-19 24.68 13.87 76 16775 113027 63359144
Product use issue 24.56 13.87 14 16837 220506 63251665
Myocardial ischaemia 24.31 13.87 23 16828 12836 63459335
Mesenteric arterial occlusion 23.46 13.87 6 16845 162 63472009
Arteriospasm coronary 23.28 13.87 14 16837 3954 63468217
Renal failure 22.89 13.87 76 16775 117576 63354595
Discomfort 22.75 13.87 8 16843 167366 63304805
Memory impairment 22.69 13.87 70 16781 104188 63367983
Cardiac failure 22.41 13.87 63 16788 89079 63383092
Infection 22.21 13.87 17 16834 229156 63243015
Dyspnoea 20.78 13.87 267 16584 661046 62811125
Migraine 20.31 13.87 67 16784 103279 63368892
Hypersensitivity 20.18 13.87 29 16822 292656 63179515
Nasopharyngitis 19.79 13.87 23 16828 254234 63217937
Hypovolaemic shock 19.71 13.87 15 16836 6226 63465945
Lip erosion 19.57 13.87 8 16843 985 63471186
Left ventricular hypertrophy 19.55 13.87 14 16837 5301 63466870
Mucosal erosion 19.37 13.87 9 16842 1507 63470664
Genital erosion 18.44 13.87 5 16846 170 63472001
Sinus bradycardia 18.43 13.87 21 16830 14530 63457641
Musculoskeletal stiffness 17.50 13.87 14 16837 184604 63287567
BRASH syndrome 17.38 13.87 6 16845 463 63471708
Gynaecomastia 17.00 13.87 5 16846 229 63471942
Lower respiratory tract infection 16.85 13.87 7 16844 132300 63339871
Drug hypersensitivity 16.69 13.87 36 16815 310651 63161520
Respiratory acidosis 16.64 13.87 14 16837 6701 63465470
Chronic kidney disease 16.58 13.87 37 16814 45361 63426810
Acute kidney injury 15.36 13.87 121 16730 263294 63208877
Ischaemic cardiomyopathy 15.21 13.87 9 16842 2468 63469703
Blood urea increased 15.12 13.87 26 16825 26353 63445818
Psoriatic arthropathy 15.03 13.87 3 16848 91517 63380654
Paraesthesia 14.75 13.87 12 16839 156954 63315217
Renal hypoplasia 14.52 13.87 3 16848 30 63472141
Exposure during pregnancy 14.48 13.87 12 16839 155535 63316636
Dizziness 14.06 13.87 175 16676 429750 63042421

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiospasm 207.25 14.10 63 19246 1525 34936097
Palmoplantar keratoderma 190.36 14.10 62 19247 1891 34935731
Pruritus genital 179.07 14.10 61 19248 2143 34935479
Sleep terror 176.06 14.10 61 19248 2257 34935365
Tension headache 167.10 14.10 63 19246 2979 34934643
Atrial tachycardia 166.45 14.10 66 19243 3579 34934043
Facial pain 161.95 14.10 65 19244 3639 34933983
Myocardial infarction 159.50 14.10 259 19050 120826 34816796
Carotid artery occlusion 154.52 14.10 63 19246 3674 34933948
Anosmia 153.37 14.10 64 19245 3960 34933662
Immunisation 141.71 14.10 43 19266 1034 34936588
Cardiac failure congestive 131.79 14.10 194 19115 83076 34854546
Chest pain 125.18 14.10 239 19070 126523 34811099
Pain of skin 121.94 14.10 62 19247 6047 34931575
Eye pruritus 104.69 14.10 60 19249 7429 34930193
Vasculitis 98.38 14.10 67 19242 11229 34926393
Muscle twitching 94.27 14.10 63 19246 10235 34927387
Pericarditis 94.19 14.10 66 19243 11579 34926043
Blindness 87.82 14.10 70 19239 14916 34922706
Subarachnoid haemorrhage 87.11 14.10 65 19244 12570 34925052
Ventricular tachycardia 86.21 14.10 89 19220 26490 34911132
Lip swelling 85.57 14.10 71 19238 16009 34921613
Transient ischaemic attack 83.38 14.10 89 19220 27524 34910098
Diplopia 76.65 14.10 68 19241 16775 34920847
Tinnitus 70.03 14.10 70 19239 20048 34917574
Rash papular 68.90 14.10 52 19257 10226 34927396
Amnesia 68.77 14.10 79 19230 26484 34911138
Migraine 64.90 14.10 63 19246 17415 34920207
Dry skin 61.52 14.10 81 19228 31206 34906416
Drug ineffective 58.51 14.10 102 19207 456649 34480973
Disturbance in attention 57.03 14.10 71 19238 25874 34911748
Coronary artery disease 56.31 14.10 98 19211 48207 34889415
Alopecia 54.10 14.10 67 19242 24288 34913334
Acute myocardial infarction 52.52 14.10 101 19208 53618 34884004
Blood glucose increased 51.74 14.10 114 19195 66604 34871018
Cognitive disorder 51.40 14.10 71 19238 28622 34909000
Palpitations 50.40 14.10 84 19225 39902 34897720
Silent myocardial infarction 48.28 14.10 15 19294 391 34937231
Angioedema 47.75 14.10 79 19230 37295 34900327
Dizziness 45.34 14.10 239 19070 218282 34719340
Angina unstable 45.14 14.10 43 19266 11610 34926012
Visual impairment 44.83 14.10 75 19234 35727 34901895
Hallucination 43.37 14.10 91 19218 51407 34886215
Feeling abnormal 41.29 14.10 101 19208 63134 34874488
Abdominal discomfort 40.59 14.10 97 19212 59738 34877884
Heart rate increased 40.32 14.10 83 19226 46260 34891362
Hyperhidrosis 36.42 14.10 108 19201 75584 34862038
Myocardial ischaemia 35.65 14.10 46 19263 17362 34920260
Memory impairment 33.54 14.10 74 19235 43244 34894378
Toxic epidermal necrolysis 33.53 14.10 50 19259 21596 34916026
Angina pectoris 33.16 14.10 61 19248 31302 34906320
Dehydration 31.75 14.10 149 19160 129820 34807802
Drug abuse 29.54 14.10 9 19300 99087 34838535
Muscular weakness 29.52 14.10 98 19211 72799 34864823
Cutaneous lupus erythematosus 28.51 14.10 12 19297 758 34936864
Off label use 26.86 14.10 130 19179 419394 34518228
Febrile neutropenia 26.51 14.10 22 19287 136827 34800795
Prinzmetal angina 25.28 14.10 12 19297 1007 34936615
Product use in unapproved indication 25.19 14.10 17 19292 117482 34820140
Intentional product misuse 24.76 14.10 68 19241 45543 34892079
Toxicity to various agents 24.40 14.10 46 19263 200316 34737306
Cardiac failure 24.03 14.10 107 19202 91141 34846481
Hypotension 22.76 14.10 204 19105 221445 34716177
Coronary artery occlusion 22.49 14.10 29 19280 10933 34926689
Dyspnoea 21.51 14.10 309 19000 376473 34561149
Coma uraemic 21.33 14.10 5 19304 42 34937580
Peripheral swelling 21.10 14.10 91 19218 76450 34861172
Bleeding time prolonged 20.25 14.10 9 19300 649 34936973
Neutropenia 19.07 14.10 36 19273 156742 34780880
Abdominal pain upper 18.94 14.10 84 19225 71406 34866216
Arteriospasm coronary 18.12 14.10 15 19294 3367 34934255
Chronic kidney disease 18.12 14.10 57 19252 41153 34896469
Oesophageal ulcer haemorrhage 17.91 14.10 6 19303 200 34937422
Bradycardia 16.62 14.10 84 19225 75334 34862288
Anxiety 16.13 14.10 102 19207 99326 34838296
Ischaemia 16.05 14.10 16 19293 4564 34933058
Completed suicide 15.33 14.10 19 19290 98149 34839473
Insomnia 15.27 14.10 104 19205 103803 34833819
Pulmonary oedema 15.06 14.10 59 19250 47470 34890152
Syncope 14.94 14.10 94 19215 91357 34846265

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiospasm 383.90 12.96 111 31359 3190 79709728
Palmoplantar keratoderma 366.59 12.96 110 31360 3606 79709312
Sleep terror 342.72 12.96 109 31361 4349 79708569
Pruritus genital 342.05 12.96 109 31361 4377 79708541
Myocardial infarction 341.28 12.96 391 31079 183738 79529180
Atrial tachycardia 310.96 12.96 114 31356 7019 79705899
Carotid artery occlusion 303.23 12.96 114 31356 7533 79705385
Tension headache 302.38 12.96 112 31358 7099 79705819
Anosmia 280.16 12.96 112 31358 8732 79704186
Subarachnoid haemorrhage 263.23 12.96 147 31323 24318 79688600
Facial pain 250.43 12.96 114 31356 12236 79700682
Immunisation 248.12 12.96 72 31398 2095 79710823
Cardiac failure congestive 226.66 12.96 280 31190 142122 79570796
Pain of skin 223.22 12.96 111 31359 14502 79698416
Eye pruritus 187.61 12.96 111 31359 20459 79692459
Ventricular tachycardia 186.52 12.96 145 31325 41790 79671128
Vasculitis 181.96 12.96 117 31353 24985 79687933
Blindness 180.74 12.96 122 31348 28261 79684657
Muscle twitching 176.00 12.96 114 31356 24650 79688268
Transient ischaemic attack 169.43 12.96 151 31319 52544 79660374
Chest pain 164.13 12.96 351 31119 281953 79430965
Diplopia 151.61 12.96 117 31353 33349 79679569
Lip swelling 141.06 12.96 122 31348 40789 79672129
Amnesia 121.77 12.96 137 31333 62920 79649998
Hallucination 121.11 12.96 159 31311 85586 79627332
Tinnitus 121.08 12.96 116 31354 44217 79668701
Disturbance in attention 120.35 12.96 123 31347 50678 79662240
Blood glucose increased 117.88 12.96 183 31287 114792 79598126
Rash papular 115.70 12.96 84 31386 21832 79691086
Drug ineffective 105.95 12.96 165 31305 1080748 78632170
Dry skin 105.31 12.96 132 31338 67863 79645055
Angioedema 101.23 12.96 137 31333 75898 79637020
Coronary artery disease 99.64 12.96 126 31344 65348 79647570
Intentional product misuse 98.27 12.96 152 31318 95013 79617905
Acute myocardial infarction 90.92 12.96 131 31339 76905 79636013
Cognitive disorder 88.57 12.96 123 31347 69803 79643115
Visual impairment 85.28 12.96 140 31330 91991 79620927
Angina unstable 84.19 12.96 62 31408 16465 79696453
Hyperhidrosis 75.12 12.96 177 31293 151315 79561603
Dehydration 73.37 12.96 240 31230 247947 79464971
Palpitations 71.76 12.96 156 31314 126454 79586464
Heart rate increased 67.56 12.96 148 31322 120576 79592342
Migraine 66.65 12.96 122 31348 87371 79625547
Myocardial ischaemia 64.47 12.96 64 31406 25455 79687463
Joint swelling 62.85 12.96 18 31452 288628 79424290
Infusion related reaction 58.90 12.96 10 31460 230227 79482691
Muscular weakness 57.30 12.96 166 31304 160563 79552355
Silent myocardial infarction 56.62 12.96 18 31452 716 79712202
Treatment failure 55.02 12.96 3 31467 170483 79542435
Bradycardia 53.21 12.96 145 31325 135412 79577506
Drug intolerance 53.01 12.96 19 31451 264100 79448818
Feeling abnormal 52.55 12.96 160 31310 159039 79553879
Memory impairment 51.55 12.96 127 31343 111607 79601311
Angina pectoris 51.11 12.96 81 31389 51651 79661267
Dizziness 49.99 12.96 367 31103 526074 79186844
Rheumatoid arthritis 49.22 12.96 11 31459 208459 79504459
Arthropathy 44.62 12.96 8 31462 177103 79535815
Generalised bullous fixed drug eruption 43.67 12.96 11 31459 184 79712734
Pericarditis 43.42 12.96 114 31356 104122 79608796
Nasopharyngitis 41.99 12.96 24 31446 253857 79459061
Tachycardia 38.94 12.96 156 31314 177612 79535306
Arteriospasm coronary 38.33 12.96 27 31443 6689 79706229
Swelling 36.53 12.96 20 31450 216691 79496227
Therapeutic product effect decreased 36.05 12.96 10 31460 163853 79549065
Cardiac failure 35.62 12.96 138 31332 154704 79558214
COVID-19 33.44 12.96 137 31333 157537 79555381
Product use issue 33.05 12.96 21 31449 209801 79503117
Toxic epidermal necrolysis 32.47 12.96 61 31409 44520 79668398
Prinzmetal angina 32.12 12.96 15 31455 1705 79711213
Hepatic enzyme increased 32.04 12.96 16 31454 182594 79530324
Renal failure 31.70 12.96 160 31310 200808 79512110
Systemic lupus erythematosus 31.55 12.96 5 31465 121144 79591774
Febrile neutropenia 31.37 12.96 27 31443 230972 79481946
Coronary artery occlusion 30.79 12.96 34 31436 15281 79697637
Maternal exposure during pregnancy 30.66 12.96 8 31462 136530 79576388
Anxiety 30.60 12.96 185 31285 248327 79464591
Hypotension 30.48 12.96 286 31184 440031 79272887
Dyspnoea 30.24 12.96 490 30980 856535 78856383
Contraindicated product administered 28.87 12.96 13 31457 157525 79555393
Insomnia 27.37 12.96 178 31292 244992 79467926
Neutropenia 26.97 12.96 45 31425 287665 79425253
Product use in unapproved indication 26.52 12.96 36 31434 250323 79462595
Syncope 26.31 12.96 140 31330 179309 79533609
Off label use 26.06 12.96 231 31239 906984 78805934
Cerebrovascular accident 25.45 12.96 125 31345 155167 79557751
Infection 25.36 12.96 35 31435 241677 79471241
Lower respiratory tract infection 24.73 12.96 10 31460 129210 79583708
Abdominal pain upper 24.07 12.96 161 31309 223658 79489260
Condition aggravated 23.96 12.96 109 31361 501015 79211903
Wound 23.90 12.96 8 31462 116171 79596747
Glossodynia 23.30 12.96 6 31464 103331 79609587
Coma uraemic 22.90 12.96 5 31465 43 79712875
Drug abuse 22.10 12.96 19 31451 162672 79550246
Musculoskeletal stiffness 21.93 12.96 22 31448 174986 79537932
Ischaemia 21.79 12.96 21 31449 8054 79704864
Cutaneous lupus erythematosus 21.76 12.96 14 31456 2989 79709929
Rhabdomyolysis 21.37 12.96 89 31381 103042 79609876
Acute coronary syndrome 20.74 12.96 33 31437 21100 79691818
Ischaemic cardiomyopathy 20.74 12.96 20 31450 7675 79705243
Cardiac disorder 20.66 12.96 65 31405 65692 79647226
Chronic kidney disease 20.42 12.96 65 31405 66089 79646829
Hypersensitivity 20.24 12.96 46 31424 262193 79450725
Neuropathy peripheral 19.81 12.96 16 31454 141289 79571629
Electrocardiogram ST segment elevation 19.27 12.96 20 31450 8377 79704541
Drug interaction 19.18 12.96 249 31221 414934 79297984
Therapeutic product effect incomplete 18.69 12.96 17 31453 141628 79571290
Mesenteric arterial occlusion 18.68 12.96 6 31464 247 79712671
Psoriatic arthropathy 18.63 12.96 4 31466 77995 79634923
Delirium 18.30 12.96 74 31396 84553 79628365
Weight increased 18.08 12.96 53 31417 277333 79435585
Discomfort 17.89 12.96 14 31456 125603 79587315
Drug hypersensitivity 17.46 12.96 60 31410 298856 79414062
Bleeding time prolonged 17.42 12.96 9 31461 1272 79711646
Coronary artery stenosis 17.37 12.96 23 31447 12461 79700457
Intentional product use issue 16.69 12.96 110 31360 152002 79560916
Pulmonary oedema 16.62 12.96 74 31396 88180 79624738
Pulseless electrical activity 16.57 12.96 24 31446 14136 79698782
Sinusitis 16.16 12.96 33 31437 195468 79517450
Helicobacter infection 15.80 12.96 4 31466 69700 79643218
Renal hypoplasia 15.50 12.96 3 31467 13 79712905
Toxicity to various agents 15.02 12.96 101 31369 421439 79291479
Impaired healing 14.89 12.96 8 31462 87647 79625271
Myopathy 14.80 12.96 28 31442 20535 79692383
Peripheral vascular disorder 14.73 12.96 17 31453 8013 79704905
Left ventricular hypertrophy 14.63 12.96 20 31450 11171 79701747
Gastrointestinal haemorrhage 14.53 12.96 104 31366 147615 79565303
Blood urea increased 14.21 12.96 47 31423 48743 79664175
Blood pressure decreased 14.16 12.96 77 31393 99389 79613529
Inflammation 13.93 12.96 10 31460 93743 79619175
Cardiac failure acute 13.90 12.96 26 31444 18903 79694015
General physical health deterioration 13.65 12.96 59 31411 275179 79437739
Ephelides 13.60 12.96 4 31466 122 79712796
Exposure during pregnancy 13.50 12.96 12 31458 101120 79611798
Oesophageal ulcer haemorrhage 13.49 12.96 6 31464 609 79712309
Back pain 13.43 12.96 181 31289 303999 79408919
Inappropriate schedule of product administration 13.36 12.96 20 31450 133608 79579310
Hypovolaemic shock 13.21 12.96 20 31450 12256 79700662
Coronary arterial stent insertion 13.16 12.96 14 31456 6030 79706888
Lip erosion 13.13 12.96 8 31462 1552 79711366

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D004232 Diuretics
MeSH PA D004234 Diuretics, Osmotic
MeSH PA D045283 Natriuretic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ocular hypertension indication 4210003 DOID:9282




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018584 VUID
N0000146900 NUI
D00347 KEGG_DRUG
4018584 VANDF
C0022251 UMLSCUI
CHEBI:6060 CHEBI
CHEMBL1200660 ChEMBL_ID
DB09401 DRUGBANK_ID
D007547 MESH_DESCRIPTOR_UI
5780 PUBCHEM_CID
6433 INN_ID
WXR179L51S UNII
6057 RXNORM
4933 MMSL
d00653 MMSL
000687 NDDF
108478001 SNOMEDCT_US
386853004 SNOMEDCT_US

Pharmaceutical products:

None