indalpine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
tricyclic compounds	1432	63758-79-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

indalpine hydrochloride
LM 50084
indalpine
lipstene
upstene
indalpine HCl

selective 5-hydroxytryptamine uptake inhibitor; RN given refers to parent cpd

Molecular weight: 228.34
Formula: C15H20N2
CLOGP: 3.39
LIPINSKI: 0
HAC: 2
HDO: 2
TPSA: 27.82
ALOGS: -4.26
ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000928	Antidepressive Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D014179	Neurotransmitter Uptake Inhibitors
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D017367	Selective Serotonin Reuptake Inhibitors
MeSH PA	D018490	Serotonin Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.13	acidic
pKa2	10.41	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium-dependent serotonin transporter	Transporter		SC6A4_RAT		Ki	8.70		CHEMBL

External reference:

ID	Source
C0063448	UMLSCUI
CHEBI:134939	CHEBI
CHEMBL276520	ChEMBL_ID
DB08953	DRUGBANK_ID
44668	PUBCHEM_CID
C018181	MESH_SUPPLEMENTAL_RECORD_UI
4612	INN_ID
V35562QSVT	UNII

Pharmaceutical products:

None